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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma L.Clayton UK Dementia Research Institute at King’s College London LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALs)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and ALs affecting upper and lower motor neurons),these two diseases are complexly *** and ALs exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk laura Nadal Marta Tomàs Carolina silvera-simón Manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Dietary processed former foodstuffs for broilers:impacts on growth performance,digestibility,hematobiochemical profiles and liver gene abundance

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Journal of Animal science and Biotechnology 2025年第1期16卷 364-376页

作者： Karthika srikanthithasan Marta Gariglio Elena Diaz Vicuna Edoardo Fiorilla Barbara Miniscalco Valeria Zambotto Eleonora Erika Cappone Nadia stoppani Dominga soglia Federica Raspa Joana Nery Andrea Giorgino Roser sala Andrés Luis Martínez Marínz Josefa Madrid sanchez Achille schiavone Claudio Forte Department of Veterinary sciences University of TurinGrugliascoItaly Animal Nutrition and Welfare service(sNiBA) Department of Animal and Food SciencesUniversitat Autònoma de BarcelonaBarcelonaSpain Departamento de Producción Animal Universidad de CórdobaCórdobaSpain Department of Animal Production University of MurciaMurciaSpain

Background The present experiment aimed to evaluate the effects of commercially processed former foodstuffs(cFF)as dietary substitutes of corn,soybean meal and soybean oil on the growth performance,apparent total tract digestibil-ity(ATTD),hematobiochemical profiles,and liver gene abundance in broiler *** hundred one-day-old male ROss-308 chicks were assigned to 4 dietary groups(5 replicates of ten birds per replicate)according to their average body weight(BW,38.0±0.11 g).All groups received a two-phase feeding program:starter,d 1–12 and grower,d 12–*** control group(cFF0)was fed a standard commercial feed based on corn,soybean meal and soybean *** other three groups received diets in which the feed based on corn,soybean meal,and soybean oil was partially replaced with cFF at a substitution level of 6.25%(cFF6.25),12.5%(cFF12.5)or 25%(cFF25)for the following 33 *** The growth performance data showed no differences in BW or average daily gain among groups,although the average daily feed intake decreased during the grower period(12–33 d)and over entire experimental period(1–33 d)in a linear manner as the cFF inclusion level rose(P=0.026),positively affecting the gain to feed ratio(P=0.001).The ATTD of dry matter of the cFF-fed groups were greater with respect to control group and increased throughout the experimental period,whereas the ATTD of ether extract linearly decreased with increasing levels of cFF-fed groups compared with control group and throughout the experimental period(Pse in the heterophil to lymphocyte ratio,serum cholesterol,triglycerides and alanine-aminotransferase were observed with increasing dietary levels of cFF(Ps were observed in lipoprotein lipase or sterol regulatory element binding transcription factor gene *** The results of this experiment demonstrate that it is possible to incorporate cFF into nutritionally balanced diets for broiler ch

关键词： Alternative feed Broiler chicken Digestibility Former foodstuff Gene abundance Growth performance

Patient and physician factors contributing to delays in inflammatory bowel diseases:Enhancing timely diagnosis

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World Journal of Gastroenterology 2025年第6期31卷 115-120页

作者： Horia Minea Ana-Maria singeap laura Huiban Cristina Maria Muzica Carol stanciu Anca Trifan Department of Gastroenterology Faculty of Medicine“Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania Institute of Gastroenterology and Hepatology “St.Spiridon”University HospitalIasi 700111Romania

In this article,we comment on the article by Blüthner et *** article provides a comprehensive analysis of the factors contributing to the late detection of Crohn’s disease and ulcerative colitis within a German *** highlights the conse-quences on patient outcomes,particularly disease progression and the increased risk of developing *** study identifies specific predictors asso-ciated with both patient-related and physician-related delays,offering a detailed exploration of the initial ***,the article delves into the distinct patterns observed in the German population,stressing the unique aspects of diagnostic delays that may differ from those reported in other *** detailed examination offers valuable insights into the specific challenges faced within the German healthcare system and underscores the necessity of targeted interventions to facilitate early *** importance of improved screening tools,patient education,and better healthcare infrastructure is emphasized as crucial steps toward improving patient care in inflammatory bowel disease.

关键词： Inflammatory bowel disease Diagnostic delay Disease awareness Healthcare system screening tools

Antibody engineering: facing new challenges in cancer therapy

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Acta Pharmacologica sinica 2005年第6期26卷 641-648页

作者： laura s.nz ■ngel M CUEsTA Mana COMPTE Luis ■LVAREZ-VALLINA servicio de Inmunologia Hospital Universitario Puerta de Hterro Madrid spntn servicio de Inmunologia Hospital Universitario Puerta de Hterro Madrid spntn servicio de Inmunologia Hospital Universitario Puerta de Hterro Madrid spntn servicio de Inmunologia Hospital Universitario Puerta de Hterro Madrid spntn

Antibody-based therapeutics are beginning to realize the promise enclosed in their early denomination as "magic bullets". Initial disappointment has turned into clinical and commercial success, and engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials. Recent structural and functional data have allowed the design of a new generation of therapeutic antibodies, with strategies ranging from complement-mediated and antibody-dependant cellular cytotoxicity enhancement to improved cytotoxic payloads using toxins, drugs, radionucleids and viral delivery. This review considers the structure of different types of recombinant antibodies, their mechanism of action and how their efficacy has been increased using a broad array of approaches. We will also focus on the additional benefits offered by the use of gene therapy methods for the in vivo production of therapeutic antibodies.

