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pH-indicative Films Based on Chitosan–PVA/Sepiolite and Anthocyanin from Red Cabbage: Application in Milk Packaging

Journal of Bionic Engineering 2022年第3期19卷 837-851页

作者： Marya Raji laila el foujji Mohamed el Mehdi Mekhzoum Mounir el Achaby Hamid Essabir Rachid Bouhfid Abou el kacem Qaiss Moroccan Foundation for Advanced Science Innovation and ResearchComposites and Nanocomposites CenterRabat Design CenterRue Mohamed El JazouliMadinat El IrfaneRabat10100Morocco Faculty of Science Laboratoire de Chimie Organique Et HétérocycliqueUniversity Mohammed V in RabatRabat10100Morocco Materials Science and Nano-Engineering Department Mohammed VI Polytechnic UniversityLot 660–Hay Moulay RachidBen Guerir43150Morocco Mechanic Materialsand Composites(MMC)Laboratory of Energy EngineeringMaterials and SystemsNational School of Applied Sciences of AgadirIbn Zohr UniversityAgadir80000Morocco

Biobased smart packaging is been the most interesting research *** this study,pH-sensitive films based on anthocyanin molecules from red cabbage and sepiolite mineral nano-clay as functional additives were *** films were fabricated by casting method of blend polymer Chitosan/Poly(Vinyl Alcohol)at two fillers loading(5wt.%and 10wt.%).The structural,morphological,thermal,optical,hygroscopic,and mechanical properties as well as the pH sensitivity of films were *** thermal properties confirm that the amount of the anthocyanin in sepiolite was around 6.4%.The tensile strength and the young’s modulus of produced composites at 10wt.%sepiolite–anthocyanin content was increased to 8.90 MPa and 163 MPa,*** maximum water absorption that the films may absorb was 12.3%.pH sensitivity analysis showed that the Smart films change the color by changing the pH level,from pink at pH lower than 6 to yellow at pH higher than ***,the developed pH-sensitive films show band gaps in visible light that make them useful for monitoring milk spoilage.

关键词： Smart packaging Anthocyanin Red cabbage pH-sensitive and milk spoilage

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Wave Reflection by Rectangular Breakwaters for Coastal Protection

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Fluid Dynamics & Materials Processing 2024年第3期20卷 579-593页

作者： Hasna Akarni Hamza Mabchour laila el Aarabi Soumia Mordane Laboratory of Polymer Physics Mechanical Sciences and MaterialsFaculty of Sciences Ben M’SikHassan II University of CasablancaCasablanca20670Morocco

In this study,we focus on the numerical modelling of the interaction between waves and submerged structures in the presence of a uniform flow *** the same and opposite senses of wave propagation are *** main objective is an understanding of the effect of the current and various geometrical parameters on the reflection *** wave used in the study is based on potential theory,and the submerged structures consist of two rectangular breakwaters positioned at a fixed distance from each other and attached to the bottom of a wave *** numerical modeling approach employed in this work relies on the Boundary element Method(BEM).The results are compared with experimental data to validate the *** findings of the study demonstrate that the double rectangular breakwater configuration exhibits superior wave attenuation abilities if compared to a single rectangular breakwater,particularly at low ***,the study reveals that wave mitigation is more pronounced when the current and wave propagation are coplanar,whereas it is less effective in the case of opposing current.

关键词： Wave current breakwaters Boundary element Method(BEM) reflection coefficient

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Prognostic Factors in Cardiorenal Syndrome Type 1: Retrospective Observational and Analytical Study

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World Journal of Cardiovascular Diseases 2024年第7期14卷 435-445页

作者： Mariam el Galiou Amal Zniber Hajar Fitah Naima Ouzeddoun Tarik Bouattar Nawal Doghmi laila Lahlou Loubna Benamar Nephrology-Dialysis-Renal Transplantation Department Ibn Sina University Hospital Mohamed V University Rabat Morocco Department of Cardiology B Ibn Sina University Hospital Mohamed V University Rabat Morocco Laboratory of Biostatistics Clinical Research and Epidemiology Department of Public Health Mohamed V University Rabat Morocco

