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National preparedness survey of pediatric intensive care units with simulation centers during the coronavirus pandemic

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World journal of Critical Care Medicine 2020年第5期9卷 74-87页

作者： Kamal Abulebda Rami A Ahmed Marc A Auerbach Anna M Bona lauren E Falvo Patrick G Hughes Isabel T Gross Elisa j Sarmiento Paul R Barach Department of Pediatrics Division of Critical CareIndiana University School of MedicineRiley Hospital for Children at Indiana University HealthIndianapolisIN 46202United States Department of Emergency Medicine School of MedicineIndiana UniversityIndianapolisIN 46202United States Department of Pediatrics Division of Pediatrics Emergency MedicineYale University School of MedicineNew HavenCT 06504United States Department of Integrated Medical Science Florida Atlantic UniversityBoca RatonFL 33431United States Department of Emergency Medicine Yale University School of MedicineNew HavenCT 06504United States Department of Pediatrics Wayne State University School of MedicineDetroitMI 48202Jefferson College of Population HealthPhiladelphiaPA19107United States

The coronavirus disease pandemic caught many pediatric hospitals unpreparedand has forced pediatric healthcare systems to scramble as they examine and planfor the optimal allocation of medical resources for the highest priority *** is limited data describing pediatric intensive care unit (PICU) preparednessand their health worker *** describe the current coronavirus disease 2019 (COVID-19) preparedness effortsamong a set of PICUs within a simulation-based network *** A cross-sectional multi-center national survey of PICU medical director(s) fromchildren’s hospitals across the United States. The questionnaire was developedand reviewed by physicians with expertise in pediatric critical care, disasterreadiness, human factors, and survey development. Thirty-five children’shospitals were identified for recruitment through a long-established nationalresearch network. The questions focused on six themes: (1) PICU and medicaldirector demographics;(2) Pediatric patient flow during the pandemic;(3)Changes to the staffing models related to the pandemic;(4) Use of personalprotective equipment (PPE);(5) Changes in clinical practice and innovations;and(6) Current modalities of training including *** report on survey responses from 22 of 35 PICUs (63%). The majority of PICUswere located within children’s hospitals (87%). All PICUs cared for pediatricpatients with COVID-19 at the time of the survey. The majority of PICUs (83.4%)witnessed decreases in non-COVID-19 patients, 43% had COVID-19 dedicatedunits, and 74.6% pivoted to accept adult COVID-19 patients. All PICUsimplemented changes to their staffing models with the most common changesbeing changes in COVID-19 patient room assignment in 50% of surveyed PICUsand introducing remote patient monitoring in 36% of the PICU units. Ninety-fivepercent of PICUs conducted training for donning and doffing of enhanced *** 6 months into the pandemic, one-third of PICUs across the U

关键词： COVID-19 Pediatric intensive care unit Simulation Practice innovations Training Preparedness

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西澳大利亚伊尔冈地块东部金矿田省太古宙地壳的演化

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华北地质 1980年第3期 87-89页

作者： N.I Groves H.j.chapman 闻桂芹西澳大利亚大学地质系西澳大利亚大学地质系

对西澳大利亚东部金矿田省太古宙花岗岩—绿岩地壳发展的几个不同模式作了系统的阐述。由于缺少以下几个方面资料,引起了许多争论: 1)绿岩和花岗岩的连续出露。 2)具有充分的区域的综合性多学科研究。 3)在对岩套研究中,用几种同位素方... 详细信息

对西澳大利亚东部金矿田省太古宙花岗岩—绿岩地壳发展的几个不同模式作了系统的阐述。由于缺少以下几个方面资料,引起了许多争论: 1)绿岩和花岗岩的连续出露。 2)具有充分的区域的综合性多学科研究。 3)在对岩套研究中,用几种同位素方法进行补充的地质年代和岩石成因方面的研究。 4)标准地区的详细地球物理资料。

关键词：太古宙太古代前寒武纪金矿田绿岩带地块条带状片麻岩地壳地球外壳地球内部西澳大利亚

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Second and Third Trimester Fetal Death in the Setting of COVID-19: A California 2020 Case Series

