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Clinical outcomes of cemented distal femur replacements with allpolyethylene tibial components for oncologic indications

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World Journal of Orthopedics 2023年第4期14卷 218-230页

作者： Alexander B Christ Brian C Chung Matthew Urness Lucas W Mayer Brandon S Gettleman Nathanael DHeckmann lawrence r menendez Department of Orthopedic Surgery Keck School of Medicine of University of Southern CaliforniaLos AngelesCA 90033United States University of South Carolina School of Medicine ColumbiaSC 29209United States

BACKGrOUND Endoprosthetic distal femoral replacement(DFr)is a well-established salvage procedure following resection of malignant tumors within the distal *** of an all-polyethylene tibial(APT)component is cost-effective and avoids failure due to locking-mechanism issues and backside wear,but limits modularity and the option for late liner *** to a paucity of literature we sought to answer three questions:(1)What are the most common modes of implant failure for patients undergoing cemented DFr with APT for oncologic indications?(2)What is the survivorship,rate of all-cause reoperation,and rate of revision for aseptic loosening of these implants?And(3)Is there a difference in implant survivorship or patient demographics between cemented DFrs with APT performed as a primary reconstruction vs those performed as a revision procedure?AIM To assess outcomes of cemented DFrs with APT components used for oncologic *** After Institutional review Board approval,a retrospective review of consecutive patients who underwent DFr between December 2000 to September 2020 was performed using a single-institutional *** criteria consisted of all patients who underwent DFr with a GMrS®(Global Modular replacement System,Stryker,Kalamazoo,MI,United States)cemented distal femoral endoprosthesis and APT component for an oncologic *** undergoing DFr for non-oncologic indications and patients with metal-backed tibial components were *** failure was recorded using Henderson's classification and survivorship was reported using a competing risks *** 55 DFrs(55 patients)with an average age of 50.9±20.7 years and average body mass index of 29.7±8.3 kg/m2 were followed for 38.8±54.9 mo(range 0.2-208.4).Of these,60.0%were female and 52.7%were *** majority of DFrs with APT in this cohort were indicated for oncologic diagnoses of osteogenic sarcoma(n=22,40.0%),giant cell tumor(n=9,16.4%),and metastatic carcin

关键词： Distal femoral replacement Modular revision Dislocation Oncologic

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Projective Hilbert modules and sequential approximations

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Science China Mathematics 2025年第1期 137-168页

作者： lawrence G.Brown Huaxin Lin Department of Mathematics Purdue University Department of Mathematics East China Normal University Department of Mathematics University of Oregon Shanghai Institute for Mathematics and Interdisciplinary Sciences

We show that when A is a separable C*-algebra,every countably generated Hilbert A-module is projective（with bounded module maps as morphisms）.We also study the approximate extensions of bounded module *** the case where A is a σ-unital simple C*-algebra with strict comparison,and every strictly positive lower semicontinuous affine function on quasitraces can be realized as the rank of an element in the Cuntz semigroup,we show that the Cuntz semigroup is equivalent to unitarily equivalent classes of countably generated Hilbert A-modules if and only if A has stable rank one.

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Precise dating of abrupt shifts in the Asian Monsoon during the last deglaciation based on stalagmite data from Yamen Cave, Guizhou Province, China

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Science China Earth Sciences 2010年第5期53卷 633-641页

作者： EDWArDS r. lawrence Department of Geology and Geophysics University of Minnesota

Based on 33 U/Th dates and 1020 oxygen isotopic data from stalagmite Y1 from Yamen Cave, Guizhou Province, China, a record of the Asian Summer Monsoon (ASM) was established. The record covers the last deglaciation and the early Holocene (from 16.2 to 7.3 ka BP) with an average oxygen isotope resolution of 9 years. The main millennial-scale deglacial events first identified in Greenland (Greenland Interstadial Events: GIS 1e through GIS 1a) and later in China are clearly present in the Y1 record. By analogy to earlier work, we refer to these as Chinese Interstadials (CIS): CIS A.1e to CIS A.1a. The onset of these events in Y1 δ18O records are nominally dated at: 14750±50, 14100±60, 13870±80, 13370±80, and 12990±80 a BP. The end of CIS A.1a or the beginning of the Younger Dryas (YD) event is nominally at 12850±50 a BP and the end of the YD dates to 11500±40 a BP. The δ18O values shift by close to 3‰ during the transition into the Bφlling-Allerφd (BA, the onset of CIS A.1e) and at the end of the YD. Comparisons of Y1 to previously published early Holocene records show no significant phase differences. Thus, the East Asia Monsoon and the Indian Monsoon do not appear to have been out of phase during this interval. The Y1 record confirms earlier work that suggested that solar insolation and North Atlantic climate both affect the Asian Monsoon.

