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CXCL5 promotes lipogenesis and lipoapoptosis of hepatocytes through NLRP3-mediated IL-1β secretion in Kupffer cells

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CXCL5 promotes lipogenesis and lipoapoptosis of hepatocytes ...

Sappanone A alleviates the severity of hepatotoxin-induced liver fibrosis in mice via regulating M1/M2 macrophage polarization

中国毒理学会第十次全国毒理学大会

作者： Qi Jing Yan Xueqing li lanqian Zhou Zixiong Department of Biochemistry and Molecular Biology Department of Pathology and Institute of OncologySchool of Basic Medical Sciences Fujian Medical University

Background: Immune-inflammatory responses play a key role in the development of nonalcoholic steatohepatitis(NASH). Previous studies have demonstrated that CXC motif chemokine ligand 5(CXCL5)correlates positively with obesity and type 2 ***: This study is to explore the functional role of CXCL5 in the pathogenesis of NASH. Materials and methods To establish a NASH model, mice were continuously fed with methionine and cholinedeficient high fatdiet for 6 weeks. Anti-CXCL5 mAb(40 μg/kg body weight) was intraperitonelly injected every other day during the same *** primary hepatocytes, Kupffer cells(KCs) and hepatic stellate cells(HSCs) were isolated. An in vitro NASH model was induced by treatment of palmitic acid(PA, 0.4 mM), using a trans-well co-culture system of hepatocytes and KCs, and rmCXCL5(100 ng/ml)was treated 1 hour after PA administration. RESULTS Our data showed that hepatic CXCL5 levels were highly expressed in the NASH mouse model. Neutralization of CXCL5 significantly alleviated the severity of NASH in mice, demonstrated by pathological analysis, biochemicals and inflammatory cytokines. Besides, anti-CXCL5 m Ab reduced the levels of de novo lipogenesis, apoptosis and fibrosis in injured livers of mice. In vitro, recombinant(rm)CXCL5 had no significant effect on activation of ***, we found that treatment of rmCXCL5 exacerbated PA-induced hepatotoxicity and lipogenesis in hepatocytes co-cultured with KCs compared with single cultured hepatocytes. Furthermore,rmCXCL5 not only promoted NOD-like receptor pyrin domain-containing protein 3(NLRP3) expression and IL-1β secretion in co-cultured KCs treated with or without PA but also increased lipid deposition in co-cultured *** addition, MCC950, an inhibitor of NLRP3, abolished the effects of rmCXCL5 on PA-treated coculture system. CONCLUSION Therefore, we speculated that CXCL5 exacerbates NASH by promoting lipogenesis of hepatocytes via upregulating NLRP3-mediated IL-1β secreti

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Sappanone A alleviates the severity of hepatotoxin-induced l...

中国毒理学会第十次全国毒理学大会

作者： Zixiong Zhou lanqian li Xueqing Yan Wenxi Hua Jing Qi Department of Pathology and Institute of Oncology Department of Biochemistry and Molecular Biology the School of Basic Medical Sciences Fujian Medical University

Background liver fibrosis is a major challenge of global health because of its various complications including cirrhosis and hepatocarcinoma, while no effective treatment is available for liver fibrosis. Sappanone A(SA) is a homoisoflavonoid extracted from the heartwood of Caesalpinia sappan linn. with anti-inflammatory and antioxidant properties. However, the effects of SA on hepatic fibrosis still remain elusive. AIM This study aimed to investigate the protective effects of SA on carbon tetrachloride(CCl)-induced liver fibrosis in mice. MATERIALS and METHODS To establish a liver fibrosis model, mice were treated intraperitoneally(i.p.) with CCl for 4 weeks. SA(25, 50, and 100 mg/kg) was i.p. injected every other day during the same period. RESULTS Our data indicated that SA decreased liver injury, fibrotic responses, and inflammation due to CCl exposure. Consistently, SA reduced oxidative stress and its-mediated hepatocyte death in fibrotic livers. Of note, SA could not directly affect the activation of hepatic stellate cells. Mechanistically, SA down-regulated the expression of M1 polarization markers and up-regulated the expression of M2 polarization markers in livers and ***, SA induced the activation of peroxisome proliferator-activated receptor gamma(PPARγ).However, decreased inflammatory responses and the trend of M2 macrophage polarization provided by SA were substantially abolished by SR202(a PPARγ inhibitor) treatment in macrophages. Additionally,SA treatment promoted fibrosis regression. CONCLUSION Taken together, our findings revealed that treatment with SA alleviated CCl-induced fibrotic liver in mice through suppression of hepatic inflammation by PPARγ-mediated M1/M2 macrophage polarization. Thus, SA might pave the way for the new hepatoprotective agent to treat liver fibrosis.

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基于谱逼近和地面资料同化的降尺度模拟研究

高原气象 2021年第4期40卷 919-931页

作者：李洪兵邵爱梅李兰倩兰州大学大气科学学院/半干旱气候变化教育部重点实验室甘肃兰州730000

谱逼近方法和变分资料同化方法都是提高动力降尺度模拟效果的有效手段,其中谱逼近方法通过引入分析或再分析资料来订正长时间连续积分造成的大尺度偏差问题,其模拟输出有望为变分同化提供质量较好的背景场。为此,本文通过WRF模式对2015... 详细信息