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Maternal-Fetal Medicine 2022年第2期4卷 127-129页

作者： Rosalyn E.Plotzker Similoluwa Sowunmi Valorie Eckert Emily Barnes Van Ngo lauren j.Stockman Chloe LeMarchand Umme-Aiman Halai Division of Communicable Disease Control Center for Infectious DiseaseCalifornia Department of Public Health(CDPH)RichmondCA 94804USA California Birth Defects Monitoring Program Center for Family HealthCalifornia Department of Public Health(CDPH)RichmondCA 94804USA Los Angeles County Department of Public Health Los AngelesCA 90012USA.

Maternal severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in the second and third trimesters of pregnancy may impact fetal development via vertical transmission,complications of coronavirus disease 2019(COVID-19),or placental ***,potential associations between prenatal SARS-CoV-2 infection and fetal loss are not well *** case series of thirteen second and third trimester fetal losses reported by local public health departments to California’s state public health surveillance included maternal clinical and demographic characteristics as well as placental pathology,fetal autopsy reports,and coroner *** was no evidence that maternal COVID-19 disease severity,placental injury,or SARS-CoV-2 vertical transmission contributed to pregnancy ***,this case series is a limited sample;more research is needed to identify factors of prenatal SARS-CoV-2 that may contribute to fetal death in the second and third trimesters.

关键词： COVID-19 Fetal death Prenatal infection Stillbirth

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Kinetic Characterization of Na,K-ATPase Inhibition by the Acetaminophen Metabolite N-Acetylbenzoquinoneimine

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Open journal of Molecular and Integrative Physiology 2015年第1期5卷 1-17页

作者： jeff B. Helms lauren P. Saunders jamie Meyer Charles j. Costa Eric Plowman Nick Williford Matthew Corbitt jeremy P. Holden Craig Gatto Department of Biology Upper Iowa University Fayette IA USA Division of Neuroscience and Physiology Department of Biological Science Illinois State University Normal IL USA Department of Internal Medicine University of Wisconsin-Madison Medical Center Madison WI USA

N-acetylbenzoquinoneimine (NABQI) is a toxic metabolite of the common analgesic acetaminophen (APAP). NABQI is an electrophilic intermediate formed via the oxidation of APAP within the cytochrome P450 system. Within the normally recommended low-dose use of APAP, NABQI is a minor metabolite which is either quickly reduced back to APAP or conjugated to Glutathione (GSH) producing an innocuous by-product. However, with overdose or prolonged high-dose usage of acetaminophen, GSH levels can become depleted and the bioactive NABQI is thought to form adducts with proteins and oxidize protein sulfhydryls producing intra- and intermolecular disulfide bridges in proteins. In this work we investigated the effect of NABQI on purified kidney Na,K-ATPase to see if the clinical renal insufficiencies seen in APAP overdose may be linked to inhibition of the Na,K-ATPase. Our work has shown that NABQI does indeed inhibit the Na,K-ATPase in a dose dependent (IC50 = 19.8 ± 2.9 μM) and irreversible manner. Interestingly, brief storage of NABQI at -20°C eliminates the irreversible effects of the compound, and leads to a product that remains a potent reversible inhibitor of the Na,K-ATPase (IC50 = 58.7 ± 19.5 μM). Further, the reversible inhibition produced by stored NABQI competes with para-nitrop.

关键词： Na K-ATPase Paracetamol N-Acetylbenzoquinoneimine Overdose Renal Electrophillic

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Conjugate Addition of Indoles to <i>α,β</i>-Unsaturated Ketones Using Bismuth (III) Bromide

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Green and Sustainable Chemistry 2019年第3期9卷 79-84页

作者： Tyler j. Rauwolf Zhijia Geng Zachary P. Kinney jared L. Renfroe jack H. Roireau lauren T. Yep Ram S. Mohan Laboratory for Environmentally Friendly Organic Synthesis Department of Chemistry Illinois Wesleyan University Bloomington IL USA

An efficient method for the conjugate addition of indoles to a variety of chalcones using BiBr3 in ethanol (190 proof) is reported. Products are isolated by a simple procedure that avoids an aqueous work up and extensive chromatography, thus minimizing waste. Bismuth (III) compounds are especially attractive from a green chemistry perspective because they are remarkably nontoxic, non-corrosive and relatively inexpensive.

