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Potential roles of functional bacterial amyloid proteins,bacterial biosurfactants and other putative gut microbiota products in the etiopathogeny of Parkinson’s Disease

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BIOCELL 2021年第1期45卷 1-16页

作者： EMILIA MANOLE laura DUMITRESCU cris.ina NICULIȚE BOGDAN OVIDIU POPESCU laura cris.ina ceafalan Victor Babeș”National Institute of Pathology Bucharest050088Romania Colentina Clinical Hospital Bucharest020125Romania Carol Davila”University of Medicine and Pharmacy Bucharest020021Romania

An increasing number of studies provide evidence for the existence of a microbiota-gut-brain axis and its potential involvement in the development of sporadic Parkinson’s disease and other neurodegenerative *** neuropathologic hallmark of Parkinson’s disease is the presence of brain intraneuronal aggregates of misfolded alpha-synuclein,known as Lewy *** gut microbiota products may trigger alpha-synuclein conformational changes in the neurons of the enteric nervous system,which can then spread to the brain in a prion-like fashion through the vagus *** may interfere with neuroinflammatory pathways and susceptibility to *** this review,we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson’s disease,with a special emphasis on functional bacterial amyloid proteins,bacterial biosurfactants,endotoxins and short-chain fatty *** possible roles of molecular hydrogen,a common byproduct of bacterial fermentation,are also addressed.

关键词： Alpha-synuclein Endotoxins Short-chain fatty acids

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Polycaprolactone/mesoporous silica MCM-41 composites prepared by in situ polymerization

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Particuology 2017年第1期15卷 135-143页

作者： laura Lopez-Figueras Nuria Navascues Silvia Irusta Department of Chemical Engineering Nanoscience Institute of Aragon (INA) University of Zaragoza 50018 Zaragoza Spain Networking Research Center on Bioengineering Biomaterials and Nanomedicine CIBER-BBN 50018 Zaragoza Spain

Composites of polycaprolactone （PCL） with mesoporous silica MCM-41 and N-[3- （trimethoxysilyl）propyl]-ethylenediamine （EPTES）-functionalized MCM-41 （EPTES/MCM-41） were prepared by in situ polymerization. The thermal properties of the composites were characterized by thermogravimetric analysis. There was an increase in the thermal decomposition temperature of PCL by more than 55 ℃, when the EPTES/MCM-41 loading was higher than 2 wt%. Tensile test results indicated that adding MCM-41 increased the brittleness of the PCL matrix, while adding 8 wt% of EPTES/MCM-41 increased the Young＇s modulus by 26%. Incorporating MCM-41 increased the crystallinity of the resulting PCL composite, compared with that of PCL. Incorporating up to 5 wt% EPTES/MCM-41 slightly reduced the crystallinity of PCL. The different effects of MCM-41 and EPTES/MCM-41 on the composite reflected the degree of interaction and dispersion of the silica filler in the polymer matrix, as evidenced by results from transmission electron microscopy and atomic force microscopy.

关键词： Nanocomposite Mesoporous silica Polycaprolactone

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Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease

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World Journal of Hepatology 2015年第8期7卷 1097-1104页

作者： Francesco Paolo Russo Kryssia Rodríguez-Castro laura Scribano Giorgia Gottardo Veronica Vanin Fabio Farinati Gas-troenterology/Multiviseral Transplant Unit Department of Surgery Oncology and Gastroenterology Padua University Hospital Gastroenterology Unit Department of Surgery Oncology and Gastroenterology Padua University Hospital

Hepatitis B virus(HBV) infection is a dynamic state ofinteractions among HBV, hepatocytes, and the host immune system. Natural history studies of chronic hepatitis B(CHB) infection have shown an association between active viral replication and adverse clinical outcomes such as cirrhosis and hepatocellular carcinoma. The goal of therapy for CHB is to improve quality of life and survival by preventing progression of the disease to cirrhosis, decompensation, end-stage liver disease, hepatocellular carcinoma(HCC) and death. This goal can be achieved if HBV replication is suppressed in a sustained manner. The accompanying reduction in histological activity of CHB lessens the risk of cirrhosis and of HCC, particularly in non-cirrhotic patients. However, CHB infection cannot be completely eradicated, due to the persistence of covalently closed circular DNA in the nucleus of infected hepatocytes, which may explain HBV reactivation. Moreover, the integration of the HBV genome into the host genome may favour oncogenesis, development of HCC and may also contribute to HBV reactivation.

关键词： Hepatocellular carcinoma Nucleos(t)ideanalogues Liver fibrosis Pegylated interferon Cirrhosis

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