关键词： stalagmite Asian Monsoon the last deglaciation Holocene U-series dating Yamen Cave

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骨科新进展：骨与软组织肿瘤诊断与治疗

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2007年

作者：（美）lawrence r. menendez 郭卫主译

本书系统介绍了骨与软组织肿瘤诊断和治疗的基本原则、良性肿瘤、恶性肿瘤、软组织肿瘤和腺癌骨转移等内容。

ISBN: (纸本)7543320363

本书系统介绍了骨与软组织肿瘤诊断和治疗的基本原则、良性肿瘤、恶性肿瘤、软组织肿瘤和腺癌骨转移等内容。

关键词：软组织肿瘤骨肿瘤诊疗

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Laser Stimulation of the Chloroplast/Endoplasmic reticulum Nexus in Tobacco Transiently Produces Protein Aggregates （Boluses） within the Endoplasmic reticulum and Stimulates Local Er remodeling

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Molecular Plant 2011年第5期4卷 886-895页

作者： lawrence r. Griffing1 3258 TAMU Biology Department Texas A＆M University College Station Texas 77843 USA

Does the Er subdomain that associates with the chloroplast in vivo, hereafter referred to as the chloroplast/Er nexus, play a role in protein flow within the Er？ In studies of tobacco cells either constitutively or transiently expressing Er-retained luminal, GFP-HDEL, or trans-membrane, YFP-rHD3, fluorescent fusion proteins, brief 405-nm （3-6-mW） laser stimulation of the nexus causes a qualitative difference in the movement and behavior of proteins in the Er. Photostimulating the nexus produces fluorescent protein punctate aggregates （boluses） within the lumen and membrane of the Er. The aggregation propagates through the membrane network throughout the cell, but within minutes can revert to normal, with disaggregation propagating back toward the originally photostimulated nexus. In the meantime, the Er grows and anastomoses around the chloroplast, forming a dense cisternal and tubular network. If this network is again photostimulated, bolus formation does not recur and, if the photostimulation results in photobleaching, fluorescence recovery after photobleaching occurs as it would typically in areas away from the nexus. Bolus propagation is not mediated by the actin cytoskeleton, but can be reversed by pre-conditioning the cells for 30 min with high, 40-45℃, temperature （heat stress）. Because it is not reversed with heat stress, the reorganization of the Er at the nexus following photostimulation is a separate event.

关键词： Er-chloroplast transport Er movement actin heat stress fluorescence recovery after photobleaching blue light reception.

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Subwavelength grating devices in silicon photonics

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Science Bulletin 2016年第11期61卷 879-888页

作者： Junjia Wang Ivan Glesk lawrence r.Chen Department of Electrical and Computer Engineering Mc Gill University Department of Electronic and Electrical Engineering University of Strathclyde

Subwavelength grating(SWG) waveguides in silicon-on-insulator are emerging as an enabling technology for implementing compact, high-performance photonic integrated devices and circuits for signal processing and sensing applications. We provide an overview of our recent work on developing wavelength selective SWG waveguide filters based on Bragg gratings and ring resonators, as well as optical delay lines. These components increase the SWG waveguide component toolbox and can be used to realize more complex photonic integrated circuits with enhanced or new functionality.

关键词： Subwavelength gratings Siliconphotonics Integrated optics - Bragg gratings ringresonators Optical delay lines

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Neuronal avalanches:Sandpiles of self-organized criticality or critical dynamics of brain waves?

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Frontiers of physics 2023年第4期18卷 337-348页

作者： Vitaly L.Galinsky lawrence r.Frank Center for Scientific Computation in Imaging University of California at San DiegoLa JollaCA 92037-0854USA Center for Functional MrI University of California at San DiegoLa JollaCA 92037-0677USA

Analytical expressions for scaling of brain wave spectra derived from the general nonlinear wave Hamiltonian form show excellent agreement with experimental“neuronal avalanche”*** theory of the weakly evanescent nonlinear brain wave dynamics[*** 2,023061(2020);*** Neurosci.32,2178(2020)]reveals the underlying collective processes hidden behind the phenomenological statistical description of the neuronal avalanches and connects together the whole range of brain activity states,from oscillatory wave-like modes,to neuronal avalanches,to incoherent spiking,showing that the neuronal avalanches are just the manifestation of the different nonlinear side of wave processes abundant in cortical *** a more broad way these results show that a system of wave modes interacting through all possible combinations of the third order nonlinear terms described by a general wave Hamiltonian necessarily produces anharmonic wave modes with temporal and spatial scaling properties that follow scale free power *** the best of our knowledge this has never been reported in the physical literature and may be applicable to many physical systems that involve wave processes and not just to neuronal avalanches.