关键词： Bismuth Bismuth Bromide Conjugate Addition Green Chemistry Indoles

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基础生物化学

基础生物化学

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作者： j.·爱耿曼(j. Edelman) j.M.·查浦曼(j.M. chapman)

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尿激酶(urokinase)治疗玻璃体出血

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国外医学参考资料.眼科学分册 1978年第2期 36-37页

作者：张士元

尿激酶用于治疗玻璃体出血有的获得了令人鼓舞的效果(Forrester et al 1974),有的则结果令人失望(Cleary er al 1974)。病例的选择差不多是相同的,如铅尿病者为最多,其他有高血压、血管意外及过量用抗凝剂引起的玻璃体出血。是什么因素... 详细信息

尿激酶用于治疗玻璃体出血有的获得了令人鼓舞的效果(Forrester et al 1974),有的则结果令人失望(Cleary er al 1974)。病例的选择差不多是相同的,如铅尿病者为最多,其他有高血压、血管意外及过量用抗凝剂引起的玻璃体出血。是什么因素致使有的治疗成功有的则无效? 玻璃体出血的结局,特别是在病理学方面,很少了解。常见到的白内障摘除术中发生的位于玻璃体表面的出血,呈亮红色的血凝块,于几周内即可消失。玻璃体下或视网膜前的出血则仍保

关键词：玻璃体出血玻璃体积血尿激酶蛋白酶 urokinase 纤维蛋白溶解酶

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放射学多选题(MCQs in Radiology)(连载)

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临床放射学杂志 1986年第6期 329-334页

作者： A·H·chapman P.j.Robinson 程家文袁德启陈凡

关键词：主动脉瓣狭窄多选题 MCQs in Radiology 主动脉缩窄积液右肺动脉二尖瓣狭窄室间隔缺损先天性心脏病

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放射学多选题(MCQs in Radiology)(连载)

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临床放射学杂志 1986年第5期 275-280页

作者： A.H.chapman ,P.j.Robinson ,程家文 ,袁德启 ,陈凡

1.31 单侧肺气肿(Macleod氏综合征) A.患肺透明度高B.患肺通常较正常肺小C.呼气时受阻不是其特征D.肿灌注扫描一般正常

关键词：肺门淋巴结增大多选题纵隔淋巴结 MCQs in Radiology 肺部病变胸腔积液支气管肺癌肺癌结节病胸片支气管囊肿闪烁照相左下叶右下叶

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具有灾难性抗磷脂综合征病史患者经氟伐他汀治疗后的局灶性癫痫发作

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世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 18-19页

作者： Miesbach W. chapman j. Scharrer I. 高中宝 Department of Internal Medicine III University Hospital Johann Wolfgang Goethe-University Theodor-Stern Kai 7 60590 Frankfurt/Main Germany

We report a 36-year-old woman with the occurrence of painful focal seizures of her left hand and the left leg. She also had focal motor seizures at the left corner of her mouth. The duration and frequency of the episodes increased over four days from a few seconds once a day to frequent intervals lasting more than four hours at a time. The symptoms appeared one day after start of the treatment with fluvastatin (40 mg) administered in order to diminish the endothelial activation induced by antiphospholipid antibo dies (aPL). The patient suffered from severe manifestations of the antiphospholi pid syndrome (APS)including Catastrophic Antiphospholipid Syndrome (CAPS, Ashers on’s syndrome). In this case a single 40 mg dose of oral fluvastatin was linked to seizures. After discontinuation of this treatment, the seizures immediately disappeared and the patient fully recovered without evidence of permanent neurol ogical damage. This data links statins to seizures in patients with compromised blood brain barrier such as APS.

关键词：局灶性癫痫发作抗磷脂综合征氟伐他汀癫痫症状神经系统损伤血脑屏障完全康复疼痛性抗磷脂抗

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