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Patient-centric dose equivalency pilot study of incobotulinumtoxin a(xeomin)*** a(dysport)in the treatment of glabellar frown lines

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Plastic and Aesthetic Research 2015年第1期2卷 12-16页

作者： Jonathan Bank Nicole A.Phillips laurie a.casas Department of Surgery Section of Plastic and Reconstructive SurgeryUniversity of Chicago Medical CenterChicagoIL 60026USA Department of Surgery Division of Plastic SurgeryBrigham and Women’s HospitalBostonMA 02115USA

Aim:Incobotulinumtoxin A(xeomin)has been proposed as an alternative to abobotulinumtoxin A(dysport)and onabotulinumtoxin A(Botox)in the treatment of glabellar frown lines.A recent study is comparing abobotulinumtoxin A and onabotulinumtoxin A revealed equivalent efficacy with a dose conversion ratio of 2.5:*** sought to establish effectiveness and dosing equivalency of incobotulinumtoxin A *** ***:Inclusion criteria for this pilot study included patients of a single surgeon(LAC)who had previously received a constant dose of abobotulinumtoxin A over at least four consecutive treatment sessions for the previous 12 months to achieve an 85-90%elimination of dynamic glabellar frown *** primary outcome sought dose comparison between established maintenance abobotulinumtoxin A dosing and incobotulinumtoxin A first-time dosing.A 2:1 conversion(abobotulinumtoxin A:incobotulinumtoxin A)was chosen in most *** outcomes were patient-reported onset of effect,physician-assessed effect at 10-12 weeks,pain associated with administration,and patient perceived need for re-treatment at 2 ***:A total of 32 subjects were *** mean dose of incobotulinumtoxin A was 17.1 units(±6.1,the median dose 20 units).The mean dose of abobotulinumtoxin A was 27.6(±11.7,the median dose 27.5 units).The mean difference in treatment units was 10.5(95%confidence interval,P<0.001).Among 30 patients who reported effect onset,the median was 8.5 days,with a range of *** 10-12 weeks,muscle paralysis was assessed to be 69.2%(±27.3),vs.90.3%(±1.8)with abobotulinumtoxin A(P<0.001).The majority of patients rated pain of administration as equal or greater to that of abobotulinumtoxin A(63%and 22%,respectively).Three patients(9%)required re-treatment at 2 weeks with abobotulinumtoxin A due to lack of effective treatment with incobotulinumtoxin *** A re-treatment was chosen by the ***:We found incobotulinumtoxin A at 17.1

关键词： Abobotulinumtoxin A glabellar frown lines incobotulinumtoxin A rhytids

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