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Journal of Environmental Sciences 2019年第5期31卷 174-199页

作者： Kar Chiew lai lai yee lee Billie Yan Zhang Hiew Suchithra Thangalazhy-Gopakumar Suyin Gan Department of Chemical and Environmental Engineering University of Nottingham Malaysia Campus

The remediation of wastewater requires treatment technologies which are robust, efficient,simple to operate and affordable such as adsorption. Lately, three-dimensional(3D)graphene based materials have attracted significant attention as effective adsorbents for wastewater treatment. The intrinsic properties of 3D graphene structure such as large surface area and interconnected porous structure can facilitate the transport of pollutants into the 3D network and provide abundant active sites for trapping the pollutants. For the synthesis of 3D graphene structure, ice-templating is commonly practiced due to its facile steps, cost effectiveness and high scalability potential. This review covers the icetemplating fabrication technique for 3D graphene based materials and their application as adsorbents in eliminating dyes and heavy metals from aqueous media. The assembly mechanisms of the ice-templating fsynthesis are comprehensively discussed. Further discussion on the fundamental principles, critical process parameters and characteristics of ice-templated 3D graphene structures is also included. A thorough review on the mechanisms for batch adsorption of dyes and heavy metals is presented based on the structures and properties of the 3D graphene materials. The review further evaluates the dynamic adsorption in packed columns and the regeneration of 3D graphene based materials.

关键词： Ice-templating 3D graphene based structure Adsorption mechanism Dyes Heavy metals

Synthesis of a highly recoverable 3D MnO2/rGO hybrid aerogel for efficient adsorptive separation of pharmaceutical residue

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Journal of Environmental Sciences 2022年第8期34卷 194-203页

作者： Billie Yan Zhang Hiew Wan Ting Tee Nicholas Yung Li Loh Kar Chiew lai Svenja Hanson Suyin Gan Suchithra Thangalazhy-Gopakumar lai yee lee Department of Chemical and Environmental Engineering University of Nottingham MalaysiaJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia Department of Chemical and Environmental Engineering University of Nottingham Ningbo ChinaNingbo 315100China

Water contamination by non-steroidal anti-inflammatory drugs,such as acetaminophen,is an emerging ecological *** this study,a newthree-dimensionalmanganese dioxideengrafted reduced graphene oxide(3D MnO_(2)/rGO)hybrid aerogel was developed for acetaminophen *** synthesis involved firstly the self-assembly of GO aerogel,followed by thermal reduction and in-situ MnO_(2) growth by *** aerogel demonstrated interlinked planes with smooth surfaces deposited with MnO_(2) nanospheres and pores of 138.4–235.3μm *** influences of adsorbent dosage,initial pH,acetaminophen concentration,temperature and contact time were *** was determined that the adsorption of acetaminophen occurred on uniform sorption sites in the aerogel,as suggested by the best fit of data to the Langmuir isotherm,yielding a maximum adsorption capacity of 252.87 mg/*** highest adsorption performance of the 3D MnO_(2)/rGO aerogel was attained at a dosage of 0.6 g/L,initial pH of 6.2 and temperature of 40℃.The process kinetics were in-line with the pseudo-first-order and pseudo-second-order kinetics at 10 and 20–500 mg/L concentrations,*** assay showed the spontaneity and endothermicity features of the 3D MnO_(2)/rGO-acetaminophen *** acetaminophen adsorption mechanisms were mainly hydrogen bonding and pore ***,the as-synthesised aerogel was effectively regenerated using acetone and re-utilised in four adsorption-desorption ***,the results highly recommend the implementation of the 3D MnO_(2)/rGO hybrid aerogel for purification of wastewater polluted by acetaminophen residue.

关键词： Acetaminophen Adsorption Adsorption mechanism 3D reduced graphene oxide Manganese oxide nanoparticles Regeneration

Intercellular and inter-organ crosstalk in browning of white adipose tissue:molecular mechanism and therapeutic complications

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Journal of Molecular Cell Biology 2021年第7期13卷 466-479页

作者： lai yee Cheong Aimin Xu The State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina

Adipose tissue(AT)is highly plastic and heterogeneous in response to environmental and nutritional *** development of heat-dissipating beige adipocytes in white AT(WAT)through a process known as browning(or beiging)has garnered much attention as a promising therapeutic strategy for obesity and its related metabolic *** is due to its inducibility in response to thermogenic stimulation and its association with improved metabolic *** consists of adipocytes,nerves,vascular endothelial cells,various types of immune cells,adipocyte progenitor cells,and *** cells contribute to the formation of beige adipocytes through the release of protein factors that significantly influence browning *** addition,inter-organ crosstalk is also important for beige adipocyte ***,we summarize recent findings on fat depot-specific differences,secretory factors participating in intercellular and inter-organ communications that regulate the recruitment of thermogenic beige adipocytes,as well as challenges in targeting beige adipocytes as a potential anti-obese therapy.

