检索结果-南通市图书馆

Reversal of idiopathic hypogonadotropic hypogonadism： a cohort study in Chinese patients

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2015年第3期17卷 497-502页

作者： Jiang-Feng Mao Hong-Li Xu Jin Duan Rong-Rong Chen Li Li Bin Li min Nie le min Hong-Bing Zhang Xue-Yan Wu Department of Endocrinology Peking Union Medical College Hospital Key Laboratory of Endocrinology Ministry of Health Beijing 100730 China Department of Physiology State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences and School of Basic Medicine Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100005 China Beijing Genomics Institute at Shenzhen Shenzhen 518083 China Division of Endocrinology Diabetes and Hypertension Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA

Although idiopathic hypogonadotropic hypogonadism （IHH） has traditionally been viewed as a life-long disease caused by a deficiency of gonadotropin-releasing hormone neurons, a portion of patients may gradually regain normal reproductive axis function during hormonal replacement therapy. The predictive factors for potential IHH reversal are largely unknown. The aim of our study was to investigate the incidence and clinical features of IHH male patients who had reversed reproductive axis function. In this retrospective cohort study, male IHH patients were classified into a reversal group （n = 18） and a nonreversal group （n = 336）. Concentration of gonadotropins and testosterone, as well as testicle sizes and sperm counts, were determined. Of 354 IHH patients, 18 （5.1%） acquired normal reproductive function during treatment. The median age for reversal was 24 years old （range 21-34 years）. Compared with the nonreversal group, the reversible group had higher basal luteinizing hormone （LH）（1,0±0.7 IU 1-1 vs 0.4±0.4 IU 1-1, P 〈 0.05） and stimulated LH （28.3 ± 22.6 IU 1-1 vs 1.9 ±1.1 IU 1-1, P 〈 0.01） levels, as well as larger testicle size （5.1 ±2.6 ml vs 1.5± 0.3 ml, P〈 0.01）, at the initial visit. In summary, larger testicle size and higher stimulated LH concentrations are favorite parameters for reversal. Our finding suggests that reversible patients may retain partially active reproductive axis function at initial diagnosis.

关键词： hypothalamic-pituitary-gonadal axis idiopathic hypogonadotropic hypogonadism reversal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

最小一乘法在岩土地基沉降中的应用

岩土力学 2016年第8期37卷 2366-2372页

作者：顾乐民同济大学材料科学与工程学院上海200092

最小一乘法是一个既古典又新颖的方法,随着最小一乘解的实现问题近年来有大的突破,一些最小二乘法所不具有的优良特性,如直观性、稳健性、零误差性、可预测性、广义性等逐渐显现。最小一乘逼近是最小绝对值误差极小化的逼近,也称为"极... 详细信息

最小一乘法是一个既古典又新颖的方法,随着最小一乘解的实现问题近年来有大的突破,一些最小二乘法所不具有的优良特性,如直观性、稳健性、零误差性、可预测性、广义性等逐渐显现。最小一乘逼近是最小绝对值误差极小化的逼近,也称为"极小极小"逼近,由于极小极小逼近的最佳结果一定是零,所以零误差原理是最小一乘法的基本原理。最小一乘解是通过"代表式"的数据处理方式来实现的,由于排除了大误差数据的干扰,使最小一乘法具有较好的稳健性。而代表数据可按不同的应用而选择并确定,使应用具有了广泛性。对于预测而言,将端点数据设定为零误差数据,使数据的权重不再相等,而是往端点方向倾斜,端点数据具有最大的权重,且建立在无误差的基点上,这使得预测理论与模式变得合理,使预测的准确性得到保证。文中通过3个工程实例,介绍了最小一乘法在探索岩石或软土地基在沉降过程中的应用,其结果与最小二乘法的进行了比较,通过分析后给出如下主要结论:(1)最小一乘法的数据处理稳定性较好,波动幅度较小,预测结果较准;(2)一般不会出现最小二乘法数据处理中的矛盾及不合理的现象;(3)虽然时间t→∞的极限下沉量具有不可验证性,但最小一乘法的预测是建立在无误差的基点上,比最小二乘法的预测建立在有误差的基点上合理,加上有较好的稳健性,其结果更具参考性。

