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Shorebirds, Stakeholders, and Competing Claims to the Beach and Intertidal Habitat in Delaware Bay, New Jersey, USA

Natural Science 2017年第6期9卷 181-205页

作者： Joanna Burger lawrence Niles Division of Life Sciences Rutgers University Piscataway NJ USA Conserve Wildlife Foundation of New Jersey Greenwich NJ USA

Birds have specific habitat needs as a function of their life cycle and reproductive stage. Migrant shorebirds that may fly from the Arctic to the southern tip of South America have foraging and habitat requirements at sites where they stop to refuel before continuing their migration north or south. Throughout the world, shorebirds mainly forage on mudflats at low tide. Red knots (Calidris canutus rufa) are threatened in the United States and elsewhere, and it is critical to determine factors that might contribute to their decline. This paper uses Delaware Bay as a case study to examine shorebird (and red knot) use of the intertidal habitat, and competing claims to habitats they require during their northward migration, as well as some of the key stakeholders that play a role in protecting red knots. Shorebirds are drawn to Delaware Bay to feed on the eggs of Horseshoe Crabs (Limulus polyphemus) that are concentrated at the high tide. But they also feed on the intertidal mudflat. We examined intertidal habitat use on 17 beaches in an extensive study in 2015, and 5 key beaches in 2016. Most of the beaches were longitudinal, but four were more complex, and were used extensively for resting as well as foraging;numbers there were higher than on the longitudinal beaches. On foraging beaches, some shorebirds were present on over 85% of the intertidal censuses, and red knots were present on over 48% of the intertidal censuses. Average numbers of red knots on the longitudinal beaches varied from 0 to 354 ± 116 when any shorebirds were present, but averaged up to 1184 ± 634 when knots were present in 2015. Some beaches in 2015 had no knots (a beach with long-term aquaculture). Tide, intertidal location, and beach (name) determined the number of knots (and all shorebirds). Numbers decreased with distance from the mean high tide line. The average number of knots present in the intertidal mudflats two hours before or after low tide when knots were present (e.g. no censuses with

关键词： Assessment Aquaculture Monitoring Red Knot Shorebirds Intertidal Recreationists Horseshoe Crabs Competing Claims

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Classical Stoicism and Renaissance Rhetoric

国际修辞学研究

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国际修辞学研究 2012年 95-106页

作者： lawrence D.Green University of Southern California

This paper addresses Stoicism and its impact upon Western rhetoric during the european *** subject is historical,but it puts into high relief some methodological questions about the nature of rhetorical study that is global,multi-cultural,and *** as a philosophy began to take shape in Greek society around 200 B.C.e.,and the full flowering of Renaissance rhetoric occurs around1600 ***’s at least two cultures in space and time,with an intersection of at least two disciplines,philosophy and ***’s impact is less a matter of the recovery of an old philosophy during the Renaissance,and more a matter of left-over residues of a philosophy that impacted rhetoric during its classical foundation.

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Selection of Reference Genes in equine White Blood Cells for Real Time PCR Normalization Following extracorporeal Shock Wave Therapy

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American Journal of Molecular Biology 2014年第2期4卷 72-80页

作者： Zibin Jiang Jinwen Chen Cornelius e. Uboh Mary A. Robinson lawrence R. Soma Department of Clinical Studies New Bolton Center Campus University of Pennsylvania School of Veterinary Medicine Philadelphia USA Department of Clinical Studies New Bolton Center Campus University of Pennsylvania School of Veterinary Medicine Philadelphia USA Pennsylvania equine Toxicology & Research Center Department of Chemistry West Chester University West Chester USA

Selection of proper reference genes (RGs) is an essential step needed for accurate normalization of results from genomic studies. expression of RGs is regulated by many factors such as species, age, gender, type of tissue, the presence of disease, and the administration of therapeutic treatment. The aim of the present study was to identify optimal RGs in a set of blood samples collected at different time points (0, 24, 48, 72 h) from horses following administration of extracorporeal shock wave therapy (eSWT). The mRNA expression of twelve RGs: HPRT1, ACTB, HSP90A, SDHA, GUSB, B2M, UBC, NONO, TBP, H6PD, RPL32, GAPDH was determined using real time quantitative polymerase chain reaction (qPCR). An SAS program developed on the algorithm of geNorm, SASqPCR, was used to determine stability of the expression and the number of optimal RGs. The results showed that the range of quantification cycle (Cq) values of the evaluated genes varied between 17 and 26 cycles, and that one optimal RG, ACTB, was sufficient for normalization of gene expression. Results of stability of expression demonstrated that ACTB was the optimal choice for all the samples studied. Notably, in samples collected at 72 h post eSWT, TBP showed a significant change in the expression level, and was not suitable for use as a RG. These results substantiate the importance of validating and selecting an appropriate RG.

