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韦斯特罗斯新旅游中心

现代装饰 2021年第5期 162-165页

作者： Mane Lancon Aileen Koh Allen Dennis Shakir Anders Bruntse Anders Holden Deleuraru Dalma Ujvari Federica Fogazzi Geetika Bhutani Ida Linnea Elvira Maria Lujak laura Watte Marius Tromholt-Richter Yunus Alperen Basak 舒禹(编译) 不详

韦斯特罗斯是瑞典最大的城市之一,该项目为韦斯特罗斯的新基础交通枢纽,同时也是-个充满活力的城市视觉新地标。韦斯特罗斯新旅游中心位于市中心,作为全新的公共场所,将成为铁路上的重要交通纽带,最终设计现已向公众公布,计划于2022年... 详细信息

韦斯特罗斯是瑞典最大的城市之一,该项目为韦斯特罗斯的新基础交通枢纽,同时也是-个充满活力的城市视觉新地标。韦斯特罗斯新旅游中心位于市中心,作为全新的公共场所,将成为铁路上的重要交通纽带,最终设计现已向公众公布,计划于2022年开始施工,于2025年完工。

关键词：韦斯特罗斯公共场所交通枢纽城市视觉新地标旅游市中心

Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： Maria Renata Valente Brandão Freire Natália Marchesan Bexiga Marco Antonio Stephano João Ezequiel Oliveira Carlos Roberto Jorge Soares Ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza laura Fernanda Garcia Luiz Felipe S. Teixeira Maria Helena Marumo Bellini Natanael Gomes da Silva Luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging

Sepsis after Administering an Intramuscular Iron Injection in the Arm of an Elder Patient with Multiple Comorbidities: A Case Report

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Journal of Biosciences and Medicines 2023年第5期11卷 158-165页

作者： Michele Paula dos Santos Taís Michele Werle Mariana Martins Dantas Santos Carolina Boeira Soares Carlos Augusto Treviso Italo Trois Maestri Stella Duarte Pinto Carolina Hack Alves laura Gomes Boabaid de Barros Maria Eduarda Perobelli Buzetto Guilherme Boeira Soares Gabriel Lorentz Trein Aline Porto Bárbara Adelmann de Lima Fernanda Bercht Merten Luane Pereira Gomes Rafaela Siviero Caron-Lienert Miriam Viviane Baron School of Medicine Pontifical Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre Brazil Course of Medicine Lutheran University of Brazil (ULBRA) Canoas Brazil School of Medicine and Health Sciences Pontifical Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre Brazil Interdisciplinary Institute of Science and Health Education Porto Alegre Brazil

Background: Skin reactions and musculoskeletal injuries caused by intramuscular injection are an increased risk for skin and soft tissue infections and may culminate in sepsis. Objective: To describe the history of an elderly patient who developed a lesion in her right arm after home administration of intramuscular iron injection in this arm and its outcome. Methods: This is a case report of a patient who participated in a study in an intensive care unit. Results: This study describes a 65-year-old patient with multiple comorbidities who was admitted to the hospital complaining of pain for two months and difficulty in moving her right shoulder associated with skin and soft tissue infections in her right arm after intramuscular iron administration by a relative for the treatment of multifactorial anemia and refractory melena. The patient worsened her general condition and was transferred to the intensive care unit. Despite the therapy instituted, the patient developed sepsis of cutaneous origin, multiple organ dysfunction, and death. Conclusions: The administration of intramuscular medication requires the participation of qualified professionals, such as nurses, mainly within the scope of the Brazilian public health system which commonly comprises patients in a context of vulnerability.

关键词： Critical Care Education Continuing Injectables Septicemia Soft Tissue Infections Suppuration

Pulmonary Tuberculosis Associated with Socioeconomic Vulnerability and Ineffective Support Network: Case Report

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Journal of Biosciences and Medicines 2023年第5期11卷 151-157页

作者： Michele Paula dos Santos Gabriela Di Lorenzo Garcia Scherer Carolina Hack Alves Italo Trois Maestri Carolina Boeira Soares Carlos Augusto Treviso Stella Duarte Pinto Ana Paula Wagner Steinmetz laura Gomes Boabaid de Barros Maria Eduarda Perobelli Buzetto Gabriel Lorentz Trein Guilherme Boeira Soares Aline Porto Brendda Pereira Gomes Fernanda Bercht Merten Luane Pereira Gomes Bárbara Adelmann de Lima Rafaela Siviero Caron-Lienert Miriam Viviane Baron School of Medicine Pontifical Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre Brazil Course of Medicine Lutheran University of Brazil (ULBRA) Canoas Brazil School of Health and Life Sciences Pontifical Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre Brazil Interdisciplinary Institute of Science and Health Education Porto Alegre Brazil

