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Evaluation of Antibiotic Prescribing in the Pediatric Department of Gabriel TouréTeaching Hospital, Bamako, Mali

Open Journal of Pediatrics 2024年第3期14卷 645-656页

作者： Pierre Togo Hawa Konaré Mariam Maïga Karamoko Sacko Djénéba Konaté Abdoul Karim Doumbia Adama Dembélé Oumar Coulibaly Aminata Sangaré Mohamed Elmouloud Cissé Fousseyni Traoré Belco Maïga Ibrahim Ahamadou Aminata Doumbia lala n’drany sidibé Amadou Touré Yacouba Aba Coulibaly Kalirou Traoré Tati Simaga Souleymane Sagara Leyla Bagna Maïga Bory Traoré Abdoul Aziz Diakité Fatoumata Dicko Mariam Sylla Sounkalo Dao Boubacar Togo Paediatric Department Gabriel Tour&#233 Teaching Hospital Bamako Mali Pediatric Department Distric VI Reference Health Center Bamako Mali Infectious Diseases Department Point G Teaching Hospital Bamako Mali

Objectives: The main objective was to evaluate antibiotic prescribing in the Department of Pediatrics at Gabriel Touré teaching hospital. Methods: This was a prospective descriptive study conducted from September 1 to november 31, 2018, in the Department of Pediatrics at Gabriel Touré teaching hospital. All children aged 0 to 15 years hospitalized for any pathology during the study period and having received at least one antibiotic had been included. Results: We collected 445 children’s records out of 1032 admissions during the study period, representing a hospital frequency of 43.1%. The sex ratio was 1.3%. The 2 - 5 age group accounted for 48.1%. Fever was the reason for consultation in 45.6% of cases. Patients’ general condition was altered in 60% of cases. The fathers were blue-collar workers in 65.4% and the mothers housewives in 85%, and had no education in 42.9% and 64.5% respectively. Hepatomegaly was present in 18.2%, splenomegaly in 9.6% and peripheral adenopathy in 3.1%. The site of infection was pulmonary in 37.6% and EnT in 9.2%. Bacterial infection was assumed on admission in 54% of cases, and meningitis in 57.7%. The discharge diagnosis was malaria in 54.6%, severe acute malnutrition in 18.6% and meningitis in 6.7%. The death rate was 3.8%. neutrophilic leukocytosis was present in 47.3% of patients. CRP was positive in 85% of patients. Blood cultures taken in 27.6% of patients were positive in 5. CSF analysis in 30% of patients showed elevated leukocytes in 6.5%. no cultures were positive. Antibiotic prescription was justified by infectious hypotheses in 43.1% of patients. β-lactam antibiotics were prescribed in 98.6%. Antibiotic therapy was not adapted to national/international recommendations in 68.3% of cases, and was not justified in 16.3% of cases on D5 of hospitalization. Conclusion: Antibiotic use was justified in more than half of patients, but remained inadequate in almost two-thirds of cases, in line with national and international recommend

关键词： Antibiotic Prescription Hospitalization Child

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The interaction mechanism between zein and folic acid in alkaline aqueous solutions:an experimental and molecular simulation study

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Food Quality and Safety 2024年第1期8卷 166-178页

作者： Jun Zhu Yiling Yao Yuying Liao lala Cai Wenqi Zhang nuo Hong Wenlin Sun Chunhua Xiong Lanying Yao School of Food Science and Biotechnology Zhejiang Gongshang UniversityHangzhouChina

Objectives:Folic acid is a vitamin that is not highly soluble in water and is sensitive to the ***,it is important to find suitable *** study aimed to exemplify the interaction of folic acid with zein in alkaline aqueous solutions and shed light on how zein can be used as a carrier for folic *** and Methods:Zein and folic acid were separately dissolved in naOH solutions with a PH of *** solution and folic acid solution were combined in specific *** methods including multi-spectroscopy,dynamic light scattering,and electron microscopy combining with molecular dynamics simulations were used to study the interaction mechanism between zein and folic acid in alkaline aqueous ***:Fluorescence spectroscopy showed that the quenching of zein by folic acid was mainly static,and the main driving force behind this interaction was van der Waals forces and hydrogen *** formation of zein–folic acid complexes was confirmed by ultraviolet–visible spectroscopy,Fourier transform infrared spectroscopy,and circular dichroism *** results also showed that the structure of zein changed when it interacted with folic *** light scattering analysis revealed that the addition of folic acid caused proteins to *** aggregates of the complexes had an irregular shape and were large,as observed by scanning electron microscopy and transmission electron *** simulation was used to further investigate the interaction *** to these findings,the folic acid molecule interacted with zein in a shallow recess near the protein *** dominant forces at play in the zein–folic acid interaction were van der Waals forces and electrostatic forces,including hydrogen ***:The zein alkali-soluble system is very suitable for folic acid delivery.

