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Human sperm immobilization effect of Carica papaya seed extracts: an in vitro study

Asian Journal of Andrology 2000年第2期2卷 103-109页

作者： Nirmal k Lohiya lalit k kothari B Manivannan Pradyumna k Mishra Neelam Pathak Reproductive Physiology Section Department of Zoology University of Rajasthan Jaipur-302 004 India Reproductive Medicine Clinic 50 Gem Enclave Malviya Nagar Jaipur IndiaReproductive Physiology Section Department of Zoology University of Rajasthan Jaipur-302 004 India Reproductive Physiology Section Department of Zoology University of Rajasthan Jaipur-302 004 India Reproductive Physiology Section Department of Zoology University of Rajasthan Jaipur-302 004 India

Aim: To examine if the seed extracts of Carica papaya, which showed anfispermatogenic/sperm immobilizationproperties in animal models, could cause human sperm immobilization in vitro. Methods: Chloroform extract, ben-zene chromatographic fraction of the chloroform extract, its methanol and ethyl acetate sub-fractions and the isolatedcompounds from the sub-fractions i. e., ECP 1 & 2 and MCP 1 & 2, of the seeds of Carica papaya were used at con-centrations of 0.1%, 0.5%, 1% and 2%. Sperm motility was assessed immediately after addition of extracts and ev-ery 5 minutes thereafter for 30 minutes. Results: There were dose-dependent spermicidal effects showing an instantfall in the sperm motility to less than 20% at 2% concentration. Isolated compounds ECP 1 & 2 were more effective in-ducing a motility of less than 10%. Many of the spermatozoa became vibratory on the spot. Total inhibition of motilitywas observed within 20-25 rain at all concentrations of all products. Scanning and transmission electron microscopyrevealed deleterious changes in the plasma membrane of the head and mid-piece of spermatozoa. Sperm viability testand the number of abnormal spermatozoa after completion of incubation suggested that the spermatozoa were *** effects were spermicidal but not spermiostatic as revealed by the sperm revival test. Conclusion: The results re-veal spermicidal activity in vitro of the seed extracts of Carica papaya.

关键词： human sperm sperm immobilization spermicidal agents Carica papaya

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