Tuberculosis is one of the 10 leading causes of death in the world. Its symptoms include fever, malaise, weakness, weight loss, chest pain, cough, expectoration, shortness of breath and sepsis, which is its most frequent complication. Due to these symptoms, many patients with tuberculosis require admission to the Intensive Care Unit, where they usually are placed on mechanical ventilation. Tuberculosis is more prevalent in the population in situations of social and economic vulnerability. The main factors that interfere with adherence to treatment and the prognosis of these patients are the patient’s support network and their socioeconomic status. We present the following report of a long-time smoker patient, with chronic kidney disease and previous treatment for tuberculosis, who was brought to the emergency room due to lowering of the sensorium, and was immediately placed on mechanical ventilation. The tests suggested sepsis with a respiratory focus, so a search for Alcohol-Acid-Resistant Bacillus was carried out, with a positive result. The patient was transferred to the Intensive Care Unit due to tachycardia and acute respiratory failure. The patient was a smoker with a high tobacco load, chronic kidney disease, in addition to precarious economic, educational and self-care conditions. This report shows that patients with tuberculosis and its complications can be stabilized through known pharmacological treatment. However, the most effective measure to interrupt the transmission of the disease remains the early diagnosis and the provision of adequate treatment, with guidelines aimed at the cessation of harmful habits, such as smoking.

关键词： Smoking Kidney Disease Sepsis Respiratory Failure

Triple-crises-induced food insecurity:systematic understanding and resilience building approaches in Africa

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Science in One Health

Science in One Health 2023年第1期2卷 55-63页

作者： Ernest Tambo Chen-Sheng Zhang Gildas B.Tazemda Bertin Fankep Ngo T.Tappa Cremona F Bette Bkamko laura M.Tsague Daniella Tchemembe Elodie F.Ngazoue Kennedy K.Korie Marie Paule N.Djobet Oluwasogo A.Olalubi Omer N.Njajou Higher Institute of Health Sciences Faculty of MedicineUniversite des MontagnesCameroon Center for Leadership in Global Health Equity University of Global Health EquityKigaliRwanda Africa Disease Intelligence Preparedness and Response(ADIPaR)YaoundéCameroon National Institute of Parasitic Disease Chinese Centre for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)ShanghaiChina Institut Universitaire et Stratégique de l'Estuaire Institut des Sciences Appliquéesàla Santé(IUEs/INSAM/ISSAS)Cameroon Department of Public Health Faculty of MedicineUniversity of DoualaCameroon Labotaroire d’Analyse et d’Expertise Biomédicales(LaboreB) Cameroon Department of Public Health Faculty of Basic Medical SciencesKwara State university(KWASU)MaleteNigeria DAI Tackling Deadly Diseases in Africa(TDDA)Programme Cameroon

The triple crises of the COVID-19 pandemic, conflict and climate change have severely impacted food systems, leading to socio-economic consequences and undermining food and nutrition security across Africa. To address the malnutrition and poverty affecting approximately 700 million people in Africa, there is potential for the One Health approach implementation and operationalization to bring together multidisciplinary solutions for tackling food insecurity and ensuring food safety net. However, there is limited documentation on the potential of the One Health approach system thinking implementation to guide responses to triple crises-induced food insecurity. Therefore, this article aims to systematically understand the triple crises-induced food insecurity, connect existing solutions, and explore the role of the One Health approach in strengthening food and agriculture systems in *** finding showed the impact of triple crises exacerbating food system vulnerability in Africa and worldwide. Mitigating and resilient actions are urgently needed in tackling the emerging and persisting challenges, and infectious diseases menace and burden across Africa. We present a conceptual model illustrating the complex nature of triple crises-induced food insecurity, vulnerability areas within the food system, and actionable strategies for building community food resilience. Additionally, recommendations are provided to create an enabling environment that supports One Health approach implementation and addresses food insecurity challenges through innovative partnerships, local-led initiatives, and enhanced governance and artificial intelligence technology capacities in achieving sustainable and inclusive growth to reduce socio-economic *** up integrated, actionable, and sustainable food systems programs and innovative long-lasting solutions requires investing in promoting new partnership and research collaboration in building conflict resolution and peace tow

关键词： Food insecurity One Health Preparedness Policies Actions Resilience Supply chain Consumption Africa

光子探测器在芬兰HIP和克罗地亚RBI的研发制作（英文）

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湘潭大学学报（自然科学版） 2018年第4期40卷 115-120页

作者： Brücken Erik Gadda Akiko Ott Jennifer Naaranoja Tiina Martikainen laura Karadzhinova-Ferrer Aneliya Kalliokoski Matti Golovlova Maria Kirschenmann Stefanie Litichevskyi Vladyslav Petrine Ana Luukka Panja Harkonen Jaakko 赫尔辛基物理研究所(HIP) 芬兰赫尔辛基FI-00014 罗德波士克维奇研究所(RBI) 克罗地亚萨格勒布10000 艾得维堪公司芬兰艾斯堡FI-02150 斯拜得康公司芬兰艾斯堡FI-02150

