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Enhanced nitrite electroreduction to ammonia via interfacial dual-site adsorption

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Journal of Energy Chemistry 2024年第9期96卷 328-335页

作者： Xiaokang Chen Shengliang Zhai Yi Tan le su Dong Zhai Wei-Qiao Deng Hao Wu Institute of Frontier Chemistry School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266071ShandongChina College of Physics and Information Engineering Shanxi Normal UniversityTaiyuan 030031ShanxiChina suzhou Research Institute of Shandong University Suzhou 215123JiangsuChina

The nitrite(NO_(2)^(−))to ammonia(NH3)electroreduction reaction(NO_(2)^(−)RR)would be impeded by sluggish proton-coupled electron transfer kinetics and competitive hydrogen evolution reaction(HER).A key to improving the NH_(3) selectivity is to facilitate adsorption and activation of NO_(2)^(−),which is generally undesirable in unitary *** this work,an efficient NO_(2)^(−)RR catalyst is constructed by cooperating Pd with In2O3,in which NO_(2)^(−)could adsorb on interfacial dual-site through“Pd–N–O–In”linkage,leading to strengthened NO_(2)^(−)adsorption and easier N=O bond cleavage than that on unitary Pd or ***,the Pd/In_(2)O_(3)composite exhibits moderate H^(*)adsorption,which may facilitate protonation kinetics while inhibiting competitive *** a result,it exhibits a fairly high NH_(3)yield rate of 622.76 mmol h^(−1)g^(−1)cat with a Faradaic efficiency(FE)of 95.72%,good selectivity of 91.96%,and cycling stability towards the NO_(2)^(−)RR,surpassing unitary In_(2)O_(3)and Pd/C ***,computed results indicate that NH_(3)production on Pd/In_(2)O_(3)follows the deoxidation to hydrogenation *** work highlights the significance of H^(*)and NO_(2)^(−)adsorption modulation and N=O activation in NO_(2)^(−)RR electrochemistry by creating synergy between a mediocre catalyst with an appropriate cooperator.

关键词： Dual-site adsorption Nitrite electroreduction Ammonia Pd Hydrogenation

Five-in-one: a novel, cost-effective yet simple use of micro needle holder

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International Journal of Ophthalmology(English edition) 2022年第4期15卷 657-660页

作者： Ning Gao Jia-Li Zhu An-le su Lie-Ling Kou Zhao Liu Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Ophthalmology Yulin No.2 HospitalYulin 719000Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina Department of Ophthalmology Ankang Hospital of Traditional Chinese MedicineAnkang 725000Shaanxi ProvinceChina

AIM: To achieve a balance between efficiency and cost in the management of medical instrument by the use of micro needle holder. METHODS: In this study, the novel multifunctional use of micro needle holders was performed between 2018 and 2019 at the Department of Ophthalmology in the 4 hospitals in Shaanxi Province. In this innovation, the micro needle holders were initially used as micro forceps to remove sutures, as eye spud to safety extract foreign body from cornea, as ciliary forceps to remove trichiasis, as well as punctal dilator to dilate most small puncta. REsuLTS: Using this technique, the medical costs of both procurement and sterilization were cut off in the selected 4 hospitals. The purchase cost has dropped by roughly 50%. The sterilization cost was decreased by about 30%. CONCLUSION: The innovation in the five-in-one multifunctional use of micro needle holders saves the medical costs.

关键词： micro needle holder medical instrument ocular surgical instruments

Highly Efficient Base Editing in Viral Genome Based on Bacterial Artificial Chromosome Using a Cas9-Cytidine Deaminase Fused Protein

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Virologica Sinica 2020年第2期35卷 191-199页

作者： Ke Zheng Fang-Fang Jiang le su Xin Wang Yu-Xin Chen Huan-Chun Chen Zheng-Fei Liu State Key Laboratory of Agricultural Microbiology and Key Laboratory of Preventive Veterinary Medicine in Hubei Province.College of Veterinary Medicine.Huazhong Agricultural University Wuhan 430070China Gene Editing Research Center Hebei University of Science and Technology.Shijiazhuang 050018China

Viruses evolve rapidly and continuously threaten animal health and economy,posing a great demand for rapid and efficient genome editing technologies to study virulence mechanism and develop effective *** present a highly efficient viral genome manipulation method using CRISPR-guided cytidine *** cloned pseudorabies virus genome into bacterial artificial chromosome,and used CRISPR-guided cytidine deaminase to directly convert cytidine(C)to uridine(U)to induce premature stop mutagenesis in viral *** editing efficiencies were 100%.Comprehensive bioinformatic analysis revealed that a large number of editable sites exist in pseudorabies virus(PRV)***,in our study viral genome exists as a plasmid in ***,suggesting that this method is virus *** application of base-editing provided an alternative approach to generate mutant virus and might accelerate study on virulence and vaccine development.