关键词：最小一乘法曲线拟合沉降预测

Unique cytologic features of thyroiditis caused by immune checkpoint inhibitor therapy for malignant melanoma

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2018年第1期5卷 46-48页

作者： Trevor E.Angell le min Tad J.Wieczorek F.Stephen Hodi Division of Endocrinology Diabetesand HypertensionBrigham and Women’s HospitalBostonMAUSA Department of Pathology Brigham and Women’s HospitalBostonMAUSA Department of Medical Oncology Dana-Farber Cancer InstituteBostonMAUSA

Blockade of immune checkpoint molecules to reverse cancer-induced immune suppression can improve anti-tumor immune responses in cancer *** antibodies targeting two such molecules,Programmed cell death protein 1(PD-1)and cytotoxic T-lymphocyte associated protein 4(CTLA-4)have shown clinical benefit in the treatment of advanced malignancies,including metastatic *** effects of these immune checkpoint inhibitors include immune-related adverse events(irAE),of which one of the most common is autoimmune *** thyroiditis is increasingly recognized,there are no reports of the pathological findings that occur in immunotherapy-induced *** present a case of immunotherapy-induced thyroiditis demonstrating its unique cytopathologic features.A 51-year-old woman with metastatic melanoma was found to have a suppressed TSH and elevated free thyroxine concentration 14 days after starting treatment with nivolumab(PD-1 antagonist)plus ipilimumab(CTLA-4 antagonist)therapy.A thyroid biopsy was performed based on ultrasound findings and cytopathology revealed unique features including abundant clusters of necrotic cells,lymphocytes and CD163-positive *** case reports cytopathologic features found in immune checkpoint inhibitor related *** appear to be unique findings and may help inform future research regarding the pathophysiology and mechanisms of this condition.

关键词： Thyroiditis PD-1 CTLA-4 Ipilimumab Nivolumab Cytology

Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin therapy in patients with congenital hypogonadotropic hypogonadism

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2017年第6期19卷 680-685页

作者： Jiang-Feng Mao Zhao-Xiang Liu min Nie Xi Wang Hong-Li Xu Bing-Kun Huang Jun-Jie Zheng le min Ursula Brigitte Kaiser Xue-Yan Wu Department of Endocrinology Peking Union Medical College Hospital Key Laboratory of Endocrinology Ministry of Health Beijing 100730 China Internal Department Division of Endocrinology Diabetes and Hypertension Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA.

Both pulsatile gonadotropin-releasing hormone （GnRH） infusion and combined gonadotropin therapy （human chorionic gonadotropin and human menopausal gonadotropin [HCG/HMG]） are effective to induce spermatogenesis in male patients with congenital hypogonadotropic hypogonadism （CH H）. However, evidence is lacking as to which treatment strategy is better. This retrospective cohort study included 202 patients with CHH： twenty had received pulsatile GnRH and 182 had received HCG/HMG. Patients had received therapy for at least 12 months. The total follow-up time was 15.6 ± 5.0 months （range： 12-27 months） for the GnRH group and 28.7 ± 13.0 months （range： 12-66 months） for the HCG/HMG group. The median time to first sperm appearance was 6 months （95% confidence interval [CI]： 1.6-10.4） in the GnRH group versus 18 months （95% Ch 16.4-20.0） in the HCG/HMG group （P〈 0.001）. The median time to achieve sperm concentrations 〉5 x 106 m1-1 was 14 months （95% Ch 5.8-22.2） in the GnRH group versus 27 months （95% Ch 18.9-35.1） in the HCG/HMG group （P 〈 0.001）, and the median time to concentrations 〉10 x 106 m1-1 was 18 months （95% Ch 10.0-26.0） in the GnRH group versus 39 months （95% CI unknown） in the HCG/HMG group. Compared to the GnRH group, the HCG/HMG group required longer treatment periods to achieve testicular sizes of 〉4 ml, 〉8 ml, 〉12 ml, and 〉16 ml. Sperm motility （a ＋ b ＋ c percentage） evaluated in semen samples with concentrations 〉1 × 106 ml-1 was 43.7% ± 20.4% （16 samples） in the GnRH group versus 43.2% ± 18.1% （153 samples） in the HCG/HMG group （P= 0.921）. Notably, during follow-up, the GnRH group had lower serum testosterone levels than the HCG/HMG group （8.3 ±4.6 vs 16.2 ± 8.2 nmol 1-1, P 〈 0.001）. Our study found that pulsatile GnRH therapy was associated with earlier spermatogenesis and larger testicular size compared to combined gonadotropin therapy. Additional prospective randomized studies would be required to confirm these findings.

