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Assessment of Sericin Biosorbent for Selective Dye Removal

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Chinese Journal of Chemical Engineering 2012年第3期20卷 426-432页

作者： CHEN Xinqing lam koon fung MAK Shuk Fong CHING Wai Kwong NG Tsz Nok YEUNG King Lun Department of Chemical and Biomolecular Engineering Division of Environment the Hong Kong University of Science and TechnologyHong KongChina

The silk sericin is the main residue in silk production and it is found to be a low cost and efficient bio-sorbent. In this study, sericin was characterized with various techniques including SEM （scanning electron micro- scope）, XRD, N2 physisorption, FTIR （Fourier transformed infrared spectroscopy） and XPS （X-ray photoelectron spectroscopy）. The nitrogen content of sericin was ca. 8.5 mmol.g-1 according to elemental analysis. Dye adsorption by sericin biosorbent was investigated with the acid yellow （AY）, methylene blue （MB） and copper （II） phthalocyanine-3,4＇4＂4＇＂-tetrasulfonic acid （CuPc） dyes from water. Sericin displayed large capacity for AY andCuPc adsorption with adsorption capacities of respectively 3.1 and 0.35 mmol.g-1, but it did not adsorbed methyl- ene blue dye. This selectivity is due to the basicity of amide groups in seriein biosorbents.

关键词： dye adsorption silk protein biosorbent

Festschrift in Honor of *** McKay——On occasion of his retirement from Department of Chemical and Biomolecular Engineering,the Hong Kong University of Science and Technology

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Chinese Journal of Chemical Engineering 2012年第3期20卷 I0003-I0004页

作者： koon fung lam Stephen ALLEN The Hong Kong University of Science and Technology

Professor Gordon McKay has a long,exciting and distinguished professional career as a chemical *** his early days in industry through to his most recent appointment as professor and Acting Head of Department of Chemical and Biomolecular Engineering at the Hong Kong University of Science and Technology(HKUST),he has made a substantial contribution to the profession.

关键词：香港科技大学生物分子工程化学工程工程学院论文集麦退休术部

Effects of length alteration of OPE-containing mono- and dinuclear alkynylplatinum(II) terpyridine complexes on photophysical, structural and morphological properties

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Nano Research 2024年第10期17卷 8893-8903页

作者： Jason koon-lam Poon Sammual Yu-Lut Leung Eric Ka-Ho Wong Vivian Wing-Wah Yam Institute of Molecular Functional Materials State Key Laboratory of Synthetic Chemistry and Department of ChemistryThe University of Hong KongHong Kong 999077China

A series of mononuclear complexes and unsymmetric dinuclear alkynylplatinum(II)terpyridine complexes with oligo(paraphenylene ethynylene)(OPE)-derived backbone with a variation of the lengths of alkoxy chains and OPE backbones was *** morphological properties,packing lattice and gelation behaviors of the mononuclear complexes were systematically studied,and the thermodynamic parameters and packing lattices of the dinuclear complexes were also investigated,providing further insights into the roles of the non-covalent interactions and their delicate balance in constructing sophisticated supramolecular *** and nanotube formation have been observed upon a delicate control of the intermolecular interactions by altering the lengths and structural dimensions of the complexes.

关键词： supramolecular chemistry self-assembled nanostructures platinum(II)complexes metallogel

Gestational age-specific neonatal mortality in Hong Kong:a population-based retrospective study

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World Journal of Pediatrics 2023年第2期19卷 158-169页

作者： Xue-Lian Wang Eman Leung Genevieve Po Gee fung Hugh Simon lam Department of Neonatology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong Kong SARChina The Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Paediatrics 6/F Lui Che Woo Clinical Sciences BuildingPrince of Wales HospitalSha TinNew TerritoriesHong Kong SARChina

Background The neonatal period is the most vulnerable period during childhood,with the risk of death being the highest even in developed countries/*** Kong’s neonatal mortality(1‰)is among the world’s lowest and has remained similar for 15 *** study aimed to explore neonatal deaths in Hong Kong in detail and determine whether neonatal mortality is reducible at such a low *** Live births in public hospitals in Hong Kong during 01 Jan 2006–31 Dec 2017 were *** data were extracted from the electronic medical *** age-specific mortality was calculated,and the trends were analyzed using the Cochran–Armitage trend *** of death were summarized,and risk factors were identified in multivariate logistic regression *** In 490,034 live births,755 cases(1.54‰)died during the neonatal period,and 293(0.6‰)died during the post-neonatal *** neonatal mortality remained similar overall(P=0.17)and among infants born at 24–29 weeks’gestation(P=0.4),while it decreased in those born at 23(P=0.04),30–36(P<0.001)and≥37(P<0.001)weeks’*** born at<27 weeks’gestation accounted for a significantly increased proportion among cases who died(27.6%to 51.9%),with hemorrhagic conditions(24%)being the leading cause of *** anomalies were the leading cause of death in neonates born≥27 weeks’gestation(52%),but its cause-specific mortality decreased(P=0.002,0.6‰to 0.41‰),with most of the decrease attributed to trisomy 13/18 and multiple *** Reduction of neonatal mortality in developed regions may heavily rely on improved quality of perinatal and neonatal care among extremely preterm infants.

