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Dependence of dynamic contour and Goldmann applanation tonometries on peripheral corneal thickness

International Journal of Ophthalmology(English edition) 2017年第10期10卷 1521-1527页

作者： Federico Saenz-Frances Claudia sanz-Pozo lara borrego-sanz Luis Ja?ez Laura MoralesFernandez Jose Maria Martinez-de-la-Casa Julian Garcia-Sanchez Julian Garcia-Feijoo Enrique Santos-Bueso Ophthalmology Department Clinico Universitario San Carlos HospitalComplutense University Institute of Knowledge Technology Complutense University

AIM：To determine the effects of peripheral corneal thickness（PCT）on dynamic contour tonometry（DCT）and Goldmann applanation tonometry（GAT）.METHODS：A cross-sectional *** created a software which calculates the corneal contour（CC）as a function of the radius from the corneal apex to each pixel of the *** software generates a central circumference with a radius of 1 mm and the remainder of the cornea is segmented in 5 rings concentric with corneal apex being its diameter not constant around the corneal circumference as a consequence of the irregular CC but keeping constant the diameter of each ring in each direction of the *** was determined as the mean thickness of the most eccentric *** weighted scatterplot smoothing（LOWESS）regression was used to determine the pattern of the relationship between PCT and both DCT and GAT ***,two multivariable linear regression models were *** each of them,the dependant variable was intraocular pressure（IOP）as determined using GAT and DCT *** both of the models the predictive variable was PCT though LOWESS regression pattern was used to model the relationship between the dependant variables and the predictor *** and sex were also introduced control variables along with their first-degree interactions with *** outcome measures include amount of IOP variation explained through regression models（R2）and regression coefficients（B）.RESULTS：Subjects included 109 eyes of 109 healthy *** regression suggested that a 2nd-degree polynomial would be suitable to model the relationshipbetween both DCT and GAT with *** PCT was introduced in both models as a linear and quadratic *** age nor sex nor interactions were statistically significant in both *** GAT model,R2was 17.14%（F=9.02;P=0.0002）,PCT linear term B was-1.163（95%CI：-1.163,-0.617）.PCT quadratic term B was 0.00081（95%CI：0.00043,0.00118）.For DCT model R2was 14.28%（F=9.29;P=0.0002

关键词： Goldmann applanation tonometry dynamic contour tonometry peripheral corneal thickness corneal thickness

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Correlations between corneal and optic nerve head variables in healthy subjects and patients with primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1156-1161页

作者： Federico Saenz-Frances Luis Janez lara borrego-sanz Clara Berrozpe-Villabona Jose Maria Martinez-de-la-Casa Laura Morales-Fernandez Julian Garcia-Sanchez Enrique Santos-Bueso Julian Garcia-Feijoo Department of Ophthalmology Clinico San Carlos HospitalComplutense University of Madrid Technology of Knowledge Institute Complutense University of Madrid

AIMTo correlate corneal variables (determined using the Pentacam) with optic nerve head (ONH) variables determined using the Heidelberg retina tomograph (HRT) in healthy subjects and patients diagnosed with primary open angle glaucoma (POAG).METHODSMeasurements were made in 75 healthy eyes and 73 eyes with POAG and correlations examined through Pearson correlation coefficients between the two sets of variables in the two subject groups. The corneal variables determined were corneal volume (CVol), central corneal thickness (CCT), overall corneal thickness (OvCT), the mean thickness of a circular zone centered at the corneal apex of 1 mm radius (zone I) and the mean thickness of several concentric rings, also centered at the apex until the limbus, each of 1 mm width (zones II to VI respectively). The ONH variables were determined using the *** following pairs of variables were correlated in the control group: CCT-disc area (DAr) (-0.48; P<0.0001), Zone I-DAr (-0.503; P<0.0001) and Zone II-DAr (-0.443; P<0.0001); and in the POAG group: CCT-cup-to-disc area ratio (CDRa) (-0.402; P<0.0001), Zone I-CDRa (-0.418; P<0.0001), Zone II-CDRa (-0.405; P=0.006), Zone I-cup shape measure (CSM) (-0.415; P=0.002), Zone II-CSM (-0.405; P=0.001), Zone IV-height variation contour (HVC) (0.378; P=0.002); Zone V-HVC (0.388, P<0.0001).CONCLUSIONSIn the healthy subjects, significant negative correlation was detected between central and paracentral corneal thickness and optic disc area. In contrast, the POAG patients showed significant negative correlation between central and paracentral corneal thickness and the cup-disc ratio and CSM, and positive correlation between peripheral corneal thickness and HVC.