该文描述了碲化镉(CdTe)探测器,硅漂移探测器和外加一层转换闪烁体硅探测器(SiS)的设计与制作方法 .这些硅及CdTe芯片制作工艺及其连接方法是在芬兰的Micronova中心完成的.与硅工艺不同的是,CdTe工艺必须在低于150℃的温度下完成.我们... 详细信息

该文描述了碲化镉(CdTe)探测器,硅漂移探测器和外加一层转换闪烁体硅探测器(SiS)的设计与制作方法 .这些硅及CdTe芯片制作工艺及其连接方法是在芬兰的Micronova中心完成的.与硅工艺不同的是,CdTe工艺必须在低于150℃的温度下完成.我们因此专门为CdTe探测器开发了一种低温原子层淀积的氧化铝(Al2O3)薄膜工艺,大小为(10×10×1)mm3的CdTe晶圆由一种无接触的光刻工艺完成.探测器性能是由电流-电压(I-V),电容-电压(C-V)、瞬间电流方法和精确微质子数方法来检测的.实验结果与具有材料和缺陷参数的TCAD模拟结果相符.

关键词：硅探测器碲化镉探测器 I-V、C-V 和TCT方法原子层淀积(ALD)法

Male genitourinary schistosomiasis-related symptoms among long-term Western African migrants in Spain:a prospective population-based screening study

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Infectious Diseases of Poverty 2024年第2期13卷 29-38页

作者： Sílvia Roure Xavier Vallès Olga Pérez-Quílez Israel López-Muñoz Anna Chamorro Elena Abad Lluís Valerio laura Soldevila Sergio España Alaa H.A.Hegazy Gema Fernández-Rivas Ester Gorriz Dolores Herena Mário Oliveira Maria Carme Miralles Carmen Conde Juan José Montero-Alia Elia Fernández-Pedregal Jose Miranda-Sánchez Josep M.Llibre Mar Isnard Josep Maria Bonet Oriol Estrada Núria Prat Bonaventura Clotet The Schisto-Stop study group International Health Program(PROSICS) Barcelona North Metropolitan Territorial Directorate for Infectious DiseasesCatalan Institute for HealthCAP La SalutPassatge dels Encants S/N08916 BadalonaSpain FundacióLluita contra les Infeccions c/Can Ruti s/n08916 BadalonaSpain Infectious Diseases Department Hospital Universitari Germans Trias i Pujolc/Can Ruti s/n08916 BadalonaSpain Germans Trias i Pujol Research Institute c/Can Ruti s/n08916 BadalonaSpain Microbiology Department Germans Trias i Pujol University Hospitalc/Can Ruti s/n08916 BadalonaSpain Department of Genetics and Microbiology Universitat Autònoma de Barcelonac/Can Ruti s/n08916 BadalonaSpain Faculty of Medicine University of AsyutEl FatehAssiut Governorate 71515Egypt Department of Urology Germans Trias i Pujol University Hospitalc/Can Ruti s/n08916 BadalonaSpain Canovelles Primary Health Care Unit Barcelona North Metropolitan Health DirectorateCatalan Institute for HealthC/Indústria 2308420 CanovellesSpain Primary Health Care Unit Mataró-3(Rocafonda-Palau) Barcelona North MetropolitanHealth DirectorateCatalan Institute for HealthCamíRal el Ravalet 208Mataró08302 BarcelonaSpain Barcelona North Metropolitan Primary Care Directorate Catalan Institute for HealthCtra.de Barcelona 473Sabadell08204 BarcelonaSpain Directorate for Innovation and Interdisciplinary Cooperation Barcelona North Metropolitan Health DirectorateCatalan Institute for HealthC/Can Ruti S/N08916 BadalonaSpain IrsiCaixa-AIDS Research Institute Hospital Universitari Germans Trias i Pujol University Hospitalc/Can Ruti s/n08916 BadalonaSpain Infectious Diseases Directorate Barcelona North Metropolitan Health DirectorateCatalan Institute for HealthC/Can Ruti S/N08916 BadalonaSpain 不详

