检索结果-南通市图书馆

Improved diagnostic yield of endoscopic ultrasound-fine needle biopsy with histology specimen processing

World Journal of Gastrointestinal Endoscopy 2020年第8期12卷 212-219页

作者： lawrence ku Mohammad A Shahshahan Linda A Hou Viktor E Eysselein Sofiya Reicher Department of Medicine Division of Gastroenterology and HepatologyHarbor-UCLA Medical CenterTorranceCA 90509United States

BACKGROUND Endoscopic ultrasound-guided fine needle biopsy(EUS-FNB)has emerged as a safe,efficacious alternative to fine needle aspiration(FNA)for tissue ***-FNB is reported to have higher diagnostic yield while preserving specimen tissue ***,data on the optimal method of EUS-FNB specimen processing is *** To evaluate EUS-FNB with specimen processing as histology vs EUS-FNA cytology with regards to diagnostic yield and specimen *** All EUS-FNA and EUS-FNB performed at our institution from July 1,2016,to January 31,2018,were retrospectively *** collected data on demographics,EUS findings,pathology,clinical outcomes,and procedural complications in two periods,July 2016 through March 2017,and April 2017 through January 2018,with predominant use of FNB in the second data collection time *** specimens were processed as cytology with cell block technique and reviewed by a cytopathologist;FNB specimens were fixed in formalin,processed for histopathologic analysis and immunohistochemical staining,and reviewed by an anatomic *** diagnosis was based on surgical pathology when available,repeat biopsy or imaging,and length of clinical follow *** One hundred six EUS-FNA and EUS-FNB procedures were *** alone was performed in 17 patients;in 56 patients,FNB alone was done;and in 33 patients,both FNA and FNB were *** all indications,diagnostic yield was 47.1%(8/17)in FNA alone cases,85.7%(48/56)in FNB alone cases,and 84.8%(28/33)in cases where both FNA and FNB were performed(P=0.0039).Specimens were adequate for pathologic evaluation in 52.9%(9/17)of FNA alone cases,in 89.3%(50/56)of FNB alone cases,and 84.8%(28/33)in cases where FNA with FNB were performed(P=0.0049).Tissue could not be aspirated for cytology in 10.0%(5/50)of cases where FNA was done,while in 3.4%(3/89)of FNB cases,tissue could not be obtained for *** patients who underwent FNA with FNB,there was a stat

关键词： Fine needle biopsy Endoscopic ultrasound Fine needle aspiration Pancreatic cancer Histology Cytopathology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatic decompensation/serious adverse events in post-liver transplantation recipients on sofosbuvir for recurrent hepatitis C virus

引用

World Journal of Gastroenterology 2016年第9期22卷 2844-2854页

作者： Neal Patel Kian Bichoupan lawrence ku Rachana Yalamanchili Alyson Harty Donald Gardenier Michel Ng David Motamed Viktoriya Khaitova Nancy Bach Charissa Chang Priya Grewal Meena Bansal Ritu Agarwal lawrence Liu Gene Im Jennifer Leong Leona Kim-Schluger Joseph Odin Jawad Ahmad Scott Friedman Douglas Dieterich Thomas Schiano Ponni Perumalswami Andrea Branch Division of Liver Diseases Icahn School of Medicine at Mount Sinai Recanati Miller Transplant Institute Icahn School of Medicine at Mount Sinai

AIM: To determine the safety profile of new hepatitis C virus (HCV) treatments in liver transplant (LT) recipients with recurrent HCV ***: Forty-two patients were identified with recurrent HCV infection that underwent LT at least 12 mo prior to initiating treatment with a Sofosbuvir-based regimen during December 2013-June 2014. Cases were patients who experienced hepatic decompensation and/or serious adverse events (SAE) during or within one month of completing treatment. Controls had no evidence of hepatic decompensation and/or SAE. HIV-infected patients were excluded. Cumulative incidence of decompensation/SAE was calculated using the Kaplan Meier method. Exact logistic regression analysis was used to identify factors associated with the composite ***: Median age of the 42 patients was 60 years [Interquartile Range (IQR): 56-65 years], 33% (14/42) were female, 21% (9/42) were Hispanic, and 9% (4/42) were Black. The median time from transplant to treatment initiation was 5.4 years (IQR: 2.1-8.8 years). Thirteen patients experienced one or more episodes of hepatic decompensation and/or SAE. Anemia requiring transfusion, the most common event, occurred in 62% (8/13) patients, while 54% (7/13) decompensated. The cumulative incidence of hepatic decompensation/SAE was 31% (95%CI: 16%-41%). Risk factors for decompensation/SAE included lower pre-treatment hemoglobin (OR = 0.61 per g/dL, 95%CI: 0.40-0.88, P 2, 95%CI: 0.90-0.99, P = 0.01), and higher baseline serum total bilirubin (OR = 2.43 per mg/dL, 95%CI: 1.17-8.65, P < 0.01). The sustained virological response rate for the cohort of 42 patients was 45%, while it was 31% for ***: Sofosbuvir/ribavirin will continue to be used in the post-transplant population, including those with HCV genotypes 2 and 3. Management of anemia remains an important clinical challenge.

