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Primary biliary cirrhosis-associated hepatocellular carcinoma in Chinese patients:Incidence and risk factors

World Journal of Gastroenterology 2015年第12期21卷 3554-3563页

作者： Xue-Xiu Zhang Li-Feng Wang Lei Jin Yuan-Yuan Li Shu-Li Hao Yan-Chao Shi Qing-Lei Zeng Zhi-Wei Li Zheng Zhang George kk lau Fu-Sheng Wang The Institute of Translational Hepatology 302 Military Hospital of China-Peking University Teaching Hospital Research Center for Biological Therapy Beijing 302 Hospital Non-Infectious Liver Disease Diagnosis and Treatment Center 302 Military Hospital of China-Peking University Teaching Hospital Research Center for Liver Transplantation 302 Military Hospital of China-Peking University Teaching Hospital Department for Hepatobiliary Surgery Beijing 302 Hospital

AIM: To investigate the incidence, characteristics, and risk factors for hepatocellular carcinoma(HCC) in Chinese patients with primary biliary cirrhosis(PBC).METHODS: We reviewed the data of 52 PB Cassociated HCC patients treated at Beijing 302 Hospital from January 2002 to December 2013 and analyzed its incidence and characteristics between the two genders. The risk factors for PBC-associated HCC were analyzed via a case-control study comprising 20 PBC patients with HCC and 77 matched controls without HCC. The matched factors included gender, age, follow-up period and Child-Pugh scores. Conditional logistic regression was used to evaluate the odds ratios of potential risk factors for HCC development. A P < 0.05 was considered statistically significant. RESULTS: The incidence of HCC in Chinese PBC patients was 4.13%(52/1255) and was significantly higher in the males(9.52%) than in the females(3.31%). Among the 52 PBC patients with HCC, 55.76%(29/52) were diagnosed with HCC and PBC simultaneously, and 5.76%(3/52) were diagnosed with HCC before PBC. The males with PBC-associated HCCwere more likely than the females to have undergone blood transfusion(18.75% vs 8.33%, P = 0.043), consumed alcohol(31.25% vs 8.33%, P = 0.010), smoked(31.25% vs 8.33%, P = 0.010), had a family history of malignancy(25% vs 5.56%, P = 0.012), and had serious liver inflammation, as indicated by the elevated levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyl transpeptidase(P < 0.05). Conditional logistic regression analysis revealed that body mass index(BMI) ≥ 25 [adjusted odds ratio(AOR) = 1.116, 95%CI: 1.002-1.244, P = 0.045] and history of alcohol intake(AOR = 10.294, 95%CI: 1.108-95.680, P = 0.040) were significantly associated with increased odds of HCC development in PBC patients. CONCLUSION: HCC is not rare in Chinese PBC patients. Risk factors for PBC-associated HCC include BMI ≥ 25 and a history of alcohol intake. In addition to regul

关键词： Primary biliary cirrhosis Hepatocellular carcinoma

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Upregulated CD4+CXCR5+ TFH cells contribute to liver damage through activating NK cells in patients with chronic hepatitis C

Upregulated CD4+CXCR5+ TFH cells contribute to liver damage ...

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第八届全国免疫学学术大会

作者： Guohua Feng Honghong Liu Ji-Yuan Zhang Zheng Zhang George kk lau Fu-Sheng Wang Institute of Translational Hepatology Research Center for Biological TherapyBeijing 302 Hospital

背景:The T follicular helper(TFH) cell is a newly identified T-cell subset and and actively take part in regulating anti-viral immune response.目的:This study examined whether the CD4+CXCR5+ TFH cells contribute to liver damage in patients with chronic hepatitis C(CHC).方法:The frequencies of peripheral blood CD4+CXCR5+ TFH cells, programmed death 1(PD-1) and inducible T cell costimulator(ICOS) positive CD4+CXCR5+ TFH cells in CHC patients and healthy controls(HC) were detected by flow *** potential association of the frequency of CD4+CXCR5+ TFH cells with clinical measures was analyzed.结果:We found that the frequency of CD4+CXCR5+ TFH cells in CHC patients was significantly higher than that of HC and the percentages of CD4+CXCR5+ TFH cells in CHC patients were negatively correlated with ***, the percentage of ICOS+ and PD-1+ in CD4+CXCR5+ TFH cells in CHC patients were significantly higher than that of HC..Interestingly, NK cells in CHC patients exhibited high levels of IL-21 receptor than that of *** an in vitro co-culture assay, we found that these NK cells produce high levels of IFN-γ and exert increased cytotoxicity under stimulated by IL-21.结论:Our data indicated that CD4+CXCR5+ TFH cells may participate in the immune-induced liver damage in CHC through enhance the killing ability of NK cells..

