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Post reperfusion syndrome during liver transplantation:From pathophysiology to therapy and preventive strategies

World Journal of Gastroenterology 2016年第4期22卷 1551-1569页

作者： Antonio Siniscalchi Lorenzo Gamberini Cristiana Laici Tommaso Bardi Giorgio Ercolani laura lorenzini Stefano Faenza Division of Anesthesiology Alma Mater Studiorum University of Bologna40138 BolognaItaly Division of Surgery Alma Mater Studiorum University of Bologna40138 BolognaItaly

This review aims at evaluating the existing evidence regarding post reperfusion syndrome, providing a description of the pathophysiologic mechanisms involved and possible management and preventive strategies. A Pub Med search was conducted using the Me SH database, "Reperfusion" AND "liver transplantation" were the combined Me SH headings; EMBASE and the Cochrane library were also searched using the same terms. 52 relevant studies and one ongoing trial were found. The concept of post reperfusion syndrome has evolved through years to a multisystemic disorder. The implications of the main organ, recipient and procedure related factors in the genesis of this complex syndrome are discussed in the text as the novel pharmacologic and technical approaches to reduce its incidence. However the available evidence about risk factors, physiopathology and preventive measures is still confusing, the presence of two main definitions and the numerosity of possible confounding factors greatly complicates the interpretation of the studies.

关键词： Liver transplantation Reperfusion Ischemiareperfusioninjury Hemodynamics Drug therapy

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Neuroprotection and neuroregeneration:roles for the white matter

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Neural Regeneration Research 2022年第11期17卷 2376-2380页

作者： Vito Antonio Baldassarro Agnese Stanzani Luciana Giardino laura Calzà Luca lorenzini Department of Veterinary Medical Science University of BolognaBolognaItaly Interdepartmental Center for Industrial Research in Life Sciences and Technologies University of BolognaBolognaItaly Fondazione IRET Ozzano EmiliaItaly Department of Pharmacy and Biotechnology University of BolognaBolognaItaly Montecatone Rehabilitation Institute ImolaItaly

Efficient strategies for neuroprotection and repair are still an unmet medical need for neurodegenerative diseases and lesions of the central nervous *** the last few decades,a great deal of attention has been focused on white matter as a potential therapeutic target,mainly due to the discovery of the oligodendrocyte precursor cells in the adult central nervous system,a cell type able to fully repair myelin damage,and to the development of advanced imaging techniques to visualize and measure white matter *** combination of these two events has greatly increased the body of research into white matter alte rations in central nervous system lesions and neurodegenerative diseases and has identified the oligodendrocyte precursor cell as a putative target for white matter lesion repair,thus indirectly contributing to *** review aims to discuss the potential of white matter as a therapeutic target for neuroprotection in lesions and diseases of the central nervous *** conditions are discussed,specifically multiple scle rosis as a white matter disease;spinal cord injury,the acute lesion of a central nervous system component where white matter prevails over the gray matte r,and Alzheimer's disease,where the white matter was considered an ancilla ry component until *** first describe oligodendrocyte precursor cell biology and developmental myelination,and its regulation by thyroid hormones,then briefly describe white matter imaging techniques,which are providing information on white matter involvement in central nervous system lesions and degenerative ***,we discuss pathological mechanisms which interfere with myelin repair in adulthood.

关键词： Alzheimer's disease multiple sclerosis oligodendrocyte precursor cells spinal cord injury thyroid hormone traumatic brain injury white matter white matter imaging

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