关键词： Pseudorabies virus(PRV) Bacterial artificial chromosome(BAC) Base-editing CRISPR7Cas9 Genome editing

Is Marcus Gunn jaw winking a primitive reflex？ Rat neuroanatomy

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 382-388页

作者： Hou-Cheng Liang Jing-Dong Zhang Pi-Fu Luo Ying Qiao An-le su Ying Zhang Hong-Na Zhu Xi'an BRIGHT Eye Hospital Xi'an 710068 Shaanxi Province China Department of Ophthalmology the Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital) Xi'an 710002 Shaanxi Province China Shaanxi Provincial Eye Research Institute and Xi'an Eye Hospital Xi'an 710002 Shaanxi Province China Department of Anesthesiology University of Cincinnati College of Medicine Cincinnati 45267 OH USA Department of Pathology King Med Diagnostics Intemational Bioisland Guangzhou 510050 Guangdong Province China

AIM： To investigate a possible trigeminal proprioceptive- oculomotor neural pathway and explore possible synaptic connections between neurons in this pathway. Attempt to bring a new insight to mechanism of Marcus Gunn syndrome （MGS）. METHODS： Anterograde and retrograde tract tracing was applied and combined with immunofluorescent stain in rats. After electrophysiological identifying mesencephalic trigeminal nucleus （Vine） neurons, intracellular injection of tracer was performed to trace axon trajectory. REsuLTS： Following injections of anterograde tracers into the Vine, labeled terminals were observed ipsilateral in oculomotor and trochlear nuclei （Ill/IV）, as well as in their premotor neurons in interstitial nucleus of Cajal and Darkschewitsch nucleus （INC/DN）. Combining with choline acetyltransferase （CHAT） immunofluorescent stain, it showed that Vme projecting terminals contact upon ChAT positive Ill/IV motoneurons under confocal microscope. By retrograde labeling premotor neurons of the III, it showed that Vme neuronal terminals contact with retrogradely labeled pre-oculomotor neurons in the INCIDN. Axons of intraceiiularly labeled Vme neurons that respond to electric stimuli of the masseter nerve traveled into the ipsilateral III. CONCLUSION： There may exist a trigeminal propdoceptive- oculomotor system neural circuit in the rat, which is probably related to vertical-torsional eye movements. Possible association of this pathway with MGS etiology was discussed.

关键词： mesencephalic trigeminal nucleus oculomotorand trochlear nuclei interstitial nucleus of Cajal and Darkschewitsch nucleus anterograde and retrograde tract tracing intracellular tract tracing

Is there a primitive reflex residue underlying Marcus Gunn Syndrome? Rat electrophysiology

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 29-35页

作者： Ying Qiao Hou-Cheng Liang Jing-Dong Zhang Pi-Fu Luo An-le su Ting Zhang Hong-Na Zhu Xi’an First Hospital Key Clinic Ophthalmology LabShaanxi Province Eye Research InstituteXi’an 710002Shaanxi ProvinceChina Xi’an BRIGHT Eye Hospital 234 West Youyi RoadXi’an 710068Shaanxi ProvinceChina Department of Ophthalmology Affiliated HospitalXi’an Jiaotong UniversityXi’an 710002Shaanxi ProvinceChina Department of Pathology University of Iowa College of MedicineIowa CityIA 52242USA

AIM: To make an electrophysiological demonstration of a possible jaw muscle afferents-oculomotor neural pathway that was proposed by our previous works on rats, which substantiates an early "release hypothesis" on pathogenesis of human Marcus Gunn Syndrome(MGS). METHODS: Extracellular unit discharge recording was applied and both orthodromic and spontaneous unitary firing were recorded in the oculomotor nucleus(III), and the complex of pre-oculomotor interstitial nucleus of Cajal and Darkschewitsch nucleus(INC/DN), following electric stimulation of the ipsilateral masseter nerve(MN) in rats. REsuLTS: Extracellular orthodromic unit discharges, with latencies of 3.7±1.3 and 4.7±2.9 ms, were recorded unilaterally in the III, and the INC/DN neurons, respectively. Spontaneous unit discharges were also recorded mostly in the INC/DN and less frequently in the III. Train stimulation could prompt either facilitation or inhibition on those spontaneous unit discharges. The inhibition pattern of train stimulation on the spontaneous discharging was rather different in the III and INC/DN. A slow inhibitory pattern in which spontaneous firing rate decreased further and further following repeated train stimulation was observed in the III. While, some high spontaneous firing rate units, responding promptly to the train stimuli with a short-term inhibition and recovered quickly when stimuli are off, were recorded in the INC/DN. However, orthodromic unit discharge was not recorded in the III and INC/DN in a considerable number of experiment animals. CONCLUSION: A residual neuronal circuit might exist in mammals for the primitive jaw-eyelid reflex observed in amphibians, which might not be well-developed in all experimental mammals in current study. Nonetheless, this pathway can be still considered as a neuroanatomic substrate for development of MGS in some cases among all MGS with different kind of etiology.

