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Frontiers of Environmental Science & Engineering 2024年第5期18卷 73-83页

作者： Marvin Yeung lan tian Yuhong Liu Hairong Wang Jinying Xi Environmental Simulation and Pollution Control State Key Joint Laboratory School of EnvironmentTsinghua UniversityBeijing100084China Graduate School at Shenzhen Tsinghua UniversityShenzhen518055China

Electrochemical disinfection(ECD)is a promising disinfection technique for wastewater reclamation;however,the impacts of ECD on the microbiome in secondary effluent wastewater remain *** this study,Propidium monoazide-qPCR(PMA-qPCR)and the plate count method were used to evaluate the inactivation performance,and the PMA-16S rRNA gene sequences of living cells were targeted to study the microbiome.A discrepancy was found between PMA-qPCR and the plate count method in the evaluation of cell count,with increases of 1.5 to 2.2 orders of magnitude in the disinfection rate after 150 s of ***,the cell count recovered and occasionally exceeded original levels within 3 d after *** was suppressed after ECD,but the microbiome after 150 s disinfection retained a higher level of evenness and stability in the community with a median Shannon index(>3.7).Pathogenic bacteria remained high in relative abundance even after 150 s of 25 V disinfection,but the biofilm-forming population was effectively suppressed by *** co-occurrence network revealed a centralized and fragile network as disinfection persisted,demonstrating the destabilizing effects of ECD on the *** pathways for cell membrane synthesis and organic compound degradation were enriched after *** reaction of the microbiome after ECD was similar to other disinfection techniques in terms of community structure.

关键词： Electrochemical disinfection Secondary effluent Microbiome

Comparing the efficacy and safety of low,medium,and high dosages of selexipag for treating pulmonary hypertension:A systematic review and meta-analysis

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Animal Models and Experimental Medicine 2024年第1期7卷 56-70页

作者： Shang Wang Yi Yan Jian Zhang Ping Yuan Ci-Jun Luo Hong-Ling Qiu Hui-Ting Li Jian Xu lan Wang tian-lan Li Rong Jiang Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Heart Center and Shanghai Institute of Pediatric Congenital Heart Disease Shanghai Children's Medical CenterNational Children's Medical CenterShanghai Jiaotong University School of MedicineShanghaiChina Department of Respiratory and Critical Care Medicine The 416 Hospital of Nuclear IndustryThe Second Affiliated Hospital of Chengdu Medical CollegeChengduChina Department of Hematology The Affiliated Hospital of Qingdao UniversityQingdaoChina

Background:The maintenance dosage of selexipag is categorized as low,medium or *** order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypertension(PAH),we performed a sys-tematic review and ***:Studies assessing PAH risk stratification indices,such as the World Health Organization functional class(WHO-FC),six-minute walk distance(6MWD),N-terminal pro-B-type natriuretic peptide(NT-proBNP)level,right atrial pressure(RAP),cardiac index(CI)and mixed venous oxygen saturation(SvO2),were ***:Thirteen studies were *** led to improvements in the 6MWD(MD:24.20 m,95%CI:10.74-37.67),NT-proBNP(SMD:-0.41,95%CI:-0.79-0.04),CI(MD:0.47 L/min/m^(2),95%CI:0.17-0.77)and WHO-FC(OR:0.564,95%CI:0.457-0.697).Subgroup analysis demonstrated that all three dosages improved the 6MWD.A moderate dosage led to improvements in the CI(MD:0.30 L/min/m^(2),95%CI:0.15-0.46)and WHO-FC(OR:0.589,95%CI:0.376-0.922).Within 6 months of treatment,only the WHO-FC and CI were significantly improved(OR:0.614,95%CI:0.380-0.993;MD:0.30 L/min/m^(2),95%CI:0.16-0.45,respectively).More than 6 months of treatment significantly improved the 6MWD,WHO-FC and NT-proBNP(MD:40.87 m,95%CI:10.97-70.77;OR:0.557,95%CI:0.440-0.705;SMD:-0.61,95%CI:-1.17-0.05,respectively).Conclusions:Low,medium,and high dosages of selexipag all exhibited good *** treatment lasted for more than 6 months,selexipag exerted obvious effects,even in the low-dosage *** finding is important for guiding individualized treatments.

