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Emerging role of the gut microbiome in post-infectious irritable bowel syndrome:A literature review

World Journal of Gastroenterology 2023年第21期29卷 3241-3256页

作者： Vasile Valeriu Lupu Cristina Mihaela Ghiciuc Gabriela Stefanescu Cristina Maria Mihai Alina Popp Maria Oana Sasaran laura bozomitu Iuliana Magdalena Starcea Anca Adam Raileanu Ancuta Lupu Faculty of General Medicine “Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania Faculty of General Medicine Ovidius UniversityConstanta 900470Romania Faculty of General Medicine “Carol Davila”University of Medicine and PharmacyBucharest 020021Romania Faculty of General Medicine “George Emil Palade”University of MedicinePharmacyScience and TechnologyTargu Mures 540142Romania

Post-infectious irritable bowel syndrome(PI-IBS)is a particular type of IBS,with symptom onset after an acute episode of infectious *** infectious disease resolution and clearance of the inciting pathogen agent,10%of patients will develop *** susceptible individuals,the exposure to pathogenic organisms leads to a marked shift in the gut microbiota with prolonged changes in host-microbiota *** changes can affect the gut-brain axis and the visceral sensitivity,disrupting the intestinal barrier,altering neuromuscular function,triggering persistent low inflammation,and sustaining the onset of IBS *** is no specific treatment strategy for *** drug classes can be used to treat PI-IBS similar to patients with IBS in general,guided by their clinical *** review summarizes the current evidence for microbial dysbiosis in PI-IBS and analyzes the available data regarding the role of the microbiome in mediating the central and peripheral dysfunctions that lead to IBS *** also discusses the current state of evidence on therapies targeting the microbiome in the management of *** results of microbial modulation strategies used in relieving IBS symptomatology are *** studies on PI-IBS animal models reported promising ***,published data that describe the efficacy and safety of microbial targeted therapy in PI-IBS patients are *** research is required.

关键词： Gut microbiome Infectious gastroenteritis Irritable bowel syndrome Post infection syndrome Pathophysiology Inflammation

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