关键词： Hepatitis C virus Sofosbuvir Ribavirin Anemia Hepatic decompensation Serious adverse event Liver transplant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluating the risk of adverse events with interventional endoscopic retrograde cholangiopancreatography and endoscopic ultrasound procedures in cirrhotic patients

引用

World Journal of Gastrointestinal Endoscopy 2019年第11期11卷 523-530页

作者： Timothy Yoo Raisa Epistola Jordan Epistola lawrence ku Michael W Fleischman Sofiya Reicher Viktor E Eysselein Linda A Hou Department of Internal Medicine Harbor-UCLA Medical CenterTorranceCA 90509United States Department of Psychology SocialDecisionand Organizational Sciences ProgramUniversity of MarylandCollege ParkMD 20742United States Department of Internal Medicine Division of GastroenterologyHarbor-UCLA Medical CenterTorranceCA 90509United States

BACKGROUND Hepatic cirrhosis is associated with greater adverse event rates following surgical procedures and is thought to have a higher risk of complications with interventional procedures in ***,these same patients often require interventional gastrointestinal procedures such as endoscopic retrograde cholangiopancreatography(ERCP)and endoscopic ultrasound(EUS).While studies examining this scenario exist,the overall body of evidence for adverse event rates associated with ERCP/EUS procedures is more *** sought add to the literature by examining the incidence of adverse events after ERCP/EUS procedures in our safety-net hospital population with the hypothesis that severity of cirrhosis correlates with higher adverse event *** To examine whether increasing severity of cirrhosis is associated with greater incidence of adverse events after interventional ERCP/EUS *** We performed a retrospective study of patients diagnosed with hepatic cirrhosis who underwent ERCP and/or EUS-guided fine needle aspirations/fine needle biopsies from January 1,2016 to March 14,2019 at our safety net *** recorded Child-Pugh and Model for End-stage Liver Disease(MELD-Na)scores at time of procedure,interventions completed,and 30-day post-procedural adverse *** analyses were done to assess whether Child-Pugh class and MELD-Na score were associated with greater adverse event rates and whether advanced techniques(single-operator cholangioscopy,electrohydraulic lithotripsy/laser lithotripsy,or needle-knife techniques)were associated with higher complication *** 77 procedures performed on 36 patients were *** study population consisted primarily of middle-aged Hispanic males.30-d procedure-related adverse events included gastrointestinal bleeding(7.8%),infection(6.5%),and bile leak(2%).The effect of Child-Pugh class C vs class A and B significantly predicted adverse events(β=0.55,P<0.01).MELD-Na scores also signifi

关键词： Endoscopic retrograde cholangiopancreatography Endoscopic ultrasound Fine-needle aspiration Fine-needle biopsy Hepatic cirrhosis Model for End-stage Liver Disease Child-Pugh Class Adverse events

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Confidence Intervals for Relative Intensity of Collaboration(RIC)Indicators

引用

Journal of Data and Information Science 2022年第4期7卷 5-15页

作者： Joel Emanuel Fuchs lawrence Smolinsky Ronald Rousseau University of Wuppertal Gaußstr.20D-42119 WuppertalGermany Louisiana State University Department of MathematicsBaton RougeLos AngelesUSA University of Antwerp Faculty of Social SciencesMiddelheimlaan 1B-2020 AntwerpBelgium ku Leuven Facultair Onderzoekscentrum ECOOMNaamsestraat 61B-3000 LeuvenBelgium

Purpose:We aim to extend our investigations related to the Relative Intensity of Collaboration(RIC)indicator,by constructing a confidence interval for the obtained ***/methodology/approach:We use Mantel-Haenszel statistics as applied recently by Smolinsky,Klingenberg,and ***:We obtain confidence intervals for the RIC indicatorResearch limitations:It is not obvious that data obtained from the Web of Science(or any other database)can be considered a random *** implications:We explain how to calculate confidence *** indicators are more often than not presented as precise values instead of an approximation depending on the database and the time of *** approach presents a suggestion to solve this ***/value:Our approach combines the statistics of binary categorical data and bibliometric studies of collaboration.

