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Debate about TGFBR1 and the susceptibility to colorectal cancer

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World Journal of Gastrointestinal Oncology 2012年第1期4卷 1-8页

作者： laura Valle Hereditary Cancer Program Catalan Institute of Oncology IDIBELL 08908 Hospitalet de Llobregat Spain

Recent years have witnessed enormous progress in our understanding of the genetic predisposition to colorectal cancer (CRC). Estimates suggest that all or most genetic susceptibility mechanisms proposed so far, ranging from high-penetrance genes to low-risk alleles, account for about 60% of the population-attributable fraction of CRC predisposition. In this context, there is increasing interest in the gene encoding the transforming growth factor β receptor 1 (TGFBR1 ); first when over a decade ago a common polymorphism in exon 1 (rs11466445, TGFBR1 *6A/9A) was suggested to be a risk allele for CRC, then when linkage studies identified the chromosomal region where the gene is located as susceptibility locus for familial CRC, and more recently when the allele-specific expression (ASE) of the gene was proposed as a risk factor for CRC. Published data on the association of TGFBR1 with CRC, regarding polymorphisms and ASE and including sporadic and familial forms of the disease, are often contradictory. This review gives a general overview of the most relevant studies in order to clarify the role of TGFBR1 in the field of CRC genetic susceptibility.

关键词： Transforming growth factor β receptor 1 Transforming growth factor β receptor 1*6A 9q linkage peak Allele-specific expression Colorectal cancer risk

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体力活动与癌症生存研究的10大问题

北京体育大学学报 2016年第2期39卷 40-48页

作者： Kerry S.Courneya laura q.Rogers Kristin L.Campbell Jeff K.Vallance Christine m.Friedenreich 阿尔伯塔大学阿拉巴马大学伯明翰分校英属哥伦比亚大学阿萨巴斯卡大学阿尔伯塔健康服务机构

今天的美国有1 400万的癌症存活者,其中的很多存活者中都接受了多种治疗,包括手术、放疗、化疗、靶向治疗等。这些治疗能够延长生存时间,但同时也会带来很多急慢性的副作用,危害健康,影响生活质量。体力活动(PA)与癌症生存这一领域发展... 详细信息

今天的美国有1 400万的癌症存活者,其中的很多存活者中都接受了多种治疗,包括手术、放疗、化疗、靶向治疗等。这些治疗能够延长生存时间,但同时也会带来很多急慢性的副作用,危害健康,影响生活质量。体力活动(PA)与癌症生存这一领域发展迅速,主要研究PA对癌症患者的影响。基于该领域的研究进展,提出了以下10大研究问题:1)PA能够降低癌症复发风险、和/或提高存活吗?2)PA能够影响癌症治疗决策、完成率、和/或患者对治疗的反应吗?3)癌症存活者的最佳运动处方是什么?4)静坐少动行为对癌症存活者有何影响?5)癌症存活者最有效的PA干预方案是什么?6)哪些癌症会影响病人对PA的反应?7)癌症存活者进行PA时需要注意的安全问题有哪些?8)哪些具体的癌症症状可以由PA解决?9)对于癌症晚期患者,PA还有何作用?10)如何将PA研究结果转化到临床和社区肿瘤实践中来?上述问题的回答至关重要,这不仅关系到PA和癌症存活这一研究领域的发展,更重要的是,能够为每年数百万新诊断为癌症的病人、正在接受癌症治疗的病人、治疗结束处于恢复中的病人或是那些正在与晚期癌症抗争的病人带来福音。

关键词：癌症病人体力活动肿瘤静坐少动行为

Design and guidance of a multi-active debris removal mission

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Astrodynamics 2023年第4期7卷 383-399页

作者： minduli C.Wijayatunga(B) Roberto Armellin Harry Holt laura Pirovano Aleksander A.Lidtke Te Pūnaha Atea–Space Institute The University of AucklandAuckland 1010New Zealand Astroscale Japan Inc. 1-16-4-16 KinshiSumida-kuTokyoJapan

Space debris have become exceedingly dangerous over the years as the number of objects in orbit continues to *** debris removal(ADR)missions have gained significant interest as effective means of mitigating the risk of collision between objects in *** study focuses on developing a multi-ADR mission that utilizes controlled reentry and *** mission comprises two spacecraft:a Servicer that brings debris to a low altitude and a Shepherd that rendezvous with the debris to later perform a controlled reentry.A preliminary mission design tool(PmDT)was developed to obtain time and fuel optimal trajectories for the proposed mission while considering the effect of J2,drag,eclipses,and duty *** PmDT can perform such trajectory optimizations for multi-debris missions with computational time under a *** guidance schemes are also studied,taking the PmDT solution as a reference to validate the design methodology and provide guidance solutions to this complex mission profile.

