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Synthesis of FeOOH scaly hollow tubes based on Cu_(2)O wire templates toward high-efficiency oxygen evolution reaction

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Rare Metals 2023年第6期42卷 1836-1846页

作者： Yu Zhang Xue-Ai Teng Ze-Qun Ma Rong-Ming Wang Woon-Ming lau Ai-Xian Shan Beijing Advanced Innovation Center for Materials Genome Engineering and Center for Green Innovation School of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing100083China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Magneto-Photoelectrical Composite and Interface ScienceSchool of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing100083China Shunde Innovation School of University of Science and Technology Beijing Foshan528000China Institute of Materials Science and Devices School of Materials Science and EngineeringSuzhou University of Science and TechnologySuzhou215009China

For catalytic materials,the characteristics of one-dimension and hollowness are the promotion factors for their full presentation of catalytic activity,and through a template-as sis ted method,both above superiorities can be fused ***,we proposed a novel strategy inspired by Pearson's principle with Cu_(2)O wires as templates,and prepared FeOOH hollow tubes,which covered by FeOOH *** applied as oxygen evolution reaction(OER)catalyst,the FeOOH scaly hollow tubes(FeOOH SHTs)showed outstanding catalytic activity with a low overpotential of 245 mV to drive a current density of10 mA·cm^(-2),excellent kinetics manifesting as a low Tafel slope of 46.9 mV·dec^(-1),and robust *** work provides a new synthesis strategy for an ideal OER catalyst,FeOOH,with high inherent activity and enhances the feasibility to broaden the design ideas of transition metalbased catalysts.

关键词： FeOOH scaly hollow tube(SHT) Cu_(2)O wire template One-dimensional(1D)hollow structure Oxygen evolution reaction(OER)

Cytogenetic and molecular genetic alterations in hepatocellular carcinoma

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Acta Pharmacologica Sinica 2005年第6期26卷 659-665页

作者： Sze-hang lau, Xin-yuan GUAN~1 Department of Clinical Oncology, Faculty of Medicine, The University of hong Kong, hong Kong, china Department of Clinical Oncology Faculty of Medicine The University of Hong Kong Hong Kong China

Specific chromosome aberrations are frequently detected during the development of hepatocellular carcinoma. Molecular cytogenetic approaches such as comparative genomic hybridization and loss of heterozygosity analyses have provided fruitful information on changes in HCC cases at the genomic level. Mapping of chromosome gains and losses have frequently resulted in the identification of oncogenes and tumor suppressors, respectively. In this review, we summarize some frequently detected chromosomal aberrations reported for hepatocellular carcinoma cases using comparative genomic hybridization and loss of heterozygosity studies. Focus will be on gains of lq, 8q, and 20q, and losses of 4q, 8p, 13q, 16q, and 17p. We then examine the candidate oncogenes and tumor suppressors located within these regions, and explore their possible functions in hepatocarcinogenesis. Finally, the impact of microarray-based screening platforms will be discussed.

关键词： hepatocellular carcinoma chromosome aberrations oncogenes tumor suppressor genes

Conserved Spatiotemporal Dynamics with Millisecond Precision During Reverberatory Activity in a Self-organized Neuronal

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Neuroscience Bulletin 2023年第5期39卷 808-812页

作者： Dong-Qing Shi Fang Xu Guo-Qiang Bi Pak-Ming lau Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230026China Interdisciplinary Center for Brain Information The BrainCognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Dear Editor,The timing of spiking activity across neurons is believed to play an important role in information coding in brain circuits1[1].At the cellular level,neurons can fire spikes with millisecond precision and the relative timing of pre-and postsynaptic spikes can determine the direction and extent of synaptic modification[2].When such spike-timing-dependent plasticity(STDP)and other physiological and anatomical properties are implemented in theoretical models,the simulated networks of interconnected spiking neurons exhibit neuronal groups with stereotypical time-locked spatiotemporal firing patterns with millisecond temporal precision[3].

