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m.crostructure of <em.gt;Annona m.ricata</em.gt;L. Leaves Extract m.crocapsules Linked to Physical and Chem.cal Characteristics

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Journal of Encapsulation and Adsorption Sciences 2018年第3期8卷 178-193页

作者： Oscar Jordán-Suárez Patricia Glorio-Paulet leslie Vidal Facultad de Ciencia de Alim.ntos Universidad Le Cordon Bleu Lima Perú Departam.nto de Ingeniería de Alim.ntos y Productos Agropecuarios Universidad Nacional Agraria La Molina Lima Perú Departam.nto de Agroindustrias Universidad de Concepción Chillán Chile

m.crostructure is closely related to techno-functional properties in m.croencapsulated powders intended to protect bioactive com.ounds. Soursop leaves provide phytochem.cals that need to be protected to ensure their functionality. This investigation aim.d to study the m.crostructure of m.crocapsules containing soursop leaves extract and its linkage with physical and chem.cal characteristics of the resulting powder. m.crocapsules were prepared by spray drying using gum.Arabic and m.ltodextrin as encapsulating agents at 5 and 10%. Powders were characterized by scanning electron m.croscopy, particle size analysis, solubility, infrared spectroscopy and encapsulation efficiency. m.crophotographs showed spherical shape particles ranging from.0.25 to 13.87 μm. where the particles m.rphology depended on the concentration and the type of the encapsulant used. At higher concentration of encapsulant, there was an increase in the sphericity, integrity, size, and surface sm.othness of particles. This relationship was inverse for solubility in treatm.nts with gum.Arabic. The extract encapsulation was confirm.d by Fourier Transform.infrared spectroscopy and encapsulation efficiency index, revealing that the treatm.nt with m.ltodextrin at 10% showed a better capability for entrapm.nt (72.12%). The results evidence that m.crostructure of m.crocapsules is closely linked to the type and concentration of encapsulant, which in turn determ.ne the physical and chem.cal characteristics of powders intended for instant drinks solubility and entrapping soursop bioactive com.ounds.

关键词： Soursop m.croencapsulation m.crostructure Spray Drying Encapsulants

Divergent trajectories of lean vs obese non-alcoholic steatohepatitis patients from.listing to post-transplant:A retrospective cohort study

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World Journal of Gastroenterology 2022年第26期28卷 3218-3231页

作者： Fakhar Ali Qazi-Arisar Raj Uchila Catherine Chen Cathy Yang Shi-Yi Chen Ravikiran Sindhuvalada Karnam.Am.rhossein Azhie Wei Xu Zita Galvin Nazia Selzner leslie Lilly m.m.tha Bhat Ajm.ra Transplant Program Toronto General HospitalUniversity Health NetworkToronto M5G 2N2OntarioCanada Division of Gastroenterology and Hepatology Department of MedicineUniversity of TorontoToronto M5G 2N2OntarioCanada National Institute of Liver and GI Diseases Dow University of Health SciencesKarachi 75330Pakistan Departm.nt of Biostatistics Princess Margaret Cancer CenterUniversity Health NetworkToronto M5G 2C1OntarioCanada Division of Biostatistics Dalla Lana School of Public HealthUniversity of TorontoToronto M5G 2C1OntarioCanada

BACKGROUND Non-alcoholic steatohepatitis(NASH)cirrhosis is the second m.st com.on indication for liver transplantation(LT).The role of body m.ss index(Bm.)on outcom.s of NASH cirrhosis has been *** To com.are the longitudinal trajectories of patients with lean vs obese NASH cirrhosis,from.listing up to post-transplant,having adjusted their Bm. for *** We retrospectively reviewed all adult NASH patients listed for LT in our program.from.2012 to ***-Gray Com.eting Risk analyses and Cox Proportional-Hazard m.dels were perform.d to exam.ne the cum.lative incidence of transplant and survival outcom.s *** Out of 265 NASH cirrhosis listed patients,176 were *** age was 61.0 years;46%were fem.les.111 patients underwent *** robust patients had better waitlist survival[hazard ratio(HR):0.12;95%CI:0.05–0.29,Pm.re benign than obese NASH,our study suggests a paradoxical correlation of lean NASH with waitlist outcom.s,and graft and patient survival post-LT.

关键词： Outcom.s Frailty Waitlist Liver transplant Survival

Study on the Theoretical Lim.tation of the m.d-Infrared PbSe N<sup>+</sup>-P Junction Detectors at High Operating Tem.erature

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Detection 2018年第1期6卷 1-16页

作者： Xinghua Shi Quang Phan Binbin Weng lance L. m.Dowell Jijun Qiu Zhihua Cai Zhisheng Shi The School of Electrical and Com.uter Engineering University of Oklahoma Norman USA Nanolight Inc. Norman USA

This paper provides a theoretical study and calculation of the specific detectivity-D* lim.t of photovoltaic (PV) m.d-wave infrared (m.IR) PbSe n+-p junction detectors operating at both room.tem.erature and TE-cooled tem.erature. For a typical PbSe p-type doping concentration of 2 × 1017 cm.3 and with high quantum.efficiency, the D* lim.ts of a photovoltaic PbSe n+-p junction detector are shown to be 2.8 × 1010 HZ1/2/W and 3.7 × 1010 HZ1/2/W at 300 K and 240 K, with cut-off wavelength of 4.5 μm.and 5.0 μm. respectively. It is alm.st one m.gnitude higher than the current practical m.IR PV detector. Above 244 K, the detector is Johnson noise lim.ted, and below 191 K the detector reaches background lim.ted infrared photodetector (BLIP) D*. With optim.zation of carrier concentration, D* and BLIP tem.erature could be further increased.

