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FDG-PET/CT and parathyroid carcinoma:Review of literature and illustrative case series

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World Journal of Clinical Oncology 2011年第10期2卷 348-354页

作者： laura evangelista Nadia Sorgato Francesca Torresan Isabella Merante Boschin Gianmaria Pennelli Giorgio Saladini Andrea Piotto Domenico Rubello Maria Rosa Pelizzo Radiotherapy and Nuclear Medicine Unit Istituto Oncologico Veneto(IOV-IRCCS)Padova 35128Italy Department of Surgical Pathology Institution of Medical and Surgical SciencesUniversity of PadovaPadova 35100Italy Department of Medical Diagnostic Sciences and Special Therapies(Surgical Pathology and Cytopathology Section) University of PadovaPadova 35100Italy Department of Nuclear Medicine Santa Maria della Misericordia Rovigo HospitalRovigo 45100Italy

Parathyroid cancer is an uncommon malignant cancer and is associated with a poor *** staging of parathyroid cancer represents an important issue both at initial diagnosis and after surgery and medical *** role of positron emission tomography/computed tomography(PET/CT)with 18F-Fluorodeoxyglucose(18F-FDG)as an imaging tool in parathyroid cancer is not clearly reported in the literature,although its impact in other cancers is *** aim of the following illustrative clinical cases is to highlight the impact of PET/CT in the management of different phases of parathyroid *** describe five patients with parathyroid malignant lesions,who underwent FDG PET/CT at initial staging,restaging and post-surgery *** each patient we report the value of PET/CT comparing its findings with other common imaging modalities(e.g.,CT,planar scintigraphy with 99mTcsestamibi,magnetic resonance imaging)thus determining the complementary benefit of FDG PET/CT in parathyroid *** hope to provide an insight into the potential role of PET/CT in assessing the extent of disease and response to treatment which are the general principles used to correctly evaluate disease status.

关键词： Parathyroid carcinoma Positron emission tomography/computed tomography 18F-Fluorodeoxyglucose Restaging Staging

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日本核医学论文摘要选登

中华核医学与分子影像杂志 2018年第7期38卷 515-517页

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甲状腺髓样癌复发患者^18F-DOPAPET／CT显像的预后预测价值【摘要】目的甲状腺髓样癌（MTC）占甲状腺癌的5%～8%。血清降钙素和癌胚抗原（CEA）的测定已被广泛应用于MTC进展的监测。但临床仍希望有能够预测预后的相关检查。该研究的目... 详细信息

甲状腺髓样癌复发患者^18F-DOPAPET／CT显像的预后预测价值【摘要】目的甲状腺髓样癌（MTC）占甲状腺癌的5%～8%。血清降钙素和癌胚抗原（CEA）的测定已被广泛应用于MTC进展的监测。但临床仍希望有能够预测预后的相关检查。该研究的目的是评价18F-多巴（DOPA）PET/CT显像在MTC复发患者中的预后预测价值。方法60例MTC复发患者[年龄44～82岁，平均（64±13）岁]行18F-DOPA PET/CT显像用于再分期，显像时间在手术后至少半年。记录患者的CEA和降钙素水平，PET/CT显像所示局部复发、淋巴结受累及远处转移情况。以峰值活度的40%作为阈值对每个病灶自动设置感兴趣容积（VOI），计算代谢性肿瘤体积（MTV）、最大标准摄取值（SUVmax）、平均标准摄取值（SUVmean）；同时以纵隔放射性摄取计算标化SUVmax和SUVmean，即nSUVmax和nSUVmean 。所有患者行临床和放射影像学随访（21±11）个月。使用Kaplan-Meier生存率曲线和时序检验评价无进展生存（PFS）率、疾病特异性生存（DSS）率，分析18F-DOPA PET/CT显像较常规影像学检查的预后预测增益价值。对预后预测的相关因素采用单变量和多变量Cox回归分析法进行评价。结果18F-DOPA PET/CT显像发现27例患者有异常病灶（45%），其余33例未见明显异常（55%）。PET/CT显像未见异常的患者PFS、DSS均高于有异常病灶的患者（P＝0.018、0.04）。与常规影像学检查比较，18F-DOPA PET/CT显像对PFS和DSS的预测有增益价值（P〈0.001、P＝0.012）。半定量的PET参数和临床资料或实验室检查结果均无法预测MTC复发患者PFS和DSS的降低。结论18F-DOPA PET/CT显像在MTC复发患者疾病进展和死亡率上有预后预测价值。

