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A Systems Biology Approach for Studying Heterotopic Ossification： Proteomic Analysis of Clinical Serum and tissue Samples

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Genomics, Proteomics & Bioinformatics 2018年第3期16卷 212-220页

作者： Erin L. Crowgey Jennifer t. Wyffels Patrick M. Osborn thomas t. Wood laura E. Edsberg Nemours Biomedical Research Nemours Alfred I. duPont Hospital for Children Wilmington DE 19803 USA Natural and Health Sciences Researeh Center Center for Wound Healing Research Daemen College Amherst NY 14226 USA Department of Computer and Information Sciences Center for Bioinformatics and Computational Biology University of Delaware Newark DE 19711 USA San Antonio Military Medical Center San Antonio TX 78219 USA

Heterotopic ossification （HO） refers to the abnormal formation of bone in soft tissue. Although some of the underlying processes of HO have been described, there are currently no clinical tests using validated biomarkers for predicting HO formation. As such, the diagnosis is made radiographically after HO has formed. to identify potential and novel biomarkers for HO, we used isobaric tags for relative and absolute quantitation （itRAQ） and high-throughput antibody arrays to produce a semi-quantitative proteomics survey of serum and tissue from subjects with （HO ＋） and without （HO-） heterotopic ossification. the resulting data were then analyzed using a systems biology approach. We found that serum samples from subjects experiencing traumatic injuries with resulting HO have a different proteomic expression controls. Subsequent quantitative ELISA identified profile compared to those from the matched five blood serum proteins that were differentially regulated between the HO-- and HO- groups. Compared to HO- samples, the amount of insulin-like growth factor I （IGF1） was up-regulated in HO＋ samples, whereas a lower amount of osteopontin （OPN）, myeloperoxidase （MPO）, runt-related transcription factor 2 （RUNX2）,and growth differentiation factor 2 or bone morphogenetic protein 9 （BMP-9） was found in HO ＋ samples （Welch two sample t-test; P 〈 0.05）. these proteins, in combination with potential serum biomarkers previously reported, are key candidates for a serum diagnostic panel that may enable early detection of HO prior to radiographic and clinical manifestations.

关键词： Heterotopic ossification Proteomics Runt-related transcriptionfactor 2 Extracellular matrixorganization Keratinization

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Probabilistic transitions for P systems

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Progress in Natural Science:Materials International 2007年第4期17卷 432-441页

作者： Gabriel Ciobanu laura Cornǎcel "A. I. Cuza" University Faculty of Computer ScienceBlvd. Carol I No. 11700506 IasiRomania Romanian Academy Institute of Computer ScienceBlvd. Carol I No.8700505 IasiRomania

In this paper we use the abstract syntax and the structural operational semantics of the P systems given in [ 1 ], and add probabilities to the rules and to the communication targets. We take into account the number of possible combinations of rules which can be applied in a computation step, as well as the consumption degree of the current resources.

关键词： probabilistic transition P systems.

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百变干细胞

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环球科学 2024年第10期 52-55页

作者：劳拉·沃克戴黛(译) 不详

干细胞是我们身体中所有细胞的“母细胞”,是构建人体的基石。不管是脚底的皮肤细胞,还是眼睛中的感光细胞,干细胞可以分化为身体内任何类型的细胞。早在1902年,就有一些科学家提出人体中存在着干细胞,但是直到1978年,科学家才在脐带血... 详细信息

干细胞是我们身体中所有细胞的“母细胞”,是构建人体的基石。不管是脚底的皮肤细胞,还是眼睛中的感光细胞,干细胞可以分化为身体内任何类型的细胞。早在1902年,就有一些科学家提出人体中存在着干细胞,但是直到1978年,科学家才在脐带血中发现了干细胞。自此,干细胞迅速成为了科学界和媒体关注的焦点。由于干细胞能够被引导分化为任何类型的细胞,取代那些受损或死亡的细胞,人们纷纷猜测干细胞也许能够帮人类治疗类似阿尔茨海默病之类的疑难杂症,也许还能培育出各种完整的新器官。

关键词：阿尔茨海默病干细胞感光细胞皮肤细胞疑难杂症脐带血母细胞媒体关注

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Green neighbourhoods in low voltage networks:measuring impact of electric vehicles and photovoltaics on load profiles

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Journal of Modern Power Systems and Clean Energy 2017年第1期5卷 105-116页

作者： laura HAttAM Danica Vukadinovic GREEtHAM Department of Mathematics and Statistics University of ReadingReading RG66AXUK

In the near future, various types of low-carbon technologies(LCts) are expected to be widely employed throughout the United Kingdom. However, the effect that these technologies will have at a household level on the existing low voltage(LV) network is still an area of extensive research. We propose an agent based model that estimates the growth of LCts within local neighbourhoods,where social influence is imposed. Real-life data from an LV network is used that comprises of many socially diverse neighbourhoods. Both electric vehicle uptake and the combined scenario of electric vehicle and photovoltaic adoption are investigated with this data. A probabilistic approach is outlined, which determines lower and upper bounds for the model response at every *** technique is used to assess the implications of modifying model assumptions and introducing new model features. Moreover, we discuss how the calculation of these bounds can inform future network planning decisions.

