检索结果-南通市图书馆

World Journal of Diabetes 2024年第7期15卷 1615-1626页

作者： Xiao-lan ma Dan Ge Xue-Jian Hu Department of Endocrinology and Metabolism The Second Affiliated Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Islets of langerhans beta cells diminish in autoimmune type 1 diabetes mellitus(T1DM).Teplizumab,a humanized anti-CD3 monoclonal antibody,may help *** long-term implications on clinical T1DM development,safety,and efficacy are *** To assess the effectiveness and safety of teplizumab as a therapeutic intervention for individuals with *** A systematic search was conducted using four electronic databases(PubMed,Embase,Scopus,and Cochrane Library)to select publications published in peerreviewed journals written in *** odds ratio(OR)and risk ratio(RR)were calculated,along with their 95%*** assessed heterogeneity using Cochrane Q and I2 statistics and the appropriate P *** There were 8 randomized controlled trials(RCTs)in the current meta-analysis with a total of 1908 T1DM patients from diverse age cohorts,with 1361 patients receiving Teplizumab and 547 patients receiving a *** was found to have a substantial link with a decrease in insulin consumption,with an OR of 4.13(95%CI:1.72 to 9.90).Teplizumab is associated with an improved Cpeptide response(OR 2.49;95%CI:1.62 to 3.81)and a significant change in Glycated haemoglobin A1c(HbA1c)levels in people with type 1 diabetes[OR 1.75(95%CI:1.03 to 2.98)],and it has a RR of 0.71(95%CI:0.53 to 0.95).CONCLUSION In type 1 diabetics,teplizumab decreased insulin consumption,improved C-peptide response,and significantly changed HbA1c levels with negligible side *** appears to improve glycaemic control and diabetes management with good safety and efficacy.

关键词： Type-1 diabetes mellitus Teplizumab Anti-CD3 monoclonal antibody Insulin Glycated haemoglobin A1c Cpeptide

Sm-like 5 knockdown inhibits proliferation and promotes apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2716-2726页

作者： Cai-Jing Mo Xiao-Yuan Deng Ru-lan ma Kun Zhu Lei Shi Kang Li Department of Surgical Oncology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND The role of Sm-like 5(LSM5)in colon cancer has not been *** this study,we investigated the role of LSM5 in progression of colon cancer and the potential underlying mechanism *** To determine the role of LSM5 in the progression of colon cancer and the potential underlying mechanism *** The Gene Expression Profiling Interactive Analysis database and the Human Protein Atlas website were used for LSM5 expression analysis and prognosis ***-time quantitative polymerase chain reaction and Western blotting were utilized to detect the expression of mRNAs and proteins.A lentivirus targeting LSM5 was constructed and transfected into colon cancer cells to silence LSM5 *** and apoptosis assays were also conducted to evaluate the growth of the colon cancer *** GeneChip assay and bioinformatics analysis were performed to identify the potential underlying mechanism of LSM5 in colon *** LSM5 was highly expressed in tumor tissue and colon cancer cells.A high expression level of LSM5 was related to poor prognosis in patients with colon *** of LSM5 suppressed proliferation and promoted apoptosis in colon cancer *** of LSM5 also facilitates the expression of p53,cyclin-dependent kinase inhibitor 1A(CDKN1A)and tumor necrosis factor receptor superfamily 10B(TNFRSF10B).The inhibitory effect of LSM5 knockdown on the growth of colon cancer cells was associated with the upregulation of p53,CDKN1A and *** LSM5 knockdown inhibited the proliferation and facilitated the apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B.

关键词： Sm-like 5 Colon cancer Proliferation Apoptosis Knockdown

Study of the intensive care unit activity scale in the early rehabilitation of patients after direct cardiac surgery

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第26期12卷 5930-5936页

作者： Li Wang Jing-Ya Lu Xiao-Xiao ma lan-Ou ma Intensive Care Unit Dongyang People’s HospitalJinhua 322100Zhejiang ProvinceChina Department of Rehabilitation Medicine Dongyang People’s HospitalJinhua 322100Zhejiang ProvinceChina