关键词：论文摘要 PET/CT显像 PET/CT显像甲状腺髓样癌常规影像学检查核医学 ^18F-DOPA 标准摄取值

Role of molecular imaging in the management of patients affected by inflammatory bowel disease:State-of-the-art

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World Journal of Radiology 2016年第10期8卷 829-845页

作者： Federico Caobelli laura evangelista Natale Quartuccio Demetrio Familiari Corinna Altini Angelo Castello Mariapaola Cucinotta Rossella Di Dato Cristina Ferrari Aurora Kokomani Iashar Laghai Riccardo Laudicella Silvia Migliari Federica Orsini Salvatore Antonio Pignata Cristina Popescu Erinda Puta Martina Ricci Silvia Seghezzi Alessandro Sindoni Martina Sollini Letterio Sturiale Anna Svyridenka Vittoria Vergura Pierpaolo Alongi Department of Nuclear Medicine Universitatsspital Basel Department of Nuclear Medicine Istituto Oncologico Veneto Wolfson Molecular Imaging Centre Univer-sity of Manchester Department of Nuclear Medicine A.R.N.A.S. Nuclear Medicine Unit Univer-sity"Aldo Moro"of Bari Department of Nuclear Medicine University of Florence Department of medical-surgical science and translational medicine "La Sapienza"University Nuclear Medicine Unit Department of Biomedical Sciences and Morphological and Functional ImagesUniversity of Messina Department of Nuclear Medicine University of Parma Department of Nuclear Medicine University Hospital"Maggiore della Carita di Novara" Department of Nuclear Medicine Niguarda Ca'Grande Hospital Department of Nuclear Medicine Hospital of Treviglio Humanitas University Department of Nuclear Medicine University of Bologna Nuclear Medicine Unit Department of Radio-logical SciencesG.Giglio Institute

AIM To present the current state-of-the art of molecular imaging in the management of patients affected by inflammatory bowel disease(IBD).METHODS A systematic review of the literature was performed in order to find important original articles on the role of molecular imaging in the management of patients affected by IBD. The search was updated until February 2016 and limited to articles in *** Fifty-five original articles were included in this review, highlighting the role of single photon emission tomography and positron emission tomography. CONCLUSION To date, molecular imaging represents a useful tool to detect active disease in IBD. However, the available data need to be validated in prospective multicenter studies on larger patient samples.

关键词： White blood cell scintigraphy Inflammatory bowel disease Inflammation ^(18)F-Fluorodehoxiglucose positron emission tomography/computed tomography Molecular imaging

甲状腺髓样癌复发患者18F-DOPA PET/CT显像的预后预测价值

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中华核医学与分子影像杂志 2018年第7期38卷 515-515页

作者：唐军 Federico Caobelli Agostino Chiaravalloti laura evangelista Giorgio Saladini Orazio Schillaci Manuela Vadrucci Federica Scalorbi Davide Donner Pierpaolo Alongi 上海交通大学医学院附属苏州九龙医院核医学科 Clinic of Radiology and Nuclear Medicine University Hospital BaselUniversity of Basel

目的甲状腺髓样癌(MTC)占甲状腺癌的5%～8%。血清降钙素和癌胚抗原(CEA)的测定已被广泛应用于MTC进展的监测。但临床仍希望有能够预测预后的相关检查。该研究的目的是评价F-多巴(DOPA)PET/CT显像在MTC复发患者中的预后预测价值。方法 60... 详细信息