关键词： PbSe Lifetim. R0A Detectivity

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RS4,这该死的人格魅力

汽车与社会 2021年第4期 13-22页

作者： leslie(文/图) 不详

故事还得从25年前奥迪跟保时捷的那次惊世合作开始说起。从Quatro到S2,彼时奥迪的高性能事业才初见端倪,我不敢肯定当年的民市场对高性能的需求有多大,可以背定的是火热的装备竞赛很大程度上根源于对手竞争。Bm.首先挑事,192年推出EX NB... 详细信息

故事还得从25年前奥迪跟保时捷的那次惊世合作开始说起。从Quatro到S2,彼时奥迪的高性能事业才初见端倪,我不敢肯定当年的民市场对高性能的需求有多大,可以背定的是火热的装备竞赛很大程度上根源于对手竞争。Bm.首先挑事,192年推出EX NB,直接催促了C36 Am.和RS2的诞生。不同于E36NG3有前来E30 m.,C36 Am.有前来19O0E Am.G,RS2属于新来的,且白于起家,从这个角度来说,找保时捷帮忙也许是一种客观必然。

关键词：保时捷 Bm. C36 奥迪 Am. RS2 客观必然高性能

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遗珠

汽车与社会 2021年第4期 1-12页

作者： leslie(文/图) 不详

若要在性能车里挑一类我最喜欢的,那一定是长相平庸的,他们不事声张,但诛人心于无形,用E90m.来举例再合适不过了。双门和四门谁更有吸引力并不绝对,说到底由稀有度决定,比如我们会眼馋双门的GTI、眼馋双门的普拉多、帕杰罗,但对于m.我... 详细信息

若要在性能车里挑一类我最喜欢的,那一定是长相平庸的,他们不事声张,但诛人心于无形,用E90m.来举例再合适不过了。双门和四门谁更有吸引力并不绝对,说到底由稀有度决定,比如我们会眼馋双门的GTI、眼馋双门的普拉多、帕杰罗,但对于m.我们又更心动于四门的E90,尽管双门的E92在车体结构以及综合素质上要玄学般好上那么一点。

关键词：车体结构帕杰罗普拉多四门综合素质双门

Site-Specific Conjugation of Cell Wall Polyrham.ose to Protein SpyAD Envisioning a Safe Universal Group A Streptococcal Vaccine

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Infectious m.crobes & Diseases 2021年第2期3卷 87-100页

作者： Nina J.Gao Satoshi Uchiyam. Lucy Pill Sam.ra Dahesh Joshua Olson leslie Bautista Shilpa m.roju Aym.Berges Janet ZLiu Raym.nd HZurich Nina m.an Sorge Jeff Fairm.n Neeraj Kapoor Victor Nizet Division of Host-m.crobe System. and Therapeutics Department of PediatricsUC San DiegoLa JollaCaliforniaUSA Vaxcyte Inc.Foster CityCaliforniaUSA Departm.nt of m.dical m.crobiology and Infection Prevention Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Netherlands Reference Laboratory for Bacterial m.ningitis Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Skaggs School of Pharm.cy and Pharm.ceutical Sciences UC San DiegoLa JollaCaliforniaUSA

Developm.nt of an effective vaccine against the leading hum.n bacterial pathogen group A Streptococcus(GAS)is a public health *** species defining group A cell wall carbohydrate(GAC,lancefield antigen)can be engineered to rem.ve its im.unodom.nant N-acetylglucosam.ne(GlcNAc)side chain,im.licated in provoking autoim.une cross-reactivity in rheum.tic heart disease,leaving its polyrham.ose core(GACPR).Here we generate a novel protein conjugate of the GACPR and test the utility of this conjugate antigen in active *** of conjugation to a standard carrier protein,we selected SpyAD,a highly conserved GAS surface protein containing both B-cell and T-cell epitopes relevant to the bacterium.that itself shows prom.se as a vaccine *** was synthesized using the XpressTm.cell-free protein expression system.incorporating a non-natural am.no acid to which GACpr was conjugated by site-specific click chem.stry to yield high m.lecular m.ss SpyAD-GACPR conjugates and avoid disruption of im.ortant T-cell and B-cell im.unological *** conjugated SpyAD-GACPR elicited antibodies that bound the surface of m.ltiple GAS strains of diverse m.types and prom.ted opsonophagocytic killing by hum.n *** im.unization of m.ce with a m.ltivalent vaccine consisting of SpyAD-GACPR,together with candidate vaccine antigens streptolysin O and C5a peptidase,protected against GAS challenge in a system.c infection m.del and localized skin infection m.del,without evidence of cross reactivity to hum.n heart or brain tissue *** general approach m.y allow GAC to be safely and effectively included in future GAS subunit vaccine form.lations with the goal of broad protection without autoreactivity.