关键词： combined gonadotropin therapy congenital hypogonadotropic hypogonadism pulsatile GnRH therapy spermatogenesis

A new method to evaluate force constants from experimental spectral data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 1994年第5期12卷 403-413页

作者： LI, le-min LIU, Yi WANG, Xiu-ZhenDepartment of Chemistry, Peking University, Beijing 100871, China Department of Chemistry Peking University Beijing 100871 China

An iterative procedure is proposed to facilitate the determination of molecular vi-brational force constants from the experimental fundamental frequencies. Proper restrictions are introduced to the force constants based on physical considerations for getting reasonable results. The experimental data of Coriolis coupling coefficients and isotopic frequency shifts are utilized to reduce the uncertainty of the calculated force constants when they are available. A series of various kinds of molecules have been calculated by this method and the results are satisfactory.

关键词： Determination of force constants iterative procedure vibrational spectra fundamental frequencies isotopic frequency shifts Coriolis coupling coefficients.

Self-assembly of tau fragments as a key pathologic event in tauopathies

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第12期19卷 2565-2566页

作者： Ly Thi Huong Luu le Jung Hoon lee min Jae lee Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulKorea

Tau protein is encoded by the microtubuleassociated protein tau(MAPT)gene and stabilizes microtubules in the *** has unique biophysical properties that make it both highly water-soluble and positively *** tau is an intrinsically disordered protein lacking defined secondary structures,it can acquire highly organized-sheet structures and stack into a filamentous inclusion such as a paired helical filament(PHF).

关键词： tau pathologic assembly

Expression characteristics of neutrophil and mononuclear-phagocyte related genes mRNA in the stable angina pectoris and acute myocardial infarction stages of coronary artery disease

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2015年第3期12卷 279-286页

作者： Chuan-Rong LI le-min WANG Zhu GONG Jin-Fa JIANG Qiang-Lin DUAN Wen-Wen YAN Xiao-Hui LIU Department of Cardiology Tongji Hospital Tongji University School of Medicine Shanghai China

Objective To investigate expression differences of neutrophil and mononuclear phagocyte related gene mRNAs among acute myocardial infarction （AMI）, stable angina （SA） and control groups, and then discuss their expression characteristics in the stable angina pectoris （SAP） and AMI stages of coronary artery disease （CAD）. Methods Whole Human Genome Oligo Microarrays were applied to assess the differential expression characteristics of neutrophil and mononuclear phagocyte related mRNAs in patients with AMI （n = 20）, SA （n = 20） and controls （n = 20）. Results （1） Almost all colony-stimulating factors （CSF） and their receptors related mRNAs was up-regulated in AMI and SA groups compared with the control group, and the expression of granulocyte-macrophage colony stimulating factor receptor （GM-CSFR） and granulocyte colony stimulating factor receptor （G-CSFR） mRNAs in the AMI group was significantly up-regulated compared with the other two groups （P 〈 0.01）. （2） The expression of mRNAs related to monocyte chemoattractant protein-1 （MCP-1）, CCR2 （MCP-1 receptor） and CXCR2 （IL-8 receptor） was significantly up-regulated （P 〈 0.01） in AMI group compared with SA and control groups IL-8 mRNA expression in the AMI group was clearly higher than the controls （P 〈 0.05）. （3） All mRNAs expression related to opsonic re- ceptors （IgG FoR and C3bR/C4bR） was significantly up-regulated in AMI group compared with SA and control group （P 〈 0.01）, and the SA group showed an upward trend compared with controls. （4） Most pattern recognition receptor （PRR）-related mRNAs expression was up-regulated in AMI group compared with SA and control groups. Most toll-like receptor （TLR） mRNAs expression was significantly up-regulated （P 〈 0.01） than the SA and control groups, macrophage scavenger receptor （MSR） mRNA was significantly up-regulated in AMI group compared with the control group （P 〈 0.01）, and the SA group showed an upward trend compared with the controls. Conclusions The expression of most n