关键词： active debris removal(ADR) trajectory design optimization autonomous guidance low-thrust electric propulsion △u-law guidance q-law guidance

Effects of chlorpyrifos on enzymatic systems of Cydia pomonella （Lepidoptera： Tortricidae） adults

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Insect Science 2017年第3期24卷 455-466页

作者： laura Beatriz Parra morales Raul Adolfo Alzogaray Liliana Cichon Silvina Garrido Jimena Soleno Cristina monica montagna Laboratorio de Investigaciones Bioquimicas Quimicas y de Medio Ambiente Facultad de Ingenieria Universidad Nacional del ComahueBuenos Aires 1400 (Q83001BX) Neuquen Facultad de Ciencias del Ambiente y la Salud Universidad Nacional del Comahue Buenos Aires 1400 Neuquen Centro de Investigaciones de Plagas e Insecticidas (CIPEIN-UNIDEFICONICET) Villa Martelli Buenos Aires Instituto de Investigacion e Ingenieria Ambiental (3iA-UNSAm) San Martin Provincia de Buenos Aires Instituto Nacional de Tecnologia Agropecuaria Estacion Experimental Alto Valle General Roca Argentina

The control program of codling moth （Cydia pomonella L.） in the Rio Negro and Neuqu6n Valley is intended to neonate larvae. However, adults may be subjected to sublethal pesticide concentrations generating stress which might enhance both mutation rates and activity of the detoxification system. This study assessed the exposure effects of chlorpyrifos on target enzyme and, both detoxifying and antioxidant systems of surviving adults from both a laboratory susceptible strain （LSS） and a field population （FP）. The results showed that the FP was as susceptible to chlorpyrifos as the LSS and, both exhibited a similar chlorpyrifos-inhibitory concentration 50 （IC50） of acetylcholinesterase （ACHE）. The FP displayed higher carboxylesterase （CarE） and 7-ethoxycoumarine O-deethylase （ECOD） activities than LSS. Both LSS and FP showed an increase on CarE activity after the exposure to low-chlorpyrifos concentrations, followed by enzyme inhibition at higher concentrations. There were no significant differences neither in the activities of glutathione S-transferases （GST）, catalase （CAT） and superoxide dismutase （SOD） nor in the reduced glutathione （GSH） content between LSS and FP. moreover, these enzymes were unaffected by chlorpyrifos. In conclusion, control adults from the FP exhibited higher CarE and ECOD activities than control adults from the LSS. AChE and CarE activities were the most affected by chlorpyrifos. Control strategies used for C. pomonella, such as rotations of insecticides with different modes of action, will probably delay the evolution of insecticide resistance in FPs from the study area.

关键词： acetylcholinesterase antioxidant system chlorpyrifos codling moth detoxification enzymes

Petrogenesis of quebrada de la mina and Altar North porphyries (Cordillera of San Juan, Argentina): Crustal assimilation and metallogenic implications

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Geoscience Frontiers 2017年第5期8卷 1135-1159页

作者： laura maydagán marta Franchini massimo Chiaradia Verónica Bouhier Noelia Di Giuseppe Roger Rey Luis Dimieri Centro Patagónico de Estudios metalogenéticos-CONICET Argentina INGEOSUR-CONICET Departamento de Geología Universidad Nacional del Sur San Juan 670 8000 Bahía Blanca Argentina Instituto de Investigación en Paleobiología y Geología Universidad Nacional de Río Negro Av. Roca 1242 8332 Roca Argentina Departamento de Geología y Petróleo Facultad de Ingeniería Universidad Nacional del Comahue Buenos Aires 1400 8300 Neuquén Argentina Section of Earth and Environmental Sciences University of Geneva Switzerland minera Peregrine Argentina S.A Santa Fe (Oeste) 117 Piso 4B Edificio Derby Ciudad San Juan Argentina