关键词： Zein folic acid alkaline aqueous solutions molecular simulation interaction mechanism.

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How International Tax Rules Adapt to the Development of the Digital Economy: The Perspective of the Republic of Azerbaijan

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Belt and Road Initiative Tax Journal 2024年第1期 106-113页

作者： lala Babayeva Chingiz Musayev State Tax Service Ministry of Economy the Republic of Azerbaijan

This article outlines the significance of the digital economy,highlighting the challenges to taxation,and introducing the focus of the article on Azerbaijan's *** recent decades,the digital revolution has transformed the global economy,reshaping industries,business models,and consumer behavior at an unprecedented *** transformation,commonly referred to as the digital economy,encompasses a broad spectrum of activities ranging from e-commerce and digital services to data analytics and cloud *** the digital economy continues to expand its influence,traditional tax systems face significant challenges in adapting to this new *** has ignited discussions worldwide across various legal and regulatory domains,and international taxation is no *** tax consequences are extensive,impacting both direct and indirect taxation,broader tax policy matters,and tax administration.

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Python Server Page Performance Analysis and Modeling

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Communications and network 2024年第1期16卷 1-30页

作者： Razafindraibe Marolahy Alix Randrianomenjanahary lala Ferdinand Rafamantanantsoa Fontaine Mahatody Thomas F. Angelo Raherinirina University of Fianarantsoa Fianarantsoa Madagascar

Today, in the field of computer networks, new services have been developed on the Internet or intranets, including the mail server, database management, sounds, videos and the web server itself Apache. The number of solutions for this server is therefore growing continuously, these services are becoming more and more complex and expensive, without being able to fulfill the needs of the users. The absence of benchmarks for websites with dynamic content is the major obstacle to research in this area. These users place high demands on the speed of access to information on the Internet. This is why the performance of the web server is critically important. Several factors influence performance, such as server execution speed, network saturation on the internet or intranet, increased response time, and throughputs. By measuring these factors, we propose a performance evaluation strategy for servers that allows us to determine the actual performance of different servers in terms of user satisfaction. Furthermore, we identified performance characteristics such as throughput, resource utilization, and response time of a system through measurement and modeling by simulation. Finally, we present a simple queue model of an Apache web server, which reasonably represents the behavior of a saturated web server using the Simulink model in Matlab (Matrix Laboratory) and also incorporates sporadic incoming traffic. We obtain server performance metrics such as average response time and throughput through simulations. Compared to other models, our model is conceptually straightforward. The model has been validated through measurements and simulations during the tests that we conducted.

关键词： Performance Analysis Queue Performance Model Web Server Internet World Wide Web Web Server Performance

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词汇加工中视觉干扰效应及影响因素

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心理与行为研究 2024年第2期22卷 189-196页

作者：顾啦啦孙悦梅磊磊华南师范大学心理学院广州510631

采用词汇判断任务,以中文词语、面孔图片和韩文非词为实验材料,通过三个实验考察了词汇加工中视觉干扰效应及影响因素。结果发现:(1)视野内的干扰材料会减慢目标词汇加工的速度;(2)词汇加工的干扰效应受到干扰材料和目标材料类别一致性... 详细信息

采用词汇判断任务,以中文词语、面孔图片和韩文非词为实验材料,通过三个实验考察了词汇加工中视觉干扰效应及影响因素。结果发现:(1)视野内的干扰材料会减慢目标词汇加工的速度;(2)词汇加工的干扰效应受到干扰材料和目标材料类别一致性的调节,同类别材料会引起更强的干扰效应。结果说明,词汇加工中视觉干扰效应可能反映了同类别的干扰刺激和目标刺激在类别特异性加工脑区内的资源竞争。