关键词： Cause of death Neonatal mortality Population based Risk factor Trend

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

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Frontiers of Medicine 2012年第4期6卷 376-380页

作者： fung Zhao Eric W.-F.lam Department of Surgery and Cancer Imperial College LondonHammersmith Hospital CampusLondon W120NNUK

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and *** research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a,a vital downstream effector of the PI3K-AKT-FOXO signaling ***,FOXM1 and FOXO3a also compete for binding to the same gene targets,which have a role in chemotherapeutic drug action and *** understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients,and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.

关键词： FOXO3a FOXM1 transcription factor cancer drug resistance tumorigenesis

Examining patterns of traditional chinese medicine use in pediatric oncology: A systematic review, meta-analysis and data-mining study

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Journal of Integrative Medicine 2022年第5期20卷 402-415页

作者： Chun Sing lam Li Wen Peng Lok Sum Yang Ho Wing Janessa Chou Chi-Kong Li Zhong Zuo Ho-Kee koon Yin Ting Cheung School of Pharmacy Faculty of Medicinethe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of Medicinethe Chinese University of Hong KongHong KongChina Hong Kong Hub of Paediatric Excellence the Chinese University of Hong KongHong KongChina Department of Paediatrics&Adolescent Medicine Hong Kong Children’s HospitalHong KongChina School of Chinese Medicine Faculty of Medicinethe Chinese University of Hong KongHong KongChina

Background Traditional Chinese medicine(TCM)is becoming a popular complementary approach in pediatric ***,few or no meta-analyses have focused on clinical studies of the use of TCM in pediatric *** We explored the patterns of TCM use and its efficacy in children with cancer,using a systematic review,meta-analysis and data mining *** strategy We conducted a search of five English(Allied and Complementary Medicine Database,Embase,PubMed,Cochrane Central Register of Controlled Trials,and ***)and four Chinese databases(Wanfang Data,China National Knowledge Infrastructure,Chinese Biomedical Literature Database,and VIP Chinese Science and Technology Periodicals Database)for clinical studies published before October 2021,using keywords related to“pediatric,”“cancer,”and“TCM.”Inclusion criteria We included studies which were randomized controlled trials(RCTs)or observational clinical studies,focused on patients aged<19 years old who had been diagnosed with cancer,and included at least one group of subjects receiving TCM *** extraction and analysis The methodological quality of RCTs and observational studies was assessed using the six-item Jadad scale and the Effective Public Healthcare Panacea Project Quality Assessment Tool,***-analysis was used to evaluate the efficacy of combining TCM with *** outcomes included the treatment response rate and occurrence of cancer-related *** rule mining(ARM)was used to investigate the associations among medicinal herbs and patient *** The fifty-four studies included in this analysis were comprised of RCTs(63.0%)and observational studies(37.0%).Most RCTs focused on hematological malignancies(41.2%).The study outcomes included chemotherapy-induced toxicities(76.5%),infection rate(35.3%),and response,survival or relapse rate(23.5%).The methodological quality of most of the RCTs(82.4%)and observational studies(80.0%)was r

关键词： Traditional Chinese Medicine Herbal medicine Pediatric oncology Data mining Associate rule mining Chemotherapy

Carvedilol Versus Other Nonselective Beta Blockers for Variceal Bleeding Prophylaxis and Death: A Network Meta-analysis