关键词： second organized timing

Echocardiographic mapping of left ventricular resynchronization during cardiac resynchronization therapy procedures

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chinese Medical Journal 2010年第13期123卷 1645-1651页

作者： CHAN Ngai-yin CHOY chi-chung CHEUNG Kar-chun lau Chun-leung LO Ying-keung CHU Pui-shan YUEN Ho-chuen lau Suet-ting CHOI Yuen-choi Department of Medicine & Geriatrics Princess Margaret Hospital 2-10 Princess Margaret Hospital Road Lai Chi Kok Kowloon Hong Kong China

Background Cardiac resynchronization therapy （CRT） is an effective electrical therapy for patients with moderate to severe heart failure and cardiac dyssynchrony. This study aimed to investigate the degree of acute left ventricular （LV） resynchronization with biventricular pacing （BVP） at different LV sites and to examine the feasibility of performing transthoracic echocardiography （TTE） to quantify acute LV resynchronization during CRT procedure. Methods Fourteen patients with NYHA Class Ⅲ-Ⅳ heart failure, LV ejection fraction 〈35%, QRS duration 〉120 ms and septal-lateral delay （SLD）〉60 ms on tissue Doppler imaging （TDI）, underwent CRT implant. TDI was obtained from three apical views during BVP at each accessible LV site and SLD during BVP was derived. Synchronicity gain index （Sg） by SLD was defined as （I＋（SLD at baseline - SLD at BVP）/SLD at baseline）. Results Seventy-two sites were studied. Positive resynchronization （R＋, Sg〉1） was found in 42 （58%） sites. R＋ was more likely in posterior or lateral than anterior LV sites （66% vs. 36%, P 〈0.001）. Concordance of empirical LV lead implantation sites and sites with R＋ was 50% （7/14）. Conclusions The degree of acute LV resynchronizaUon by BVP depends on LV lead location and empirical implantation of LV lead results in only 50% concordance with R＋. Performing l-rE during CRT implantation is feasible to identify LV sites with positive resynchronization.

关键词： echocardiography cardiac resynchronization therapy heart failure left ventricular lead device implantation optimization

Pretreatment neutrophil-to-lymphocyte ratio predicts worse survival outcomes and advanced tumor staging in patients undergoing radical cystectomy for bladder cancer

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Asian Journal of Urology 2017年第4期4卷 239-246页

作者： Yu Guang Tan Ernest Eu Weber lau Kam On hong hong Huang Department of Urology Singapore General HospitalSingapore

Objective:To determine the role of neutrophil-to-lymphocyte ratio(NLR)in prognosticating survival outcomes in patients with advanced/metastatic urothelial bladder ***:We retrospectively reviewed 84 patients undergoing radical cystectomy(RC)for UCB from January 2002 to June *** was computed(median:5 days)prior to *** patients received neoadjuvant *** was analyzed as a continuous variable and a cut-off point of 2.7 was obtained,with a statistical receiver operating characteristics of *** curves,multivariate Cox proportional hazard and logistics regression models were used to predict NLR association with survival ***:The median follow-up period was 30.1 months(range:3.2e161.7)owing to high recurrence rate and subsequent mortalities,compared to the median 64.7 months in patients alive at the end of study ***2.7 was associated with worse survival outcomes(5-year disease-specific survival:22%vs 58%,p Z 0.017,95%CI:1.193e6.009;5-year overall survival:23%vs 60%,p Z 0.008,95%CI:1.322e6.147).Furthermore,on multivariate analyses,higher NLR was independently associated with higher recurrence rate(p Z 0.007,HR Z6.999,95%CI:1.712e28.606),higher T staging(p Z 0.021,HR Z 3.479,95%CI:1.212e9.990)and lymph node involvement(p Z 0.009,HR Z 4.534,95%CI:1.465e14.034).