关键词： individualized treatments meta-analysis prostacyclin receptor agonist risk stratification systematic review

Widely targeted metabolomics analysis of the effects of probiotic fermentation on the phytochemicals of kiwifruit juice and prediction of key metabolic pathways

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Food Science and Human Wellness 2024年

作者： tian lan Qinyu Zhao Jiaqi Wang Xiangyu Sun Yulin Fang Tingting Ma College of Food Science and Engineering， Northwest A&F University College of Enology， Northwest A&F University

Metabolomics can be used to identify the changes and metabolic pathways of nutrients and flavor substances in foods at specific processing or fermentation stages. This study revealed the accumulation and degradation of phytochemicals during the fermentation of kiwifruit juice (KJ) by lactic acid bacteria (LAB) through widely targeted metabolomics and explored the impact of different fermentation strategies on the nutritional quality and functional characteristics of KJ. LAB utilized the original sugars， acids， amino acids， and nucleotides of the matrix to produce numerous bioactive compounds， including phenols， organic acids， free fatty acids， and vitamins， while achieving bacterial proliferation and reduced anti-nutritional factors such as alkaloids， thus improving the nutritional and functional properties of KJ. Moreover， compared with monoculture fermentation， mixed fermentation promoted the production of more biologically active phenols and alkaloids， among which vanillic acid and luteolin-8-C-arabinoside were the characteristic metabolites of mixed and mono- fermentation. Subsequently， the metabolic pathways of key metabolites were predicted， including the glycolytic Embden–Meyerhof–Parnas pathway， pentose phosphoketolase pathway， organic acid metabolic and arginine deiminase pathways for improving the acid resistance of LAB， and the phenolic-acid–based phenylalanine and tyrosine metabolic pathway.

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Nitro-oleic acid ameliorates erectile dysfunction in a streptozotocin-induced rat model of diabetes by inhibiting oxidative stress and apoptosis and activating the NO/cGMP pathway

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Asian Journal of Andrology 2024年第1期26卷 57-66页

作者： Chang-Bo Zhao Wei-Bo Chen Wen-Zhen Wang Fang-Xin Gong Cui-Qin Fan Ye Li tian lan Wen-Jing Wang Ming-Zhen Yuan Department of Urology Shandong Provincial HospitalShandong UniversityJinan 250012China Department of Andrology Liaocheng People's HospitalShandong UniversityLiaocheng 252000China Department of Urology The Second Hospital of Shandong UniversityJinan 250012China Department of Physiology School of Basic Medical SciencesShandong UniversityJinan 250012China

The major vascular complications associated with diabetes make the management of diabetic mellitus erectile dysfunction(DMED)a challenging *** factors contributing to DMED include oxidative stress,nitric oxide(NO)/cyclic guanosine monophosphate(cGMP)pathway activation,and apoptosis,while nitro-oleic acid(NO,-OA)has been shown to be beneficial in treating these aspects of this ***,herein,investigated the effects and possible mechanisms of NO,-OA on erectile function as assessed in a streptozotocin-induced rat model of *** results revealed that the erectile function of DMED rats was significantly impaired compared with that of the control ***,in response to 4 weeks of NO,-OA treatment,there was an improvement in erectile *** expression of oxidative stress-related indicators was significantly increased and the NO/cGMP pathway was impaired in the DMED *** expression of proapoptotic factors was increased,while that of antiapoptotic factors was decreased in the DMED ***,the cell morphology in the cavernous tissue of the DMED group also changed ***,-OA treatment significantly reversed all these changes observed in the DMED *** conclusion,NO,-OA treatment partially improved erectile function in DMED rats through mechanisms that included inhibition of oxidative stress,activation of the NO/cGMP pathway,and a reduction in apoptosis.

关键词： apoptosis diabetic mellitus erectile dysfunction nitro-oleic acid NO/cGMP pathway oxidative stress

Gappy POD算法重构储能电池组核心温度及与BP神经网络预测能力对比

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工程科学学报 2024年第1期46卷 166-177页

作者：苑清扬薛珂张博兰天大连理工大学能源与动力工程学院大连100083 大连理工大学宁波研究院宁波315000 浙江一舟储能集团宁波315191

储能电池组中电池核心温度的实时监控对于防控电池热失控有着重要的意义.为克服工业实际中电池组内部无法布置多温度测点导致的温度数据获取不全面等问题,本文将Gappy POD重构算法引入储能电池核心温度实时监控问题中,通过监测电池组表... 详细信息

储能电池组中电池核心温度的实时监控对于防控电池热失控有着重要的意义.为克服工业实际中电池组内部无法布置多温度测点导致的温度数据获取不全面等问题,本文将Gappy POD重构算法引入储能电池核心温度实时监控问题中,通过监测电池组表面温度预测内部核心温度.通过搭建简化的拟储能电池实验台模拟电池温升,测试了Gappy POD算法在工况平稳变化和工况剧烈变化条件下的稳定性和对核心温度的实时重构能力;对比了Gappy POD算法的重构能力和BP神经网络(Back propagation neural network)的预测能力,并探究了Gappy POD算法和BP神经网络在不同大小的数据库训练条件下的重构预测能力.研究表明,Gappy POD重构算法具有高预测精度、稳定性强并且对数据库数据量依赖性低等优势,为算法在储能电池热管理中的实际应用提供了基础.