We investigate the geology of Altar North(Cu-Au) and quebrada de la mina(Au) porphyry deposits located in San Juan Province(Argentina), close to the large Altar porphyry copper deposit(995 mt,0.35% Cu, 0.083 g/t Au), to present constraints on the magmatic processes that occurred in the parental magma chambers of these magmatic-hydrothermal systems. Altar North deposit comprises a plagioclase-amphibole-phyric dacite intrusion(Altar North barren porphyry) and a plagioclaseamphibole-biotite-phyric dacite stock(Altar North mineralized porphyry, 11.98 ± 0.19 ma). In quebrada de la mina, a plagioclase-amphibole-biotite-quartz-phyric dacite stock(qDm porphyry,11.91±0.33 ma) crops out. High Sr/Y ratios(92-142) and amphibole compositions of Altar North barren and qDm porphyries reflect high magmatic oxidation states(fO_2= NNO+1.1 to+1.6) and high fH_2O conditions in their magmas. Zones and rims enriched in anorthite(An_(37-48))), SrO(0.22-0.33 wt.%)and FeO(0.21-0.37 wt.%) in plagioclase phenocrysts are evidences of magmatic recharge processes in the magma chambers. Altar North and quebrada de la mina intrusions have relatively homogeneous isotopic compositions(^(87)Sr/^(86)Sr_(t)= 0.70450-0.70466, ε_(ND)(t) = +0.2 to +1.2) consistent with mixed mantle and crust contributions in their magmas. Higher Pb isotopes ratios(^(207)Pb/^(204)Pb=15.6276-15.6294) of these intrusions compared to other porphyries of the district, reflect an increase in the assimilation of high radiogenic Pb components in the magmas. Ages of zircon xenocrysts(297,210,204,69 ma) revealed that the magmas have experienced assimilation of miocene, Cretaceous, Triassic and Carboniferous crustal *** that precipitated sulfides in the Altar deposit may have remobilized Pb from the host rocks, as indicated by the ore minerals being more radiogenic(207Pb/204 Pb = 15.6243-15.6269) than their host intrusions. Au/Cu ratio in Altar porphyries(average Au/Cu ratio of 0.14 ×10^(-4)by weight in Altar Central)is hig

关键词： Porphyry High sulfidation epithermal magmatic recharge Radiogenic isotopes Crustal assimilation Argentinian Andes

SIGN PATTERNS REqUIRING ALL DISTINCT EIGENVALUES

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Numerical mathematics A Journal of Chinese Universities(English Series) 2000年第S1期9卷 15-17页

作者： Harris laura Department of mathematics and Statistics Georgia State University Atlanta

A sign pattern(matrix)is a matrix whose entries are the symbols+,-and *** n×n sign pattern matrix A,the sign pattern class of A,denoted by q(A),is the set ofall n×n real matrices whose entries have signs indicated by the corresponding entries of *** say that a sign pattern matrix A requires a matrix property P if every real matrix in q(A)has the property P.A matrix with all distinct eigenvalues has many nice

关键词： length cycle SIGN PATTERNS REqUIRING ALL DISTINCT EIGENVALUES DE real

molecular Cloning and Characterization of a Candidate Plant Growth-Related and Time-Keeping Constitutive Cell Surface Hydroquinone (NADH) Oxidase (ENOX1) from <i>Arabidopsis lyrata</i>

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Advances in Biological Chemistry 2015年第1期5卷 1-15页

作者： Xiaoyu Tang laura m. C. Ades Dorothy m. morré D. James morré morNuCo Inc. Purdue Research Park West Lafayette IN USA

ENOX (ECTO-NOX) proteins are proteins of the external surface of the plasma membrane that catalyze oxidation of both NADH and hydroquinones as well as carry out protein disulfidethiol interchange. They exhibit both prion-like and time-keeping (clock) properties. The oxidative and interchange activities alternate to generate a regular period of 24 min in length. Here we report the cloning, expression, and characterization of a plant candidate constitutive ENOX (CNOX or ENOX1) protein from Arabidopsis lyrata. The gene encoding the 335 (165) amino acid protein is found in accession XP-002882467. Functional motifs characteristics of ENOX proteins previously identified by site-directed mutagenesis and present in the candidate ENOX1 protein from plants include adenine nucleotide and copper binding motifs along with essential cysteines. However, the drug binding motif (EEmTE) sequence of human ENOX2 is absent. The activities of the recombinant protein expressed in E. coli were unaffected by capsaicin, EGCg, and other ENOX2-inhibiting substances. Periodic oxidative activity was exhibited both with NAD(P)H and reduced coenzyme q as substrate. Bound copper was necessary for activity and activity was inhibited by the ENOX1-specific inhibitor simalikalactone D. Addition of melatonin phased the 24-min period such that the next complete period began 24 min after the melatonin addition as appeared to be characteristic of ENOX1 activities in general. Periodic protein disulfide-thiol interchange activity also was demonstrated along with the 2 oxidative plus 3 interchange activity pattern characteristics of the 24-min ENOX1 protein period. Concentrated solutions of the purified plant ENOX1 protein formed insoluble aggregates, devoid of enzymatic activity, resembling amyloid. Activity was restored to aggregate preparations by isoelectric focusing.