关键词： Bladder cancer Neutrophil-tolymphocyte ratio Radical cystectomy Bladder carcinoma

Risk of ischaemic and haemorrhagic stroke in chinese undergoing percutaneous coronary intervention treated with potent P2Y12 inhibitor versus clopidogrel

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Stroke & Vascular Neurology 2022年第4期7卷 310-318,I0015-I0019页

作者： Andrew Kei-Yan Ng Pauline Yeung Ng April Ip Kui Kai lau Chung-Wah Siu Cardiac Medical Unit Grantham HospitalHong KongHong Kong Department of Adult Intensive Care Queen Mary HospitalHong KongHong Kong Department of Medicine The University of Hong KongHong KongHong Kong The State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong KongHong Kong

Background Stroke after acute coronary syndrome(ACS)can be *** is uncertain whether the risks of ischaemic stroke or intracranial haemorrhage(ICH)are associated with different choices of P2Y12 inhibitors(potent P2Y12 inhibitors such as ticagrelor and prasugrel vs clopidogrel).Even though East Asians are known to have different thrombotic and haemorrhagic profiles from Caucasians,data on chinese patients are *** This was a retrospective cohort study conducting in chinese patients with ACS who underwent first-ever percutaneous coronary intervention from 14 hospitals in hong Kong between 2010 and *** primary efficacy endpoint was ischaemic *** secondary efficacy endpoint was a composite outcome of thrombotic events including all-cause mortality,non-fatal myocardial infarction and ischaemic *** primary safety endpoint was *** secondary safety endpoint was a composite of major bleeding *** After adjustment of baseline characteristics by 1:1 propensity score matching,a total of 6220 patients(3110 on each group)were *** with clopidogrel,potent P2Y12 inhibitors were associated with a lower risk of ischaemic stroke(HR 0.57;95%CI 0.37 to 0.87;p=0.008)and a lower risk of thrombotic events(HR 0.77;95%CI 0.66 to 0.90;p=0.001).Potent P2Y12 inhibitor was associated with similar risk of ICH(HR 0.65;95%CI 0.34 to 1.25,p=0.20)and major bleeding(HR 0.83;95%CI 0.68 to 1.01,p=0.069).Conclusions Potent P2Y12 inhibitors were associated with a lower adjusted risk of ischaemic stroke and thrombotic events,compared with *** risks of ICH and major bleeding were similar.

关键词： P2Y12 coronary haemorrhagic

Cellulose Nanocrystal from Washingtonia Fibre and Its Characterization

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Journal of Renewable Materials 2022年第6期10卷 1459-1470页

作者： Mohammad Jawaid lau Kia Kian Hassan Fouad Ramzi Khiari Othman Y.Alothman Mohamed Hashem Laboratory of Biocomposite Technology Institute of Tropical Forestry and Forest Products(INTROP)Universiti Putra MalaysiaSelangorMalaysia Applied Medical Science Department Community CollegeKing Saud UniversityRiyadhSaudi Arabia CNRS University of Grenoble AlpesGrenobleFrance Department of Textile Higher Institute of Technological Studies of Ksar HellalKsar HellalTunisia University of Monastir Laboratory of Environmental Chemistry and Cleaner Process(LCE2P-LR21ES04)MonastirTunisia Chemical Engineering Department College of EngineeringKing Saud UniversityRiyadhSaudi Arabia Dental Health Department College of Applied Medical SciencesKing Saud UniversityRiyadhSaudi Arabia

Cellulose nanocrystal(CNC)is a biomaterial derived from plant lignocellulosic components,widely applied in various industrial ***,with the growth of awareness in developing green nanomaterial,the explored Washingtonia fibre could be alternative biomass for obtaining CNC *** the present work,different acid concentrations of 5%,15%,and 25%hydrochloric solutions were employed to produce CNCs from Washingtonia *** the chemical treatments,the yield of the CNC product was successfully retained at 21.6%-25.1%.Individually separated and needle-shaped CNC particles could be observed under the microscopic viewing with the increased acid *** elemental analysis,a relatively pure cellulose compartment was produced for all CNC *** zeta potential values between-10 to-16 mV proved that each nanoparticle sample possessed dispersion ability within an aqueous ***,the degree of crystallinity and the thermal behavior of CNCs were enhanced with the increased acidic ***,the isolated CNCs(with 15%)from Washingtonia fibre lead a CNC with the highest aspect ratio(30).This parameter is so important that these structures show empowering points of view as nanomaterials for reinforced polymer composites,and it could be a reliable nano-filler for the composite fabrication process in the future.

