检索结果-南通市图书馆

Epidemiology and Clonal Spread Evidence of Carbapenem-Resistant Organisms in the Center of Care and Protection of Orphaned Children, Vietnam

引用

Open Journal of Medical Microbiology 2024年第3期14卷 165-189页

作者： Van Kim Nguyen Pirom Noisumdaeng Pol. Maj. Katiya Ivanovitch Stephen Baker Eugene Athan Stephanie Jones Le Thi Lan larry croft Yin Peng Lee Tara Cassidy Van Hung Tran Thi Hang Phan Huu Tinh Ho Faculty of Public Health Thammasat University Bangkok Thailand Department of Prevention and Infection Control Hung Vuong Hospital HCM City Vietnam Microbiology of Faculty of Public Health Thammasat University Bangkok Thailand Thammasat University Research Unit in Modern Microbiology and Public Health Genomics Thammasat University Bangkok Thailand National Heart & Lung Institute (NHLI) University of Cambridge Cambridge UK Barwon South West Public Health Unit Geelong Australia Center for Innovation in Infectious Disease and Immunology Research (CIIDIR) Geelong Australia School of Medicine Deakin University Burwood Australia Monash Health Berwick Australia Center of Care and Protection of Orphaned Children HCM City Vietnam Charles River Laboratories Microbial Solutions Melbourne Australia Personnel Department of Nhan Dan Gia Dinh Hospital HCM City Vietnam Hung Vuong Hospital HCM City Vietnam Department of Epidemiology Institute of Public Health HCM City Vietnam

Objective: To determine the prevalence of colonization and transmission of carbapenem-resistant Gram-negative organisms in order to develop of an effective infection prevention program. Design: Cross-sectional study with carbapenem-resistant organisms (CRO) colonization detection from the fecal specimens of 20 Health Care Workers (HCWs) and 67 residents and 175 random environment specimens from September 2022 to September 2023. Setting: A Care and Protection Centre of Orphaned Children in South of HCM City. Participants: It included 20 HCWs, 67 residents, and 175 randomly collected environmental specimens. Method: Rectal and environmental swabs were collected from 20 HCWs, 67 residents (most of them were children), and 175 environmental specimens. MELAB Chromogenic CARBA agar plates, Card NID, and NMIC-500 CPO of the BD Phoenix TM Automated Microbiology System and whole genome sequencing (WGS) were the tests to screen, confirm CROs, respectively and determine CRO colonization and transmission between HCWs, residents, and the environment. Result: We detected 36 CRO isolates, including 6, 11 and 19 CROs found in 6 HCWs, 10 residents and 19 environments. The prevalence of detectable CRO was 30% (6/20) in HCWs, 14.92% (10/67) in residents, and 10.86% (19/175) in environmental swabs in our study. WGS demonstrated CRO colonization and transmission with the clonal spread of E. coli and A. nosocomialis, among HCWs and residents (children). Conclusion: Significant CRO colonization and transmission was evident in HCWs, residents, and the center environment. Cleaning and disinfection of the environment and performing regular hand hygiene are priorities to reduce the risk of CRO colonization and transmission.

关键词： Carbapenem-Resistant Organisms Contamination Hand Hygiene Whole Genome Sequencing Infection Prevention

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pseudomonas aeruginosa:Infections and novel approaches to treatment“Knowing the enemy”the threat of Pseudomonas aeruginosa and exploring novel approaches to treatment

Infectious Medicine

引用

Infectious Medicine 2023年第3期2卷 178-194页

作者： Nikhil Sathe Peter Beech larry croft Cenk Suphioglu Arnab Kapat Eugene Athan Reliance Life Sciences Pvt.Ltd. Dhirubhai Ambani Life Sciences CentreThane Belapur RoadRabaleNavi Mumbai 400701India School of Life and Environmental Sciences Deakin UniversityMelbourne Burwood Campus221 Burwood HighwayBurwood Victoria 3125Australia NeuroAllergy Research Laboratory School of Life and Environmental SciencesDeakin UniversityGeelong Campus at Waurn Ponds75 Pigdons RoadWaurn Ponds Victoria 3216Australia School of Medicine Deakin UniversityPO Box 281 Geelong 3220Australia

Pseudomonas aeruginosa is an aerobic Gram-negative rod-shaped bacterium with a comparatively large genome and an impressive genetic capability allowing it to grow in a variety of environments and tolerate a wide range of physical *** biological flexibility enables the *** to cause a broad range of infections in patients with serious underlying medical conditions,and to be a principal cause of health care associated infection *** clinical manifestations of *** include mostly health care associated infections and community-acquired *** possesses an array of virulence factors that counteract host defence *** can directly damage host tissue while utilizing high levels of intrinsic and acquired antimicrobial resistance mechanisms to counter most classes of *** co-regulates multiple resistance mechanisms by perpetually moving targets poses a significant therapeutic ***,there is an urgent need for novel approaches in the development of anti-Pseudomonas *** we review the principal infections caused by *** and we discuss novel therapeutic options to tackle antibiotic resistance and treatment of *** infections that may be further developed for clinical practice.

关键词： Pseudomonas Infections Antibiotics Resistance Novel Approaches Bacteriophages Immunotherapy Vaccines

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：