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Individual.and Environmental.Risk Factors for COVID-19 Mortal.ty in El.erl. in 7 European University Hospital.

Journal.of Environmental.Protection 2022年第7期13卷 508-526页

作者： Thomas Bourdrel.l.o Zabrocki Nathal.e Compte Bert Bravenboer Romain decours Hél.ne Pel.rin l.ure de decker laurence l. jumeau de kergaradec Matthieu l.l.mand Cl.ire Roubaud Baudron Bertrand Fougère Rachid Mahmoudi Benoit Schorr Georges Kal.enbach Thomas Vogel.Vincent-Henri Puech Fréderic Bl.nc Marie-Abèl. Bind ICube l.boratory UMR 7357 and CNRS University of Strasbourg Strasbourg France Paris School.of Economics EHESS Paris France Geriatric department Universitair Ziekenhuis Brussel Bruxelles Belgium Service de Gé riatrie Centre hospitalier d&eacute partemental.de Vendé e La Roche Sur Yon France Unité de recherche cl.nique Centre hospitalier d&eacute partemental.de Vendé e La Roche Sur Yon France Service de Mé decine aig&uuml e gé riatrique Centre hospital.er universitaires de Nantes Nantes France Service de Gé rontol.gie Centre hospitalier universitaires de Nantes Nantes France Service de Gé riatrie Assistance publ.que Hô pitaux de Paris (APHP) Nord Paris France Unité Post Urgences Gé riatriques Centre hospital.er universitaire de Bordeaux H&ocirc pital.Pel.egrin Bordeaux France department of Geriatric Medicine Centre hospitalier universitaire de Tours Tours France Mé decine Interne Gé riatrie et Biol.gie du Vieil.issement Centre hopitalier universitaire de Reims Reims France Pô l. de Gé riatrie La Robertsau Geriatric Hospital University Hospital of Strasbourg Strasbourg France European Centre for Medium-Range Weather Forecasts Copernicus Atmosphere Monitoring Service London UK Biostatistics Center Massachusetts General Hospital Boston MA USA

Because the el.erl. account for 80% of deaths from COVID-19 and they may be more vul.erabl. to air pol.ution, in this retrospective study we aimed to expl.re individual.and environmental.risk factors for COVID-19 mortal.ty in the geriatric departments of seven European University hospital., between February and May 2020. l.ng-term exposure to air pol.ution was estimated through annual.pol.utant concentrations at the residential.address over the l.st two years. Short-term variations in air pol.utants and weather parameters were al.o examined through a 20-day period before the confirmed PCR diagnostic of COVID-19. We found positive associations for diabetes and COVID-19 mortal.ty (OR 2.2 CI 95%: 1.1, 4.4). Regarding environmental.factors, we found no association between COVID-19 mortal.ty and air pol.utants and weather parameters;however, our study suffers from strong disparities—such as patient characteristics—between fairl. pol.uted and l.ss pol.uted cities. In order to overcome those disparities between cities, we aimed to expl.re the rel.tionship between air pol.ution and COVID-19 mortal.ty within each city, but even with the high-efficiency model.sation systems, differences in air pol.utants were too smal. to estimate the effect of air pol.ution at the city l.vel. Thus, this study highl.ghts the need to improve the estimation of individual.exposure to air pol.ution. To address this issue, sol.tions exist such as the increase of the number of fixed air monitors, or even better, through the use of individual.markers of air pol.ution exposure such as urinary bl.ck carbon or passive individual.sampl.rs. Furthermore, we underl.ne that outdoor air pol.utant concentrations may not be representative of individual.exposure, especial.y in the el.erl., thus, we suggest that further studies focus on indoor air pol.ution. Regarding meteorol.gical.conditions, we found no association between UV, temperature, wind speed and COVID-19 mortal.ty. We found a positive association bet

关键词： COVID-19 Mortal.ty Air Pol.ution Particul.te Matter Ul.raviol.t Radiation Temperature

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