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1143-1149页

作者： Ka-Shing Cheung Chiu-Hang Mok Lok-Ka lam Xian-Hua Mao Lung-Yi Mak Wai-Kay Seto Man-fung Yuen Department of Medicine School of Clinical MedicineThe University of Hong KongQueen Mary HospitalHong KongChina Department of Medicine The University of Hong Kong-Shenzhen HospitalShenzhenGuangdongChina School of Clinical Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background and Aims:We aimed to perform a network meta-analysis(NWM)to examine comparative effectiveness of non-selective beta blockers(NSBBs)on prophylaxis of gastroesophageal variceal bleeding(GVB)and mortality ***:MEDLINE(OVID)and EMBASE databases were searched for eligible randomized clinical trials(RCTs)from inception to July 3,*** of interest included primary/secondary prophylaxis of GVB,failure to achieve hepatic venous pressure gradient(HVPG)decremental response,liver-related and all-cause mortality.A Bayesian NWM was performed to derive relative risk(RR)with 95%credible intervals(CrIs).The ranking probability of each NSBB was assessed by surface under cumulative ranking curve(SUCRA).Results:Thirty-three RCTs including 3,188 cirrhosis patients with gastroesophageal varices were *** with placebo,nadolol ranked first for reducing variceal bleeding[RR:0.25,(95%CrI:0.11–0.51);SUCRA:0.898],followed by carvedilol[RR:0.33,(95%CrI:0.11–0.88);SUCRA:0.692]and propranolol[RR:0.52,(95%CrI:0.37–0.75);SUCRA:0.405].Carvedilol was more effective than propranolol in achieving HVPG decremental response[RR:0.43,(95%CrI:0.26–0.69)].Carvedilol ranked first for reducing all-cause mortality[RR:0.32,(95%CrI:0.17–0.57);SUCRA:0.963],followed by nadolol[RR:0.48,(95%CI:0.29–0.77);SUCRA:0.688],and propranolol[RR:0.77,(95%CI:0.58–1.02);SUCRA:0.337].Similar findings were observed for liver-related *** ranked the *** RR of adverse events was 4.38,(95%CrI:0.33–161.4);SUCRA:0.530,followed by propranolol[RR:7.54,(95%CrI:1.90–47.89);SUCRA:0.360],and nadolol[RR:18.24,(95%CrI:91.51–390.90);SUCRA:0.158].Conclusions:Carvedilol is the preferred NSBB with better survival benefit and lower occurrence of adverse events among patients with gastroesophageal varices.

关键词： NSBB Carvedilol Nadolol Propranolol Varices Cirrhosis CPSH

Cerebral vasodilator activities of major active constituents of a Danshen and Gegen formulation on rat basilar artery

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Cerebral vasodilator activities of major active constituents...

Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance

中国药理学会第十一次全国学术会议

作者： ESK NG JHK YEUNG YW KWAN CBS LAU JCM koon PC LEUNG KP fung FFY lam School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong Kong Institute of Chinese Medicine The Chinese University of Hong Kong State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong

OBJECTIVE Danshen and Gegen are traditional Chinese medicines commonly used for the treatment of cardiovascular *** this study,we have identified the major constituents of a Danshen and Gegen formulation(DG;ratio 7:3) and investigated their actions on rat-isolated cerebral basilar *** Rat basilar artery rings were precontracted with 100 nmol·L *** of endothelium-dependent mechanisms was investigated by mechanical removal of the *** cyclase, guanylyl cyclase,and potassium channel involvement were examined by pretreatment of the artery rings with their respective inhibitors. Calcium channel involvement was tested in artery rings incubated with Ca-free buffer and primed with U46619 prior to adding CaCl to elicit *** constituents of a DG water extract were identified by *** Salvianolic acid B, danshensu,puerarin,daidzein and daidzin were identified in the DG water *** these agents produced concentration-dependent relaxation of the artery rings that were unaffected by adenylyl cyclase inhibitor,guanylyl cyclase inhibitor,or by endothelium removal, except the latter reduced the maximum response to puerarin by 28%.Moreover,puerarin had no influence on CaCl-induced vasocon-striction but all the other agents produced concentration-dependent *** with a combination of K channel inhibitors produced significant inhibition on the vasodilator actions to all these agents,but not on *** The vasorelaxant actions of salvianolic acid B,daidzein and daidzin involved opening of K channels and inhibition of Ca influx in the vascular smooth muscle *** produced vasorelaxation solely by inhibition of Ca influx in the vascular smooth muscle *** contrast, puerarin produced vasodilatation via an endothelium-dependent mechanism and an endothelium-independent pathway mediated by the opening of K *** spite of differences in their mechanisms of actions,the co

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来源： cnki会议评论

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Chinese Journal of Cancer 2013年第7期32卷 365-370页

作者： Ana R.Gomes fung Zhao Eric W.F.lam Department of Surgery and Cancer Imperial College LondonHammersmith Hospital Campus

The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation,progression,and drug *** research shows that FOXM1 is a direct transcriptional target of FOXO3a,a vital downstream effector of the PI3K-AKT-FOXO signaling *** addition,FOXM1 and FOXO3a also antagonize each other's activity by competitively binding to the same target genes,which are involved in chemotherapeutic drug sensitivity and *** the role and regulation of the FOXO-FOXM1 axis will provide insight into chemotherapeutic drug action and resistance in patients,and help to identify novel therapeutic approaches as well as diagnostic and predictive biomarkers.

关键词：转录因子耐药性叉头致癌性化疗药物生物标志物竞争力敏感性