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FOXP3 protects conventional human T cells from premature restimulation-induced cell death

Cellular & Molecular Immunology 2021年第1期18卷 194-205页

作者： Kelsey Voss Camille lake Christopher R.Luthers Nathaniel M.Lott Batsukh Dorjbal Swadhinya Arjunaraja Bradly M.Bauman Anthony R.Soltis Gauthaman Sukumar Clifton LDalgard Andrew L.Snow Department of Pharmacology&Molecular Therapeutics Uniformed Services University of the Health SciencesBethesdaMD 20817USA The American Genome Center(TAGC) Collaborative Health Initiative Research ProgramUniformed Services University of the Health SciencesBethesdaMDUSA Department of Anatomy Physiology&GeneticsUniformed Services University of the Health SciencesBethesdaMDUSA

The adaptive immune response relies on specific apoptotic programs to maintain *** effector T cell(Tcon)expansion is constrained by both forkhead box P3(FOXP3)^(+)-regulatory T cells(Tregs)and restimulation-induced cell death(RICD),a proprlocidal apoptosis pathway triggered by repeated stimulation through the T-cell receptor(TCR).Constitutive FOXP3 expression protects Tregs from RICD by suppressing SLAM-associated protein(SAP),a key adaptor protein that amplifies TCR signaling *** role of transient FOXP3 induction in activated human CD4 and CD8 Tcons remains unresolved,but its expression is inversely correlated with acquired RICD ***,we describe a novel role for FOXP3 In protecting human Tcons from premature RICD during *** FOXP3-mediated protection from RICD in Tregs,FOXP3 protects Tcons through a distinct mechanism requiring de novo transcription that does not require SAP *** profiling and functional analyses of expanding Tcons revealed that FOXP3 enhances expression of the SLAM family receptor CD48,which in turn sustains basal autophagy and suppresses pro-apoptotic p53 *** CD48 and FOXP3 expression reduced p53 accumulation upon TCR ***,silencing FOXP3 expression or blocking CD48 decreased the mitochondrial membrane potential in expanding Tcons with a concomitant reduction in basal *** findings suggest that FOXP3 governs a distinct transcriptional program in early-stage effector Tcons that maintains RICD resistance via CD48-dependent protective autophagy and p53 suppression.

关键词： conventional T cells RICD FOXP3 autophagy CD48

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An Additive Manufacturing Approach that Enables the Field Deployment of Synthetic Biosensors

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Engineering 2019年第1期5卷 173-180页

作者： Daniel Wolozny John R. lake Paul G. Movizzo Zhicheng Long Warren C. Ruder Department of Biological Systems Engineering Virginia Polytechnic Institute and State University Blacksburg VA 24061 USA Department of Bioengineering University of Pittsburgh Pittsburgh PA 15219 USA

The tools of synthetic biology can be used to engineer living biosensors that report the presence of analytes. Although these engineered cellular biosensors have many potential applications for deployment outside of the lab, they are genetically modified organisms (GMOs) and are often considered dangerous. Mitigating the risk of releasing GMOs into the environment while enabling their use outside a laboratory is critical. Here, we describe the development of a biosensing system consisting of a synthetic biological circuit, which is engineered in Escherichia coli that are contained within a unique 3D-printed device housing. These GMOs detect the chemical quorum signal of Pseudomonas aeruginosa, an opportunistic pathogen. Using this device, the living biosensor makes contact with a specimen of interest without ever being exposed to the environment. Cells can be visually analyzed in the field within culture tubes, or returned to the lab for further analysis. Many biosensors lack the versatility required for deployment in the field, where many diseases can go undiagnosed due to a lack of resources and equipment. Our bioassay device utilizes 3D printing to create a portable, modular, and inexpensive device for the field deployment of living biosensors.

关键词： Synthetic biology Additive manufacturing Biosensors

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用VB轻松导入IE收藏夹

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电脑爱好者 2000年第23期 82-83页

作者： lake

VB是给我最大震撼的编程语言。记得初中时,当大家还正沉迷于Trubo C 2.0或者Pascal时,我便开始学习VB并给好友冯做了一个Windows界面的电子生日贺卡,那声色俱佳的礼物给我们带来了多少欢乐!虽然现在不常用VB,也经常听见关于VB的是非争论... 详细信息

VB是给我最大震撼的编程语言。记得初中时,当大家还正沉迷于Trubo C 2.0或者Pascal时,我便开始学习VB并给好友冯做了一个Windows界面的电子生日贺卡,那声色俱佳的礼物给我们带来了多少欢乐!虽然现在不常用VB,也经常听见关于VB的是非争论,但是她曾给我的美妙感觉却永不会淡忘。况且,VB拥有盖茨——以Basic起家的软件帝王撑腰,据说VB7.0

关键词：收藏夹 IE VB 构造函数

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Hepatic Histopathological Characteristics and Antioxidant Response of Phytoplanktivorous Silver Carp Intraperitoneally Injected with Extracted Microcystins

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Biomedical and Environmental Sciences 2009年第4期22卷 297-302页

作者： LI LI AND PING XIE Fisheries College of Huazhong Agricultural University, Wuhan 430070, Hubei, China Donghu Experimental Station of lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, Hubei, China Fisheries College of Huazhong Agricultural University Wuhan 430070 Hubei China Donghu Experimental Station of lake Ecosystems State Key Laboratory of Freshwater Ecology and Biotechnology of China Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 Hubei China

