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Automatic quantification of superficial foveal avascular zone in optical coherence tomography angiography implemented with deep learning

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Visual Computing for Industry,Biomedicine,and Art 2019年第1期2卷 205-213页

作者： Menglin Guo Mei Zhao Allen M.y.Cheong Houjiao Dai Andrew K.C.lam yongjin Zhou School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen University Xili CampusRoom 208Block A2Taoyuan StreetShenzhen 518055China Centre for Myopia Research School of OptometryFaculty of Health and Social SciencesThe Hong Kong Polytechnic UniversityKowloonHong KongChina

An accurate segmentation and quantification of the superficial foveal avascular zone(sFAZ)is important to facilitate the diagnosis and treatment of many retinal diseases,such as diabetic retinopathy and retinal vein *** proposed a method based on deep learning for the automatic segmentation and quantification of the sFAZ in optical coherence tomography angiography(OCTA)images with robustness to brightness and contrast(B/C)variations.A dataset of 405 OCTA images from 45 participants was acquired with Zeiss Cirrus HD-OCT 5000 and the ground truth(GT)was manually segmented subsequently.A deep learning network with an encoder–decoder architecture was created to classify each pixel into an sFAZ or non-sFAZ ***,we applied largestconnected-region extraction and hole-filling to fine-tune the automatic segmentation results.A maximum mean dice similarity coefficient(DSC)of 0.976±0.011 was obtained when the automatic segmentation results were compared against the *** correlation coefficient between the area calculated from the automatic segmentation results and that calculated from the GT was *** all nine parameter groups with various brightness/contrast,all the DSCs of the proposed method were higher than *** proposed method achieved better performance in the sFAZ segmentation and quantification compared to two previously reported *** conclusion,we proposed and successfully verified an automatic sFAZ segmentation and quantification method based on deep learning with robustness to B/C *** clinical applications,this is an important progress in creating an automated segmentation and quantification applicable to clinical analysis.

关键词： Optical coherence tomography angiography Deep learning Foveal avascular zone Automatic segmentation and quantification

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Ophthalmology in the time of COVID-19: experience from Hong Kong Eye Hospital

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 851-859页

作者： Stephanie S.L.Cheung Cherie y.K.wong Jason C.K.Chan Carmen K.M.Chan N.M.lam Hunter K.L.yuen Victoria w.y.wong Chi wai Tsang Clement C.y.Tham Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongHong Kong SARChina Hong Kong Eye Hospital Hong Kong SARChina

AIM:To review international guidelines and to share our infection control experience during the coronavirus disease 2019(COVID-19)pandemic at a tertiary eye centre in Hong ***:Infection control guidelines and recommendations from international ophthalmological bodies are reviewed and *** measures at our hospital were drawn up as per international and local health authorities’guidelines and implemented with the collaboration of doctors,nurses and administrative ***:The aims of our infection control measures are to 1)minimize cross-infection within the hospital;2)protect and support hospital staff;3)ensure environmental *** minimize the risk of cross-infection,outpatient attendance and elective surgery have been reduced by 40%,and general anesthesia procedures were reduced by 90%.Patients entering the hospital are screened for fever,travel history,contact and cluster history,and COVID-19 related *** protect and support hospital staff,we ensure provision of adequate personal protective equipment(PPE)and provide clear guidelines on the level of PPE needed,depending on the clinical *** protective measures include provision of work uniforms,easy access to alcohol-based hand rub,opening new lunch areas,implementation of self-monitoring and self-reporting systems,and communication via online education and ***,environmental control is achieved by ensuring regular disinfection of the hospital premise,enhancing ventilation,and usage of disposable ophthalmic ***:Our multi-pronged approach to infection control is,so far,successful in minimizing infection risks,while allowing the maintenance of essential ophthalmic services.

关键词： COVID-19 coronavirus SARS-CoV-2 ophthalmology infection control Hong Kong

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用带不同侧链的双取代聚乙炔衍生物增溶多壁碳纳米管

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高分子学报 2007年第10期17卷 901-904页

作者：袁望章赵辉徐海鹏孙景志 lam J w y 毛宇金佳科张双郑强唐本忠浙江大学高分子科学与工程学系教育部高分子合成与功能构造重点实验室杭州310027 香港科技大学化学系

采用不同的双取代聚乙炔与多壁碳纳米管复合,通过π-π相互作用和聚合物链缠绕实现了对碳纳米管的增溶.这种方法对碳纳米管的结构没有损害,而且包覆到碳纳米管表面的双取代聚乙炔也显示了自身的荧光发射特性.

