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Diet and microbiome in the beginning of the sequence of gut inflammation

World Journal of Clinical Cases 2021年第36期9卷 11122-11147页

作者： Daniel Ceballos A Hernández-Camba laura ramos Department of Gastroenterology Hospital Universitario de Gran Canaria Doctor NegrinLas Palmas 35019CanariasSpain Department of Gastroenterology Hospital Universitario Nuestra Señora de La CandelariaSanta Cruz de Tenerife 38010CanariasSpain Department of Gastroenterology Hospital Universitario de CanariasSan Cristóbal de La Laguna 38320CanariasSpain

Inflammatory bowel disease(IBD)is a chronic inflammatory condition of the gastrointestinal tract due,at least partially,to an aberrant and excessive mucosal immune response to gut bacteria in genetically-predisposed individuals under certain environmental factors.The incidence of IBD is rising in western and newly industrialized countries,paralleling the increase of westernized dietary patterns,through new antigens,epithelial function and permeability,epigenetic mechanisms(e.g.,DNA methylation),and alteration of the gut microbiome.Alteration in the composition and functionality of the gut microbiome(including bacteria,viruses and fungi)seems to be a nuclear pathogenic factor.The microbiome itself is dynamic,and the changes in food quality,dietary habits,living conditions and hygiene of these western societies,could interact in a complex manner as modulators of dysbiosis,thereby influencing the activation of immune cells’promoting inflammation.The microbiome produces diverse small molecules via several metabolic ways,with the fiber-derived short-chain fatty acids(i.e.,butyrate)as main elements and having anti-inflammatory effects.These metabolites and some micronutrients of the diet(i.e.,vitamins,folic acid,beta carotene and trace elements)are regulators of innate and adaptive intestinal immune homeostasis.An excessive and unhealthy consumption of sugar,animal fat and a low-vegetable and-fiber diet are risk factors for IBD appearance.Furthermore,metabolism of nutrients in intestinal epithelium and in gut microbiota is altered by inflammation,changing the demand for nutrients needed for homeostasis.This role of food and a reduced gut microbial diversity in causing IBD might also have a prophylactic or therapeutic role for IBD.The relationship between dietary intake,symptoms,and bowel inflammation could lead to dietary and lifestyle recommendations,including diets with abundant fruits,vegetables,olive oil and oily fish,which have anti-inflammatory effects and could prevent dysbiosis and IBD.Dietary modulation and ap

关键词： Diet Microbiome Inflammatory bowel disease Pathogenia

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A complicated peribiliary cyst:An unusual hilar cholangiocarcinoma mimic

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 193-195页

作者： Oriana Barrios Kristel Mils laura Lladó Josefina Lopez-Dominguez Emilio ramos Division of Hepatobiliary Surgery Bellvitge University HospitalBarcelona 08907Spain

To the Editor:Peribiliary cysts are cystic dilatations of the extramural peribiliary glands that appears in the connective tissue around the hepatic hilum.They can affect up to the fourth order intrahepatic bile ducts and do not communicate with the bile lumen.It is a rare entity first described in 1984 by Nakanuma et al.[1].Its diagnosis is usually an incidental discovery in patients with advanced liver disease,portal thrombosis,and portal hypertension [2].

关键词： biliary diagnosis

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Building geometry data from online maps for accurate thermal simulations of districts

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建筑模拟(英文) 2023年第9期16卷 1659-1674页

作者： laura Romero Rodríguez JoséSánchez ramos ServandoÁlvarez Domínguez Grupo Termotecnia.Departamento de Máquinas y Motores Térmicos University of CádizPuerto RealCádizSpain Grupo Termotecnia.Departamento de Ingenieria Energética University of SevilleSevilleSpain

Current approaches for simulating the energy performance of buildings on a large scale are limited by numerous assumptions and simplifications,which can lead to inaccurate estimations.While new tools and procedures are emerging to improve accuracy,there remains a need for more user-friendly methods.This study proposes a new tool based on online maps to create the geometry of districts in a simple way.The tool also enables an automatic evaluation of all buildings through dynamic hourly simulations,using a building simulation software and allowing to consider different weather conditions.To illustrate the procedure,a district at risk of energy poverty in Seville(Spain)is modeled,where hourly temperature data for a whole year are available to demonstrate the need for building improvements.The tool is used to evaluate the energy demands of the district under several retrofitting alternatives,and free-floating simulations are also performed to evaluate the improvement of thermal comfort without air-conditioning systems.The aim is not to discuss the actual values for this particular case,but rather to identify the correct direction for large-scale studies,so as to make them more easily conducted.Overall,it may be concluded that the results provided by comprehensive tools,such as the one proposed in this study,enable easy yet accurate evaluations of buildings on a large scale with significant time savings,as well as the identification of locations where retrofitting interventions would have the greatest impact.