关键词： Gappy POD BP神经网络储能电池热管理核心温度预测

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黑果枸杞和黄果枸杞的广泛靶向代谢组学分析

食品科学 2024年第12期45卷 52-58页

作者：兰天段国珍祁有朝樊光辉青海大学农牧学院青海西宁810016 青海大学农林科学院青海西宁810016 青海大学医学部青海西宁810016 青海大学藏医学院青海西宁810016

目的:全面分析和鉴定枸杞果实中的代谢物,比较不同品种间代谢物的差异,为深入挖掘和利用不同品种枸杞提供参考。方法:以黑果枸杞和黄果枸杞干果为材料,利用超高效液相色谱-串联质谱进行广泛靶向代谢组学分析,鉴定和比较两种枸杞的代谢... 详细信息

目的:全面分析和鉴定枸杞果实中的代谢物,比较不同品种间代谢物的差异,为深入挖掘和利用不同品种枸杞提供参考。方法:以黑果枸杞和黄果枸杞干果为材料,利用超高效液相色谱-串联质谱进行广泛靶向代谢组学分析,鉴定和比较两种枸杞的代谢物。结果:两种枸杞果实中共检测出1098种代谢产物,包括氨基酸及其衍生物、酚酸、黄酮、生物碱、脂质等12类,其中酚酸、黄酮和生物碱3类代谢产物占比最高。通过主成分分析和聚类分析发现,黄果枸杞与黑果枸杞相比,存在235种差异代谢物上调和252种差异代谢物下调。京都基因与基因组百科全书富集分析发现,不同品种枸杞间的差异代谢物主要涉及黄酮生物合成,托烷、哌啶和吡啶生物碱的生物合成,次生代谢物的生物合成,ABC转运等途径。结论:不同品种对枸杞代谢物的含量影响较大,本研究结果对黑枸杞和黄枸杞的开发和利用提供一定的理论指导。

关键词：黑枸杞黄枸杞代谢组学代谢物黄酮生物碱

计算流体力学途径揭示寒武纪乌溜期吐卓虫(Tuzoia)种间游动能力分化图景

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古生物学报 2024年第2期63卷 273-282页

作者：耿新宇兰天贵州大学资源与环境工程学院贵阳550025

吐卓虫(Tuzoia)是寒武纪出现且广泛分布于全球海洋中的一类具双瓣壳节肢动物,其软躯体性状不完备,并不能直观判断吐卓虫是否是一种擅长游泳的生物,因此其生态位长期存在争议。计算流体力学(Computational Fluid Dynamics,CFD)可以基于... 详细信息

吐卓虫(Tuzoia)是寒武纪出现且广泛分布于全球海洋中的一类具双瓣壳节肢动物,其软躯体性状不完备,并不能直观判断吐卓虫是否是一种擅长游泳的生物,因此其生态位长期存在争议。计算流体力学(Computational Fluid Dynamics,CFD)可以基于保存较好的生物骨骼化石,直观、量化地分析深时生物运动模式,为还原古生态提供了依据。本文采用计算流体力学模拟了加拿大布尔吉斯页岩生物群中的两种吐卓虫(T. retifera, T. canadensis)在底栖和远洋环境下的多种运动状态,对比分析了两种吐卓虫运动流体性能、垂向灵活性的差异。流体模拟结果表明,相同速度下T. retifera相比T. canadensis受到更小的阻力和更大的浮力。所以T. retifera具有更高游泳速度的潜力,同时垂向移动能力更好。计算结果暗示T. canadensis营底栖游泳生活,而T. retifera的栖息范围可以更广,营远洋游泳生活。这表明可能早在寒武纪乌溜期吐卓虫属级分类单元内就出现了生态位的分化。

关键词：计算流体力学寒武纪乌溜期吐卓虫生态位分化

Chain Elongation Using Native Soil Inocula:Exceptional n-Caproate Biosynthesis Performance and Microbial Mechanisms

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Engineering 2024年第8期39卷 262-272页

作者： Lin Deng Yang Lv tian lan Qing-Lian Wu Wei-Tong Ren Hua-Zhe Wang Bing-Jie Ni Wan-Qian Guo State Key Laboratory of Urban Water Resource and the Environment Harbin Institute of TechnologyHarbin 150090China Centre for Technology in Water and Wastewater&School of Civil and Environmental Engineering University of Technology SydneySydneyNSW 2007Australia

