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Translational challenges in amyotrophic lateral sclerosis therapy with macrophage migration inhibitory factor

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Neural Regeneration Research 2025年第9期20卷 2583-2584页

作者： Leenor Alfahel Aleksandar Rajkovic adrian Israelson Department of Physiology and Cell Biology Faculty of Health SciencesBen-Gurion University of the NegevBeer ShevaIsraelThe School of Brain Sciences and CognitionBen-Gurion University of the NegevBeer ShevaIsrael

Macrophage migration inhibitory factor(MIF):MIF acts as a pleiotropic inflammatory mediator,playing regulatory roles in innate and adaptive immunity,neuroinflammation,neuroendocrine functions,and nervous system development(Matejuk et al.,2024).In recent years,MIF has attra cted significant inte rest from research groups as a potential target for the treatment of various neurodegenerative diseases,including Alzheimer's disease,Parkinson's disease,multiple sclerosis,and glioblastoma(Matejuk et al.,2024).

关键词： immunity sclerosis

Dispersion in oscillatory electro-osmotic flow through a parallel-plate channel with kinetic sorptive exchange at walls

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Journal of Hydrodynamics 2014年第3期26卷 363-373页

作者： SOng Jie 吴朝安 law w.ng-k.ung adrian School of Civil and Environmental Engineering Nanyang Technological University Department of Mechanical Engineering The University of Hong Kong

Dispersion in time-oscillatory electro-osmotic flows in a slit micro-channel under the effect of kinetic sorptive exchange at walls is theoretically investigated using the homogenization method. The two walls of the channel are considered to be made up of different materials, and therefore have different zeta potentials and sorption coefficients. A general expression for the Taylor dispersion coefficient under different zeta potentials as well as various sorption conditions at the walls is derived analytically. The dispersion coefficient is found to be dependent on the oscillation frequency, the Debye parameter, the species partition coefficient, the reaction kinetics and the ratio of the wall potentials. The results demonstrate that the presence of wall sorption tends to enhance the dispersion when the oscillation frequency is low, but the effect is negligible in high-frequency oscillatory flows. Moreover, it is found that the dispersion coefficient could be significantly changed by adjusting the relative wall potentials for low-frequency flows.

关键词： oscillatory electro-osmotic flows dispersion sorptive walls homogenization method

The dispersion of surface contaminants by Stokes drift in random waves

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Acta Oceanologica Sinica 2018年第7期37卷 55-61页

作者： HUAng Guoxing law w.ng-k.ung adrian State key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China State key Laboratory of Hydrology Water Resources and Hydraulics Engineering Nanjing 210029 China School of Civil and Environmental Engineering Nanyang Technological University Singapore 639798 Singapore

Contaminants that are floating on the surface of the ocean are subjected to the action of random *** the literature,it has been asserted by researchers that the random wave action will lead to a dispersion mechanism through the induced Stokes drift,and that this dispersion mechanism may have the same order of significance comparable with the others means due to tidal currents and *** is investigated whether or not surface floating substances will disperse in the random wave environment due to the induced Stokes *** analytical derivation is first performed to obtain the drift velocity under the random *** the analysis,it is shown that the drift velocity is a time-independent value that does not possess any fluctuation given a specific wave energy ***,the random wave drift by itself should not have a dispersive effect on the surface floating *** were then conducted with small floating objects subjected to P-M spectral waves in a laboratory wave flume,and the experimental results reinforced the conclusion drawn.

关键词： dispersion surface contaminants random wave Stokes drift

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref kevin k.w.ng J.adrian Tyndall Binu Tharakan Firas kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. we then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Taylor Dispersion of Contaminants by Dual-peak Spectral Random waves

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China Ocean Engineering 2019年第5期33卷 537-543页

作者： HUAng Guo-xing adrian w.ng-k.ung law GUO Xiao-meng State key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China School of Civil and Environmental Engineering and Environmental Process Modelling Centre Nanyang Environment and Water Resources Institute (NEWRI) Nanyang Technological University Singapore 639798 Singapore State key Laboratory of Hydrology-water Resources and Hydraulic Engineering Nanjing Hydraulic Research Institute Nanjing 210029 China

Recent extensive and important studies have provided detailed information and compelling evidence on how the presence of waves influences the vertical diffusivity/dispersivity in the coastal environment, which can affect various water quality considerations such as the distribution of suspended sediments in the water column as well as the potential of eutrophication. Comparatively, how the presence of waves influences the horizontal diffusivity/dispersivity has received only scant attention in the literature. Our previous works investigated the role played by the Taylor mechanism due to the wave-induced drift profile which leads to the longitudinal dispersion of contaminants in the horizontal direction, under regular sinusoidal waves and random waves with single-peak spectra. Natural waves in the coastal environment, however, often possess dual-peak spectra, comprising both higher frequency wind waves and lower frequency swells. In this study, the Taylor dispersion of contaminants under random waves with dual-peak spectra is examined through analytical derivation and numerical calculations. The effects of various dual-peak spectral parameters on the horizontal dispersion, including the proportion of lower frequency energy, peak frequency ratio and spectral shape parameter, are investigated. The results show that the relative energy distribution between the dual peaks has the most significant effect. Compared with single-peak spectra with equivalent energy, the Taylor dispersion with dual-peak spectra is stronger when the lower frequency is close to the peak frequency of the single-peak spectrum, and weaker with the higher frequency instead. Thus, it can be concluded that with a dual-peak wave spectrum, wind-dominated seas with higher frequency lead to stronger dispersion in the horizontal direction than swell-dominated seas with lower frequency.