关键词： Reference Genes Real Time PCR Normalization equine White Blood Cell extracorporeal Shock Wave Therapy

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Anterior glenohumeral instability:Current review with technical pearls and pitfalls of arthroscopic soft-tissue stabilization

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World Journal of Orthopedics 2021年第1期12卷 1-13页

作者： John M Apostolakos Joshua Wright-Chisem lawrence V Gulotta Samuel A Taylor Joshua S Dines Department of Sports Medicine and Shoulder Surgery Hospital for Special SurgeryNew YorkNY 10021United States

The glenohumeral joint(GHJ)allows for a wide range of motion,but is also particularly vulnerable to episodes of *** GHJ instability is especially frequent among young,athletic populations during contact sporting *** first time dislocators can be managed non-operatively with a period of immobilization and rehabilitation,however certain patient populations are at higher risk for recurrent instability and may require surgical intervention for adequate *** of the optimal treatment strategy should be made on a case-by-case basis while weighing both patient specific factors and injury patterns(i.e.,bone loss).The purpose of this review is to describe the relevant anatomical stabilizers of the GHJ,risk factors for recurrent instability including bony lesions,indications for arthroscopic vs open surgical management,clinical history and physical examination techniques,imaging modalities,and pearls/pitfalls of arthroscopic soft-tissue stabilization for anterior glenohumeral instability.

关键词： Arthroscopic Soft-tissue Anterior instability Glenohumeral Functional anatomy Recurrent instability

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大学生英语听力定向性动机流的微变化研究

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现代外语 2020年第2期43卷 200-212页

作者：常鹏云 ZHANG Jun lawrence 重庆大学西安交通大学外国语学院陕西省西安市710049 新西兰奥克兰大学

新兴的"定向性动机流"理论(Directed Motivational Currents)既是二语动机研究的基础,也是激发二语学习动机的有效工具(Dornyei,et al.2014,2015;Larsen-Freeman 2015)。本研究以该理论为支撑,结合复杂动态系统理论视角,跟踪5名外语学... 详细信息

新兴的"定向性动机流"理论(Directed Motivational Currents)既是二语动机研究的基础,也是激发二语学习动机的有效工具(Dornyei,et al.2014,2015;Larsen-Freeman 2015)。本研究以该理论为支撑,结合复杂动态系统理论视角,跟踪5名外语学习者近3年听力学习过程,通过听力水平测试,定向性动机流问卷调查,回溯性访谈及使用Anion Variable Tester微变化研究工具探索学习动机变化机制。研究结果表明:1)学习动机历时波动轨迹呈现出"定向性动机流"(Directed Motivational Currents)变化特点;2)学习者任务中动机动态变化受内在(如个人目标)和外在(如学习环境)因素共同影响,在持续性和强弱度两个维度上存在个体差异,呈现三种不同类型。

关键词：复杂动态系统理论定向性动机流微变化动态研究方法

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C-reactive protein in gallbladder diseases:diagnostic and therapeutic insights

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Biophysics Reports 2020年第Z1期6卷 49-67页

作者： Ibraheem M.Rajab Daniel Majerczyk Margaret e.Olson Jenna M.B.Addams Mihee L.Choe Matthew S.Nelson lawrence A.Potempa College of Pharmacy Roosevelt University

The gallbladder is an important component of the hepatobiliary system whose primary function is to aid in digestion of foodstuffs, excretion of drugs and facilitate removal of waste products from the *** gall bladder is principally a storage organ for bile, chemically modified salts and acids of cholesterol which are synthesized in the liver and which function as surfactants to solubilize fatty substances of limited aqueous solubility. Any disruption in the amount or activity of bile surfactant can lead to an accumulation of insoluble molecular clumps(e.g., gallstones) that deposit in and obstruct fluid movement within the gallbladder, and which can lead to pathological congestion and tissue *** natural host defense response to any event that causes tissue damage is to stimulate inflammation,which non-specifically but aggressively reacts to the stimuli so to remove the cause and repair damaged tissues. The C-reactive protein(CRP) is a primarily hepatically produced serum protein whose blood levels increase within 6–10 h of any tissue-damaging event. The extent with which it increases correlates with the level of tissue damage and associated inflammation. CRP levels are reported to be of value in diagnosing acute cholecystitis severity, in predicting the outcome and prognosis of cancerassociated gallbladder resection, and in helping identify cystic structures during emergency laparoscopic cholecystectomies. As an understanding of distinctive CRP structural isoforms is evolving, its role not only as a biomarker but as regulator of both physiologic and pathophysiologic processes of inflammation may be relevant in the understanding of and treatment approaches for gallbladderassociated disease.