Background Schistosomiasis is highly endemic in sub-Saharan Africa and frequently imported to *** urogenital manifestations are often *** aimed to ascertain the prevalence of genitourinary clinical signs and symptoms among long-term African migrants in a non-endemic European country using a serology *** We carried out a prospective,community-based cross-sectional study of adult male migrants from sub-Saharan Africa living in *** serology tests and microscopic urine examinations were carried out,and clinical data were obtained from an electronic medical record search and a structured *** We included 388 adult males,mean age 43.5 years[Standard Deviation(SD)=12.0,range:18-76].The median time since migration to the European Union was 17[Interquartile range(IQR):11-21]*** most frequent country of origin was Senegal(N=179,46.1%).Of the 338,147(37.6%)tested positive for *** eggs were present in the urine of only 1.3%.Nine genitourinary clinical items were significantly associated with positive Schistosoma serology results:pelvic pain(45.2%;OR=1.57,95%CI:1.0-2.4),pain on ejaculation(14.5%;OR=1.85,95%CI:1.0-3.5),dyspareunia(12.4%;OR=2.45,95%CI:1.2-5.2),erectile dysfunction(9.5%;OR=3.10,95%CI:1.3-7.6),self-reported episodes of infertility(32.1%;OR=1.69,95%CI:1.0-2.8),haematuria(55.2%;OR=2.37,95%CI:1.5-3.6),dysuria(52.1%;OR=2.01,95%CI:1.3-3.1),undiagnosed syndromic STIs(5.4%),and orchitis(20.7%;OR=1.81,95%CI:1.0-3.1).Clinical signs tended to *** Urogenital clinical signs and symptoms are prevalent among male African long-term migrants with a positive Schistosoma serology *** involvement can be frequent even among those with long periods of non-residence in their sub-Saharan African countries of *** research is needed to develop diagnostic tools and validate therapeutic approaches to chronic schistosomiasis.

关键词： Schistosomiasis Chronic schistosomiasis Urogenital schistosomiasis Male genital schistosomiasis Longterm migrant

2014年俄勒冈州一起与娱乐用天然湖泊有关联的诺如病毒暴发

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上海预防医学 2016年第6期28卷 429-431,F0004页

作者： Amy Zlot Maayan Simckes Jennifer Vines laura Reynolds Amy Sullivan Magdalena Kendall Scott J.Michael McLuckie Dan Kromer Vincent R.Hill Jonathan S.Yoder Michele C.Hlavsa 宫宵欢陆仁敏 Multnomah County Health Department CDC/CSTE Applied Epidemiology Fellowship Program Oregon Public Health Division Metro Blue Lake Regional Park Fairview Oregon Division of Foodborne Waterborne and Environmental Diseases National Center for Emerging and Zoonotic Infectious Diseases CDC

2014年7月,摩特诺玛郡（Multnomah County）公共卫生人员对一起在俄勒冈州蓝湖地区公园的游客中发生的诺如病毒暴发进行了调查。在报告病例的周末（7月11日周五至7月13日周日）,约1.54万人入园游览。调查确定了65例诺如病毒感染疑似病例... 详细信息

2014年7月,摩特诺玛郡（Multnomah County）公共卫生人员对一起在俄勒冈州蓝湖地区公园的游客中发生的诺如病毒暴发进行了调查。在报告病例的周末（7月11日周五至7月13日周日）,约1.54万人入园游览。调查确定了65例诺如病毒感染疑似病例和5例诺如病毒感染实验室诊断病例（共70例）,未报告住院病例或死亡病例。回顾性队列研究发现。

关键词：诺如病毒俄勒冈州疑似病例天然湖泊卫生人员实验室诊断回顾性队列研究游泳者大肠埃希菌志贺菌

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大都会及杜嘉班纳总部大楼意大利米兰

世界建筑导报 2018年第5期33卷 72-75页

作者： Luca Lazzerotti Micaela Bonomessi Silvia Calzetti laura Cassani Gabriele Coi Marco Dragoni Davide Fascione Suewoo Kim Magali Roig Liverato Michele Megna Elena Migliorati Gianni Mollo Andrea Palaia Salvatore Seggio 布鲁克.泰勒 Andrea Martiradonna Piuarch

大都会（Metrop01）项目是对米兰一座著名的地标建筑——可追溯到20世纪40年代的大都会影院进行的翻新。影院坐落于市中心的维亚尔皮亚韦（viale Piave）繁华地段，玛丽亚·卡拉斯（Maria Callas）曾在这里进行歌剧《诺玛》的录制。项... 详细信息

大都会（Metrop01）项目是对米兰一座著名的地标建筑——可追溯到20世纪40年代的大都会影院进行的翻新。影院坐落于市中心的维亚尔皮亚韦（viale Piave）繁华地段，玛丽亚·卡拉斯（Maria Callas）曾在这里进行歌剧《诺玛》的录制。项目对原建筑进行了全面改造，并扩建1，000平方米左右，现总占地面积约为3，500平方米。可以用于举办各类活动和接待宾客等。设计采用了建筑师和公司共同制定的常见主题：线性结构为主，采用地中海式材料，如浮石和暗乳白玻璃等，表面光鲜亮丽．灯光效果尤佳，完全符合杜嘉班纳（Dolce＆Gabbana）的风格。

关键词：大都会米兰意大利大楼地标建筑占地面积线性结构乳白玻璃