目的甲状腺髓样癌(MTC)占甲状腺癌的5%～8%。血清降钙素和癌胚抗原(CEA)的测定已被广泛应用于MTC进展的监测。但临床仍希望有能够预测预后的相关检查。该研究的目的是评价F-多巴(DOPA)PET/CT显像在MTC复发患者中的预后预测价值。方法 60例MTC复发患者[年龄44～82岁,平均(64±13)岁]行F-DOPAPET/CT显像用于再分期,显像时间在手术后至少半年。记录患者的CEA和降钙素水平,PET/CT显像所示局部复发、淋巴结受累及远处转移情况。以峰值活度的40%作为阈值对每个病灶自动设置感兴趣容积(VOI),计算代谢性肿瘤体积(MTV)、最大标准摄取值(SUV)、平均标准摄取值(SUV);同时以纵隔放射性摄取计算标化SUV和SUV,即nSUV和nSUV。所有患者行临床和放射影像学随访(21±11)个月。使用Kaplan-Meier生存率曲线和时序检验评价无进展生存(PFS)率、疾病特异性生存(DSS)率,分析FDOPA PET/CT显像较常规影像学检查的预后预测增益价值。对预后预测的相关因素采用单变量和多变量Cox回归分析法进行评价。结果F-DOPA PET/CT显像发现27例患者有异常病灶(45%),其余33例未见明显异常(55%)。PET/CT显像未见异常的患者PFS、DSS均高于有异常病灶的患者(P=0.018、0.04)。与常规影像学检查比较,F-DOPA PET/CT显像对PFS和DSS的预测有增益价值(P<0.001、P=0.012)。半定量的PET参数和临床资料或实验室检查结果均无法预测MTC复发患者PFS和DSS的降低。结论F-DOPA PET/CT显像在MTC复发患者疾病进展和死亡率上有预后预测价值。

关键词：甲状腺髓样癌 18F-DOPA PET/CT 预后预测价值再分期

Black soldier fly and gut health in broiler chickens:insights into the relationship between cecal microbiota and intestinal mucin composition

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Journal of Animal Science and Biotechnology 2020年第3期11卷 841-852页

作者： Ilaria Biasato Ilario Ferrocino Sihem Dabbou Rocchina evangelista Francesco Gai laura Gasco Luca Cocolin Maria Teresa Capucchio Achille Schiavone Department of Agricultural Forest and Food SciencesUniversity of TurinLargo Paolo Braccini 210095 GrugliascoTOItaly Department of Veterinary Sciences University of TurinLargo Paolo Braccini 210095 GrugliascoTOItaly Institute of Science of Food Production National Research CouncilLargo Paolo Braccini 210095 GrugliascoTOItaly

Background:The relationship between diet and intestinal microbiota and mucin composition appears to be fundamental for poultry gut *** effects of insect meal(whose role as alternative feed ingredient is now well recognized)on gut microbiota and mucin composition have recently been reported in Tenebrio molitor-fed free-range and broiler chickens,but no data are currently available for Hermetia illucens(HI)-fed *** present study evaluated the effects of dietary HI meal inclusion on cecal microbiota and intestinal mucin composition of broiler ***:A total of 256 male broiler chickens were allotted to 4 dietary treatments(control diet[C]and 5%,10%and 15%HI meal inclusion,with 8 replicate pens/treatment and 8 birds/pen)and slaughtered at 35 d of age(2 animals/pen,16 birds/diet).The cecal microbiota assessment by 16S rRNA amplicon based sequencing showed lower alpha diversity in HI15 chickens(Shannon,P<0.05)and higher beta diversity(Adonis and ANOSIM,P<0.001)in birds fed HI diets than ***,HI15 birds displayed significant increase of the relative abundance of Proteobacteria phylum(False Discovery Rate[FDR]<0.05)when compared to HI10.L-Ruminococcus(Ruminococcus from Lachnospiraceae family),Faecalibacterium,Blautia and Clostridium genera were found to be characteristic of HI5 cecal microbiota(FDR<0.05),while broiler chickens fed HI10 and HI15 diets were characterized(FDR<0.05)by Lactobacillus and Ruminococcus(HI10)and Bacteroides,Roseburia and Helicobacter genera(HI15).Periodic-acid Schiff,Alcian Blue pH 2.5 and high iron diamine staining on small and large intestine also demonstrated lower mucin staining intensity in the intestinal villi of HI10 and HI15 birds than C(P<0.05).Conclusions:Dietary HI meal utilization at low inclusion levels(i.e.,5%)positively influenced either the cecal microbiota or the gut mucin dynamics in terms of selection of potentially beneficial bacteria and increase in villi ***,high inclusion levels(in

关键词： 16S rRNA Gut health Hermetia illucens L. Histochemistry Insect meal Microbiota Mucin Poultry