关键词： glaucoma optic nerve head corneal thickness

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Anatomical characterization of central, apical and minimal corneal thickness

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International Journal of Ophthalmology(English edition) 2014年第4期7卷 668-672页

作者： Federico Saenz-Frances Martha Cecilia Bermúdez-Vallecilla lara borrego-sanz Luis Jaez J osé Marìa Martinez-de-la-Casa Laura Morales-Fernandez Enrique Santos-Bueso Julián Garcia-Sanchez Julián Garcia-Feijoo Department of Ophthalmology Hospital Clínico San CarlosUniversidad Complutense de Madrid Instituto de Tecnologìa del Conocimiento Universidad Complutense de Madrid

·AIM: To anatomically locate the points of minimum corneal thickness and central corneal thickness(pupil center) in relation to the corneal apex.·METHODS: Observational, cross-sectional study, 299 healthy volunteers. Thickness at the corneal apex(AT),minimum corneal thickness(MT) and corneal thickness at the pupil center(PT) were determined using the pentacam. Distances from the corneal apex to MT(MD)and PT(PD) were calculated and their quadrant position(taking the corneal apex as the reference) determined:point of minimum thickness(MC) and point of central thickness(PC) depending on the quadrant position. Two multivariate linear regression models were constructed to examine the influence of age, gender, power of the flattest and steepest corneal axes, position of the flattest axis, corneal volume(determined using the Pentacam)and PT on MD and PD. The effects of these variables on MC and PC were also determined in two multinomial regression models.·RESULTS: MT was located at a mean distance of 0.909 mm from the apex(79.4% in the inferior-temporal quadrant). PT was located at a mean distance of 0.156 mm from the apex. The linear regression model for MD indicated it was significantly influenced by corneal volume(B =-0.024; 95% CI:-0.043 to-0.004). No significant relations were identified in the linear regression model for PD or the multinomial logisticregressions for MC and PC.·CONCLUSION: MT was typically located at the inferiortemporal quadrant of the cornea and its distance to the corneal apex tended to decrease with the increment of corneal volume.

关键词： cornealthickness anatomy glaucoma

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Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

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Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita O.Teodoro Mafalda Ribeiro Ramos lara Carvalho iNOVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta lara Ordó?ez-Gutiérrez Francisco Wandosell Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM) Nicolas Cabrera 1 Universidad Autónoma de Madrid Fisiología Animal Departamento de Biología Facultad de Ciencias Universidad Autónoma de Madrid Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset Solna Departamento de Bioquímica y Biología Molecular Universidad Complutense de Madrid Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called "autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

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Profitability of RE-Technology Regarding the Economic Environment:A Case Study of Swiss SMEs

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Journal of Electronic Science and Technology 2018年第4期16卷 351-366页

作者： lara Thalmann Yves Hertig international institute of management in technology University of Fribourg Fribourg 1700Switzerland

Considering the important changes in the Swiss energy sector, especially in renewable energy(RE)technologies, new revenue possibilities for small and medium sized enterprises(SMEs) emerge. However, the adaption of RE-technologies for Swiss enterprises relies on tangible financial returns, based on complex calculations. This article analyses business opportunities(BOs) of eight Swiss SMEs considering the net present value of RE-investments in an uncertain economic environment. We identify two profitable BOs for Swiss SMEs and three which are not profitable. Further, the article demonstrates that the profitability of such investments remains mostly positive even under economic uncertainties. Surprisingly the profitability does not change significantly if the SME receives a subsidy or not. The support instrument of the Swiss Government has not a ponderous impact on the decision to invest in RE-technologies or not. Therefore, the article emphasizes the importance of including SME in the Swiss attempt to decentralize the energy market.