Introduction: Type 1 cardiorenal syndrome (CRS 1) is characterized by acute impairment of cardiac function leading to acute renal dysfunction. CRS1 is present in 25% of patients admitted for heart failure. The objective of our study is to analyze the epidemiological, clinical, therapeutic profile and the risk and prognostic factors of these patients. Materials and Methods: We identified 120 patients with cardiorenal syndrome (CRS) over a one-year period to determine the prevalence and risk factors for developing CRS 1. We analyzed the clinical, biological, and evolutionary profiles of patients with CRS 1 and determined the risk factors for the occurrence of acute kidney injury (AKI) as well as the mortality factors in these patients. Résultats: The average age of our patients with CRS1 is 58 ± 9 years, with a sex ratio of 1.4. The average eGFR of our patients is 35 ± 6.5 ml/min/1.73m2. Diabetes was found in 17% of our patients and hypertension in 14%. The etiology of cardiac impairment is predominantly acute coronary syndrome (ACS), followed by rhythm disorders. Renally, all our patients have acute kidney injury (AKI), with 86% having functional acute renal failure and 14% having acute tubular necrosis. Therapeutically, 50% of our patients are on diuretics, 42% receive beta-blocker treatment, and RAAS blockers are used in 29% of cases. Renal replacement therapy (RRT) sessions were required in 13.8% of cases. In univariate analysis, male gender, tachyarrhythmia, and hypertension are associated with the early onset of acute kidney injury (AKI). The use of diuretics, anemia, and low left ventricular ejection fraction (LVEF) are linked to a higher risk of developing CRS 1 (p = 0.021, p = 0.037, p = 0.010 respectively). In multivariate analysis, advanced age is significantly associated with increased mortality risk in CRS 1 patients (p = 0.030), while beta-blocker use is considered a protective factor (p = 0.014). Conclusion: Our study identifies several key factors asso

关键词： Acute Kidney Injury Type 1 Cardiorenal Syndrome Acute Heart Failure Diuretics

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Deposition of Phosphate Nanoparticles onto Textile Fabrics via Sol-gel Method and Their Kinetics Desorption Studies

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Chemical Research in Chinese Universities 2020年第5期36卷 877-884页

作者： Mohamed el MESSOUDI Aicha BOUKHRISS laila SADALLAH laila SAJID M'hamed el KOUALI Said GMOUH Laboratory REMTEX ESITHHigher School of Textile and Clothing Industties(ESITH)Kni8Route d'EL JADIDACasablancaMorocco Laboratory LIN1AT Faculty of Sciences Ben M'SikHassan II University of CasablancaB.P 5366 KiaarifCasablancaMorocco Laboratory LCAPCM Faculty of Sciences Ben M'SikHassan II Universityof CasablancaB.P 5366 MaarifCasablancaMorocco Laboratory L3GIE Mohamntadia School of EngineersMohammad V UniversityBP.765 Av.Ibn SinaAgdalRabatMorocco Laboratory LEC Higher School of Textile and Clothing Industries(ESITH)Km 8Route d'EL JADIDACasablancaMorocco

In this paper,phosphate nanoparticles were coated on cotton(CO)and polyester(PES)textile surfaces by sol-gel method using tetraethylorthosilicate(TEOS)and chloropropyltriethoxysilane(CPTS)as silica *** deposited nanoparticles were observed with scanning electronic microscopy energv-dispersive X-ray spectroscopy(SEM-EDX).The release kinetics of phosphorus(P)from these textiles into the aqueous medium(Aq),acid(Ac),and basic(Ba)artificial sweats were then *** released amount of phosphorus was evaluated by the inductively coupled plasma(ICP)according to ISO NF EN 16711-2 *** results revealed that the release of P into the aqueous medium is lower than in the artificial *** kinetics data[the phosphoras desorption amount(mg/g)as a iunction of time]were modeled according to five models:the first order,the second order,the third order,simple elovich and parabolic *** suitable model was chosen based on the coefficient of determination(R2)and the calculation of the sum of the absolute errors(EABS),which describes the error between the theoretical and experimental *** observations were also carried out on the fabrics after desorption in order to show the impact of desorption on their ***,the impact of P release on the tensile strength of CO and PES fabrics was investigated using a uniaxial tensile *** thennal stability of all samples before and after desorption was assessed by thermogravimetric aiialysis(ATG).