关键词： ENOX1 ECTO-NOX Proteins Plant Growth Hydroquinone (NADH) Oxidation Plasma membrane Electron Transport Arabadopsis lyrata

IBD5 polymorphisms in inflammatory bowel disease: Association with response to infliximab

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World Journal of Gastroenterology 2005年第8期11卷 1187-1192页

作者： Elena Urcelay Juan Luis mendoza Alfonso martínez laura Fernández Carlos Taxonera manuel Díaz-Rubio Emilio G.de la Concha Immunology Department Gastroenterology Department

AIm: Inflammatory bowel diseases (IBD) are multifactorial pathologies of unknown etiology. One susceptibility locus, IBD5, has been mapped to chromosome 5q31. We analyzed our Spanish cohorts of Crohn's disease (CD) and ulcerative colitis (DC) patients to determine whether this locus is associated with IBD, and to ascertain the main clinical phenotype influenced by this risk factor. The kind of interaction, either genetic heterogeneity or epistasis, between this IBD5 susceptibility region and the NOD2/CARD15 gene mutations was studied as well. Finally, we assessed whether this locus can predict response to infliximab therapy. mETHODS: A case control study was performed with 274 CD and 211 UC patients recruited from a single center and 511 healthy ethnically matched controls. Two polymorphisms were genotyped in the IBD5 locus and three in the CARD15/NOD2 gene. RESULTS: Our results evidence association only with CD especially with the fistulizing phenotype and in the absence of NOD2/CARD15 variants (mutant allele frequency in patients vs controls: OR = 2.03, 95% CI = 1.35-3.06, Pquency of the IBD5 homozygous mutant genotype significantly increased in CD patients lacking response to infliximab (RR = 3.88, 95% CI = 1.18-12.0, Pq31 polymorphisms, although a similar trend to the one observed in CD is found within the worse prognosis group. CONCLUSION: The IBD5 variants may enhance an individual carrier's risk for CD, mainly in the absence of the NOD2/CARD15 mutations and in fistulizing patients. The data presented suggest the potential role of the 5q31 polymorphisms as markers of response to infliximab.

关键词： Crohn's disease Ulcerative colitis 5q31 polymorphisms Infliximab

Comparison of Secnidazole and Fenbendazole for the Treatment of Asymptomatic Giardia Infection in Dogs

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Veterinary Science Research 2019年第1期1卷 24-28页

作者： Jhon D Ruiz Gloria P Ramírez Ana m múnera Carlos Arroyave laura Castano Pablo López Grupo de Investigación en Ciencias de los Animales.Facultad de medicina Veterinaria y Zootecnia.Universidad CES.medellín Colombia

The objetive of this study was to compare a single dose of secnidazole versus multiple doses of fenbendazole for the treatment of dogs with asymptomatic Giardia *** and methods:Twenty-four asymptomatic dogs with a positive test result for Giardia spp were randomized in two equal groups to receive a single dose of secnidazole at 30 mg/kg PO,or fenbendazole at 50 mg/kg PO q24h for 3 *** parameters were evaluated before and 8 days after treatment,and feces were re-examined at days 8,15,and 30 post-treatment by fecal flotation and antigen ***:The number of positive dogs in the fenbendazole group was:1(day 8)and 3(days 15 and 30).In the secnidazole group,the number of positive cases were:4(day 8),3(day 15),and 1(day 30).Conclusion:Treatment with secnidazole or fenbendazole,were effective between 75%and 92%to eliminate the excretion of Giardia cysts in canines together with hygienic measures to control,like disinfection with quaternary ammonium of patients and their *** studies that include more animals and multiple fecal exams on consecutive days would be necessary to confirm its efficacy in dogs.

关键词： Drugs effects Parasitology Pharmacology Zoonosis