关键词： Net present value renewable energy(RE)-investments sensitivity analysis small and medium sized enterprises(SMEs)

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The “PAWPER-on-a-page”: Increasing global access to a low-cost weight estimation system

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World Journal of Emergency Medicine 2019年第2期10卷 101-108页

作者： Mike Wells lara Nicole Goldstein Division of Emergency Medicine Faculty of Health Sciences University of the Witwatersrand

BACKGROUND: The PAWPER tape is one of the most accurate weight estimation systems available today, but international access to the tape is limited because it has no commercial distribution. For this reason, the "PAWPER-on-a-page" concept was devised: downloadable image fi les that allow users to print and assemble their own tapes. However, the feasibility of this method is dependent on users being able to produce accurate tapes. This study was devised to determine whether untrained participants could print and assemble the "PAWPER-on-a-page" easily and ***: Doctor and nurse volunteers downloaded the "PAWPER-on-a-page" and "PAWPER XL-on-a-page" image files and printed copies on a home-printer and also at a commercial printer. One copy of each tape was then assembled according to instructions from an online video. The accuracy of printing and assembly, the time taken for assembly and the cost were then ***: There were 32 participants. The median time for assembly was 8 minutes 19 seconds and 7 minutes 31 seconds for the "PAWPER-on-a-page" and "PAWPER XL-on-a-page" respectively, with a median cost of USD 0.09 and USD 1.00 respectively. For the assembled tapes, 71.9% of the "PAWPER-on-a-page" tapes and 65.6% of the "PAWPER XL-on-a-page" achieved the required accuracy of 0.2%. Printing errors, related to scaling, were common, but easily ***: The "PAWPER-on-a-page" system can be easily, quickly, affordably and accurately printed and assembled by end users. Stringent double checking of the printed and fully assembled tapes is essential to ensure accuracy.

关键词： PAWPER tape Weight estimation Paediatric emergency care

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Use of improved cold-finger technique to assess effects of basicity on heat transfer through solidified mold flux

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Journal of Iron and Steel Research International 2019年第4期26卷 393-402页

作者： Karina lara Santos Assis Petrus Christiaan Pistorius Department of Materials Science and Engineering Center for Iron and Steelmaking ResearchCarnegie Mellon UniversityPittsburgh 15213PAUSA

Cold-finger measurements were used to estimate the contact resistance and average thermal conductivity of mold flux films solidified on a water-cooled copper *** industrial mold fluxes,with basicities from low to high,were *** steady-state rate of convective heat transfer between the solid film and liquid flux was compared with calculations based on natural convection correlations;the comparison indicates that the surface of the solid film(in contact with molten flux)is approximately at its solidus *** roughness of the mold flux film in contact with copper was larger for films grown from higher-temperature mold flux and for higher-basicity mold *** glassy(low-basicity)film had an estimated thermal conductivity of 1.1 W/(m K).The crystalline or partially crystalline films had higher estimated thermal conductivities of 2.2-3.2 W/(m K).The measured values of thermal resistance were extrapolated to typical mold flux film thicknesses for industrial conditions;the extrapolations confirmed that the high contact resistance of higher-basicity mold fluxes can yield higher thermal resistances than the low-basicity *** morphology of the rough interface of higherbasicity mold flux films that gives the higher contact resistance is consistent with that observed in previous work and appears not to be directly related to crystallization.

关键词： Mold flux Heat transfer Conduction Contact resistance-Cold-finger technique

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Neuroprotective effects of metalosalen complexes against oxidative stress

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Neural Regeneration Research 2021年第1期16卷 121-122页

作者： lara Rouco Marcelino Maneiro Departamento de Química Inorgánica Universidade de Santiago de CompostelaLugoSpain

Neurodegenerative diseases and oxidative stress:During the metabolic processes,O2 can accept unpaired electrons to form superoxide radical species(O2^·–),which are able to generate hydrogen peroxide(H2O2)with a fast dismutation,therefore increasing the hydroxyl radical(HO^·)*** species and other radicals(·OOH,ROO^·,RO^·,CO3^·–),which can be produced through a sequence of reactions,constitute the designated reactive species of oxygen(ROS).Oxidative stress is caused by a disequilibrium between the ROS produced and the antioxidant defence against them(catalase enzymes,superoxide dismutase(SOD)and glutathione peroxidases,in addition to other non-enzymatic antioxidants,such asα-tocopherol,ascorbic acid and carotenes).

关键词： oxidative complexes radical

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