关键词： adipose tissue browning circulating factors energy homeostasis adipose biology obesity

A novel unsupervised approach for multilevel image clustering from unordered image collection

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Frontiers of Computer Science 2013年第1期7卷 69-82页

作者： lai KANG Lingda WU yee-Hong YANG College of Information System and Management National University of Defense Technology Changsha 410073 China The Key Lab the Academy of Equipment Command & Technology Beijing 101400 China Department of Computing Science University of Alberta Edmonton Alberta T6G 2E8 Canada

A novel unsupervised approach to automatically constructing multilevel image clusters from unordered im- ages is proposed in this paper. The whole input image col- lection is represented as an imaging sample space （ISS） con- sisting of globally indexed image features extracted by a new efficient multi^view image feature matching method. By mak- ing an analogy between image capturing and observation of ISS, each image is represented as a binary sequence, in which each bit indicates the visibility of a corresponding feature. Based on information theory-inspired image popularity and dissimilarity measures, we show that the image content and distance can be quantitatively described, guided by which an input image collection is organized into multilevel clusters automatically. The effectiveness and the efficiency of the pro- posed approach are demonstrated using three real image col- lections and promising results were obtained from both qual- itative and quantitative evaluation.

关键词： multilevel image clustering imaging sample space (ISS) unordered image collection

Role and outcome of conventional surgery in the treatment of pyogenic liver abscess in the modern era of minimally invasive therapy

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World Journal of Gastroenterology 2008年第5期14卷 747-751页

作者： Simon Siu-Man Ng Janet Fung-yee lee Paul Bo-San lai Department of Surgery The Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong China

AIM:To evaluate the role and outcome of conventional surgery in the treatment of pyogenic liver abscess in the modern era of minimally invasive therapy. METHODS:The medical records of thirteen patients with pyogenic liver abscess who underwent surgical treatment between January 1995 and December 2002 were retrospectively reviewed to determine the clinical presentation, indication and nature of surgery, and out-come of surgery. RESULTS:The patients were predominantly women (10/13) with a mean age of 65 ± 17 years. Their main presenting symptoms were abdominal pain (100%) and fever (77%). The aetiologies included biliary (n = 6), cryptogenic (n = 3), portal (n = 2), and trauma (n = 2). Seven patients underwent percutaneous drainage as the initial treatment. Of these, three patients developed peritonitis secondary to peritoneal spillage. Another four patients failed to respond because of multilocula-tion. Salvage surgery was required in these patients. Six patients proceeded to straight laparotomy:two had marked sepsis and multiloculated abscess that precluded percutaneous drainage, and four presented with perito-nitis of uncertain pathology. Surgical procedures included deroofment and drainage (n = 9), liver resection (n = 3), peritoneal lavage (n = 2), cholecystectomy (n = 4), and exploration of common bile duct (n = 2). One patient required reoperation because of bleeding. Three patients required further percutaneous drainage after surgery. The overall mortality was 46%. Four patients died of multiorgan failure and two patients died of pulmonary embolism. CONCLUSION:Surgical treatment of pyogenic liver ab-scess is occasionally needed when percutaneous drainage has failed due to various reasons. Mortality rate in this group of patients has remained high.

关键词： Pyogenic liver abscess Surgical drainage Liver resection Percutaneous drainage Outcome

Modifications of ALPPS–from complex to more complex or from complex to less complex operations

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Hepatobiliary & Pancreatic Diseases International 2017年第4期16卷 346-352页

作者： Wan yee Lau Eric CH lai Faculty of Medicine The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina Department of Surgery Pamela Youde Nethersole Eastern HospitalHong Kong SARChina

BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has recently been developed to induce rapid liver hypertrophy to reduce the chance of post-hepatectomy liver failure in patients with borderline or insufficient future liver remnant. ALPPS is still in an early developmental stage and its techniques have not been standardized. This study aimed to review the technical modifications of the conventional ALPPS procedure. DATA SOURCES: Studies were identified by searching MEDLINE and PubMed for articles published from January 2007 to December 2016 using the keywords 'associating liver partition and portal vein ligation for staged hepatectomy' and 'ALPPS'. Additional articles were identified by a manual search of references from key articles. RESULTS: There have been a lot of modifications of the conventional ALPPS. These are classified as: (1) modifications aiming to improve surgical results; (2) modifications aiming to expand surgical indications; (3) salvage ALPPS; (4) ALPPS using the minimally invasive approach. Some of these modifications have made the conventional ALPPS procedure to become even more complex, although there have also been other attempts to make the procedure less complex. The results of most of these modifications have been reported in small case series or case reports. We need better well-designed studies to establish the true roles of these modifications. However, it is interesting to see how this conventional ALPPS procedure has evolved since its introduction. CONCLUSIONS: There is a trend for the use of minimally invasive procedure in the phase 1 or 2 of the conventional ALPPS procedure. Some of these modifications have expanded the use of ALPPS in patients who have been considered to have unresectable liver tumors. The long-term oncological outcomes of these modifications are still unknown.

