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Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

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Military Medical Research 2024年第1期11卷 115-147页

作者： yuan-Peng Zhang Xin-yun Zhang yu-Ting Cheng Bing Li Xin-Zhi Teng Jiang Zhang Saikit lam Ta Zhou Zong-Rui Ma Jia-Bao Sheng Victor CwTam Shara wyLee Hong Ge Jing Cai Department of Medical Informatics Nantong UniversityNantong 226001JiangsuChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518000GuangdongChina Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’***,the interpretation of medical images can be highly subjective and dependent on the expertise of ***,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical *** contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical *** have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized ***,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical *** this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with *** focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical ***,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of ***,we offer possible solutions to current challenges in radiomics research.

关键词： Artificial intelligence Radiomics Feature extraction Feature selection Modeling Interpretability Multimodalities Head and neck cancer

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含苯并菲盘状液晶聚炔的相结构

含苯并菲盘状液晶聚炔的相结构

2010年两岸三地高分子液晶态与超分子有序结构学术研讨会（暨第十一次全国高分子液晶态与超分子有序结构学术论文报告会）

作者：余振强朱才镇刘剑洪 lam jacky.w.y. 赵可清唐本忠深圳大学化学与化工学院深圳市功能高分子重点实验室香港科技大学化学系四川师范大学化学与材料科学学院

盘状液晶材料在光存储、有机半导体、光电导体、光电池电荷传输材料及液晶显示材料等方面显示出巨大的应用前景。聚乙炔等具有刚性主链的侧链液晶高分子的相结构与相转变的研究对理解高分子液晶凝聚态结构具有重要意义。单取代侧链液晶... 详细信息

盘状液晶材料在光存储、有机半导体、光电导体、光电池电荷传输材料及液晶显示材料等方面显示出巨大的应用前景。聚乙炔等具有刚性主链的侧链液晶高分子的相结构与相转变的研究对理解高分子液晶凝聚态结构具有重要意义。单取代侧链液晶聚炔的本体相行为的研究表明,具有刚性主链的侧链液晶聚炔以整个分子形成

关键词：聚炔盘状液晶相结构 X-射线衍射

侧链含苯并菲盘状液晶基元的侧链液晶聚炔的相行为

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侧链含苯并菲盘状液晶基元的侧链液晶聚炔的相行为

2011年全国高分子学术论文报告会

作者：余振强朱才镇刘剑洪 lam jacky.w.y. 赵可清唐本忠深圳大学化学与化工学院香港科技大学化学系四川师范大学化学与材料科学学院

＜正＞单取代侧链液晶聚炔的本体相行为的研究表明,当主链为顺式构型时,分子形状为刚性柱状结构,柱状分子通过堆砌可以形成柱状液晶相;当主链为反式构型时,分子形状为片状结构,片状结构之间堆积形成近晶相。本文以侧链含苯并菲盘状液晶... 详细信息

＜正＞单取代侧链液晶聚炔的本体相行为的研究表明,当主链为顺式构型时,分子形状为刚性柱状结构,柱状分子通过堆砌可以形成柱状液晶相;当主链为反式构型时,分子形状为片状结构,片状结构之间堆积形成近晶相。本文以侧链含苯并菲盘状液晶基元的侧

关键词：聚炔盘状液晶相结构 X-射线衍射

具有不同液晶基元的双取代聚炔的相转变与相结构

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具有不同液晶基元的双取代聚炔的相转变与相结构

2009年全国高分子学术论文报告会

作者：余振强朱才镇刘剑洪陈尔强 lam jacky.w.y. 唐本忠深圳大学化学与化工学院北京大学化学与分子工程香港科技大学化学系

＜正＞单取代侧链液晶聚炔的本体相行为的研究表明,当主链为螺旋的顺式-顺式、顺式-反式构象时将形成刚性棒状结构,进而形成柱状液晶相;当主链为反式-顺式、反式-反式构象时形成片状结构,片状结构之间堆积形成近晶相。即单取代侧链液晶... 详细信息

＜正＞单取代侧链液晶聚炔的本体相行为的研究表明,当主链为螺旋的顺式-顺式、顺式-反式构象时将形成刚性棒状结构,进而形成柱状液晶相;当主链为反式-顺式、反式-反式构象时形成片状结构,片状结构之间堆积形成近晶相。即单取代侧链液晶聚炔是以整个分子形成的棒状