关键词： C-reactive protein Monomeric C-reactive Inflammation Gallbladder Gallstone Cholecystitis Cholesterol

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Analysis of Pathway Activity in Primary Tumors and NCI60 Cell Lines Using Gene expression Profiling Data

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Genomics, Proteomics & Bioinformatics 2007年第1期5卷 15-24页

作者： Xing-Dong Feng Shu-Guang Huang Jian-Yong Shou Bi-Rong Liao Jonathan M. Yingling Xiang Ye Xi Lin lawrence M. Gelbert eric W. Su Jude e. Onyia Shu-Yu Li Integrative Biology Lilly Research Laboratories Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285 USA Global Discovery ＆ Development Statistics Lilly Research Laboratories Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285 USA Cancer Discovery Research Lilly Research Laboratories Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285 USA

To determine cancer pathway activities in nine types of primary tumors and NCI60 cell lines, we applied an in silico approach by examining gene signatures reflective of consequent pathway activation using gene expression data. Supervised learning approaches predicted that the Ras pathway is active in -70% of lung adenocarcinomas but inactive in most squamous cell carcinomas, pulmonary carcinoids, and small cell lung carcinomas. In contrast, the TGF-β, TNF-α, Src, Myc, e2F3, and β-catenin pathways are inactive in lung adenocarcinomas. We predicted an active Ras, Myc, Src, and/or e2F3 pathway in significant percentages of breast cancer, colorectal carcinoma, and gliomas. Our results also suggest that Ras may be the most prevailing oncogenic pathway. Additionally, many NCI60 cell lines exhibited a gene signature indicative of an active Ras, Myc, and/or Src, but not e2F3, β-catenin, TNF-α, or TGF-β pathway. To our knowledge, this is the first comprehensive survey of cancer pathway activities in nine major tumor types and the most widely used NCI60 cell lines. The ＂gene expression pathway signatures＂ we have defined could facilitate the understanding of molecular mechanisms in cancer development and provide guidance to the selection of appropriate cell lines for cancer research and pharmaceutical compound screening.

关键词： cancer pathways gene expression profiling supervised learning classification

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智慧的七大支柱上第1版

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丛书名：发现遗产书系

2003年

作者：（英）T.e.劳伦斯（T.e.lawrence）史惠风译

本书包括：初识费萨尔，开始向阿拉伯进攻，向阿卡巴扩展，死海战役，希望的破灭最后的胜利十部分内容。

ISBN: (纸本)7801306058

本书包括：初识费萨尔，开始向阿拉伯进攻，向阿卡巴扩展，死海战役，希望的破灭最后的胜利十部分内容。

关键词：劳伦斯回忆录

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渠道断面优化设计

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江西水利科技 1991年第2期17卷 167-174页

作者： lawrence e. Flynn 付敏江西省水利科学研究所

本文用无纲量形状参数比较了均匀流渠道横断面设计,并阐述了横断面形状与设计变量(如:湿周、水深、水面宽、断面面积、衬砌方量和开挖方量等)的基本关系。利用这些关系可揭示渠道的内在规律。对于一般渠道的优化设计可直接通过水流形态... 详细信息

本文用无纲量形状参数比较了均匀流渠道横断面设计,并阐述了横断面形状与设计变量(如:湿周、水深、水面宽、断面面积、衬砌方量和开挖方量等)的基本关系。利用这些关系可揭示渠道的内在规律。对于一般渠道的优化设计可直接通过水流形态,例如:流量、流速、纵坡和糙率来确定。对于要考虑复杂的约束条件与经济分析问题,则通过与优化结合的方法求解最优经济横断面,合理的断面由多于两个变量参数确定。这样,渠道设计就不需要利用复杂的优化方法或大型计算机。

关键词：渠道横断面最佳化设计

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生物学和医学中时间的地位——时间生物学

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上海交通大学学报(医学版) 1983年第1期 60-67页

作者： lawrence e Scheving,王宝美美国阿肯色大学医学院解剖系上海第二医学院病解教研室 M.S.Ph.D.

时间生物学,这个迅速发展的领域,已经在植物和动物的研究工作中产生了深刻的影响。作者讨论了特殊的命名,举出昼夜节律(Circadian rhythm)范例,并描述其性质。节律(rhythm)可对药物和其它刺激对抗体的作用产生严重的影响;在动物中的确... 详细信息

时间生物学,这个迅速发展的领域,已经在植物和动物的研究工作中产生了深刻的影响。作者讨论了特殊的命名,举出昼夜节律(Circadian rhythm)范例,并描述其性质。节律(rhythm)可对药物和其它刺激对抗体的作用产生严重的影响;在动物中的确可左右生与死。本文探讨了在医学和基础研究中应用时间生物学(Chronobiology)的可能性。

关键词：时间生物学昼夜节律生物节律节律性医学现代医药学

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