This study demonstrates the feasibility and effectiveness of utilizing native soils as a resource for inocula to produce n-caproate through the chain elongation(CE)platform,offering new insights into anaerobic soil *** results reveal that all five of the tested soil types exhibit CE activity when supplied with high concentrations of ethanol and acetate,highlighting the suitability of soil as an ideal source for n-caproate *** with anaerobic sludge and pit mud,the native soil CE system exhibited higher selectivity(60.53%),specificity(82.32%),carbon distribution(60.00%),electron transfer efficiency(165.00%),and conductivity(0.59 ms∙cm^(-1)).Kinetic analysis further confirmed the superiority of soil in terms of a shorter lag time and higher yield.A microbial community analysis indicated a positive correlation between the relative abundances of Pseudomonas,Azotobacter,and Clostridium and n-caproate ***,metagenomics analysis revealed a higher abundance of functional genes in key microbial species,providing direct insights into the pathways involved in n-caproate formation,including in situ CO_(2)utilization,ethanol oxidation,fatty acid biosynthesis(FAB),and reverse beta-oxidation(RBO).The numerous functions in FAB and RBO are primarily associated with Pseudomonas,Clostridium,Rhodococcus,Stenotrophomonas,and Geobacter,suggesting that these genera may play roles that are involved or associated with the CE ***,this innovative inoculation strategy offers an efficient microbial source for n-caproate production,underscoring the importance of considering CE activity in anaerobic soil microbial ecology and holding potential for significant economic and environmental benefits through soil consortia exploration.

关键词： Soil Chain elongation n-caproate Reverse beta-oxidation Fatty acid biosynthesis Metagenomics

T1 mapping技术用于评估心尖肥厚型心肌病患者心肌钆沉积

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中国医学影像技术 2024年第2期40卷 226-230页

作者：杨宏志兰天杨如武西电集团医院医学影像科陕西西安710077 国家心血管病中心北京协和医学院中国医学科学院阜外医院磁共振影像科北京100037

目的观察T1 mapping技术用于评估心尖肥厚型心肌病(AHCM)患者心肌钆沉积的可行性。方法回顾性分析60例AHCM患者资料,根据是否接受含钆对比剂(GBCA)注射分为增强组和对照组各30例;基于2组心脏T1 mapping测量左心室基底部、中间部、心尖... 详细信息

目的观察T1 mapping技术用于评估心尖肥厚型心肌病(AHCM)患者心肌钆沉积的可行性。方法回顾性分析60例AHCM患者资料,根据是否接受含钆对比剂(GBCA)注射分为增强组和对照组各30例;基于2组心脏T1 mapping测量左心室基底部、中间部、心尖部心肌T1值及相应层面脾脏T1值,计算T1相对值(T1R),比较组间及增强组内左心室不同部位心肌T1R,并对增强组T1R基于性别、年龄、体质量指数、心功能、高血压、高血脂、糖尿病、心尖厚度、射血分数、延迟强化、首次增强检查至末次复查间隔时间及GBCA总量进行进一步分析。结果组间T1R_(基底部)、T1R_(中间部)、T1R_(心尖部)差异均无统计学意义(t=0.329、1.484、0.720,P均>0.05)。增强组内,左心室不同部位心肌T1R差异无统计学意义(F=0.765,P>0.05),不同性别及有无高血压患者间心肌T1R差异均有统计学意义(P均<0.05)。结论T1 mapping技术可用于评估AHCM患者心肌钆沉积。

关键词：心肌病,肥厚型 T1 mapping 心肌钆沉积

Preliminary clinical application of total free-breathing cardiac MR examination

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中国医学影像技术 2024年第8期40卷 1183-1188页

作者： YANG Kai YIN Gang AN Jing YANG Xinling lan tian ZHAO Shihua LU Minjie Department of Magnetic Resonance Imaging Fuwai HospitalNational Center for Cardiovascular DiseasesPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100037China Siemens Shenzhen Magnetic Resonance Ltd. Shenzhen 518057China Key Laboratory of Cardiovascular Imaging Chinese Academy of Medical SciencesBeijing 100730China

Objective To observe the clinical application value of total free-breathing cardiac MR(CMR)examination *** Two patients who underwent CMR scanning under free-breathing state,including cine,motion correction T1 and T2 mapping,blood flow imaging,and late gadolinium enhancement scanning were retrospectively enrolled,and the qualities of the above images were evaluated and compared with that of conventional CMR images under breath-holding *** No significant difference of imaging quality was found between total free-breathing and conventional breath-holding *** differences of left ventricular ejection fraction,cardiac output,left ventricular end-diastolic volume index and left ventricular mass measured based on CMR images under different breath conditions were *** Total free-breathing CMR was feasible in clinical practice,which could provide"one-stop"evaluation of cardiac structure,function and myocardial histological characteristics,hence having promising clinical prospects.

关键词： heart magnetic resonance imaging respiratory motion motion correction