关键词： T follicular helper(TFH) cell chronic hepatitis C liver damage IL-21

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缺血性脑卒中患者诊间血压变异性对长期预后的影响

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中华高血压杂志 2015年第5期23卷 498-498页

作者： lau kk Wong YK Teo KC Chang RS Chan KH Hon SF Wat KL Cheung RT Li LS Siu CW Tse HF

血压变异性（blood pressure variablity，BPV）是动脉粥样硬化疾病发展的新的危险因素。最近研究显示，高BPV能预测腔隙性梗死患者的全因和心血管死亡率。除因小血管阻塞造成的脑卒中患者外，BPV是否对缺血性脑卒中患者的预后产生影响... 详细信息

血压变异性（blood pressure variablity，BPV）是动脉粥样硬化疾病发展的新的危险因素。最近研究显示，高BPV能预测腔隙性梗死患者的全因和心血管死亡率。除因小血管阻塞造成的脑卒中患者外，BPV是否对缺血性脑卒中患者的预后产生影响仍然不清楚。

关键词：脑卒中患者血压变异性长期预后缺血性动脉粥样硬化心血管死亡率腔隙性梗死危险因素

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Theoretical analysis of PAM-N and M-QAM BER computation with single-sideband signal

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Science China(Information Sciences) 2021年第8期64卷 172-181页

作者： Dongxu LU Xian ZHOU Yuqiang YANG Jiahao HUO Jinhui YUAN Keping LONG Changyuan YU Alan Pak Tao lau Chao LU Beijing Engineering and Technology Research Center for Convergence Networks and Ubiquitous Services University of Science and Technology Beijing Department of Electrical Engineering The Hong Kong Polytechnic University Department of Electronic and Information Engineering The Hong Kong Polytechnic University

In this paper, the theoretical bit error rate(BER) of N-level pulse amplitude modulation(PAMN)and M-ary quadrature amplitude modulation(M-QAM) have been studied and compared under different scenarios, including(i) PAM with intensity modulation with direct detection(IM/DD) and field modulation with detection(FMD)(including coherent detection and single-sideband modulation with direct detection(SSB-DD)), and(ii) QAM with coherent detection and SSB-DD. Considering the relationship between the symbol spacing and signal-to-noise ratio(SNR), we provide the mathematical BER equations, including the optical signal-to-noise ratio(OSNR) and carrier-to-signal power ratio(CSPR), especially for PAM *** verify the validity of our theoretical expressions for SSB systems, transmissions with 224-Gb/s SSBPAM4/16 QAM signals using the Kramers-Kronig(kk) receiver were implemented on a unified optical system platform. The simulation results agreed well with theoretical calculations both in back-to-back(BtB) and120-km transmission scenarios, which showed that the BER evaluation methods can serve as a theoretical guidance and system assessment criteria for SSB scenarios.

关键词： N-level pulse amplitude modulation(PAM-N) M-ary quadrature amplitude modulation(MQAM) BER computation single-sideband(SSB) Kramers-Kronig receiver

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国际妇产科超声学会早孕期胎儿超声指南

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妇产与遗传(电子版) 2014年第3期4卷 54-64页

作者： L.J.Salomon Z.Alfirevic C.M.Bilardo G.E.Chalouhi T.Ghi K.O.Kagan T.K.lau A.T.Papageorghiou N.J.Raine-Fenning J.Stirnemann S.Suresh A.Taborl I.E.Timor-Tritsch A.Toi G.Yeo 杨芳梁国贤 Department of Obstetrics and Fetal Medicine and SFAPE(Societe Francaise d' Ameliorationdes Pratiques Echographique) Paris Descartes UniversityAssistance Publique-Hopitaux de ParisHopital Necker Enfants Department for Women' s and Children's Health University of Liverpool Fetal Medicine Unit Department of Obstetrics and GynaecologyUniversity Medical Centre Groningen Department of Obstetrics and Gynaecology Policlinico S.Orsola-MalpighiUniversity of Bologna Department of Obstetrics and Gynecology University of Tuebingen Fetal Medicine Centre Paramount ClinicCentral 7. Fetal Medicine UnitSt George' sUniversity of London 8. Division of Obstetrics & GynaecologySchool of Clinical SciencesUniversity of Nottingham 9. Obstetrics and Fetal MedicineGHU Necker-Enfants MaladesUniversity Paris Descartes 10. Mediscan Systems&Fetal Care Research Foundation 11. Fetal Medicine UnitDepartment of ObstetricsRigshospitaletCopenhagen University Hospital 12. Department of Obstetrics and GynecologyNew York University School of Medicine 13. Medical Imaging andObstetrics and GynaecologyMount Sinai HospitalUniversity of Toronto 14. Department of Maternal Fetal MedicineObstetric Ultrasound and Prenatal Diagnostic UnitKK Women' s and Children's Hospital 15. 南方医科大学南方医院妇产科产前诊断中心 16. 香港伊丽莎伯医院妇产科

一、临床标准委员会国际妇产科超声学会(ISUOG)是以推进安全的临床实践、提供高质量的医学教学、推动与妇女健康相关的影像学诊断研究为宗旨的科学组织。ISUOG临床标准委员会(CSC)的工作范畴包括制订实践指南、发布共识声明,为医疗工作... 详细信息

一、临床标准委员会国际妇产科超声学会(ISUOG)是以推进安全的临床实践、提供高质量的医学教学、推动与妇女健康相关的影像学诊断研究为宗旨的科学组织。ISUOG临床标准委员会(CSC)的工作范畴包括制订实践指南、发布共识声明,为医疗工作者提供基于业内共识的影像学诊断方法。这些指南和共识是ISUOG在其发表时确认的最优方案。虽然ISUOG会尽力确保发布内容的准确性,但学会及其雇员或会员均不会为CSC所发表的不准确或具误导性的资料、意见或陈述所造成的后果承担任何责任。ISUOG、CSC所发表的

关键词：早孕期超声检查胎儿超声头臀长双顶径妇产科

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