关键词：双取代聚乙炔缠绕碳纳米管增溶

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进化

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家庭影院技术 2008年第8期 45-47页

作者： jacky.lam

进化（Evolution），这个词汇最能联想到达尔文有关自然界生物为了回应环境压力、自然选择和基因突变而逐渐（经过好几百万年）产生由低级到高级的发展变化过程。回顾单枪影院投影机的发展，数码工业化生产将这一进程微缩到不到10年的... 详细信息

进化（Evolution），这个词汇最能联想到达尔文有关自然界生物为了回应环境压力、自然选择和基因突变而逐渐（经过好几百万年）产生由低级到高级的发展变化过程。回顾单枪影院投影机的发展，数码工业化生产将这一进程微缩到不到10年的演变过程，从480p到720p再到1080p Full HD大约不到5年时间，而实际上早在2003年6月JVCD—ILA3840×2048像素数码投影机已开启4K时代。2004年6月SONy SXRD—R110已完成Digital Cinema 4096×2160的4Kp技术发展。

关键词：数码投影机工业化生产环境压力基因突变自然选择

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Grasping Motion Control of Robotic Hands Using MIDS

Grasping Motion Control of Robotic Hands Using MIDS

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2003年中国智能自动化会议

作者： Alan H．F．lam Martin y．y．Leung Raymond H．w．lam Centre for Micro and Nano Systems Dept. of Automation and Computer-Aided Engineering The Chinese University of Hong Kong Hong Kong SAR

A novel input and sensing system - the Micro Input Devices System (MIDS) is under development by merging MEMS sensors and existing wireless technologies. Previously,we have demonstrated MIDS to be applicable as a new form of humancomputer interface to potentially replace the mouse, keyboard, and light-pen. we have also shown that MIDS can be used as a generalized wireless distributed sensing system and successfully utilized it to measure the motion of the fingers of a robotic hand under manipulation. In this paper, we will present our recent results on using MIDS for grasping motion control of robotic hands. MIDS acts as a human-robot-interface that is used to detect and transduce an operator’s finger motion to control a five-finger robotic hand to perform grasping motion. Experimental results indicate that MIDS is capable of obtaining real-time acceleration signals and tilt angle data for the operator’s fingers. with the PD control algorithm, the robotic finger angles (measured by the joint angle sensors) tracked the angle data from MIDS, and hence, allowing the operator to control the robotic hand manipulator wirelessly using his own arm and finger motion.

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Ground movements due to deep excavations in Shanghai： Design charts

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Frontiers of Structural and Civil Engineering 2014年第3期8卷 201-236页

作者： Malcolm D. BOLTON Sze-yue lam Paul J. VARDANEGA Charles w. w. NG Xianfeng MA Department of Engineering University of Cambridge Cambridge CB2 1PZ United Kingdom Advanced Geomechanics Perth Western Australia 6009 Australia Department of Civil Engineering University of Br&tol Bristol BS8 1TR United Kingdom Department of Civil and Environmental Engineering The Hong Kong University of Science and Technology Hong Kong China Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tong/i University Shanghai 200092China

Recent research has clarified the sequence of ground deformation mechanisms that manifest themselves when excavations are made in soft ground. Furthermore, a new framework to describe the deformability of clays in the working stress range has been devised using a large database of previously published soil tests. This paper aims to capitalize on these advances, by analyzing an expanded database of ground movements associated with braced excavations in Shanghai. It is shown that conventional design charts fail to take account either of the characteristics of soil deformability or the relevant deformation mechanisms, and therefore introduce significant scatter. A new method of presentation is found which provides a set of design charts that clarify the influence of soil deformability, wall stiffness, and the geometry of the excavation in relation to the depth of soft ground.

关键词： Shanghai excavations mobilizable strength design dimensionless groups design charts

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LINEAR AND HyPERBRANCHED POLyMERS wITH HIGH THERMAL STABILITy AND LUMINESCENCE EFFICIENCy

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Chinese Journal of Polymer Science 2001年第6期19卷 585-590页

作者： jacky wing yip lam Jing-dong Luo Han Peng Zhi-liang Xie Kai-tian Xue yu-ping Dong Lin Cheng Cheng-feng Qiu Hoi Sing Kwok Ben-zhong Tang Departments of Chemistry and Electrical & Electronic Engineering Hong Kong University of Science & Technology Clear water Bay, Kowloon, Hong Kong China Hong Kong Univ Sci & Technol Dept Chem Kowloon Hong Kong Peoples R China Hong Kong Univ Sci & Technol Dept Elect & Elect Engn Kowloon Hong Kong Peoples R China

New acetylene monomers, 6-{[(1-naphthylethynyl-4-phenyl)carbonyl]oxy}-1-phenyl-1-hexyne (1), 2,5-diethynyl-thiophene (3), and 4,4'-diethynylbiphenyl (6) were synthesized. Homopolymerization of 1 and copolycyclotrimerizations of 3 and 6 with 1-heptyne and 1-octyne have been achieved with wCl6- and TaCl5-Ph4Sn catalysts, respectively, giving soluble linear disubstituted polyacetylene (2) and hyperbranched polyarylenes (5 and 8) with high molecular weights (up to 1.2 x 10(5)) in high yields (up to 98%). The structures and properties of the polymers are characterized and evaluated by R NMR, TGA, UV, photoluminescence (PL), and electroluminescence (EL) analyses. All the polymers possess high thermal stability and emit strong blue light upon photoexcitation. The intensity of the emitted light is greater than that of poly(1-phenyl-1-octyne), a well-known highly luminescent disubstituted polyacetylene. Little aggregation-induced red shift in the PL was observed in the thin films of the polymers. By constructing a multi-layer EL device, high EL quantum yield (0.18%) has been achieved in 2, which are the best results for substituted polyacetylenes attainable so far.