关键词： Acute myocardial infarction Coronary atherosclerosis Mononuclear-macrophage Neutrophil

Acupuncture-moxibustion Theories of Wang Shu-he

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Acupuncture and Tuina Science 2013年第1期11卷 64-66页

作者： le Yi-min Chen Yong Yang Zong-bao Wei jia Hong Jue Jiangxi University of Traditional Chinese Medicine Fuda Cancer Hospital

Wang Shu-he, or Wang Xi, was anoutstanding physician from Gaoping （Gaoping of Shanxi Province; another saying is Ji＇ning of Shandong Province） of Western Jin Dynasty who lived around the 3rd CeIltUi3T His major con... 详细信息

关键词： Acupuncture-Moxibustion Theories Literature Research Points, Fivetransport-Shu Points, Back-Shu Points, Front-Mu Diagnosis (TraditionalChinese medicine) MaiJing

LINC00475在多发性骨髓瘤中的表达与临床意义

在线全文

学校读者我要写书评

暂无评论

中国实验血液学杂志 2024年第3期32卷 789-793页

作者：卢玲郭丹洪乐旻蒋钰雯范洪明黄春群卢金凤陈洁徐宏慧黄红铭南通大学附属医院血液内科江苏南通226001

目的:探讨LINC00475在多发性骨髓瘤(MM)患者血清中的相对表达水平及临床意义。方法:用实时荧光定量PCR技术检测108例MM患者血清及RPMI 8226、NCI-H929、U266、OPM2、CAG这5个MM细胞系中LINC00475的表达情况,受试者工作特征曲线评估其对M... 详细信息

目的:探讨LINC00475在多发性骨髓瘤(MM)患者血清中的相对表达水平及临床意义。方法:用实时荧光定量PCR技术检测108例MM患者血清及RPMI 8226、NCI-H929、U266、OPM2、CAG这5个MM细胞系中LINC00475的表达情况,受试者工作特征曲线评估其对MM的诊断价值,并结合患者的临床资料分析LINC00475与患者临床特征的关系。结果:与健康对照组相比,MM患者血清及MM细胞系中LINC00475的表达明显上调(均P<0.05)。受试者工作特征曲线分析显示,LINC00475的最佳截断值为262.4,曲线下面积为0.924(95%CI:0.884-0.964),灵敏度83.3%,特异度91.7%,表明LINC00475在MM患者中具有良好的评估价值。与LINC00475低表达组的MM患者相比,高表达组的患者具有较高水平的β2-微球蛋白和胱抑素C(均P<0.05),但白蛋白水平较低(P<0.05)。与ISS分期Ⅰ期的MM患者相比,Ⅱ期和Ⅲ期患者LINC00475的表达水平均明显增高(均P<0.05)。结论:检测LINC00475的相对表达水平有助于区分MM患者和正常人群,其相对表达水平与MM患者的β2-微球蛋白、白蛋白、ISS分期等预后指标相关。

关键词：多发性骨髓瘤 LINC00475 长链非编码RNA