关键词： nonlinear waves critical exponent Hamiltonian system neuronal avalanches critical dynamics

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Update on cell therapy for stroke

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Stroke & Vascular Neurology 2017年第2期2卷 59-64页

作者： Cynthia L Kenmuir lawrence r Wechsler Department of Neurology University of Pittsburgh Medical CenterPittsburghPennsylvaniaUSA

Ischaemic stroke remains a leading cause of death and *** stroke treatment options aim to minimise the damage from a pending stroke during the acute stroke period using intravenous thrombolytics and endovascular thrombectomy;however,there are no currently approved treatment options for reversing neurological damage once a stroke is *** studies suggest that cell therapy may be safe and effective in improving functional *** recent clinical trials have reported safety and some improvement in outcomes following cell therapy administration in ischaemic stroke,which are *** therapy may provide a promising new treatment for stroke reducing stroke-related *** investigation is needed to determine specific effects of cell therapy and to optimise cell delivery methods,cell dosing,type of cells used,timing of delivery,infarct size and location of infarct that are likely to benefit from cell therapy.

关键词： damage acute treatment

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On the algorithmic construction of classifying spaces and the isomorphism problem for biautomatic groups

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Science China Mathematics 2011年第8期54卷 1533-1545页

作者： BrIDSON Martin r. rEEVES lawrence Mathematical Institute University of Oxford Department of Mathematics and Statistics University of Melbourne

We show that the isomorphism problem is solvable in the class of central extensions of word-hyperbolic groups,and that the isomorphism problem for biautomatic groups reduces to that for biautomatic groups with finite *** describe an algorithm that,given an arbitrary finite presentation of an automatic group Γ,will construct explicit finite models for the skeleta of K(Γ,1) and hence compute the integral homology and cohomology of Γ.

关键词： geometric group theory automatic groups isomorphism problem

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STEP AP 242 Managed Model-based 3D Engineering:An Application Towards the Automation of Fixture Planning

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International Journal of Automation and computing 2021年第5期18卷 731-746页

作者： remil George Thomas Deepak lawrence K. Manu r. Department of Mechanical Engineering National Institute of Technology CalicutKerala 673601India

Fixture design and planning is one of the most important manufacturing activities, playing a pivotal role in deciding the lead time for product development. Fixture design, which affects the part-quality in terms of geometric accuracy and surface finish, can be enhanced by using the product manufacturing information(PMI) stored in the neutral standard for the exchange of product model data(STEP) file, thereby integrating design and manufacturing. The present paper proposes a unique fixture design approach, to extract the geometry information from STEP application protocol(AP) 242 files of computer aided design(CAD) models, for providing automatic suggestions of locator positions and clamping surfaces. Automatic feature extraction software "FiXplan", developed using the programming language C#, is used to extract the part feature, dimension and geometry information. The information from the STEP AP 242 file is deduced using geometric reasoning techniques, which in turn is utilized for fixture planning. The developed software is observed to be adept in identifying the primary, secondary, and tertiary locating faces and locator position configurations of prismatic components. Structural analysis of the prismatic part under different locator positions was performed using commercial finite element method software, ABAQUS, and the optimized locator position was identified on the basis of minimum deformation of the *** area-ratio(base locator enclosed area(%)/work piece base area(%)) for the ideal locator configuration was observed as 33%. Experiments were conducted on a prismatic workpiece using a specially designed fixture, for different locator configurations. The surface roughness and waviness of the machined surfaces were analysed using an Alicona non-contact optical profilometer. The best surface characteristics were obtained for the surface machined under the ideal locator positions having an area-ratio of 33%, thus validating the predicted numerical resul

关键词： Standard for the exchange of product model data(STEP)application protocol(AP)242 product manufacturing information computer-aided fixture design computer aided design(CAD)/computer aided manufacturing(CAM) automation computer integrated manufacturing 3D surface roughness

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