关键词： Taylor dispersion dual-peak spectrum random waves

Ultraslow electron-phonon scattering and polaron formation in magnetite

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Journal of Materiomics 2022年第1期8卷 150-155页

作者： adrian Radoń DariuszŁukowiec Patryk włodarczyk Łukasiewicz Research Network-Institute of Non-Ferrous Metals Sowinskiego 5 St.44-100GliwicePoland Faculty of Mechanical Engineering Silesian University of TechnologyKonarskiego 18 a St.44-100GliwicePoland

The comprehensive analysis of AC electrical conductivity in magnetite was performed in order to find relations between the formation of polarons,phonons and conduction by a virtual free electron *** analysis performed here for the first time shows experimental data for the behavior of electrons for magnetite with the scattering time shifted to the GHz *** to our study,the DC electrical conductivity can be described by the virtual free electron gas model,and high frequency conductivity can be described by the combination of the Drude model for disordered materials and Jonscher's universal power *** observed peak at the imaginary part of AC conductivity was related to the scattering time of the electron-phonon *** interaction between electrons and thermally formed phonons results in the formation of large polarons,and these are responsible for high frequency conductivity in magnetite.

关键词： Magnetite Drude model Power law Electrical conductivity Virtual free electron gas

Cancer of the uncinate process of the pancreas:surgical anatomy and clinicopathological features

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Hepatobiliary & Pancreatic Diseases International 2009年第6期8卷 569-574页

作者： adrian w. O'Sullivan Nigel Heaton Mohamed Rela Institute of Liver Studies King's College Hospital National Health Service(NHS) Foundation Trust

BACkGROUND:The clinicopathological features of uncinate process pancreatic cancer(UPPC) are poorly *** the anatomy of the uncinate process and its division during surgery are central to pancreaticoduodenectomy for *** set out to describe the embryology and anatomy of the uncinate process and the clinicopathological features of *** SOURCES:All published case series of UPPC were reviewed and included in this ***:The true incidence of UPPC is difficult to quantify,with the reported incidence ranging from 2.5% to 10.7% of pancreatic *** are 5 published series of UPPC including 117 patients,72 males and 45 females,aged from 45-53 years to 61-84 *** median survival was 5 or 5.5 months in 3 of the series,12.1 months in another based only on potentially resectable lesions and 17 months in another based only on resected ***:The number of reported series of UPPC is limited,with vague symptoms as the predominant presenting features of the *** prognosis is poor with synchronous venous resection demonstrating a survival advantage.

关键词： pancreatic neoplasms uncinate process anatomy embryology surgery

Results on non-SUSY searches for physics beyond standard model in pp collisions at CMS

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Frontiers of physics 2013年第3期8卷 257-269页

作者： adrian Perieanu Physikalisches Institut B RWTH-Aachen Germany

In this paper a review of the results on searches for pnysics beyond the standard model in pp collisions with the CMS experiment at √s = 7 and 8 TeV is presented. Aspects of the analyses and their achieved limits on ... 详细信息

关键词： beyond standard model gauge bosons leptoquarks extra dimensions

wARMIng ISSUES ASSOCIATED wITH THE LOng TERM SIMUL ATION OF HOUSIng USIng CFD ANALYSIS

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Journal of Green Building 2016年第2期11卷 59-74页

作者： Aiman Albatayneh Dariusz Alterman adrian w.Page Behdad Moghtaderi The Priority Research Centre(PRC)for Frontier Energy Technologies&Utilisation The Priority Research Centre(PRC)for Frontier Energy Technologies&Utilisation dariusz

The determination of internal building air temperature has an impact on the design and performance of a building in measuring thermal comfort and heating and cooling *** is software to assist with measuring internal building air tem-perature such as Autodesk CFD ***,the use of Autodesk CFD simulation for the analysis appears to have an issue with simulations extending over a long term(*** or years)as the internal air temperature in a building keeps rising with *** paper addresses the challenges encountered using CFD simu-lation in the modelling of a building for long term performance.A new method to overcome the issue of the progressive rising of internal air temperature using two external air boundaries,one for the external volume(sky boundary)and the other surrounding the building,is suggested in the paper.

关键词： thermal performance CFD analysis long term simulation building enclosure external boundary