关键词：词汇加工词汇判断任务视觉干扰效应类别特异性加工

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Eyelid Kaposi Sarcoma in HIV-negative Patient

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Journal of Cancer Therapy 2024年第3期15卷 92-97页

作者： Malalaniaina Andrianarison Malala Razakanaivo Rindra Rafanomezantsoa Mendrika Fifaliana Rakotoarisaona Odilon Laza Fandresena Arilala Sendrasoa Irina Mamisoa Ranaivo Léa Raobela lala Soavina Ramarozatovo Fahafahantsoa Rapelanoro Rabenja Unit of Dermatology University Hospital Center of Public Health and Care Analakely Antananarivo Madagascar Unit of Radiotherapy University Hospital Center Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Unit of Ophthalmology University Hospital Center Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Unit of Pathology University Hospital Center Tambohobe Fianarantsoa Madagascar Unit of Dermatology University Hospital Center of Joseph Raseta Befelatanana Antananarivo Madagascar Unit of Dermatology University Hospital Center Morafeno Toamasina Madagascar Unit of Dermatology and Internal Medicine University Hospital Center of Joseph Raseta Befelatanana Antananarivo Madagascar

Introduction: Kaposi sarcoma disease is a proliferative and multifocal disorder with dual components, vascular and fibroblastic cellular, cutaneous and visceral expression. Kaposi Sarcoma can affect the ocular surface and adnexa and can masquerade as other entities, delaying prompt diagnosis can lead to diagnostic wandering delaying treatment. Our aim is to describe a case of KS of the eyelid in an HIV seronegative patient. Case Presentation: A seventy-year-old man developed a bilateral growing tumoral reddish purple vascular mass on both the lower and upper eyelid involving rapidly for 6 months. Both feet and the two shanks show the presence of a brown-violet tumor-shaped formation. The patient was negative for HIV. Histology examination showed a nodular tumor-like mass with a fibro hemangioma-epitheliomatous. Polymerase chain reaction was positive for human herpes virus 8. Initial chemotherapy followed by surgery was proposed to the patient. Unfortunately, the patient rejected treatment and was lost to follow-up. Conclusion: This case reports the difficulty of managing KS in developing countries.

关键词： Eyelid HHV-8 Interferon Kaposi Sarcoma

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Targeting the chromatin structural changes of antitumor immunity

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Journal of Pharmaceutical Analysis 2024年第4期14卷 460-482页

作者： nian-nian Li Deng-xing Lun ningning Gong Gang Meng Xin-ying Du He Wang Xiangxiang Bao Xin-yang Li Ji-wu Song Kewei Hu lala Li Si-ying Li Wenbo Liu Wanping Zhu Yunlong Zhang Jikai Li Ting Yao Leming Mou Xiaoqing Han Furong Hao Yongcheng Hu Lin Liu Hongguang Zhu Yuyun Wu Bin Liu Weifang People's Hospital WeifangShandong261000China School of Life Sciences Nankai UniversityTianjin300071China Weifang Traditional Chinese Medicine Hospital WeifangShandong261000China Shaanxi Key Laboratory of Sericulture Ankang UniversityAnkangShaanxi725000China Guizhou Education University Guiyang550018China Guizhou normal University Guiyang550025China School of Medical Imaging Weifang Medical UniversityWeifangShandong261053China Department of Bone and Soft Tissue Oncology Tianjin HospitalTianjin300299China Xinqiao Hospital of Army Military Medical University Chongqing400038China Teda Institute of Biological Sciences&Biotechnology Nankai UniversityTianjin300457China

Epigenomic imbalance drives abnormal transcriptional processes,promoting the onset and progression of *** defective gene regulation generally affects carcinogenesis and tumor suppression networks,tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes,which may have significant implications for the development and application of epigenetic therapy,cancer immunotherapy,and their ***,we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes,DnA methylation,histone post-translational modification,and chromatin structure in tumor immunogenicity,and introduce these epigenetic research *** emphasize the value of small-molecule inhibitors of epigenetic modulators in enhancing antitumor immune responses and discuss the challenges of developing treatment plans that combine epigenetic therapy and immuno-therapy through the complex interaction between cancer epigenetics and cancer immunology.

