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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili patricia Graham Adriana Brooks Risset Silvera Alexander J.p.Goldschmidt damien d.pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami project to Cure paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

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内洛尔公牛的饲料转化率及其与胴体品质、非胴体品质和肉品质的关系

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饲料博览 2016年第5期26卷 55-55页

作者： Nascimento M L Souza A R d L Chaves A S MCesar A S Tullio R R Medeiros S R Mour?o G B Rosa A N FeijóG L d Alencar M M lanna d p d

试验选取内诺尔公牛575只,研究剩余采食量(RFI)、1*RFI与体增重的总和(RIG)与胴体品质、非胴体品质和肉品质之间的关系。RFI是由预测采食量与实际采食量的差值。根据RFI和RIG的平均值偏差±0.5来划分高效和低效的动物。建立一个混合模型... 详细信息

试验选取内诺尔公牛575只,研究剩余采食量(RFI)、1*RFI与体增重的总和(RIG)与胴体品质、非胴体品质和肉品质之间的关系。RFI是由预测采食量与实际采食量的差值。根据RFI和RIG的平均值偏差±0.5来划分高效和低效的动物。建立一个混合模型,RFI或RIG和同期群作为固定影响因素,初始年龄作为协变量,雄性牲畜和试验周期作为随机变量,建立每个评估特征的回归斜率方程。RIG与眼肌面积呈正相关关系。高效RFI组动物的肝脏和内部脂肪比例均低于低效RFI组。与低效RFI组和低效RIG组相比,高效RFI组RIG高效组动物的肌内脂肪提取率分别减少了11.8%和11.2%。与RFI低效组相比,RFI高效组的动物的瘦肉率更高。

关键词：肉用牛印度牛饲料效率体内脂肪嫩度内脏器官

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera dina p.Bracho-Rincon Luis H.pagan Rivera Jorge d.Miranda department of physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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preparation and characterization of colloidal dispersions of graphene-like structures from different ranks of coals

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燃料化学学报 2017年第8期45卷 897-907页

作者： d.p.Savitskii Institute of Biochemical Technology and Nanotechnology RUDN University

This paper focuses on preparation of colloidal solution of graphene-like structures from different ranks of coals: brown coal,bituminous coal,low-volatile bituminous coal,anthracite. It was found that brown coal thermo-oxidative destruction leads to formation of small d = 32 nm( V = 17%) and large d = 122 nm( V = 11%) fractions of nanoparticles. The thermo-oxidative destruction of bituminous coal leads to formation of nanoparticles d = 50 nm( V = 5.2%) and d = 164 nm( V = 16%). Thermooxidative destruction of low-volatile bituminous coal and anthracite leads to formation of nanoparticles,predominantly,d = 122-190 nm. Carbon nanostructures obtained from coal are negatively charged at pH= 2-12. Colloidal solution of carbon nanostructures at dispersed phase concentration 0. 01 mg/mL is stable for 1 month. Electron diffraction patterns and X-ray analysis of carbon nanostructures showed that nanostructure from brown coal is amorphous and nanostructure from anthracite is crystalline. Results of coal macromolecules modeling and graphene-like structures obtained from them are presented.

关键词：象 graphene 一样结构煤胶体的分散粒子尺寸分发 electrokinetic 潜力

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Elastic modulus and hardness of cortical and trabecular bovine bone measured by nanoindentation

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中国有色金属学会会刊：英文版 2006年第B02期16卷 744-748页

作者： HOdGSON p d Centre for Material and Fibre Innovationdeakin University Geelong VIC 3217Australia

The elastic modulus and hardness of several microstructure components of dry bovine vertebrae and tibia have been investigated in the longitude and transverse directions using nanoindentation. The elastic modulus for the osteons and the interstitial lamellae in the longitude direction were found to be (24.7±2.5) Gpa and (30.1±2.4) Gpa. As it's difficult to distinguish osteons from interstitial lamellae in the transverse direction, the average elastic modulus for cortical bovine bone in the transverse direction was (19.8±1.6) Gpa. The elastic modulus for trabecular bone in the longitude and transverse direction were (20±2) Gpa and (14.7±1.9) Gpa respectively. The hardness also varied among the microstructure components in the range of 0.41-0.89 Gpa. Analyses of variance show that the values are significantly different.