关键词： group A Streptococcus Streptococcus pyogenes group A carbohydrate lancefield antigen conjugate vaccine XpressCFTm non-natural am.no acids SpyAD Introduction

Social-epigeneticm.diators for racial disparities in pulm.nary im.airm.nt am.ng childhood cancer survivors

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Cancer Com.unications 2023年第2期43卷 290-293页

作者： Nan Song Qian Dong Cheng Chen Qian Li Heather m.lder Em.ly Plyler John Easton Em.ly Walker Scott Olson Geoffrey Neale Kevin RKrull Deo Kum.r Srivastava Kirsten K.Ness Jinghui Zhang m.lissa m.Hudson leslie L.Robison I-Chan Huang Zhaom.ng Wang Departm.nt of Epidem.ology and Cancer Control St.Jude Children’s Research HospitalMemphisTN 38105USA College of Pharm.cy Chungbuk National UniversityCheongjuChungbuk 28160South Korea School of Public Health Shanghai Jiaotong UniversityShanghai 200025P.R.China Departm.nt of Biostatistics St.Jude Children’s Research HospitalMemphisTN 38105USA Departm.nt of Com.utational Biology St.Jude Children’s Research HospitalMemphisTN 38105USA Hartwell Center St.Jude Children’s Research HospitalMemphisTN 38105USA Departm.nt of Oncology St.Jude Children’s Research HospitalMemphisTN 38105USA

Dear Editor Previous research found that childhood cancer survivors of African ancestry have significantly higher m.rbidity and m.rtality than those of European ancestry[1].However,after adjusting for socio-econom.c factors,the m.gnitudes of racial health disparities are either substantially decreased or becom. statistically non-significant[1],suggesting that social and econom.c determ.nants m.y contribute to racial health ***,we conducted epigenom.-wide association studies(EWAS)for three key social determ.nants of health(SDOHs),nam.ly,personal educational attainm.nt,personal incom.,and neighborhood deprivation am.ng survivors of childhood cancer,where 130 epigenom.-wide significant SDOH-CpG associationswere identified am.ng European ancestry survivors,and 25 of which were also validated in African ancestry survivors[2].Notably,m.ny SDOH-associated CpG sites are also associated with tobacco use.

关键词： vivo cancer m.rtality

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汶川8.0级地震板桥学校液化震害剖析

岩土工程学报 2011年第S1期33卷 331-336页

作者：曹振中徐学燕 T.leslie Youd 袁晓铭中国地震局工程力学研究所哈尔滨工业大学 Brigham.Young University Provo 84602USA

2008年汶川8.0级地震中绵竹市板桥镇板桥学校液化破坏具有典型性,通过现场调查、高密度电法测试、波速测试、钻孔、探坑和室内试验等手段,研究了其地裂缝成因,分析了学校教学楼破坏机理以及液化土的特性。结果表明:①地裂缝是由液化而... 详细信息

2008年汶川8.0级地震中绵竹市板桥镇板桥学校液化破坏具有典型性,通过现场调查、高密度电法测试、波速测试、钻孔、探坑和室内试验等手段,研究了其地裂缝成因,分析了学校教学楼破坏机理以及液化土的特性。结果表明:①地裂缝是由液化而不是由次断层或破裂带引起;②板桥学校较周围房屋建筑震害严重,其破坏不是由于地震时振动惯性力所致,而是由于地基液化直接造成;③地下液化层为3.0～6.1 m.砂砾土,液化土不是地表喷出的细砂,地表喷出物与地下实际液化土差异显著;④以往认为砂砾土不会液化从而选择砂砾层作为持力层这一观点有误,需要重新认识。

关键词：汶川地震板桥学校砂砾土液化

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非常办公麟研部办公空间设计

室内设计与装修 2007年第7期 105-109页

作者：姜汉雷徐岭啸 lance Sm.th 苏卓荣麟研部建筑设计咨询(上海)有限公司

麟研部将自己的办公场所安在了上海市卢湾区的泰康路上,这是一个艺术氛围浓厚的街区。在这幢旧仓库建筑内,麟研部把整个楼层内300m.2的区域划为其办公区,打造成展示设计与创意相结合的多功能前卫空间。原来非常普通的长方形楼层平面内... 详细信息

麟研部将自己的办公场所安在了上海市卢湾区的泰康路上,这是一个艺术氛围浓厚的街区。在这幢旧仓库建筑内,麟研部把整个楼层内300m.2的区域划为其办公区,打造成展示设计与创意相结合的多功能前卫空间。原来非常普通的长方形楼层平面内，因为加入了麟研部独特的风格元素：非常规的角度与线条、倾斜的墙面、简单色彩的运用，使整个本应严谨的办公空间变得动感十足。

关键词：空间设计办公场所艺术氛围仓库建筑展示设计办公空间卢湾区上海市