关键词： Cellulose nanocrystal washingtonia fibre structure degree of crystallinity thermal behavior

Integrated metabolomics analysis of the effect of PPARδ agonist GW501516 on catabolism of BCAAs and carboxylic acids in diabetic mice

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chinese Chemical Letters 2021年第7期32卷 2197-2202页

作者： Li Xiang Juan Nie Li Wang Yu Wang Jingchun Shi Juntong Wei chi-Wai lau Zongwei Cai Yu Huang Heart and Vascular Institute School of Biomedical Sciences and Shenzhen Research Institute.Chinese University of Hong KongHong KongChina State Key Laboratory of Environmental and Biological Analysis and Department of Chemistry Hong Kong Baptist UniversityHong KongChina

The peroxisome proliferator-activated receptor(PPARδ)agonists are reported to improve insulin sensitivity,reduce glucose levels,and alleviate dysfunctional lipid metabolism in animal models of type 2 diabetes ***,the underlying mechanisms remain incompletely *** plays an essential role in the biological *** of metabolic changes in response to disease conditions or drug treatment is critical for better understanding of the pathophysiological *** this study,metabolic profiling analysis by gas chromatography-mass spectrometry integrated with targeted analysis by liquid chro matography-mass spectrometry was carried out in plasma samples of db/db diabetic mice after six-week treatment of PPARδagonist ***501516 treatment significantly altered levels of metabolites,such as branched-chain amino acids(BCAAs),BCAA metabolites(3-hydroxyisobutyric acid and 3-hydroxyisovaleric acid),long-chain fatty acids,uric acid and ketone bodies(3-hydroxybutyric acid and 2-hydroxybutyric acid)which are all associated with the impaired systemic insulin *** pre sent results indicate the beneficial effect of PPARδagonist in alleviating insulin resistance of diabetic mice by favorably modulating metabolic profile,thus providing valuable information in understanding the therapeutic potential of PPARδagonists in correcting metabolic dysfunction in diabetes.

关键词： PPARδ BCAAs BCAA metabolites Metabolomics Diabetic mice

Blastocyst-like embryo surrogates from stem cells in implantation models

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Reproductive and Developmental Medicine 2022年第4期6卷 225-233页

作者： Siyu Tian Hanzhang Ruan William Shu-Biu Yeung Yin lau Lee Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterThe University of Hong Kong-Shenzhen HospitalShenzhen 518053China Centre for Translational Stem Cell Biology Building 17WThe Hong Kong Science and Technology ParkHong Kong 999077China

Successful embryo implantation requires highly coordinated maternal-embryo *** failure is a major factor contributing to ***,the mechanism underlying implantation failure remains *** improved understanding of the early implantation process not only improves the success rate of assisted reproductive treatments but also helps in studying the pathophysiology of reproductive *** to ethical concerns,in vivo studies of human embryo implantation are not ***,the results obtained from animal models cannot be directly applied to *** the years,in vitro implantation models have been developed to investigate implantation *** this review,we discuss the use of different models for generating embryo-like surrogates to study early embryo development and implantation in vitro,with a specific focus on stem cell-derived blastocyst-like embryo *** is no definitive evidence that the recently established embryo-like models re-capitulate all developmental events of human embryos during the peri-implantation ***,stem cell-derived embryo surrogates are the most valuable tools for studying the mechanisms of early cell lineage differentiation and developmental failures during implantation.

关键词： implantation models Stem cells Embryo surrogates Endometrium Trophoblastic spheroid Blastoids