谱逼近方法和变分资料同化方法都是提高动力降尺度模拟效果的有效手段,其中谱逼近方法通过引入分析或再分析资料来订正长时间连续积分造成的大尺度偏差问题,其模拟输出有望为变分同化提供质量较好的背景场。为此,本文通过WRF模式对2015年夏季秦巴山区实施水平分辨率为5 km的短期气候动力降尺度模拟,探讨在谱逼近方法的基础上利用三维变分(3DVar)同化方法同化地面观测资料的降尺度模拟效果,以期为获取复杂地形下高精度的高分辨率降尺度数据集提供一种有效途径。结果表明,在动力降尺度过程中使用谱逼近方法能够改善2 m温度、10 m风速和降水的模拟结果。只同化地面观测资料对模拟的2 m温度和10 m风速有明显改善,但对降水模拟有负作用。谱逼近方法和地面资料同化方法的结合使用能够得到2 m温度、10 m风速的最佳模拟效果,对降水的模拟结果也优于只同化地面观测资料的试验效果。使用谱逼近方法能够有效地对风场和水汽场做出合理调整,这是其降水模拟精度提高的原因之一。

关键词：动力降尺度谱逼近地面观测复杂地形 WRF模式

聚苯胺/蚕丝复合织物的制备及其pH值响应性

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纺织学报 2016年第4期37卷 91-95页

作者：李兰倩卢明刘一萍谭炼赵振云刘祖兰西南大学纺织服装学院重庆400716 西南大学重庆市生物质纤维材料与现代纺织工程技术研究中心重庆400716

为研究聚苯胺/蚕丝复合织物对酸碱的颜色响应性和可逆重复性,以平纹蚕丝织物作为基底,过硫酸铵为氧化剂,十二烷基苯磺酸为掺杂剂,通过原位化学氧化法制备了聚苯胺/蚕丝复合导电织物,采用测色仪测定织物表面颜色、色彩坐标,积分球测定织... 详细信息

为研究聚苯胺/蚕丝复合织物对酸碱的颜色响应性和可逆重复性,以平纹蚕丝织物作为基底,过硫酸铵为氧化剂,十二烷基苯磺酸为掺杂剂,通过原位化学氧化法制备了聚苯胺/蚕丝复合导电织物,采用测色仪测定织物表面颜色、色彩坐标,积分球测定织物的紫外光可见光反射曲线,研究了聚苯胺/蚕丝织物对p H值的响应性。结果表明:该复合织物的表面颜色随p H值从1增加至12发生由墨绿色—蓝绿色—蓝黑色之间的变化,具有良好的p H值响应性;此外,聚苯胺/蚕丝织物可在不同p H值溶液中重复可逆使用,表面色差小于2,颜色差异轻微,具有稳定的开关效应。

关键词：聚苯胺蚕丝复合织物 pH值响应性

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基于簇状氧化锌的抗紫外蚕丝织物整理

丝绸 2015年第3期52卷 21-25页

作者：刘祖兰李兰倩谭炼刘一萍卢明西南大学纺织服装学院重庆400716

为了赋予蚕丝织物抗紫外性能,采用层层组装技术在蚕丝织物表面构筑簇状氧化锌粒子。采用扫描电镜(SEM)、动态光散射(DLS)表征了簇状氧化锌粒子的表面形态和粒径,测试了蚕丝织物抗紫外效果、透气性等性能。结果表明:采用水热合成法制备... 详细信息

为了赋予蚕丝织物抗紫外性能,采用层层组装技术在蚕丝织物表面构筑簇状氧化锌粒子。采用扫描电镜(SEM)、动态光散射(DLS)表征了簇状氧化锌粒子的表面形态和粒径,测试了蚕丝织物抗紫外效果、透气性等性能。结果表明:采用水热合成法制备的氧化锌粒子呈团簇状,经十六烷基三甲基溴化铵(CTAB)改性后氧化锌粒子的粒径为215.9 nm,分散性得到明显提高;整理后的蚕丝织物表面出现簇状氧化锌结构,抗紫外效果随组装层数的增加而增加;同时,层层组装后织物的透气性并未产生明显变化,并具有较好的耐水洗性和耐光性。

关键词：层层组装簇状氧化锌粒子蚕丝织物抗紫外性

基于激光测风雷达的两种低空风切变告警算法对比研究

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干旱气象 2021年第4期39卷 652-661页

作者：张开俊伏龙延李兰倩邵爱梅中国民用航空西北地区空中交通管理局甘肃分局甘肃兰州730087 兰州大学大气科学学院甘肃兰州730000

利用兰州中川国际机场2020年7—11月激光测风雷达观测资料和飞行员报告的12次风切变事件,对比分析单、双斜坡结合检测法和区域散度法两种低空风切变告警算法的应用效果,并与实际业务中的IRIS告警算法监测结果进行对比。结果表明:(1)两... 详细信息

利用兰州中川国际机场2020年7—11月激光测风雷达观测资料和飞行员报告的12次风切变事件,对比分析单、双斜坡结合检测法和区域散度法两种低空风切变告警算法的应用效果,并与实际业务中的IRIS告警算法监测结果进行对比。结果表明:(1)两种算法对于对流天气或动量下传天气背景下的风切变具有较好的告警能力,但对于湍流背景下的风切变告警能力较弱;(2)相比斜坡检测法,区域散度法采用多个径向重构逆风廓线,在一定程度上能够反映出跑道及其延长线上径向风的时空演变信息,有利于风切变的提前识别和告警;(3)12次风切变事件的告警准确率表明区域散度法优于斜坡检测法和IRIS算法。

关键词：激光测风雷达低空风切变告警算法区域散度法斜坡检测法

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu Xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei Xiao Qianqian Gu Haoyu li Mengyao li Yude Wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Internal electric field Cationic accelerator Ion diffusion kinetics Cathode modification strategy Aqueous zinc ion battery