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The Tibetan Plateau darkening initiates positive feedback through the Arctic

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Science Bulletin 2025年第3期70卷 299-300页

作者： laurent Li Laboratoire de Météorologie Dynamique Centre National de la Recherche ScientifiqueSorbonne UniversitéParis 75005France

With its high elevation and its geographic location in the subtropics,the Tibetan Plateau exerts strong mechanic forcing and thermodynamic control on the atmospheric general circulation,and consequently on climate var... 详细信息

关键词： Tibetan Plateau Arctic

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui Li laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

Deciphering theαrelaxation and the anelastic-to-plastic transition in the deep glassy state

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Science China(Physics,Mechanics & Astronomy) 2025年第3期68卷 131-138页

作者： Qi Hao Guanghui Xing Eloi Pineda Claudio Fusco laurent Chazeau Jean-Marc Pelletier Yunjiang Wang Yong Yang Jichao Qiao School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710072China Department of Physics Institute of Energy TechnologiesUniversitat Politècnica de CatalunyaBarcelona08019Spain Univ Lyon INSA LyonUniversitéClaude Bernard Lyon 1CNRSMATEISUMR5510Villeurbanne69621France State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing100190China School of Engineering Science University of Chinese Academy of SciencesBeijing100049China Department of Mechanical Engineering College of EngineeringCity University of Hong KongHong Kong999077China Department of Materials Science and Engineering College of EngineeringCity University of Hong KongHong Kong999077China State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment Northwestern Polytechnical UniversityXi’an710072China Key Laboratory of Aircraft Structural Integrity Ministry of Industry and Information TechnologyXi’an710072China

In contrast to their conventional crystalline counterparts,amorphous solids exhibit diverse dynamic relaxation mechanisms under external *** challenge to understanding their behavior lies in unifying microscopic dynamics,relaxation,and macroscopic *** study establishes a potential link by quantifying the characteristic time of the anelastic-to-plastic transition through dynamic mechanical relaxation and stress relaxation tests across a wide temperature range in both the supercooled liquid and the glassy *** is found that the stress relaxation time in the glassy solids follows an Arrhenius relationship,aligning with the mainαrelaxation time,and unveils a finding:αrelaxation continues to govern deformation even below the glass transition,challenging previous assumptions of the role of secondaryβrelaxation.A hierarchically constrained atomic dynamics model rationalizes the temperature dependence ofαrelaxation and the transition fromβtoαrelaxation,also providing evidence that the stretched exponent in the Kohlrausch-Williams-Watts equation can serve as an order *** work highlights the role ofαrelaxation in the glassy state and contributes to elucidating the potential correlation between relaxation and deformation in amorphous materials.

关键词： dynamic relaxation nonelastic deformation metallic glasses aging

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LPAR3:a shared target for neurodegenerative diseases?

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Neural Regeneration Research 2025年第12期20卷 3527-3528页

作者： Susan Acton laurent Chesnel Adiso Therapeutics ConcordMAUSA

Neurodegenerative diseases are often studied in isolation due to the vast differences in their underlying causes,the diversity in neuron types affected,and the variations in their clinical ***,there are common elements among these diseases,namely neuroinflammation,mitochondrial pathology,and an association with the gut-brain-immune axis that together suggest that these diseases a re more similar to each other than they first seem (Zhang et al.,2023).

关键词： diseases degenerative

Distribution and Resistance Profile of Klebsiella pneumoniae Strains at the Yaoundé Central Hospital: Analysis and Implications

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Advances in Microbiology 2025年第1期15卷 19-29页

作者： Megne Mimbe Lys Cannella Assiene Oyong Damase Serge Cedric Gueguim laurent Akono Magloire Sida Biwole Adiogo Dieudonné Department of Biology Higher Institute of Medical Technology Yaound Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Environmental Sciences Higher Institute of Agriculture Wood Water and the Environment University of Bertoua Cameroon Pharmacy laboratory Galenics and Pharmaceutical Legislation Faculty of Medicine and Biomedical Sciences University of Yaound 1 Yaound Cameroon

Introduction: The misuse of antibiotics has driven the emergence of antimicrobial resistance, with certain bacterial species, including Klebsiella pneumoniae, initially susceptible to most antibiotics, now exhibiting resistance to multiple antimicrobial agents. The objective of this study was to investigate the distribution and antimicrobial resistance profiles of Klebsiella pneumoniae strains isolated at the Yaoundé Central Hospital. Methodology: The study was conducted over a period of 4 months (March 1st, 2023-July 1st, 2023) and involved 32 strains isolated from bacterial cultures performed on patients, regardless of sex. The different Klebsiella pneumoniae strains were isolated using conventional methods. Identification, antibiogram, and detection of resistance enzyme production were generated using the VITEK 2 system. The Carbapenem-resistant K.N.I.V.O. kit was used to detect carbapenemases. Data analysis was performed using EXCEL 2019 software. Results: Out of 196 samples collected from various biological products, 32 Klebsiella pneumoniae strains were isolated, representing 16.32% (196/32). Urine samples were most frequently affected, accounting for 53.125%. The emergency department was the most represented (40.63%) by these isolates. The mean age was 50 years, with a minimum of 20 years and a maximum of 80 years. The sex ratio was equal to 1. The identified strains were resistant to cefotaxime (78.13%), cefoxitin (62.50%), tobramycin (71.88%), gentamicin (56.25%), ofloxacin (81.25%), and cotrimoxazole (78.13%). 78.25% were ESBL producers. Three strains were resistant to carbapenems, accounting for 9.37%;one of which exhibited the NDM type. Conclusion: This study highlights the evolving bacterial resistance to antibiotics, which requires adequate measures through the strengthening of the Antimicrobial Resistance (AMR) program in Cameroon.