关键词： Sol-gel Coating Kinetic Desorption Phospliate nanoparticle

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The Effect of the Fin Length on the Solidification Process in a Rectangular Enclosure with Internal Fins

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Fluid Dynamics & Materials Processing 2019年第2期15卷 125-137页

作者： laila Khatra Hamid el Qarnia Mohammed el Ganaoui Cadi Ayyad University Faculty of Sciences SemlaliaDepartment of PhysicsP.O.2390Fluid Mechanics and Energetic(affiliated to CNRSTURAC 27)MarrakeshMorocco Lorraine University Energetic Laboratory of Longwy(FJV/LERMAB)Henri PoincaréInstitute of LongwyFrance

The aim of the proposed work is to study the solidification process within a rectangular enclosure provided with three internal rectangular fins attached to the left vertical wall of the *** latest is filled with a phase change material(PCM),initially liquid,at a temperature above its melting *** solidification process was initiated by cooling the left wall and fins to a temperature lower than the melting *** order to study and examine the thermal behavior and thermal performance of the proposed system,a mathematical model,based on the conservation equations of mass,momentum and energy was *** governing equations and their associated boundary and initial conditions were next ***,several controlling parameters were *** volume control method was used to discretize the *** resulting algebraic equations were solved *** investigations were carried out to study and examine the effect of the dimensionless fin length on the hydrodynamic and thermal fields of the flow,the dimensionless heat flux,the solidified mass fraction and the dimensionless time of complete solidification.

关键词： Phase change material solidification enthalpy method fins rectangular enclosure

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Safety of intravitreal triamcinolone acetonide:an electrophysiologic and histopathological study in rabbits

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 790-795页

作者： laila Hassan M.el-Shazly Amal Ahmad el-Gohary Ghada Ghanem el-Hossary Department of Ophthalmology Memorial Institute of Ophthalmology Department of Physiology Research Institute ofOphthalmology Department of Pharmacology Research Institute ofOphthalmology

AIM:To evaluate the retinal safety of various doses of intravitreal triamcinolone acetonide(TA)in ***:Thirty New Zealand albino rabbits were divided into five groups(six animals each).In group 1(control group),each animal received a single intravitreal injection of 0.1 mL phosphate buffered *** groups2,3,4 and 5,each rabbit received a single intravitreal injection of 4,8,16 and 32mg of TA,*** dose was contained in 0.1 mL phosphate buffered *** ocular examinations were performed before the injection and on the 1st,3rd,10th and 17th postinjection days.A standard dark adapted electroretinogram(ERG)was obtained before injection and on the 3rd,10th and 17th post-injection ***17d,animals were sacrificed and their eyes prepared for pathological ***:By monitoring ERG as a functional index for the retina,intravitreal injection of 4mg TA showed no significant ERG *** doses of 8,16 and 32,hyper-abnormal responses in a-and b-waves of ERG were detected on the 3rd post-injection *** changes gradually returned back to normal limits *** examination of the retina of all animals showed no pathological ***:High doses of intravitreal TA seemed to have enhancing effects on the retinal function with gradual return to normal limits with no pathological changes detected in examined eyes.