关键词： Contingency tables Confidence intervals Relative intensity of collaboration(RIC) Mantel-Haenszel statistics Science of science

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dimethyltyrosine, the Viagra of Opioids

引用

Chemical Research in Chinese Universities 2006年第2期22卷 258-262页

作者： lawrence H. Lazarus Sharon D. Bryant Severo Salvadori Remo Geurrini Gianfranco Balboni Yuko Tsuda Yoshio Okada Peptide Neurochemistry LCBRA National Institute of Environmental Health Sciences Research Triangle Park NC 27709 USA Department of Pharmaceutical Science University of Ferrara I-44100 Ferrara Italy Department of Pharmaceutical Science University of Ferrara I-44100 Ferrara Italy Department of Toxicology University of Cagliary Cagliary 109126 Italy Faculty of Pharmaceutical Science Kobe Gakuin University Nishi-ku Kobe 651-2180 Japan

Introduction The introduction of 2＇ ,6＇-dimethyl-L＇tyrosine （Dmt） at the N-terminus of Tyr-Tic （1,2,3,4-tetra-hydroisoquinoline-3-carboxylic acid ）-containing δ-opioid antagonists enhances receptor affinity and in vitro bioactivity to several orders of magnitude and its application in the formation of ligands with new properties, such as potent inverse agonism. For example, the δ2 agonist,

关键词： Dimethyltryrosine Opioid Agonist

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Plasma Edge Kinetic-MHD Modeling in Tokamaks Using Kepler Workflow for Code Coupling,Data Management and Visualization

引用

Communications in Computational Physics 2008年第8期4卷 675-702页

作者： J.Cummings A.Pankin N.Podhorszki G.Park S.ku R.Barreto S.Klasky C.S.Chang H.Strauss L.Sugiyama P.Snyder D.Pearlstein B.Ludascher G.Bateman A.Kritz the CPES Team California Institute of Technology PasadenaCA 91125 Lehigh University BethlehemPA 18015 University of California at Davis DavisCA 95616 Courant Institute of Mathematical Sciences New York UniversityNY 10012 Oak Ridge National Laboratory Oak RidgeTN 37830 Massachusetts Institute of Technology CambridgeMA 02139 General Atomics San DiegoCA 92186 lawrence Livermore National Laboratory LivermoreCA 94550 SciDAC FSP Center for Plasma Edge Simulation

A new predictive computer simulation tool targeting the development of the H-mode pedestal at the plasma edge in tokamaks and the triggering and dynamics of edge localizedmodes(ELMs)is presented in this *** tool brings together,in a coordinated and effective manner,several first-principles physics simulation codes,stability analysis packages,and data processing and visualization tools.A Kepler workflow is used in order to carry out an edge plasma simulation that loosely couples the kinetic code,XGC0,with an ideal MHD linear stability analysis code,ELITE,and an extended MHD initial value code such as M3D or ***0 includes the neoclassical ion-electron-neutral dynamics needed to simulate pedestal growth near the *** Kepler workflow processes the XGC0 simulation results into simple images that can be selected and displayed via the Dashboard,a monitoring tool implemented in AJAX allowing the scientist to track computational resources,examine running and archived jobs,and view key physics data,all within a standard Web *** XGC0 simulation is monitored for the conditions needed to trigger an ELM crash by periodically assessing the edge plasma pressure and current density profiles using the ELITE *** an ELM crash is triggered,the Kepler workflow launches the M3D code on a moderate-size Opteron cluster to simulate the nonlinear ELM crash and to compute the relaxation of plasma profiles after the *** process is monitored through periodic outputs of plasma fluid quantities that are automatically visualized with AVS/Express and may be displayed on the ***,the Kepler workflow archives all data outputs and processed images using HPSS,as well as provenance information about the software and hardware used to create the *** complete process of preparing,executing and monitoring a coupled-code simulation of the edge pressure pedestal buildup and the ELM cycle using the Kepler scientific workflow system is described

关键词： Plasma simulation magnetohydrodynamic and fluid equation gyrofluid and gyrokinetic simulations hybrid methods

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：