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Mechanical Behavior and Failure Mechanism of an As-Extruded Mg-11wt%Y Alloy at Elevated Temperature

Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 969-981页

作者： lan Zhang Dao-Kui Xu Bao-Jie Wang Cui-lan lu Shuo Wang Xiang-Bo Xu Dong-Liang Wang Xin Lv En-Hou Han School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Environmental and Chemical Engineering Shenyang Ligong UniversityShenyang110159China Key Lab of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang110819China Institute of Corrosion Science and Technology Guangdong510070China

Through carrying out the high-temperature tensile experiments on an as-extruded Mg-11wt%Y alloy at 350℃,400℃,450℃,500℃and 550℃,the mechanical behavior and fracture mechanisms at elevated temperatures are investigated and *** results show that with the increase of temperature,the yield strength and ultimate tensile strength of the alloy increase at first and then decrease,while that the elongation ratio decreases firstly and then *** the sample being tested at 350℃,the values of yield strength,ultimate tensile strength and the elongation ratio are 188 MPa,266 MPa and 11%,*** 400℃,the yield strength and ultimate tensile strength reach the maximum values of,respectively,198 MPa and 277 MPa,but the elongation ratio is the lowest and its value is only 8%.When the applied temperature is increased to 550℃,the values of yield strength and ultimate tensile strength,respectively,decrease to 140 MPa and 192 MPa and the elongation ratio increases to 38%.Failure analysis demonstrates that the fracture surfaces of different samples are mainly composed of plastic dimples and exhibit the typical characteristic of ductile *** observation to the fracture side surfaces indicates that at the temperatures of 350℃and 400℃,microcracks mainly initiate in the interior of Mg_(24)Y_(5)*** the temperatures are 450℃,500℃and 550℃,the cracks preferentially initiate at the Mg_(24)Y_(5)/α-Mg interfaces.

关键词： Mg-Y alloy High-temperature tensile properties Fracture mechanism Failure analysis

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Contemporary strategies and approaches for characterizing composition and enhancing biofilm penetration targeting bacterial extracellular polymeric substances

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Journal of Pharmaceutical Analysis 2024年第4期14卷 506-524页

作者： lan lu Yuting Zhao Mingxing Li Xiaobo Wang Jie Zhu Li Liao Jingya Wang Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of AntibioticsSchool of PharmacyChengdu UniversityChengdu610000China Meishan Pharmaceutical Vocational College School of PharmacyMeishanSichuan620200China Laboratory of Molecular Pharmacology Department of PharmacologySchool of PharmacySouthwest Medical UniversityLuzhouSichuan646000China Hepatobiliary Surgery Langzhong People's HospitalLangzhongSichuan646000China

Extracellular polymeric substances(EPS)constitutes crucial elements within bacterial biofilms,facili-tating accelerated antimicrobial resistance and conferring defense against the host's immune *** precise and effective antibiofilm approaches and strategies,tailored to the specific charac-teristics of EPS composition,can offer valuable insights for the creation of novel antimicrobial ***,in turn,holds the potential to mitigate the alarming issue of bacterial drug *** analysis of EPS compositions relies heavily on colorimetric approaches with a significant bias,which is likely due to the selection of a standard compound and the cross-interference of various EPS *** the pivotal role of EPS in biofilm functionality,it is imperative for EPS research to delve deeper into the analysis of intricate compositions,moving beyond the current focus on polymeric *** ne-cessitates a shift from heavy reliance on colorimetric analytic methods to more comprehensive and nuanced analytical *** this study,we have provided a comprehensive summary of existing analytical methods utilized in the characterization of EPS ***,novel strategies aimed at targeting EPS to enhance biofilm penetration were explored,with a specific focus on high-lighting the limitations associated with colorimetric ***,we have outlined the challenges faced in identifying additional components of EPS and propose a prospective research plan to address these *** review has the potential to guide future researchers in the search for novel compounds capable of suppressing EPS,thereby inhibiting biofilm *** insight opens up a new avenue for exploration within this research domain.