关键词： Agent based modelling Low voltage networks Electric vehicles Photovoltaics

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Debate about tGFBR1 and the susceptibility to colorectal cancer

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World Journal of Gastrointestinal Oncology 2012年第1期4卷 1-8页

作者： laura Valle Hereditary Cancer Program Catalan Institute of Oncology IDIBELL 08908 Hospitalet de Llobregat Spain

Recent years have witnessed enormous progress in our understanding of the genetic predisposition to colorectal cancer (CRC). Estimates suggest that all or most genetic susceptibility mechanisms proposed so far, ranging from high-penetrance genes to low-risk alleles, account for about 60% of the population-attributable fraction of CRC predisposition. In this context, there is increasing interest in the gene encoding the transforming growth factor β receptor 1 (tGFBR1 ); first when over a decade ago a common polymorphism in exon 1 (rs11466445, tGFBR1 *6A/9A) was suggested to be a risk allele for CRC, then when linkage studies identified the chromosomal region where the gene is located as susceptibility locus for familial CRC, and more recently when the allele-specific expression (ASE) of the gene was proposed as a risk factor for CRC. Published data on the association of tGFBR1 with CRC, regarding polymorphisms and ASE and including sporadic and familial forms of the disease, are often contradictory. this review gives a general overview of the most relevant studies in order to clarify the role of tGFBR1 in the field of CRC genetic susceptibility.

关键词： transforming growth factor β receptor 1 transforming growth factor β receptor 1*6A 9q linkage peak Allele-specific expression Colorectal cancer risk

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Impact of lactic acid bacteria on the control of Listeria monocytogenes in ready-to-eat foods

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Food Quality and Safety 2022年第3期6卷 375-385页

作者： laura Webb Luyao Ma Xiaonan Lu Department of Food Science and Agricultural Chemistry Faculty of Agricultural and Environmental SciencesMcGill UniversitySainte-Anne de-BellevueQcCanada

Due to the increased demand for ready-to-eat(RtE)minimally processed foods,alternatives to chemical and thermal preservation methods to maintain food safety are highly demanded.A significant safety hazard in RtE food products is the growth of the foodborne pathogen Listeria monocytogenes(***).After processing,recontamination or cross-contamination of *** in RtE food products may occur and the lack of cooking can lead to an increased risk of ***,some RtE food products(*** and cured meat)can have a long processing period and shelf life,thus allowing for the growth and proliferation of *** in the food *** acid bacteria(LAB)are generally recognized as safe probiotics and have been proposed as a biological control approach to eliminate foodborne pathogens including *** have been reported to extend the shelf life of food products and inhibit pathogen proliferation via growth competition and metabolite *** are native microflora of many RtE foods,but only certain LAB may inhibit pathogen ***,the specificity of LAB species should be employed in their use in RtE *** review will discuss the antimicrobial mechanisms of LAB against ***,selective use of LAB in food matrices,and their uses in food processing and packaging.

关键词： Ready-to-eat food products lactic acid bacteria Listeria monocytogenes food safety

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tree species richness enhances stand productivity while stand structure can have opposite effects, based on forest inventory data from Germany and the United States of America

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Forest Ecosystems 2018年第1期5卷 36-52页

作者： laura Zeller Jingjing Liang Hans Pretzsch Center of Life and Food Sciences Weihenstephan Technical University of MunichHans-Carl-von-Carlowitz-Platz 285354 FreisingGermany Division of Forestry and Natural Resources Davis College of AgricultureNatural Resources&DesignWest Virginia University340 Percival HallMorgantownWV 26506-6108USA

Background： in recent studies, mixed forests were found to be more productive than monocultures with everything else remaining the same. Methods： to find out if this productivity is caused by tree species richness, by a more heterogeneous stand structure or both, we analyzed the effects of forest structure and tree species richness on stand productivity, based on inventory data of temperate forests in the United States of America and Germany. Results： Having accounted for effects such as tree size and stand density, we found that：（I） tree species richness increased stand productivity in both countries while the effect of tree size heterogeneity on productivity was negative in Germany but positive in the USA; （11） productivity was highest at sites with an intermediate amount of precipitation; and （111） growth limitations due water scarcity or low temperature may enhance structural heterogeneity. Conclusions： In the context of forest ecosystem goods and services, as well as future sustainable forest resource management, the associated implications would be：