BACKGROUND Direct cardiac surgery often necessitates intensive post-operative care,and the intensive care unit(ICU)activity scale represents a crucial metric in assessing and guiding early rehabilitation efforts to enhance patient *** To clarify the clinical application value of the ICU activity scale in the early recovery of patients after cardiac *** One hundred and twenty patients who underwent cardiac surgery between September 2020 and October 2021 were selected and divided into two groups using the random number table *** observation group was rated using the ICU activity scale and the corresponding graded rehabilitation interventions were conducted based on the ICU activity *** control group was assessed in accordance with the routine rehabilitation activities,and the postoperative rehabilitation indexes of the patients in both groups were compared(time of tracheal intubation,time of ICU admission,occurrence of complications,and activity scores before ICU transfer).The two groups were compared according to postoperative rehabilitation indicators(time of tracheal intubation,length of ICU stay,and occurrence of complications)and activity scores before ICU *** In the observation group,tracheal intubation time lasted for 18.30±3.28 h and ICU admission time was 4.04±0.83 d,which were significantly shorter than the control group(t-values:2.97 and 2.038,respectively,P<0.05).The observation group also had a significantly lower number of complications and adverse events compared to the control group(P<0.05).Before ICU transfer,the observation group(6.7%)had few complications and adverse events than the control group(30.0%),and this difference was statistically significant(P<0.05).Additionally,the activity score was significantly higher in the observation(26.89±0.97)compared to the control groups(22.63±1.12 points)(t-value;-17.83,P<0.05).CONCLUSION Implementation of early goal-directed activities in patients who underwent c

关键词： Early recovery activities Goal orientated ICU mobility scale Intensive care unit Cardiac surgery

Single atom doping induced charge-specific distribution of Cu1-TiO_(2)for selective aniline oxidation via a new mechanism

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Catalysis 2024年第9期64卷 98-111页

作者： Jiaheng Qin Wantong Zhao Jie Song Nan Luo Zheng-lan ma Baojun Wang Jiantai ma Riguang Zhang Yu Long State Key Laboratory of Applied Organic Chemistry(SKLAOC) the Key Laboratory of Catalytic Engineering of Gansu ProvinceCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000GansuChina State Key Laboratory of Clean and Efficient Coal Utilization College of Chemical Engineering and TechnologyTaiyuan University of TechnologyTaiyuan 030024ShanxiChina

Utilizing single atom sites doping into metal oxides to modulate their intrinsic active sites,achieving precise selectivity control in complex organic reactions,is a highly desirable yet challenging ***,identifying the active site also represents a significant obstacle,primarily due to the intricate electronic environment of single atom site doped metal ***,a single atom Cu doped TiO_(2)catalyst(Cu_(1)-TiO_(2))is prepared via a simple“colloid-acid treatment”strategy,which switches aniline oxidation selectivity of TiO_(2)from azoxybenzene to nitrosobenzene,without using additives or changing solvent,while other metal or nonmetal doped TiO_(2)did not *** mechanistic investigations and DFT calculations unveil that Ti-O active site is responsible for triggering the aniline to form a new PhNOH intermediate,two PhNOH condense to azoxybenzene over TiO_(2)*** for Cu_(1)-TiO_(2),the charge-specific distribution between the isolated Cu and TiO_(2)generates unique Cu_(1)-O-Ti hybridization structure with nine catalytic active sites,eight of them make PhNOH take place spontaneous dissociation to produce *** work not only unveils a new mechanistic pathway featuring the PhNOH intermediate in aniline oxidation for the first time but also presents a novel approach for constructing single-atom doped metal oxides and exploring their intricate active sites.

关键词： Single atom doped metal oxide Aniline oxidation Selectivity New mechanism Active site

基于BERT与生成对抗的民航陆空通话意图挖掘

在线全文

学校读者我要写书评

暂无评论

系统工程与电子技术 2024年第2期46卷 740-750页

作者：马兰孟诗君吴志军中国民航大学空中交通管理学院天津300300 中国民航大学电子信息与自动化学院天津300300 中国民航大学安全科学与工程学院天津300300

针对民航陆空通话领域语料难以获取、实体分布不均,以及意图信息提取中实体规范不足且准确率有待提升等问题,为了更好地提取陆空通话意图信息,提出一种融合本体的基于双向转换编码器(bidirectional encoder representations from transf... 详细信息