关键词： buildings districts energy demand efficiency GIS urban scale

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Outflow reconstruction with arterial patch in domino liver transplantation: a new technical option

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Hepatobiliary & Pancreatic Diseases International 2014年第5期13卷 551-554页

作者： laura Lladó Emilio ramos Sofia De LaSerna Joan Fabregat Liver Transplant Unit Hospital Universitari de Bellvitge

Domino liver transplantation（LT）, using livers from familial amyloidotic polyneuropathy（FAP） patients, is a well described technique useful to expand donor pool. One of the main difficulties of this type of LT arises from the necessity to share the vascular pedicles between the graft and the donor. The most important challenge resides in restoring a proper hepatic venous outflow in the FAP-liver recipient.This is specially challenging when using the piggy-back technique, because the hepatic stumps may be too short. To overcome this issue, surgeons explored several techniques using different types of venous grafts. We describe a new technical option by using an arterial graft from the deceased donor. By using both iliac arteries a long graft is created and sutured as needed to the hepatic vein stump. We describe herein this new technique employed in a domino liver recipient who underwent retransplantation for ischemic cholangitis. The procedure was performed using the piggy-back technique; the venous stump of the FAP liver was reconstructed with the arterial graft. The patient had uneventful postoperative and mid-term hepatic function, and anastomosis was patent 24 months after LT.

关键词： liver transplantation technique graft hepatic vein iliac artery

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Extra-anatomic aortic bypass for the treatment of a mycotic pseudoaneurysm after liver transplantation for hilar cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2021年第3期20卷 285-287页

作者： laura Llado Elena Iborra Emilio ramos Nuria Sabé Alba Cachero Joan Fabregat Liver Transplant Unit Hospital Universitari BellvitgeUniversity of BarcelonaBarcelonaSpain Vascular Surgery Department Hospital Universitari BellvitgeUniversity of BarcelonaBarcelonaSpain Infectious Disease Department Hospital Universitari BellvitgeUniversity of BarcelonaBarcelonaSpain

Liver transplantation(LT) after neoadjuvant chemoradiotherapy in patients with unresectable hilar cholangiocarcinoma(HC) is an accepted treatment strategy [1]. Neoadjuvant therapy is associated with an increased risk of arterial and portal complications after LT [1,2]. In most cases, radiation therapy makes the use of the native hepatic artery inadvisable, and an aortic anastomosis is needed, either with or without a graft [2].

关键词： aortic arterial treatment after

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Metabolic dysregulation in term infants from SARS-CoV-2-infected mothers

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World Journal of Pediatrics 2023年第9期19卷 912-917页

作者： Mari Merce Cascant-Vilaplana Inmaculada Lara-Cantón Victoria ramos-Garcia Alejandro Pinilla-González Álvaro Solaz-García Guillermo Quintás Purificación Marín-Reina Marta Aguar laura Torrejón-Rodríguez Máximo Vento Julia Kuligowski María Cernada Neonatal Research Unit Health Research Institute Hospital La FeUniversity Polytechnic Hospital La FeAvda.Fernando Abril Martorell 10646026ValenciaSpain Leitat Technological Center ValenciaSpain Analytical Unit Health Research Institute La FeValenciaSpain Division of Neonatology University and Polytechnic Hospital La FeValenciaSpain

Severe acute respiratory syndrome coronavirus 2(SARSCoV-2)is a novel beta coronavirus that causes coronavirus disease 2019(COVID-19),a severe infectious respiratory disease.In January 2020,the World Health Organizatio... 详细信息

关键词： mother respiratory acute

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Antibacterial,pro-angiogenic and pro-osteointegrative zein-bioactive glass/copper based coatings for implantable stainless steel aimed at bone healing