关键词： Big data Overyielding tree size heterogeneity tree species mixing Climate Biodiversity-productivityrelationship

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Discovering plasticity models without stress data

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npj Computational Materials 2022年第1期8卷 857-866页

作者： Moritz Flaschel Siddhant Kumar laura De Lorenzis Department of Mechanical and Process Engineering ETH Zürich8092ZürichSwitzerland Department of Materials Science and Engineering Delft University of Technology2628 CDDelftThe Netherlands

We propose an approach for data-driven automated discovery of material laws,which we call EUCLID(Efficient Unsupervised Constitutive Law Identification and Discovery),and we apply it here to the discovery of plasticity models,including arbitrarily shaped yield surfaces and isotropic and/or kinematic hardening *** approach is unsupervised,i.e.,it requires no stress data but only full-field displacement and global force data;it delivers interpretable models,i.e.,models that are embodied by parsimonious mathematical expressions discovered through sparse regression of a potentially large catalog of candidate functions;it is one-shot,i.e.,discovery only needs one *** material model library is constructed by expanding the yield function with a Fourier series,whereas isotropic and kinematic hardening is introduced by assuming a yield function dependency on internal history variables that evolve with the plastic *** selecting the most relevant Fourier modes and identifying the hardening behavior,EUCLID employs physics knowledge,i.e.,the optimization problem that governs the discovery enforces the equilibrium constraints in the bulk and at the loaded boundary of the *** promoting regularization is deployed to generate a set of solutions out of which a solution with low cost and high parsimony is automatically *** virtual experiments,we demonstrate the ability of EUCLID to accurately discover several plastic yield surfaces and hardening mechanisms of different complexity.

关键词： stress plasticity selecting

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Poly(ADP-ribose),adherens junctions,vinculin and the actin cytoskeleton:Current evidence,future perspectives and implications

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BIOCELL 2022年第12期46卷 2531-2535页

作者： laura LAFON-HUGHES Instituto de Investigaciones Biológicas Clemente Estable Ministerio de Educación y CulturaMontevideo11600Uruguay Centro Universitario Regional Litoral Norte Universidad de la RepúblicaSalto50000Uruguay

Poly(ADP-ribose)(PAR)is a highly negatively charged *** is synthesized by poly(ADP-ribose)polymerases(PARPs)and is involved in the assembly and stabilization of macromolecular ***,the presence and putative roles of poly(ADP-ribosyl)ation(PARylation)associated to adherens junctions(AJ)and the actin cytoskeleton in epithelial and Schwann cells,is *** hypothesis generated by analogy,stating that PAR is associated to AJ in other cell types,is *** to this hypothesis,PAR associated to puncta adherentia in chemical synapses would participate in plasticity,learning and *** turn,PAR associated to fascia adherens in cardiomyocytes,would affect heart *** inhibitors are currently under development and clinical *** research in different tissues will probably influence their clinical uses.

关键词： PARP tankyrase Epithelia Neuron Schwann cell Cardiomyocyte Vinculin

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Polycaprolactone/mesoporous silica MCM-41 composites prepared by in situ polymerization

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Particuology 2017年第1期15卷 135-143页

作者： laura Lopez-Figueras Nuria Navascues Silvia Irusta Department of Chemical Engineering Nanoscience Institute of Aragon (INA) University of Zaragoza 50018 Zaragoza Spain Networking Research Center on Bioengineering Biomaterials and Nanomedicine CIBER-BBN 50018 Zaragoza Spain

Composites of polycaprolactone （PCL） with mesoporous silica MCM-41 and N-[3- （trimethoxysilyl）propyl]-ethylenediamine （EPtES）-functionalized MCM-41 （EPtES/MCM-41） were prepared by in situ polymerization. the thermal properties of the composites were characterized by thermogravimetric analysis. there was an increase in the thermal decomposition temperature of PCL by more than 55 ℃, when the EPtES/MCM-41 loading was higher than 2 wt%. tensile test results indicated that adding MCM-41 increased the brittleness of the PCL matrix, while adding 8 wt% of EPtES/MCM-41 increased the Young＇s modulus by 26%. Incorporating MCM-41 increased the crystallinity of the resulting PCL composite, compared with that of PCL. Incorporating up to 5 wt% EPtES/MCM-41 slightly reduced the crystallinity of PCL. the different effects of MCM-41 and EPtES/MCM-41 on the composite reflected the degree of interaction and dispersion of the silica filler in the polymer matrix, as evidenced by results from transmission electron microscopy and atomic force microscopy.

关键词： Nanocomposite Mesoporous silica Polycaprolactone

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