关键词： immunoglobulin fragments monoclonal antibodies antibody formation gene therapy recombinant proteins biomedical engineering

Research landmarks on the 60th anniversary of Epstein-Barr virus

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science China(Life sciences) 2025年第2期68卷 354-380页

作者： Lan-Yi Zhong Chu Xie Le-Le Zhang Yan-Lin Yang Yuan-Tao Liu Ge-Xin Zhao Guo-Long Bu Xian-shu Tian Zi-Ying Jiang Bo-Yu Yuan Peng-Lin Li Pei-Huang Wu Wei-Hua Jia Christian Münz Benjamin E.Gewurz Qian Zhong Cong sun Mu-sheng Zeng state Key Laboratory of Oncology in south China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Viral Immunobiology Institute of Experimental ImmunologyUniversity of ZürichZürich 8092Switzerland Division of Infectious Diseases Department of MedicineBrigham and Women’s HospitalBoston MA 02115USA Department of Microbiology Harvard Medical SchoolBoston MA 02115USA Harvard Program in Virology Boston MA 02115USA Broad Institute of Harvard and MIT Cambridge MA 02142USA

Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human *** we commemorate the 60th anniversary of EBV's discovery,it is an opportune moment to reflect on the major advancements in our understanding of this complex *** this review,we highlight key milestones in EBV research,including its virion structure and life cycle,interactions with the host immune system,association with EBV-associated diseases,and targeted intervention strategies.

关键词： Epstein-Barr virus oncovirus immune response epidemiology vaccines antibodies

small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HsPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HsPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HsPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HsPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HsPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HsPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HsPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HsPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HsPB8 neuroinflammation neuromuscular diseases therapy

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse school of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Cyber security and Privacy Issues in Industrial Internet of Things

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Computer systems science & Engineering 2021年第6期37卷 361-380页

作者： nz Jhanjhi Mamoona Humayun saleh NAlmuayqil school of Computer science and Engineering(sCE) Taylor’s UniversitySelangorMalaysia Department of Information systems College of Computer and Information SciencesJouf UniversityAl-JoufSaudi Arabia

The emergence of industry 4.0 stems from research that has received a great deal of attention in the last few ***,there has been a huge paradigm shift in the manufacturing and production ***,this poses a challenge for cybersecurity and highlights the need to address the possible threats targeting(various pillars of)industry ***,before providing a concrete solution certain aspect need to be researched,for instance,cybersecurity threats and privacy issues in the *** fill this gap,this paper discusses potential solutions to cybersecurity targeting this industry and highlights the consequences of possible attacks and countermeasures(in detail).In particular,the focus of the paper is on investigating the possible cyber-attacks targeting 4 layers of IIoT that is one of the key pillars of Industry *** on a detailed review of existing literature,in this study,we have identified possible cyber threats,their consequences,and ***,we have provided a comprehensive framework based on an analysis of cybersecurity and privacy *** suggested framework provides for a deeper understanding of the current state of cybersecurity and sets out directions for future research and applications.

关键词： Industrial Internet of things(IIoT) cybersecurity industry 4.0 cyber-attacks

security Threat and Vulnerability Assessment and Measurement in secure software Development

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Computers, Materials & Continua 2022年第6期71卷 5039-5059页

作者： Mamoona Humayun nz Jhanjhi Maram Fahhad Almufareh Muhammad Ibrahim Khalil Department of Information systems College of Computer and Information SciencesJouf UniversityAl-JoufKSA school of Computer science and Engineering(sCE) Taylor’s UniversitySelangorMalaysia Department of Computer science Bahria UniversityIslamabadPakistan

security is critical to the success of software,particularly in today’s fast-paced,technology-driven *** ensures that data,code,and services maintain their CIA(Confidentiality,Integrity,and Availability).This is only possible if security is taken into account at all stages of the sDLC(software Development Life Cycle).Various approaches to software quality have been developed,such as CMMI(Capabilitymaturitymodel integration).However,there exists no explicit solution for incorporating security into all phases of *** of the major causes of pervasive vulnerabilities is a failure to prioritize *** the most proactive companies use the“patch and penetrate”strategy,inwhich security is accessed once the job is *** cost,time overrun,not integrating testing and input in sDLC,usage of third-party tools and components,and lack of knowledge are all reasons for not paying attention to the security angle during the sDLC,despite the fact that secure software development is essential for business continuity and survival in today’s ICT *** is a need to implement best practices in sDLC to address security at all *** fill this gap,we have provided a detailed overview of secure software development practices while taking care of project costs and *** proposed a secure sDLC framework based on the identified practices,which integrates the best security practices in various sDLC phases.A mathematical model is used to validate the proposed framework.A case study and findings show that the proposed system aids in the integration of security best practices into the overall sDLC,resulting in more secure applications.

关键词： security secure software development software development life cycle(sDLC) confidentiality integrity availability