关键词： triamcinolone acetonide intravitreal injection electroretinogram

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Photopic negative response in diagnosis of glaucoma:an experimental study in glaucomatous rabbit model

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 459-464页

作者： Amal A.el Gohary laila Hassan M.elshazly Department of Ocular Physiology Research Institute of Ophthalmology Department of Ophthalmology Memorial Institute of Ophthalmology

AIM: To determine whether the photopic negative response(Ph NR) elicited by transient white flash on white background is characterizing for glaucoma model in ***: Glaucoma was induced in twelve rabbits by subconjunctival injection of 0.05 m L of betamethasone in right eyes(each 1 m L contain betamethasone dipropionate5 mg and betamethasone sodium phosphate 2 mg).The intraocular pressure(IOP), electroretinogram(ERG) and visual evoked potential(VEP) were measured successively prior and on the 3, 7d, two weeks and four weeks postglaucoma induction. After four weeks, the animals were sacrificed and the globes were histopathologically ***: The IOP increased significantly after one week(P =0.0001), then it gradually returned to the control level. In ERG examination, the means of a and b wave amplitude and latency were not affected *** NR amplitude decreased significantly within one week(P =0.0001), but its latency was not affected significantly(P =0.132). The means of VEP latency and amplitude were significantly affected after two weeks and four weeks of glaucoma induction(P =0.0001 and 0.02,respectively). The histopathologic examination of the globes showed reduced number of cells in the retinal ganglion cell layer with multiple vacuoles in the retinal nerve fibre *** was significant positive correlation between ganglion cell layer cells and Ph NR amplitude( r =0.8, P =0.002).CONCLUSION: The rise in IOP resulted in irreversible changes or incomplete recovery of VEP and Ph NR amplitude. Both Ph NR and VEP represented good additional tools in early diagnosis of glaucoma.

关键词： glaucoma electrophysiology photopic negative response rabbits

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Spectrofluorimetric and Spectrophotometric Stability- Iwndicating Methods for the Analysis of Veralipride in Presence of Its Degradants and in Spiked Human Plasma

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Chinese Journal of Chemistry 2012年第1期30卷 183-189页

作者： Salama,Nahla Nour el Din Ahmed Salem,Maissa Yacoub Abd el Halim,Lobna Mohammed Abdel Fattah,laila EI-Sayed National Organization for Drug Control and Research(NODCAR) 6 Abu Hazem StreetPyramids AveP.O.Box 29GizaEgypt Analytical Chemistry Department Faculty of PharmacyCairo UniversityCairoEgypt Analytical Chemistry Department Faculty of PharmacyMisr University for Science and Technology6th of OctoberEgypt

Spectrofluorimetric and spectrophotometric stability-indicating methods were developed and validated for analysis of veralipride （Ver） in presence of its hydrolytic and oxidative degradants. The spectrofluorimetric method was based on direct measurement of the intrinsic fluorescence of Ver at 366 nm after excitation at 299 nm using sodium lauryl sulfate （SLS） as micelle enhancer. The fluorescence intensity plot was linear over the concentration range 1.0-10.0 ***-1. The high sensitivity of the method allowed its successful application to the analysis of Ver in spiked human plasma. Two other methods were developed. They are based on the oxidative coupling reac- tion of Vet with 3-methyl benzothiazolin-2-one hydrazone （MBTH） hydrochloride in presence of ceric ammonium sulphate in an acidic medium. The first method depends on spectrophotometric measurement of the stable green colored oxidative coupling product at 660 nm. The different experimental parameters affecting the reaction were optimized. Linearity range is 10.0--100.0 ~tgomL-1. The second method depends on a fluorescence quenching effect of Vet on the fluorescence of Ce3＋. The difference in fluorescence intensity was measured at 380 nm after excitation at 300 nm. This method is applicable over the concentration ranges 0.25-2.50 pg-mL-1. The methods were validated according to the ICH guidelines. They were successfully applied for the analysis of Ver in drug substance, drug product and in laboratory prepared mixtures containing different percentages of hydrolytic and oxidative degradants.