关键词： Analytic strategies and approaches Composition characterization Extracellular polymeric substances(EPS) Promoting biofilm penetration

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思想政治教育数字化转型的逻辑意蕴与范式革命

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思想教育研究 2024年第6期 61-69页

作者：卢岚上海理工大学马克思主义学院上海200093

数字化转型是由数字技术驱动,数据要素赋能而引发的系统性创变。由数字技术与思想政治教育之间的相互建构形成的关系维度,成为解析思想政治教育数字化转型的分析框架。这一框架始于数字技术与思想政治教育之间的互嵌与共生,延展于思想... 详细信息

数字化转型是由数字技术驱动,数据要素赋能而引发的系统性创变。由数字技术与思想政治教育之间的相互建构形成的关系维度,成为解析思想政治教育数字化转型的分析框架。这一框架始于数字技术与思想政治教育之间的互嵌与共生,延展于思想政治教育数字化转型的逻辑链解析,最终指向思想政治教育数字化转型与范式革命之目标。其理论日益走向精细,其阐释也不断深化:一是阐释由数字系统贯通跨主体、跨领域的教育过程中利用传统优势延链、升链,形成“全链条”数字育人的新形态;二是勘察数字孪生映射思想政治教育“全场域”时,依靠盘活存量、涌现增量来建链与补链,进而系统性呈现与考量思想政治教育研究范式变革。

关键词：数字化思想政治教育逻辑链研究范式

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Bioactive phytochemicals and associated multifunctional health-promoting effects of Polygonati Rhizoma

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Food Science and Human Wellness 2024年

作者： Shuzhen Wang Feng He Yunli Xiao Fu Xiang lan lu Wei Wu Chi-Tang Ho Shiming Li College of Biology and Agricultural Resources， Huanggang Normal University School of Computer and Information Technology， Beijing Jiaotong University Department of Food Science， Rutgers University New Brunswick

Polygonati Rhizoma， a functional food and a traditional Chinese medicine broadly used in China and several Southeast Asia countries， possesses effective health-promoting activities. Prepared from three plants in Polygonatum family (P. kingianum， P. sibiricum， and P. cyrtonema)， Polygonati Rhizoma has drawn increasing attention due to its remarkable immune-enhancing and metabolic regulatory activities in recent years. In this review， we summarized the updated research of chemical constituents and biological activities of Polygonati Rhizoma， especially the metabolic regulation， immunomodulatory effects， and anti-fatigue activities， aiming to provide a comprehensive understanding， broaden the usage and promote more in-depth exploration of Polygonati Rhizoma as a functional food.

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Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo Yi Su Yu-Ya-Nan Zhang Hao Yu Zhe lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-lan lu Jun Li Yun-Dan Liao Zhe-Wei Kang Li-Fang Wang Yue Li Ming Li Bing Liu Hai-Liang Huang lu-Xian Lv Yin Yao Yun-Long Tan Gerome Breen Ian Everall Hong-Xing Wang Zhuo Huang Dai Zhang Wei-Hua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

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从“在线”走向“在场”:元宇宙赋能思想政治教育的多维审视

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高校辅导员学刊 2024年第1期16卷 73-81,99页

作者：卢岚上海理工大学马克思主义学院上海200093

元宇宙是一个有着虚实相融、具身沉浸、实时交互性特征的虚拟世界,在互联网进化的基础上增加了全真互动一维。较之于以平面信息交互为主的网络思想政治教育,元宇宙赋能把点、线交互层面拓展到主体多维实时的交互空间里,极大地丰富和还... 详细信息

元宇宙是一个有着虚实相融、具身沉浸、实时交互性特征的虚拟世界,在互联网进化的基础上增加了全真互动一维。较之于以平面信息交互为主的网络思想政治教育,元宇宙赋能把点、线交互层面拓展到主体多维实时的交互空间里,极大地丰富和还原了真实思想政治教育的场景,人们可以以“真身”“化身”随时“进入”“退出”和“切换”空间。互联网实现了主体由“离线”走向“在线”,而元宇宙赋能却能实现主体从“在线”走向“在场”,促进了人类生活方式迈向虚实结合,实现了在虚拟空间的“面对面交流”与“心与心碰撞”,进而推动了精神生活模式的深化与丰富,为思想政治教育创新与发展提供了全方位的赋能与革命性的重塑。