关键词：聚炔液晶高分子相转变相结构

A novel classification method for mild adolescent idiopathic scoliosis using 3D ultrasound imaging

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Medicine in Novel Technology and Devices 2021年第3期11卷 151-161页

作者： D.yang T.T.y.Lee K.K.L.Lai y.S.wong L.N.wong J.L.yang T.P.lam R.M.Castelein J.C.y.Cheng y.P.Zheng Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong KongChina SH Ho Scoliosis Research Lab Joint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing UniversityDepartment of Orthopaedics&TraumatologyThe Chinese University of Hong KongHong KongChina Department of Orthopaedic Surgery University Medical Center Utrechtthe Netherlands Spine Center Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghaiChina

Mild adolescent idiopathic scoliosis(AIS),with Cobb<20°,was hypothesized as the right stage to intervene to prevent *** curve can be categorized into either structural or non-structural depending on the spine morphol... 详细信息

Mild adolescent idiopathic scoliosis(AIS),with Cobbwas hypothesized as the right stage to intervene to prevent *** curve can be categorized into either structural or non-structural depending on the spine morphology(flexibility).Using X-ray to characterize AIS curves remains the clinical gold standard whilecompromising the risks of radiation *** previous works,3D ultrasound imaging had proved the reli-ability of the coronal spinal curvature measurement This research aimed at developing a mild AIs clasificationscheme through examining spine flexibility using 3D ultrasound *** the preliminary study,90 mild AIS subjects(21 M and 69 F;Age:14.5±1.7 years old;Cobb:18.2±6.4°)underwent both 3D ultrasound and X-ray scanning on the same *** each case,a clinician measured Cobbs and denoted major curve as ground *** Asymmetry Index(BAl)was developed to indicate the presence of a possible structural *** curve classification was coded to a modfied Lenke classification for mild cases(m-Lenke).The results of 3D ultrasound classification were evaluated with the *** was shown that 70.1%of the subjects had identical curve clssification results and 72.0%had the correct major curve ***-dominated curves had distinctive performance(p=0.91,r=0.91)against *** study demonstrated the possibility of a 3D ultrasound-based method for mild AIS curve *** could be partially explained by the limitations of the ultrasound scanning in proximal thoracicreg *** studies will validate the proposed method with a larger cohort.

关键词： AIS classification 3D ultrasound Mild AIS Spine flexibility

Treatment Effects of Acupuncture and Calligraphy Training on Cognitive Abilities in Senile Demented Patients

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Chinese Medicine and Culture 2019年第2期2卷 95-98页

作者： Henry S.R.Kao Miqu wang Shuguang yu Shihong yuan Miranda My Fung Lin Zhu Stewart P.w.lam Tin Tin Kao Xiaoyang Kao Departments of Psychology 9Psychology and GeographyUniversity of Hong KongHKSAR Calligraphy Therapy Research Laboratory Shenzhen Institute of NeuroscienceShenzhen Institute of Psychology and Genetics of Chinese Medicine School of Acup uncture and Tuina Chengdu University of Traditional Chinese MedicineChengdu Department of Medicine Shanxi Medical College for Continuing Education Beijing Tong Ren Tang Chinese Medicine Clinic Beijing Tong Ren Tang Taiyuan Chinese Medicine Hospital Department of Chinese Medicine China Academy of Chinese Medical Sciences Division of Research Advocacy 21^st Century Education Research InstituteBeijingChina 不详 Department of Electrical Engineering University of Illinois at Urbana-ChampaignChampaignIllinoisUSA

Purpose:This study compared the relative effectiveness of Chinese calligraphy handwriting(CCH)and acupuncture in the treatment of patients with senile *** and Methods:A randomized controlled trial(RCT)with 17 mild-to-moderate dementia patients with an average age of 77.29 years were randomly assigned with 9 to the calligraphy handwriting group and 8 to the acupuncture treatment group for a month of consecutive *** participants'cognitive abilities,as well as symptoms of senile dementia,were measured by the Chinese version of the Mini-mental State Examination(CMMSE)and the Chinese Medicine Quantitative Diagnostic Survey for Senile Dementia Symptoms,respectively,before and after the ***:The calligraphy group showed a significant increase in calculation and memory as well as a decline in the symptoms of senile *** in the acupuncture group experienced a significant growth in total CMMSE scores and the subscales in orientation to time and place,behavioral operations,as well as reduced clinical ***,no significant changes were found in their memory and calculation ***:Both CCH and acupuncture treatments were found significantly effective for,respectively,enhancing the patients'cognitive abilities and reducing their clinical ***,calligraphy handwriting also improved the level of their attention and concentration,physical relaxation,and emotional stability.