关键词： veralipride micelle-enhanced fluorescence MBTH validation stability fluorescence quenching Ce3+

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Cytotoxic, antioxidant and antimicrobial activities of Nerium oleander collected in Morocco

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Asian Pacific Journal of Tropical Medicine 2019年第1期12卷 32-37页

作者： Messaoudi Mouhcine Laglaoui Amin Amzazi Saaid Hammani Khalil Benbacer laila el Mzibri Mohammed Unité de Biologie et Recherche Médicale CNESTEN Laboratoire de Biochimie-Immunologie Faculté des Sciences Mohammed V University équipe de Recherche en Biotechnologies & Génie des Biomolécules Faculté des Sciences et Techniques de Tanger Abdelmalek Essaadi University Laboratoire de Ressources Naturelles et Environnement Faculté Polydisciplinaire de Taza Sidi Mohammed Ben Abdellah University

Objective: To investigate the cytotoxic, antioxidant and antibacterial activities of ethanolic and aqueous crude extracts of Nerium oleander(N. oleander) leaves. Methods: Cytotoxic activities were evaluated by WST-1 bioassay on two human cancer cell lines, namely human colon adenocarcinoma cell line HT-29 and human breast cancer cell line MDA-MB-231. The antioxidant property of N. oleander extracts was assessed by DPPH scavenging and he agar disc diffusion method was used for the determination of an毬-carotene bleaching tests. Ttimicrobial activity against different strains. Results: Using cell viability indices, the WST-1 test revealed that both extracts reduced cell viability in both cell lines. Our results also showed that aqueous extract was more active than ethanolic extract, with IC50 values of(1.67±0.22) μg/mL and(2.36±0.44) μg/mL on MDA-MB-231 cells, and(2.89±0.35) μg/mL and(5.09±0.52) μg/mL on HT29 cells, respectively. The study of the antioxidant activity showed that N. oleander extracts had a considerable scavenging capacity and exerted a significant preventive effect against the oxidation of 毬-carotene by the peroxide radicals. However, the antibacterial test showed that both ethanolic and aqueous extracts of N. oleander had a moderate antibacterial effect limited only to Gram-positive bacteria. Conclusions: Our results shows that N. oleander aqueous and ethanolic extracts have significant cytotoxic activities against tumor cell lines and possesses a strong antioxidant capacity, suggesting the presence of active compounds in N. oleander leaves that could be a potential source of phytochemicals with high medicinal value to be used in cancer treatment and prevention.

关键词： Nerium oleander Anti-cancer Cytotoxicity Antioxidant Antimicrobial Bioactive compounds

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Effect of mesenchymal stem cells on anti-Thy1,1 induced kidney injury in albino rats

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Asian Pacific Journal of Tropical Biomedicine 2013年第3期3卷 174-181页

作者： Saber Sakr laila Rashed Waheba Zarouk Rania el-Shamy Department of Zoology Faculty of ScienceMenoufia University Department of Biochemistry Faculty of MedicineCairo University Center of Human Genetics and Human Genome Research National Research Center

Objective:To evaluate the effect of mesenchymal stem cells(MSCs)in rats with anti-Thy 1,***:Female albino rats were divided into three groups,control group,anti-Thy 1,1group and treatment with *** *** were derived from bone marrow of male albino rats,Y—chromosome gene was detected by polymerase chain reaction in the *** urea and creatinine were estimated for all *** of all studied groups was examined histologically and histochemically(total carbohydrates and total proteins).DNA fragmentation and expression ofα-SMA were ***:Kidney of animals injected with anti-Thy 1,1showed inflammatory leucocytic infiltration,hypertrophied glomeruli,tubular necrosis and congestion in the renal blood *** kidney tissue also showed reduction of carbohydrates and total proteins together with increase in apoptosis and in expression ofα-***,the levels of urea and creatinine were *** animals with MSCs revealed that kidney tissue displayed an improvement in the histological and histochemical *** andα-SMA expression were decreased,and the levels of urea and creatinine ***:The obtained results demonstrated the potential of MSCs to ameliorate the structure and function of the kidney in rats with anti-Thy 1,1 nephritis possibly through the release of paracrine growth factor(s).

关键词： Anti-Thy1,1 Nephritis Mesenchymal stem cells α-SMA Apoptosis

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