关键词： Antitumor immunity Chromatin structural Cancer epigenetics DnA methylation Histone modification Chemotherapy

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基于物联网和深度学习的智能城市交通管理系统

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无线互联科技 2024年第7期21卷 50-52页

作者：孙腊腊郑州城建职业学院河南郑州450000

随着城市化的快速发展,城市交通问题日益严峻。准确预测交通流量是缓解交通拥堵、提高交通管理效率的关键。文章提出了一种基于LSTM的城市交通流量预测方法。该方法首先对交通数据进行预处理,包括数据清洗、归一化等;其次,利用LSTM模型... 详细信息

随着城市化的快速发展,城市交通问题日益严峻。准确预测交通流量是缓解交通拥堵、提高交通管理效率的关键。文章提出了一种基于LSTM的城市交通流量预测方法。该方法首先对交通数据进行预处理,包括数据清洗、归一化等;其次,利用LSTM模型学习交通数据的时空依赖关系;最后,利用训练好的模型预测未来的交通流状态。文章在METR-LA数据集上进行了实验,实验结果证明了方法的有效性。该方法可以应用于实际交通管理系统,为交通管理部门提供决策支持,如交通信号灯控制、交通路线规划等。

关键词：交通流量预测 LSTM 时间序列预测智能城市

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母语与第二语言的相互作用机制及影响因素

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华南师范大学学报（社会科学版） 2024年第3期 78-93,206页

作者：梅磊磊李会玲顾啦啦华南师范大学心理学院广州510631 贵州师范大学心理学院贵阳550025

已有认知行为和脑成像研究发现,第二语言是在母语和第二语言不断相互作用中习得的。在认知机制上,母语和第二语言在字形、语音、句法等多个层面的加工上存在相互作用,并对母语和第二语言的加工效率产生影响。在神经机制上,母语经验会塑... 详细信息

已有认知行为和脑成像研究发现,第二语言是在母语和第二语言不断相互作用中习得的。在认知机制上,母语和第二语言在字形、语音、句法等多个层面的加工上存在相互作用,并对母语和第二语言的加工效率产生影响。在神经机制上,母语经验会塑造第二语言的神经机制,第二语言反过来也会对母语加工的神经机制产生影响,这一相互作用会受到个体因素、语言因素、任务因素等影响。未来还需综合使用具有高空间分辨率的脑成像技术和高时间分辨率的电生理技术,利用横断和纵向研究,在单词、句子、篇章等层面,系统揭示母语和第二语言的相互作用机制及动态变化过程。

关键词：双语者母语第二语言语言学习神经机制

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盾构始发即斜交下穿高速公路路基填石边坡专项设计研究

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铁道建筑技术 2024年第1期 87-91页

作者：刘腊腊中铁第五勘察设计院集团有限公司北京102600

以东莞市城市轨道交通1号线一期工程黄牛埔站~黄江中心站区间隧道为依托,研究了双线盾构始发即小角度下穿高速公路填石路基及路基边坡的专项设计。并基于数值模拟及现场监测数据验证,得出结论:设置大管棚隔离层切断盾构下穿与路基路面... 详细信息

以东莞市城市轨道交通1号线一期工程黄牛埔站~黄江中心站区间隧道为依托,研究了双线盾构始发即小角度下穿高速公路填石路基及路基边坡的专项设计。并基于数值模拟及现场监测数据验证,得出结论:设置大管棚隔离层切断盾构下穿与路基路面应力传递路径,可有效控制盾构下穿填石路基过程的路面沉降;盾构下穿过程中的掘进参数控制,对路基沉降起主导作用是土仓压力、注浆压力两个参数,应特别注意结合监测数据进行调整;沉降敏感地段,宜适当放慢盾构掘进速度、匀速掘进,尽量减小对土体的扰动。此次盾构小角度下穿高速公路填石路基及路基边坡专项设计的相关工程措施,满足路面沉降限制要求,确保了莞深高速在盾构下穿过程的安全运营,可对类似工程提供参考和借鉴。

关键词：盾构隧道小角度下穿填石路基沉降控制专项设计

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