关键词： Acupuncture calligraphy handwriting cognitive abilities senile dementia

Lymphoproliferative disorders in inflammatory bowel disease patients on immunosuppression: Lessons from other inflammatory disorders

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world Journal of Gastrointestinal Pathophysiology 2015年第4期6卷 181-192页

作者： Grace y lam Brendan P Halloran Anthea C Peters Richard N Fedorak Department of Medicine Division of Internal Medicine University of Alberta Department of Medicine Division of Gastroenterology University of Alberta Department of Medicine Division of HematologyUniversity of Alberta

Immunosuppressive agents, such as thiopurines, methotrexate, and biologics, have revolutionized the treatment of inflammatory bowel disease(IBD). However, a number of case reports, case control studies and retrospective studies over the last decade have identified a concerning link between immunosuppression and lymphoproliferative disorders(LPDs), the oncological phenomenon whereby lymphocytes divide uncontrollably. These LPDs have been associated with Epstein-Barr virus(EBV) infection in which the virus provides the impetus for malignant transformation while immunosuppression hampers the immune system's ability to detect and clear these malignant cells. As such, the use of immunosuppressive agents may come at the cost of increased risk of developing LPD. while little is known about the LPD risk in IBD, more is known about immunosuppression in the post-transplantation setting and the development of EBV associated posttransplantation lymphoproliferative disorders(PTLD). In review of the PTLD literature, evidence is available to demonstrate that certain immune suppressants such as cyclosporine and T-lymphocyte modulators in particular are associated with an increased risk of PTLD development. As well, high doses of immunosuppressive agents and multiple immunosuppressive agent use are also linked to increased PTLD development. Here,we discuss these findings in context of IBD and what future studies can be taken to understand and reduce the risk of EBV-associated LPD development from immunosuppression use in IBD.

关键词： Epstein-Barr virus Immunosuppression Post-transpla

A Hypothetical Anti-Aging Mechanism of “yang-Invigorating” Chinese Tonic Herbs

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Chinese Medicine 2012年第1期3卷 72-78页

作者： Philip y. lam Hoi Shan wong Jihang Chen Kam Ming Ko Division of Life Science The Hong Kong University of Science & Technology Hong Kong China

Chinese tonic herbs are generally classified into yin and yang categories based on their health-promoting action. Emerging evidence has suggested that in addition to up-regulating mitochondrial functional status, yang tonic herbs also enhance cellular/mitochondrial antioxidant capacity, and may thus prevent age-related diseases and prolong the healthy part of lifespan (i.e. healthspan). The proposed biochemical mechanism underlying the antioxidant action of yang tonic herbs involves a sustained and low level of mitochondrial reactive oxygen species production, which is secondary to the increased activity of the electron transport chain, with the possible involvement of mitochondrial uncoupling. “yang invigoration” improves antioxidant defense in the body in the long term and thereby offers a promising prospect for preventing or possibly delaying age-related diseases and the detrimental effects of aging.

关键词： Chinese Medicine yang Mitochondrial Decay Age-Related Diseases

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如何进行煤气化厂的环境影响评价

煤炭转化 1986年第3期 67-72页

作者： A.w.Metwally,E.y.lam,赵振本美国Bechtel公司美国Bechtel公司

一、引言使用煤气化厂生产的煤气同直接烧煤相比较,具有减轻对环境污染的效益,这是考虑建设煤气化厂的一个重要原因。对于拟建的煤气化厂进行环境影响评价是煤气化厂建设程序的首要步骤。环境影响评价可以给决策机关提供关于拟建煤气化... 详细信息

一、引言使用煤气化厂生产的煤气同直接烧煤相比较,具有减轻对环境污染的效益,这是考虑建设煤气化厂的一个重要原因。对于拟建的煤气化厂进行环境影响评价是煤气化厂建设程序的首要步骤。环境影响评价可以给决策机关提供关于拟建煤气化厂的技术资料,并在环境上可能产生的不利影响和利益之间提供比较评定。环境影响评价还分析讨论可供选择的其他设计方案和减轻不利影响的措

关键词：煤气化厂不利影响废物环境影响分析环境质量评价环境影响评价煤气化技术气化反应器气化炉大气排放物