关键词： masseter nerve single unit discharge oculomotor nucleus pre-oculomotor neurons interstitial nucleus of Cajal/Darkschewitsch nucleus Marcus Gunn Syndrome

Uveal effusion following acute primary angle-closure:a retrospective case series

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 406-412页

作者： Jian-Gang Yang Jian-Jun Li Hua Tian Yan-Hong Li Yu-Jing Gong An-le su Na He Xi’an Eye Hospital Xi’an First Hospital Department of Ophthalmology Xian XD Group Hospital Department of Ophthalmology the Second Affiliated Hospital of Xi’an Jiaotong University

AIM：To evaluate the morphological changes in anterior segment in Chinese patients with uveal effusion（UE）after the attack of acute primary angle-closure（APAC）using ultrasound biomicroscopy（UBM）,and to assess the clinical course and prognosis of the ***：In a retrospective case series,26 eyes in 26 consecutive patients diagnosed with UE after the treatment of intraocular pressure（IOP）-lowering medication for the attack of APAC were enrolled. The unaffected fellow eyes served as controls. The morphological changes were observed by ultrasonography,slit lamp microscopy and gonioscopy. UBM was used to assess the degree and extent of effusion based on the analysis of parameters associated with ***：The mean IOP was 9.2（SD 2.1）mm Hg at the diagnosis of UE after IOP-lowering medication,while 14.1（SD,2.6）mm Hg in the fellow eyes（P=0.000）. The anterior chamber depth（ACD）（P=0.000）,angle opening distance at 500 μm（AOD500）（P〈0.01）and anterior chamber angle（ACA）（P〈0.05）were decreased significantly,while ciliary body thickness（CBT）（P〈0.05）increased significantly in UE eyes. UE grade analysis showed 7 eyes in grade 1,9 eyes in grade 2,and 10 eyes in grade 3. Quadrant scores were performed of 4 eyes in 1 quadrant,3 eyes in 3 quadrants,and 19 eyes in 4 quadrants. There was the positive correlation between grade and quadrant score（R=0.644,P=0.000）. The effusion on all eyes were recovered after medication,which mean IOP was 13.9（SD,2.8）mm ***：UE is a frequent complication in Chinese patients after the attack of APAC,partially associated with hypotony. The severity of UE is correlation with height of effusion,extent of detachment,and shallower ACD.

关键词： uveal effusion acute primary angle-closure intraocular pressure ultrasound biomicroscopy

Phospho-proteomics identifies a critical role of ATF2 in pseudorabies virus replication

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Virologica Sinica 2022年第4期37卷 591-600页

作者： Fang-Fang Jiang Ren-Qi Wang Chao-Yue Guo Ke Zheng Hai-Long Liu le su Sheng-Song Xie Huan-Chun Chen Zheng-Fei Liu State Key Laboratory of Agricultural Microbiology Hongshan Laboratory and Key laboratory of Preventive Veterinary Medicine in Hubei ProvinceCollege of Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China Key Lab of Agricultural Animal Genetics Breedingand Reproduction of Ministry of EducationHuazhong Agricultural UniversityWuhan430070China

Pseudorabies virus(PRV),an etiological agent of pseudorabies in livestock,has negatively affected the porcine industry all over the *** cells are reported as the first site of PRV ***,the role of host proteins and its related signaling pathways in PRV replication is largely *** this study,we performed a quantitative phosphoproteomics screening on PRV-infected porcine kidney(PK-15)epithelial *** 5723phosphopeptides,corresponding to 2180 proteins,were obtained,and the phosphorylated states of 810 proteins were significantly different in PRV-infected cells compared with mock-infected cells(Pled that these differentially expressed phosphorylated proteins were predominantly related to RNA transport and MAPK signaling *** functional studies of NF-κB,transcription activator factor-2(ATF2),MAX and SOS genes in MAPK signaling pathway were analyzed using RNA interference(RNAi)*** showed that only ATF2-knockdown reduces both PRV titer and viral genome copy *** pathway inhibition and CRISPR/Cas9 gene knockout showed that ATF2 was required for the effective replication of PRV,especially during the biogenesis of viral genome ***,by overexpression of the ATF2 gene and point mutation of the amino acid positions 69/71 of ATF2,it was further demonstrated that the phosphorylation of ATF2 promoted PRV *** findings suggest that ATF2 may provide potential therapeutic target for inhibiting PRV infection.