Objective To investigate the hispathological characteristics and antioxidant responses in liver of silver carp after intraperitoneal administration of microcystins （MCs） for further understanding hepatic intoxication and antioxidation mechanism in fish. Methods Phytoplanktivorous silver carp was injected intraperitoneally （i.p.） with extracted hepatotoxic microcystins （mainly MC-RR and -LR） at a dose of 1000 μg MC-LReq./kg body weight, and liver histopathological changes and antioxidant responses were studied at 1, 3, 12, 24, and 48 h, respectively, after injection. Results The damage to liver structure and the activities of hepatic antioxidant enzymes including catalase （CAT）, superoxide dismutase （SOD）, and glutathione peroxide （GPX） were increased in a time-dependent manner. Conclusion In terms of clinical and histological signs of intoxication and LD50 （i.p.） dose of MC-LR, silver carp appears rather resistant to MCs exposure than other fishes. Also the significantly increased SOD activity in the liver of silver carp suggests a higher degree of response to MCs exposure than CAT and GPX.

关键词： Antioxidant response Histopathological characteristics Liver Microcystins Fish

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完全VB窗体特效

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电脑爱好者 2001年第1期 79-81页

作者： lake

关于用VB制作不规则窗口的文章,在各种杂志报纸、网站上面也不知提过多少回了,我都有点不好意思再谈。但是我们编程序不仅仅要实现功能,更要寻求最佳的实现方案。本着这样的原则,让我们再来回顾一下这个老命题,也向大家介绍一下我的心得... 详细信息

关于用VB制作不规则窗口的文章,在各种杂志报纸、网站上面也不知提过多少回了,我都有点不好意思再谈。但是我们编程序不仅仅要实现功能,更要寻求最佳的实现方案。本着这样的原则,让我们再来回顾一下这个老命题,也向大家介绍一下我的心得。 Windows提供了一个API函数SetWindowRgn,凭着

关键词：窗体函数 Long As 背景图片 VB

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信息技术授予知识网络的权力——信息竞争

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科技进步与对策 2001年第1期18卷 113-114页

作者： lake Ives irkka L. 洪水峰

对目前企业发生的一些变化进行了分析，并对 21世纪的企业组织形式和竞争手段进行了展望。

关键词：信息竞争信息技术知识网络企业管理组织形式市场竞争

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STRUCTURES OF CONFINED VORTEX BREAKDOWN IN CONSTANT DIAMETER PIPE FLOW

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Journal of Hydrodynamics 2009年第3期21卷 341-346页

作者： WANG Ze CHEN Shan-qun College of Environmental Science and Engineering Hohai University Nanjing 210098 China MOE Key Laboratory for Integrated Regulation and Resources Exploration on Shallow lake Nanjing 210098China

Numerical solutions of three-dimensional, incompressible and unsteady Navier-Stokes equations for constant diameter swirling pipe flows are used to study vortex breakdown, including the detailed flow structures in the bubble domain and the ＂tail＂ behind the bubble during the vortex breakdown, and a comparison is made between the numerical solutions and the experimental results.

关键词： vortex breakdown confined swirling flow numerical simulation

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今天我学会控制情绪

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疯狂英语（新悦读） 2018年第6期 42-43页

作者： Sam lake

潮起潮落,冬去春来,夏末秋至,日出日落,月圆月缺,雁来雁往,花飞花谢,草长瓜熟,自然界万物都在循环往复的变化中,我也不例外,情绪会时好时坏.

关键词：控制情绪自然界潮起潮落循环

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Cesium accumulation by bacterium Thermus sp. TibetanG7:hints for biomineralization of cesium-bearing geyserite in hot springs in Tibet,China

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Chinese Science Bulletin 2007年第19期52卷 2680-2686页

作者： WANG HaiLei1,2,3, ZHENG MianPing1,2,3 & HUANG XiaoXing4 1 Institute of Mineral Resources, Chinese Academy of Geological Sciences (CAGS), Beijing 100037, China 2 R&D Center for Saline lake and Epithermal Deposits, CAGS, Beijing 100037, China 3 Open Laboratory of Saline lake Resourses and Environment, CAGS, Beijing 100037, China 4 Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100081, China Institute of Mineral Resources Chinese Academy of Geological Sciences (CAGS) Beijing China R&D Center for Saline lake and Epithermal Deposits CAGS Beijing China Open Laboratory of Saline lake Resourses and Environment CAGS Beijing China Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences Beijing China

The bacterium Thermus sp. TibetanG7, isolated from hot springs in Tibet, China, was examined for the ability to accumulate cesium from solutions. Environmental conditions were simulated and the effects of pH, K+, Na+ and K+-regimes were then studied to determine the possible role of the bacterium in the formation of cesium-bearing geyserite around these hot springs. In despite of the inhibition of K+ and Na+, the bacterium Thermus sp. TibetanG7 revealed noticeable accumulation of cesium from solutions, with maximum accumulations of 53.49 and 40.41 μmol Cesium/g cell dry weight in Na+ and K+ inhibition experiments, respectively. The accumulation of cesium by this microorganism is rapid, with 40%―50% accumulated within the first 5 min. K+-deficient cells showed a much higher capacity of cesium accu- mulation compared with K+-sufficient cells. It is evident that the bacteria within the genus thermus play a significant role in the cesium assembly. The formation of cesium-bearing geyserite is also considered.

关键词：铯元素沉积物硅华生物矿化

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再谈Shell语句的用法

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新潮电子 1998年第12期 54-56页

作者： lake

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