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Levels of circulating follicular helper T cells,T helper 1 cells,and the prognostic significance of soluble form of CD40 ligand on survival in patients with alcoholic cirrhosis

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Liver Research 2018年第1期2卷 52-59页

作者： Kristin Hollister Praveen Kusumanchi Ruth Ann Ross Kristina Chandler AdePeju Oshodi laura heathers Sean Teagarden Li Wang Alexander L.Dent Suthat Liangpunsakul Department of Microbiology and Immunology Indiana University School of MedicineIndianapolisINUSA Division of Gastroenterology and Hepatology Department of MedicineIndiana University School of MedicineIndianapolisINUSA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisINUSA Department of Physiology and Neurobiology The Institute for Systems GenomicsUniversity of ConnecticutStorrsCTUSA Veterans Affairs Connecticut Healthcare System West HavenCTUSA Department of Internal Medicine Section of Digestive DiseasesYale UniversityNew HavenCTUSA School of Pharmaceutical Sciences Wenzhou Medical UniversityWenzhouZhejiangChina Department of Biochemistry and Molecular Biology Indiana University School of MedicineIndianapolisINUSA Roudebush Veterans Administration Medical Center IndianapolisINUSA

Background:Excessive drinkers(ED)and patients with alcoholic liver disease(ALD)are several times more susceptible to bacterial and viral infections and have a decrease in antibody responses to *** helper T(TFH)cells are essential to select B cells in the germinal center and to produce *** cells express both a membrane-associated and a soluble form of CD40 ligand(sCD40L),in which the latter form is released to circulation upon T cell *** effect of alcohol on TFH cells has not been ***:The goals of this study are to determine the levels of TFH and T helper 1(Th1)cells in ED and those with alcoholic cirrhosis(AC)when compared to healthy controls and to determine the prognostic significance of sCD40L in a cohort of patients with ***:Controls,ED,and those with AC were *** demographic,laboratory tests,and peripheral blood mononuclear cells(PBMCs)were isolated and assessed via flow cytometry for TFH *** vitro study was performed to determine the ability of PBMCs to secrete interferon(IFN)-ɣupon *** sCD40L was also determined and its prognostic significance was tested in a cohort of AC ***:The levels of circulating TFH(cTFH)cells were significantly lower in peripheral blood of subjects with ED and AC compared to controls(P<0.05).IFN-ɣsecretion from PBMCs upon stimulation was also lower in ED and those with *** sCD40L was significantly lower in ED and AC when compared to that in controls(P<0.0005).Its level was an independent predictor of ***:Patients with AC had significantly lower level of cTFH and *** level of sCD40L was an independent predictor of mortality in these patients.

关键词： Follicular helper T(TFH)cells Circulating follicular helper T(cTFH)cells T helper 1(Th1) Soluble form of CD40 ligand(sCD40L) Alcoholic liver disease(ALD) Alcoholic cirrhosis(AC)

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