关键词： disubstituted polyacetylene hyperbranched polyarylene light emission

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Overview of surface ozone variability in East Asia-North Pacific region during IGAC/APARE(1994—1996)

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Journal of Environmental Sciences 2004年第4期16卷 599-609页

作者： K.S. lam T.J.wang T. wang J. Tang . y.Kajii C.M. Liu S.G. Shim Environmental Engineering Unit Department of Civil and Structural Engineering The Hong Kong Polytechnic University Hong Kong Department of Atmospheric Science Nanjing University Nanjing 210093 China Chinese Academy of Meteorological Science Beijing 100081 China Research Center for Advanced Science and Technology University of Tokyo Tokyo Japan Department of Atmospheric Science "National" Taiwan University Taipei Taiwan China Global Environmental Research Center Korea Institute of Science and Technology Seoul South Korea

Surface ozone(O\-3) was measured at Oki Island(Japan), Cheju Island(South Korea), Lanyu Island(Taiwan Province, China), Cape D'Aguilar(Hong Kong SAR) and Lin'an, Longfenshan, waliguan(China mainland) during January 1994—December 1996 as a component of IGAC/APARE(International Global Atmospheric Chemistry/East Asia-North Pacific Regional Experiment). This paper gave a joint discussion on the observational results at these stations over the study region. Investigations showed that the average of surface O 3 mixing ratios at the seven sites are 47.9±15.8, 48.1±17.9, 30.2±16.4, 31.6±17.5, 36.3±17.5, 34.8±11.5 and 48.2±9.5 ppbv, respectively. Significant diurnal variations of surface O 3 have been observed at Oki, Cheju, D’Aguilar, Lin'an and Longfenshan. Their annual averaged diurnal differences range from 8 to 23 ppbv and differ in each season. Surface O 3 at Lanyu and waliguan do not show strong diurnal variability. Seasonal cycles of surface O 3 showed difference at the temperate and the subtropical remote sites. Oki has a summer minimum-spring maximum, while Lanyu has a summer minimum-autumn maximum. The suburban sites at D'Aguilar and Lin'an report high-level O 3 in autumn and low level O 3 in summer. Surface O 3 remains high in autumn and low in winter at the rural site Longfenshan. For the global background station waliguan, surface O 3 exhibits a broad spring-summer maximum and autumn-winter minimum. The backward air trajectories to these sites have shown different pathways of long-range transport of air pollution from East Asia Continent to North Pacific Ocean. Surface O 3 was found to be strongly and positively correlated with CO at Oki and Lanyu, especially in spring and autumn, reflecting the substantial photochemical buildup of O\-3 on a regional scale. It is believed that the regional sources of pollution in East Asia have enhanced the average surface O 3 concentrations in the background atmosphere of North Pacific.

关键词： surface ozone trajectory transport photochemistry

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Hyperbranched Organometallic Polyynes:Optical and Thermal Properties and Their Transformation into Soft Ferromagnetic Ceramics

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复旦学报（自然科学版） 2005年第5期44卷 859-860页

作者： M. Hauβlert H. Dong J. w. y. lam A. Qin H. Tong B. Z. Tang Department of Chemistry The Hang Kong University of Science ＆ Technology Clear Water Bay KowloonHong Kong China Department of Polymer Science and Engineering ~nejiang University Hangzhou 310027 China

Organometallic polymers have emerged as a group of interesting materials due to their useful catalytic,optical, electrical, sensing, and magnetic properties inaccessible by their pure organic parents. It is therefore highly desirable to utilize this class of high performance macromolecules for the preparation of micro- and nanosized patterns by photolithographic techniques and as precursors for advanced ceramics[1].

关键词：有机金属聚炔烃热性质铁磁体催化反应

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Prader-willi Syndrome:16-year Experience in Hong Kong

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Journal of Genetics and Genomics 2012年第4期39卷 191-194页

作者： Ivan F.M. Lo Ho Ming Luk luksite@*** Tony M.F. Tong Kent K.S. Lai Daniel H.C. Chan Albert C.F. lam David K.H. Chan Edgar w.L. Hau Connie O.y. Fung Stephen T.S. lam Clin Genet Serv Dept Hlth Kowloon Hong Kong Peoples R China

Prader-willi syndrome （PwS） is an important, well-recognized syndromic form of neurodevelopmental disorder. The incidence is about 1 in 15,000-25,000 live births, and it affects both males and females （Vogels et al... 详细信息

关键词： PwS Prader-willi Syndrome

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