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Bioactive Materials 2021年第5期6卷 1479-1490页

作者： laura ramos Rivera Andrea Cochis Sarah Biser Elena Canciani Sara Ferraris Lia Rimondini Aldo R.Boccaccini Institute of Biomaterials Department of Materials Science and EngineeringUniversity of Erlangen-NurembergErlangenGermany Department of Health Sciences Universita del Piemonte UPONovaraItaly Center for Translational Research on Autoimmune and Allergic Diseases-CAAD NovaraItaly Department of Department of Biomedical Surgical and Dental SciencesThin Section LabUniversity of MilanMilanItaly Department of Applied Science and Technology Politecnico di TorinoTurinItaly

Stainless steel implants are suitable candidates for bone replacement due to their cytocompatibility and mechanical resistance,but they suffer from lack of bioactivity and are prone to bacterial infections.Accordingly,to overcome those limitations,in this study we developed by electrophoretic deposition(EPD),an innovative surface coating made of(i)zein,a natural fibroblast-friendly polymer,(ii)bioactive glass,a pro-osteogenic inorganic material and(iii)copper containing bioactive glass,an antibacterial and pro-angiogenic material.FESEM images confirmed that porous,uniform and free of cracks coatings were obtained by EPD;moreover,coatings were resistant to mechanical stress as demonstrated by the tape test,resulting in a 4B classification of adhesion to the substrate.The coatings were cytocompatible as indicated by metabolism evaluation of human fibroblasts,endothelial cells and mature or progenitor osteoblasts cultivated in direct contact with the specimens.They also maintained pro-osteogenic properties towards undifferentiated progenitor cells that expressed osteogenic genes after 15 days of direct cultivation.Copper conferred antibacterial properties as biofilm formation of the joint pathogens Staphylococcus aureus,Staphylococcus epidermidis and Escherichia coli was significantly reduced in comparison with copper-free coatings(p<0.05).Moreover,this anti-infective activity resulted as targeted towards bacteria while the cells viability was preserved when cells and bacteria were cultivated in the same environment by a co-culture assay.Finally,copper ability to recruit blood vessels and to inhibit bacterial infection was confirmed in vivo where the growth of S.aureus biofilm was inhibited and the formation of new(<50μm diameter spread)blood vessels was observed.

关键词： Zein Bioactive glass Copper Bone Antibacterial

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Interaction of piRNA-like sequences from the 3′-UTR of SARS-CoV-2 with mRNA regions

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Genes & Diseases 2023年第6期10卷 2282-2284页

作者： laura Pérez-Campos Mayoral María Teresa Hernández-Huerta Carlos Romero Díaz Carlos Alberto Matias-Cervantes Eduardo Pérez-Campos Mayoral Margarito Martínez Cruz Juan de Dios Ruiz-Rosado Edgar Gustavo ramos Martínez Marco Antonio Sánchez Medina Eduardo Pérez-Campos Research Center Faculty of Medicine UNAM-UABJOAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 68020Mexico CONACyT Faculty of Medicine and Surgery.Autonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 68020Mexico National Technology of Mexico(TecNM)/IT Oaxaca Oaxaca de JuárezOaxaca 68030Mexico The Research Institute at Nationwide Children's Hospital Columbus 43205USA Facultad de Química Universidad Nacional Autónoma de MéxicoCoyoacán 04510Mexico

Piwi-interacting RNAs(piRNAs of 26-32 nt in length)regulate gene expression,epigenetics,and transcriptional and post-transcriptional processes.1 In humans,piRNAs are expressed in germline and somatic tissues,and generally have a uracil at the 5'-end(position+1),an adenine at the+10 position,and are 2'-0 methylated at the 3'-end.2 Onice piRNAs form the RNA-induced silencing complex(RISC)with PIWl proteins,they serve as guides to find their complementary sequences of the target mRNA,thus initiating their degradation.The Wuhan patient's genome is approximately 265 nucleotides(nts)in its 3'-UTR;piRNAs-like sequences have been reported in this region.3 Our objective was to search,through bioinformatics,for mRNA sequences that were homologous to the reverse complementary of the previously reported piRNA-like sequences from the 3'-UTR of SARS-Cov-2,3 and identify the possible interaction between them.