关键词：元宇宙互联网虚拟现实赋能思想政治教育

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龙江河谷灌区分级提水方案比选

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广西水利水电 2024年第4期 82-86页

作者：陆蓝翔广西水利电力勘测设计研究院有限责任公司南宁530023

介绍了龙江河谷灌区北山南灌片和石福灌片的基本情况,从地形地质条件、施工组织、环境影响、工程投资、运行管理等多方面对这两个提水灌片采用一次提水还是多级提水方案进行比选,提出合理的分级提水及泵站出水池选址方案,达到既能满足... 详细信息

介绍了龙江河谷灌区北山南灌片和石福灌片的基本情况,从地形地质条件、施工组织、环境影响、工程投资、运行管理等多方面对这两个提水灌片采用一次提水还是多级提水方案进行比选,提出合理的分级提水及泵站出水池选址方案,达到既能满足灌溉功能,又能降低工程投资,方便运行管理的目的。

关键词：分级提水方案比选龙江河谷灌区

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龙江河谷灌区南干管选址选线

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广西水利水电 2024年第3期 94-98页

作者：陆蓝翔广西水利电力勘测设计研究院有限责任公司南宁530023

灌区工程长距离输水管道选址选线是影响工程投资、工程顺利建设与否的关键要素。本文对龙江河谷灌区中南干管的分水口、交水点和线路进行多因素比选,提出南干管线路选择的建议。

关键词：输水管线长距离选址选线龙江河谷灌区

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概念转喻视域下《浮生六记》英译研究

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五邑大学学报（社会科学版） 2024年第1期26卷 78-81,94页

作者：兰满露辽宁师范大学外国语学院辽宁大连116000

结合概念转喻理论,研究中外译者的《浮生六记》英译差异,可以为概念转喻翻译的认知手段和影响因素提供解释性理据。研究表明:中外译者在事物与部分之间的转喻、事件转喻、范畴与其特征之间的转喻、行为转喻、容器转喻和地点转喻等多个... 详细信息

结合概念转喻理论,研究中外译者的《浮生六记》英译差异,可以为概念转喻翻译的认知手段和影响因素提供解释性理据。研究表明:中外译者在事物与部分之间的转喻、事件转喻、范畴与其特征之间的转喻、行为转喻、容器转喻和地点转喻等多个角度都体现出翻译差异。译者的文化背景和译者在翻译中的识解型式是形成概念转喻翻译差异的主要原因。

关键词：概念转喻《浮生六记》英译本翻译差异影响因素

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智能技术生态:解析互联网时代思想政治教育创新的逻辑力量

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上海理工大学学报（社会科学版） 2024年第2期46卷 143-152页

作者：卢岚李静怡上海理工大学马克思主义学院上海200093 萨凡纳艺术与设计学院美国萨凡纳31401

随着技术与社会深度融合,人类难以脱离技术的裹挟,并在各种场所、活动中被技术量化或准入,形成了新的社会交往秩序。回应技术与思想政治教育在学科逻辑上的对话问题,对思想政治教育而言将拥有更大的创新空间。技术间的加速融合、协同创... 详细信息

随着技术与社会深度融合,人类难以脱离技术的裹挟,并在各种场所、活动中被技术量化或准入,形成了新的社会交往秩序。回应技术与思想政治教育在学科逻辑上的对话问题,对思想政治教育而言将拥有更大的创新空间。技术间的加速融合、协同创新与相互赋能所形成的智能技术生态是驱动互联网时代思想政治教育创新的关键。掌握技术生态的应用和高品质数字资源的共享,旨在对抗单一技术在创新思想政治教育时所遭遇到的技术瓶颈问题,进而以智能技术生态的方式,与思想政治教育进行交融连接与能量激活。这不仅赋予了思想政治教育研究的新视角与新问题域开发,而且有助于在交叉学科领域找寻思想政治教育理论生长的生命之源,重构其理论体系,推进思想政治教育科学化、精细化发展。

关键词：互联网智能技术生态思想政治教育

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