关键词： Pseudorabies virus(PRV) Transcription activator factor-2(ATF2) iTRAQ Proteomics Phosphorylation

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双馈风电并网系统的宽频振荡机理分析与抑制

电力系统保护与控制 2023年第12期51卷 1-13页

作者：程静苏乐岳雷可再生能源发电与并网控制教育部工程研究中心(新疆大学) 新疆乌鲁木齐830017 新疆铁道勘察设计院有限公司新疆乌鲁木齐830011

电力系统振荡失稳严重威胁其安全稳定运行,在“双碳”目标和能源转型的推动下,风电并网使新型电力系统的振荡稳定性问题加剧。综合考虑传动系统、风机变换器、锁相环、串联补偿等电力系统各部分,建立了双馈风电并网系统的精确化综合模... 详细信息

电力系统振荡失稳严重威胁其安全稳定运行,在“双碳”目标和能源转型的推动下,风电并网使新型电力系统的振荡稳定性问题加剧。综合考虑传动系统、风机变换器、锁相环、串联补偿等电力系统各部分,建立了双馈风电并网系统的精确化综合模型。在此基础上,基于模式分析法分析系统振荡模式与参与因子关系特性,确定引发系统振荡模式的强相关状态变量和主导因素,探究双馈风电并网电力系统的宽频振荡机理,并寻找振荡抑制方法。与传统模型相对比,并在Matlab软件平台进行仿真分析与验证。结果表明:所建模型及机理分析方法以更多的状态变量表征了更丰富的振荡模式信息,更详尽地解释了系统宽频振荡机理,并能有效消除振荡,提高系统阻尼,提升系统稳定性,为进一步研究和开发电力系统宽频振荡检测和抑制方法奠定理论基础。

关键词：宽频振荡机理分析综合模型模式分析电力系统双馈风电并网

Delivery room resuscitation intensity and associated neonatal outcomes of 24^(+0)-31^(+6) weeks'preterm infants in China:a retrospective cross-sectional study

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World Journal of Pediatrics 2024年第1期20卷 64-72页

作者： Si-Lu Wang Chun Chen Xin-Yue Gu Zhao-Qing Yin le su Si-Yuan Jiang Yun Cao Li-Zhong Du Jian-Hua sun Jiang-Qin Liu Chuan-Zhong Yang Department of Neonatology Shanghai Key Laboratory of Maternal Fetal MedicineShanghai Institute of Maternal-Fetal Medicine and Gynecologic OncologyShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityNo.2699Gaoke Western RoadPudong DistrictShanghai 201204China Department of Neonatology Affiliated Shenzhen Maternity and Child Healthcare HospitalSouthern Medical UniversityNo.2004Hongli RoadFutian DistrictShenzhen 518028China NHC Key Laboratory of Neonatal Diseases Fudan UniversityChildren's Hospital of Fudan UniversityShanghaiChina Department of Neonatology People's Hospital of DehongKunming Medical UniversityDehongChina Department of Neonatology Children's Hospital of Fudan UniversityShanghaiChina Department of Neonatology Children's HospitalZhejiang University School of MedicineHangzhouChina Department of Neonatology Shanghai Children's Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background The aim of this study was to review current delivery room(DR)resuscitation intensity in Chinese tertiary neonatal intensive care units and to investigate the association between DR resuscitation intensity and short-term outcomes in preterm infants born at 24+0_31+6 weeks gestation age(GA).Methods This was a retrospective cross-sectional *** source population was infants born at 24+0_31+6 weeks'GA who were enrolled in the Chinese Neonatal Network 2019 *** infants were categorized into five groups:(1)regular care;(2)oxygen supplementation and/or continuous positive airway pressure(O2/CPAP);(3)mask ventilation;(4)endotracheal intubation;and(5)cardiopulmonary resuscitation(CPR).The association between DR resuscitation and shortterm outcomes was evaluated by inverse propensity score-weighted logistic *** Of 7939 infants included in this cohort,2419(30.5%)received regular care,1994(25.1%)received O,/CPAP,1436(18.1%)received mask ventilation,1769(22.3%)received endotracheal intubation,and 321(4.0%)received CPR in the *** maternal age and maternal hypertension correlated with a higher need for resuscitation,and antenatal steroid use tended to be associated with a lower need for resuscitation(Psuscitation in DR after adjusting for perinatal *** strategies vary widely between centers,with over 50%of preterm infants in eight centers requiring higher intensity *** Increased intensity of DR interventions was associated with increased mortality and morbidities in very preterm infants in *** is wide variation in resuscitative approaches across delivery centers,and ongoing quality improvement to standardize resuscitation practices is needed.

关键词： Cardiopulmonary resuscitation Delivery room Endotracheal intubation Neonatal resuscitation Preterm