关键词：牛骨弹性模量硬度骨皮质骨小梁纳米压痕法测量生物力学

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FRACTAL pORE dIFFUSION MOdEL OF FLUIdS IN pOROUS MEdIA

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Acta Metallurgica Sinica(English Letters) 2000年第3期13卷 877-882页

作者： Tao, d.p. Kunming Univ of Science and Technology Kunming China

A fractal pore diffusion model of fluids in porous media which is in good agreement with the experimental data of the coke-CO2 reaction, has been derived by using the Mandelbrot's fractal length-area relation. Based on the model, a new formula and its interpretation about the tortuosity of pore structures of a porous medium have been suggested, from which the fractal pore diffusion resistance has been defined. The resistance ascends obviously with the fractal pore dimension and the conversion ratio increasing, especially in the middle-latter period of fluid-solid reactions.

关键词： Carbon dioxide Chemical reactions Coke Fractals Geometry Models porous materials

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Novel approach for modified forms of Camassa–Holm and degasperis–procesi equations using fractional operator

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Communications in Theoretical physics 2020年第10期72卷 12-18页

作者： p Veeresha d G prakasha department of Mathematics Karnatak UniversityDharwad-580003KarnatakaIndia department of Mathematics Faculty of ScienceDavangere UniversityShivagangothriDavangere 577007KarnatakaIndia

In the present study,we consider the q-homotopy analysis transform method to find the solution for modified Camassa–Holm and degasperis–procesi equations using the Caputo fractional *** the considered equations are nonlinear and exemplify shallow water *** present the solution procedure for the fractional operator and the projected solution procedure gives a rapidly convergent series *** solution behaviour is demonstrated as compared with the exact solution and the response is plotted in 2d plots for a diverse fractional-order achieved by the Caputo derivative to show the importance of incorporating the generalised *** accuracy of the considered method is illustrated with available results in the numerical *** convergence providence of the achieved solution is established in?-curves for a distinct arbitrary ***,some simulations and the important nature of the considered model,with the help of obtained results,shows the efficiency of the considered fractional operator and algorithm,while examining the nonlinear equations describing real-world problems.

关键词： Laplace transform Camassa–Holm equation q-homotopy analysis method degasperis–procesi equation fractional derivative

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The microstructure evolution and tensile properties of medium-Mn steel heat-treated by a two-step annealing process

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Journal of Materials Science & Technology 2021年第16期75卷 205-215页

作者： d.p.Yang p.J.du d.Wu H.L.Yi State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819China

The martensitic hot-rolled 0.3 C-6 Mn-1.5 Si(wt%)steel was annealed at 630℃for 24 h to improve its cold rollability,followed by cold rolling and annealing at 670℃for 10 *** annealing process was designed based on the capacities of industrial batch annealing and continuous annealing lines.A duplex submicron austenite and ferrite microstructure and excellent tensile properties were obtained finally,proved the above process is feasible."Austenite memory"was found in the hot-rolled and annealed sample which restricted recrystallization of lath martensite,leading to lath-shaped morphology of austenite and ferrite grains."Austenite memory"disappeared in the cold-rolled and annealed sample due to austenite random nucleation and ferrite recrystallization,resulting in globular microstructure and refinement of both austenite and ferrite *** austenite to martensite transformation contributed most of strain hardening during deformation and improved the uniform elongation,but the dislocation strengthening played a decisive role on the yielding *** tensile curves change from continuous to discontinuous yielding as the increase of cold-rolled reduction due to the weakening dislocation strengthening of austenite and ferrite grains related to the morphology change and grain refinement.A method by controlling the cold-rolled reduction is proposed to avoid the Lüders strain.

关键词： Medium-Mn steel Intercritical annealing Austenite memory Yielding behavior TRIp effect

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prediction and analysis of process failures by ANN classification during wire-EdM of Inconel 718

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Advances in Manufacturing 2020年第4期8卷 519-536页

作者： Abhilash p.M. Chakradhar d. department of Mechanical Engineering Indian Institute of Technology PalakkadPalakkadKeralaIndia

Wire breakages and spark absence are two typical machining failures that occur during wire electric discharge machining(wire-EdM),if appropriate parameter settings are not *** after several attempts to optimize the process,machining failures cannot be eliminated completely.A n offline classification model is presented herein to predict machining *** aim of the current study is to develop a multiclass classification model using an artificial neural network(ANN).The training dataset comprises 81 full factorial experiments with three levels of pulse-on time,pulse-off time,servo voltage,and wire feed rate as input *** classes are labeled as normal machining,spark absence,and wire *** model accuracy is tested by conducting 20 confirmation experiments,and the model is discovered to be 95%accurate in classifying the machining *** effects of process parameters on the process failures are discussed and analyzed.A microstructural analysis of the machined surface and worn wire surface is *** developed model proved to be an easy and fast solution for verifying and eliminating process failures.

关键词： Wire electric discharge machining(wire-EdM) process failure Spark absence Wire breakage Artificial neural network(ANN)classification Failure prediction

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