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Human bocavirus in children hospitalized for acute respiratory tract infection in Rome

World Journal of Pediatrics 2020年第3期16卷 293-298页

作者： laura petrarca Raffaella Nenna Antonella Frassanito Alessandra Pierangeli Greta Di Mattia Carolina Scagnolari Fabio Midulla Maternal-Infantile and Urological Science Department "Sapienza"University of RomeRomeItaly Virology Laboratory Department of Molecular Medicine"Sapienza"University of RomeRomeItaly

Background The role of human bocavirus (HBoV) as a respiratory pathogen has not been fulfilled *** aimed to describe clinical and serological characteristics of children with HBoV hospitalized for acute respiratory tract infection and to evaluate whether differences occur between HBoV alone and in *** We retrospectively reviewed data from 60 children (median age of 6.2 months,range 0.6-70.9) hospitalized for acute respiratory symptoms,with HBoV detected from a respiratory sample,using a reverse transcriptase-PCR for 14 respiratory viruses (including respiratory syncytial virus (RSV),influenza virus A and B,human coronavirus OC43,229E,NL-63 and HUK1,adenovirus,rhinovirus,parainfluenza virus 1-3,and human metapneumovirus).Results HBoV was detected alone in 29 (48.3%) patients,while in co-infection with other viruses in 31 patients (51.7%),with a peak between December and *** the 60 patients,34 were bronchiolitis,19 wheezing,3 pneumonia,2 upper respiratory tract infection,and 2 whooping *** children (11.6%) required admission to the paediatric intensive care unit (PICU) for respiratory *** differences was observed in age,family history for atopy and/or asthma,clinical presentations,chest X-ray,or laboratory findings in children with HBoV alone *** viral *** was the most frequently co-detected virus (61.3%).When compared with HBoV detection alone,the co-detection of RSV and HBoV was associated with male sex (P=0.013),younger age (P=0.01),and lower blood neutrophil count (P=0.032).Conclusions HBoV can be detected alone and in co-infection respiratory samples of children with an acute respiratory tract infection.A cause-effect relationship between HBoV and respiratory infection is not clear,so further studies are needed to clarify this point.

关键词： Human bocavirus Pediatrics Respiratory tract infection Viral infection

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Dyspepsia and celiac disease: Prevalence, diagnostic tools and therapy

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World Journal of Methodology 2014年第3期4卷 189-196页

作者： laura petrarca Raffaella Nenna Gerarda Mastrogiorgio Matteo Florio Manuela Brighi Stefano Pontone Department of Pediatrics "Sapienza" University of Rome Department of Surgical Sciences "Sapienza" University of Rome

The prevalence of dyspepsia is up to 40% in population-based study. Functional dyspepsia is an exclusion diagnosis and it is classified as a chronic abdominal pain-related functional disorder, characterized by the presence of persistent or recurrent pain or discomfort centered in the upper abdomen, neither relief by defecation, nor association with the onset of a change in stool frequency or form. Celiac disease(CD) is a common autoimmune enteropathy, with a prevalence around 1% in the general population. Its diagnosis includes a serological screening and an upper gastrointestinal endoscopy with multiple biopsies. Gluten-free diet is the only effective treatment. CD diagnosis is often delayed in asymptomatic patients or in individuals with less clinical gastrointestinal symptoms. Several studies performed coeliac disease screening in patients with symptoms suggestive of dyspepsia, showing a biopsy-proved prevalence that ranged from 0.5% to 2%. The typical endoscopic markers of villous atrophy are not sufficiently sensitive, so some endoscopic techniques, such as "water immersion" and confocal endomicroscopy were proposed to improve the diagnosticsensitivity and target biopsies. A recent meta-analysis estimated that the prevalence of CD was higher in patients with dyspepsia, but not in a statistically significant way. However this assumption should be confirmed further larger studies.

关键词： Dyspepsia Coeliac disease Upper endoscopy Villus atrophy Screening

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