关键词： Klebsiella pneumoniae Resistance Antibiotics Carbapenemase

Determination of Fungal Species to Investigate the Aflatoxin Contamination in Rice(Oryza sativa L.)

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Phyton-International Journal of Experimental Botany 2025年第2期94卷 407-420页

作者： Eman Alhomaidi Aisha Umar Mustansar Mubeen laurent Dufossé Yasir Iftikhar Arpita Das Soumya Ghosh Muhammad Sibt-e-Abbas Department of Biology College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Institute of Botany University of the PunjabLahore54000Pakistan Department of Plant Pathology College of AgricultureUniversity of SargodhaSargodha40100Pakistan Universitéde La Réunion Laboratoire CHEMBIOPRO(Chimie et Biotechnologie des Produits Naturels)ESIROI Département agroalimentaire15 avenue RenéCassinSaint-DenisF-97490France Department of Biotechnology Adamas UniversityBarasat-Barrackpore Road24 Parganas NorthJagannathpurKolkata700126West BengalIndia Natural and Medical Sciences Research Center University of NizwaNizwa616Oman Department of Food Science&Technology Faculty of Food&Home SciencesMNS-University of AgricultureMultan630496Pakistan

Aspergillus species produce aflatoxins and raise concerns about food safety in departmental stores and manufacturing *** address the risks posed by aflatoxins,and to advise the public on the highest quality rice that serves as a nutritious food source,an inquiry following the guidelines outlined in both local and international standards of food safety for the presence of aflatoxins is an essential ***,16 white rice samples were selected randomly from low/high socio-economic departmental stores from 16 different *** powdered rice filtrate was extracted using *** filtrate applied on TLC plates and the amount of aflatoxin and moisture contents were *** the non-infected rice,moisture content was low(9.08%)whereas high[13.65%>12%(standard>value)]in infected *** out of 8 samples of low-quality rice were contaminated with AFB_(1) and AFB_(2)(ranging from 22.2 to 29.3μg/kg).All the samples except one(22.3μg/kg)from high-quality rice were certified fit despite the contamination with AFB_(1).Furthermore,phylogenetic analysis showed Aspergillus flavus from unfit low(Long grain brown and Brown basmati)and high-quality(Basmati-198)rice whereas *** from unfit low-quality Medium-grain brown *** presented research proves that the detection of fungi and aflatoxins in rice grains poses a huge risk to the health of ***,it is necessary to check the rice grains before distribution.

关键词： Mycotoxin aflatoxin rice contamination TLC principal component analysis

Words as tracers in the history of science and technology:the case of photogrammetry and remote sensing

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Geo-Spatial Information Science 2021年第1期24卷 167-177,I0018页

作者： laurent Polidori CESBIO Universitéde ToulouseCNES/CNRS/INRAE/IRD/UPSToulouseFrance

The evolution of terminology in a given field of science and technology is a good indicator of the context in which inventions originated and how concepts have *** is the case of photogrammetry,remote sensing and related methods,whose terminology evolved,first under the influence of the early inventors Laussedat and Meydenbauer,in French and German,respectively,and then in English and other languages as an international professional community *** development of space remote sensing and analytical photogrammetry led to the modification of old concepts and the renewal of terminology,and more recently,the advent of digital photography has blurred the boundaries between different fields and the meaning of the *** article proposes an analysis of the evolution of technical terms through the Google Ngram Viewer tool,which allows the visualization of the occurrence of terms in documents accessible on the *** its biases,this tool allows an interpretation of the evolution of the terminology over a long period of time,as well as a comparison of the evolution observed in the different *** particular,it makes it possible to highlight the periods when these methods were very popular,as well as a recent decline in the use of classical terms such as photogrammetry and remote sensing in favor of a new vocabulary,due to the blurring of boundaries between disciplines and to the emergence of new solutions related to UAVs,computer vision,etc.,which have renewed the potential of classical methods.

关键词： Photogrammetry remote sensing terminology Ngram Viewer

Topics on the Geometry of Rational Homogeneous Spaces

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Acta Mathematica Sinica,English Series 2020年第8期36卷 851-872页

作者： laurent MANIVEL Toulouse Mathematics Institute UMR 5219 UPSF-31062 Toulouse Cedex 9France

This is a survey paper about a selection of results in complex algebraic geometry that appeared in the recent and less recent litterature,and in which rational homogeneous spaces play a prominent *** selection is larg... 详细信息

关键词： Calabi-Yau manifold derived category Hyperkahler manifold rational homogeneous space grassmannian flop fano variety abelian surface

Auger effect in weakly confined nanocrystals

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Light(Science & Applications) 2023年第8期12卷 1454-1456页

作者： Jiawen Liu laurent Coolen Laboratoire de Physique de I'Ecole Normale Superieure ENSUniversite PSLCNRSSorbonne UniversiteUniversite Paris CiteF-75005 ParisFrance Sorbonne Universite CNRSInstitut de NanoSciences de ParisINSPF-75005 ParisFrance

An extensive analysis of biexciton luminescence in high-quality,large perovskite CsPbBr_(3) nanocrystals shows how the biexciton Auger decay rate deviates from the"universal"volume scaling as the exciton confinement b... 详细信息

关键词： weakly confined perovskite