针对民航陆空通话领域语料难以获取、实体分布不均,以及意图信息提取中实体规范不足且准确率有待提升等问题,为了更好地提取陆空通话意图信息,提出一种融合本体的基于双向转换编码器(bidirectional encoder representations from transformers,BERT)与生成对抗网络(generative adversarial network,GAN)的陆空通话意图信息挖掘方法,并引入航班池信息对提取的部分信息进行校验修正,形成空中交通管制(air traffic control,ATC)系统可理解的结构化信息。首先,使用改进的GAN模型进行陆空通话智能文本生成,可有效进行数据增强,平衡各类实体信息分布并扩充数据集;然后,根据欧洲单一天空空中交通管理项目定义的本体规则进行意图的分类与标注;之后,通过BERT预训练模型生成字向量并解决一词多义问题,利用双向长短时记忆(bidirectional long short-term memory,BiLSTM)网络双向编码提取上下句语义特征,同时将该语义特征送入条件随机场(conditional random field,CRF)模型进行推理预测,学习标签的依赖关系并加以约束,以获取全局最优结果;最后,根据编辑距离(edit distance,ED)算法进行意图信息合理性校验与修正。对比实验结果表明,所提方法的宏平均F_(1)值达到了98.75%,在民航陆空通话数据集上的意图挖掘性能优于其他主流模型,为其加入数字化进程奠定了基础。

关键词：民航陆空通话信息提取生成对抗网络本体双向转换编码器

迭代式创新、双元机会开发对消费升级的影响机制研究

在线全文

学校读者我要写书评

暂无评论

工程管理科技前沿 2024年第2期43卷 62-68页

作者：马蓝安立仁西北大学经济管理学院陕西西安710127

数字经济不仅打破了传统的企业生产模式也改变了消费模式。在数字技术更新换代的环境下,企业要更加重视选代式创新的重要作用,挖掘消费升级的机会。本文运用226家企业的研究样本数据进行实证分析,结果:选代式创新对消费升级具有显著正... 详细信息

数字经济不仅打破了传统的企业生产模式也改变了消费模式。在数字技术更新换代的环境下,企业要更加重视选代式创新的重要作用,挖掘消费升级的机会。本文运用226家企业的研究样本数据进行实证分析,结果:选代式创新对消费升级具有显著正向影响;选代式创新分别对均衡型机会开发和创新型机会开发具有显著正向影响;均衡型机会开发和创新型机会开发分别对消费升级具有显著正向影响;均衡型机会开发和创新型机会开发在选代式创新与消费升级关系间具有中介作用。企业在寻找符合自身发展的商业模式和新市场的开辟中,要更加重视选代式创新的重要作用,借助双元机会开发视角去探索不同的商业路径,提升消费的渠道和规模,实现价值创造。

关键词：迭代式创新双元机会开发消费升级

基于氢氧同位素示踪的黄土区不同植被类型小流域降雨⁃径流分割

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

应用生态学报 2024年第2期35卷 399-406页

作者：左玉珠潘成忠马勇星马岚北京师范大学北京100875 北京林业大学山西吉县森林生态系统国家野外科学观测研究站北京100083

流域径流过程及其组分来源识别是水资源合理利用的前提。为明确植被类型对流域径流组分的影响与定量贡献,本研究以山西吉县蔡家川主沟流域及5个不同植被类型小流域为研究对象,监测2场典型降雨产流过程及其氢氧同位素时空变化特征,探讨... 详细信息

流域径流过程及其组分来源识别是水资源合理利用的前提。为明确植被类型对流域径流组分的影响与定量贡献,本研究以山西吉县蔡家川主沟流域及5个不同植被类型小流域为研究对象,监测2场典型降雨产流过程及其氢氧同位素时空变化特征,探讨小流域径流过程差异及其组分来源。结果表明:在中雨条件下,事件水对各个流域河道流量的贡献率为封禁森林(94.3%)>蔡家川主沟(83.1%)>农牧复合(64.3%)>人工⁃次生林(52.4%)>农地(0.3%)>次生林(0.0%);而在小雨条件下,人工⁃次生林(52.4%)>封禁森林(58.5%)>农地(40.6%)>次生林(15.8%)>农牧复合(12.5%)>蔡家川主沟(9.3%),次生林、封禁森林小流域事件水对径流贡献率大于人工林,次生林具有更强的径流调蓄能力。封禁森林、农牧复合流域在中雨强度条件下事件水的贡献率大于小雨强度条件,而农地、人工⁃次生林、次生林流域则相反。事件水对林地小流域径流贡献率大于农地小流域,可能与农地小流域沟口建有淤地坝有关。本研究结果可为晋西黄土区水源涵养和径流变化归因分析提供科学依据。