关键词： sequences complementary initiating

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ECIEN-2020 study:the effect of COVID-19 on admissions for non-COVID-19 diseases

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World Journal of Pediatrics 2021年第1期17卷 85-91页

作者： Beatriz ramos-Lacuey Mercedes Herranz Aguirre Clara Calderón Gallego Andrea Ilundain López de Munain Eva Gembero Esarte laura Moreno-Galarraga Department of Pediatrics CHNComplejo Hospitalario de NavarraServicio Navarro de SaludC/Irunlarrea 331080 PamplonaSpain Pediatric Infectious Diseases Department CHNComplejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain Pediatric Hospitalization Department of PediatricsCHNComplejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain IdiSNA Navarra Institute for Health ResearchPamplonaSpain Department of Preventive Medicine and Public Health School of MedicineUniversity of NavarraPamplonaSpain Pediatric Pulmonology Department of PediatricsCHNComplejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain

Background The pandemic caused by severe acute respiratory coronavirus 2(SARS-CoV-2)has had great effects on health systems worldwide,not only in relation to coronavirus disease 2019(COVID-19)cases but also affecting patients with other pathologies.Methods ECIEN-2020 is an observational study conducted in a tertiary referral hospital in Navarra,Spain.It describes the effects of COVID-19 pandemic and the preventive measures adopted,in pediatric admissions for non-COVID-19 diseases.Admissions during March-June 2020(first wave of the COVID-19 pandemic in Spain)are described and compared with the same quarter in 2019.A sub-analysis was performed delving into epidemiology.Patient characteristics(age,sex,past medical history),disease characteristics(symptoms,duration of symptoms,previous consultation in Primary Care Health Center),and admission characteristics(place and average stay)were analyzed.Results A 33% reduction in the number of pediatric hospital admissions was observed,decreasing from 529 hospitaliza-tions in 2019 to 353 in 2020(P<0.001).This highlights a 48% reduction in patients admitted for pulmonary diseases.There were no significant changes in average hospital-stay,percentage of intensive care unit admissions,or in admissions for other reasons.Percentage of patients admitted among those seen in the emergency department rose from 5.1%in 2019 to 10.9% in 2020,whereas the total number of consultations in the emergency department decreased by 68%.Conclusion The pandemic and the measures adopted due to SARS-CoV-2 have significantly decreased pediatric admissions for non-COVID-19 diseases,especially due to a reduction in the hospitalization for respiratory diseases.

关键词： Admission COVID-19 Hospitalization SARS-CoV-2

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ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease

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World Journal of Gastroenterology 2010年第37期16卷 4685-4690页

作者： Sánchez-Cuén Jaime Aguilar-Medina Maribel Arámbula-Meraz Eliakym Romero-Navarro José Granados Julio Sicairos-Medina laura ramos-Payán Rosalío División de Gastroenterología Hospital Regional ISSSTE Facultad de Ciencias Químico Biológicas Doctorado en Biotecnología y Maestría en Ciencias Biomédicas Universidad Autónoma de Sinaloa División de Inmunogenética Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

AIM: To determine the possible association of the ApoB100 (Xba Ⅰ ), ApoE (Hha Ⅰ ) and CYP7A1 (Bsa Ⅰ ) gene polymorphisms, with the development of cholesterol gallstone disease (GD) in a Mexican population. METHODS: The polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by ethnicity, age and sex: patients with GD (n = 101) and stone-free control subjects (n = 101). RESULTS: Allelic frequencies in patients and controls were: 34.16% vs 41.58% (P = 0.124) for X+of ApoB-100; 4.46% vs 5.94% (P = 0.501) for E2, 85.64% vs 78.22% (P = 0.052) for E3, 9.90% vs 15.84% (P = 0.075) for E4 of ApoE; and 25.74% vs 27.72% (P = 0.653) for C of CYP7A1. Differences in genotypic frequencies between the studied groups were not significant (P < 0.05). CONCLUSION: These results demonstrated that no association exists between the studied polymorphisms and cholelithiasis in this high prevalent population.

关键词： Apolipoprotein CYP7A1 Gallstones Mexicans Polymorphisms

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