关键词：氢氧同位素二元混合模型径流分割蔡家川小流域

在线全文

学校读者我要写书评

暂无评论

太赫兹全息成像的超表面设计算法研究

激光与光电子学进展 2024年第12期61卷 19-32页

作者：马兰廖云鸿龚岩栋北京信息科技大学仪器科学与光电工程学院北京100192

全息成像基于干涉和衍射原理实现了对物体的振幅和相位信息的再现,得到了广泛的研究。超表面是人为设计的具有亚波长单元结构的新型材料,可以实现许多自然界中不具备的物理性质,可以通过超表面材料实现对电磁波相位和振幅的灵活调控,完... 详细信息

全息成像基于干涉和衍射原理实现了对物体的振幅和相位信息的再现,得到了广泛的研究。超表面是人为设计的具有亚波长单元结构的新型材料,可以实现许多自然界中不具备的物理性质,可以通过超表面材料实现对电磁波相位和振幅的灵活调控,完成复杂的波前调控。超表面提升了传统空间光调制器在成像分辨率、成像效率、成像视场角等方面的性能。超表面材料的出现为研究太赫兹波段的全息成像提供了解决方案。首先介绍全息成像的基本光学原理,回顾近年来国内外对不同电磁波波段特别是太赫兹波段超表面全息成像中使用的算法的研究进展,介绍几种重要的超表面设计算法的基本原理和各种算法对成像效果的影响,并且对各种算法进行比较与总结,研究结果为选择太赫兹波段全息成像的超表面设计算法提供了参考。

关键词：太赫兹超表面全息成像全息成像算法

在线全文

学校读者我要写书评

暂无评论

教育促进新质生产力发展的理论逻辑与路径

河北师范大学学报（教育科学版） 2024年第3期26卷 32-40页

作者：张志杰马岚河北师范大学教育学院河北石家庄050024 河北师范大学国际合作交流中心河北石家庄050024

新质生产力是以新质劳动力、新质生产工具和新质劳动对象为构成要素,以科技创新为内核,以推动高质量发展为目标的生产力新质态。新质生产力的发展离不开教育的高质量发展,教育通过人才创新、知识创新、技术创新以及产业创新分别作用于... 详细信息

新质生产力是以新质劳动力、新质生产工具和新质劳动对象为构成要素,以科技创新为内核,以推动高质量发展为目标的生产力新质态。新质生产力的发展离不开教育的高质量发展,教育通过人才创新、知识创新、技术创新以及产业创新分别作用于新质生产力三要素,从而对新质生产力发展形成基础性、战略性支撑。因此,在微观层面,以科技创新人才自主培养夯实新质生产力发展的劳动力基础;在中观层面,以产学研深度融合加速适应新质生产力发展的创新集聚;在宏观层面,以高水平教育对外开放为新质生产力发展注入外部动力。

关键词：教育新质生产力理论逻辑

在线全文

学校读者我要写书评

暂无评论

基于三段论的日语篇章回指概念转移机制研究

外语导刊 2024年第5期47卷 78-86,120,159页

作者：马兰英卢欢国防科技大学外国语学院江苏南京210039

日语篇章回指现象较为复杂,尤其是当先行语为语段时,回指语形式多样,不同形式的回指语对先行语概念的转移方式也有所不同。本文运用“回指研究三段论”对该问题进行了研究。当回指语是单独的指示词时,先行语所详细叙述的事件概念被语义... 详细信息

日语篇章回指现象较为复杂,尤其是当先行语为语段时,回指语形式多样,不同形式的回指语对先行语概念的转移方式也有所不同。本文运用“回指研究三段论”对该问题进行了研究。当回指语是单独的指示词时,先行语所详细叙述的事件概念被语义空泛、词形简单的指示词重述为“这/那(件事)”,重现在回指语的位置;当回指语为“连体指示词+体言”时,由于体言有相对丰富的语义,该形式既可以对先行语进行语义相同的概念转移,也可以增加主观评价性语义,还可以对先行语概念进行延伸;当回指语为光杆名词时,尽管没有连体指示词的辅助,但它也可以实现与“连体指示词+体言”相同的概念转移。这些概念转移方式都以回指语对先行语的体言化或副词化为基础,体言化或副词化的先行语才可以出现在下文句子的某个句法位置,表达与先行语相同或相关的概念,推动语篇的发展。

关键词：三段论日语篇章回指概念转移语段