关键词： associating liver partition and portal vein ligation for stage hepatectomy hepatocellular carcinoma hepatectomy liver metastasis portal vein embolization

Hepatic venous outflow obstruction after piggyback liver transplantation by an unusual mechanism:Report of a case

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World Journal of Gastroenterology 2006年第33期12卷 5416-5418页

作者： Simon Siu-Man Ng Simon Chun-Ho Yu Janet Fung-yee lee Paul Bo-San lai Wan-yee Lau Departments of Surgery and Diagnostic Radiology & Organ Imaging Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong China

Hepatic venous outflow obstruction after piggyback liver transplantation is a very rare complication. An unusual mechanism aggravating it is reported. A 33-year-old man with end-stage hepatitis B liver cirrhosis underwent a piggyback orthotopic liver transplantation using a full-size cadaveric graft. Two months after transplantation, he developed gross ascites refractory to maximal diuretic therapy. Doppler ultrasound showed patent portal and hepatic veins. Serial computed tomography scans revealed a hypoperfused right posterior segment of the liver which subsequently underwent atrophy. Hepatic venography demonstrated a high-grade stenosis with an element of torsion of venous drainage at the anastomosis. The stenosis was successfully treated with repeated percutaneous balloon angioplasty. The patient remained asymptomatic six months afterwards with complete resolution of ascites and peripheral edema. We postulate that liver allograft segmental hypoperfusion and atrophy may aggravate or result in a hepatic venous outflow problem by the mechanism of torsion effect. Percutaneous balloon angioplasty is a safe and effective treatment modality for anastomotic stenosis.

关键词： Hepatic venous outflow obstruction Piggyback Liver transplantation Percutaneous balloon angioplasty

Asymmetric hydrogenation of aromatic ketones using new chiral-bridged diphosphine/diamine-Ru(Ⅱ) complexes

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Chinese Chemical Letters 2010年第12期21卷 1403-1406页

作者： Yu Ming Cui lai lai Wang Fuk yee Kwong Wei Sun State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical technology The Hong Kong Polytechnic University Hong Kong China Graduate University of Chinese Academy of Sciences Beijing 100039 China

A series of chiral secondary alcohols were easily prepared by means of asymmetric hydrogenation of prochiral aromatic ketones using a new（（Rax）-BuP）/（R,R）-DPEN-Ru（Ⅱ） complex catalyst *** hydrogenation of 2-methylacetophenone in n-butanol （t-BuOK/Ru =45.6/1,S/C = 500,20 *** H2,20℃,48 h） afforded（S）-1-（2＇-methylphenyl）ethanol in 92%ee and〉99% conversion.

关键词： Asymmetric hydrogenation Chiral alcohols Diphosphine ligand Ruthenium complexes Diamine

Hemodynamics and oxygen transport dynamics during hepatic resection at different central venous pressures in a pig model

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Hepatobiliary & Pancreatic Diseases International 2011年第5期10卷 516-520页

作者： Wan-yee Lau Eric CH lai Department of Hepatic and Biliary Surgery First Affiliated Hospital Guangxi Medical University Faculty of Medicine the Chinese University of Hong Kong Shatin New Territories Hongkong SAR China

BACKGROUND: Although low central venous pressure (CVP) has been used to minimize blood loss during hepatectomy the impact of variations of CVP on the rate of blood loss and on the perfusion of end-organs has not been evaluated This animal study aimed to evaluate the hemodynamics and oxygen transport changes during hepatic resection at different CVP levels. METHODS: Forty-eight anesthetized Bama miniature pigs were divided into 8 groups with CVP during hepatic resection controlled at 0 to <1, 1 to <2, 2 to <3, 3 to <4, 4 to <5, 5 to <6, 6 to <7, and 7 to <8 cmH 2 O. Intergroup comparisons were made for hemodynamic parameters, oxygen transport dynamics, and the rate of blood loss. RESULTS: The rate of blood loss and the hepatic venous pressure during hepatic resection were almost linearly related to the CVP. A significant drop in the mean arterial pressure cardiac output, and cardiac index occurred between CVP ≥2 and <2 cmH 2 O. Oxygen delivery (DO 2 ), oxygen consumption (VO 2 ) and oxygen extraction ratio (ERO 2 ) remained relatively constant between CVPs of 2 to <8 cmH 2 O. There was a significant drop in DO 2 when the CVP was <2 cmH 2 O. There was also a significant drop in VO 2 and ExO 2 when the CVP was <1 cmH 2 ***: The optimal CVP for hepatic resection is 2to 3 cmH2O.

关键词： hepatectomy hemorrhage central venous pressure tissue oxygenation hemodynamics

Associating liver partition and portal vein ligation for staged hepatectomy： the current role and development

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Hepatobiliary & Pancreatic Diseases International 2017年第1期16卷 17-26页

作者： Wan yee Lau Eric CH lai Stephanie HY Lau Faculty of Medicine The Chinese University of Hong Kong Shatin New Territories Department of Surgery Pamela Youde Nethersole Eastern Hospital Department of Surgery Queen Elizabeth Hospital Hong Kong China

BACKGROUND： Associating liver partition and portal vein ligation for staged hepatectomy （ALPPS） has recently been developed to induce rapid liver hypertrophy and reduce posthepatectomy liver failure in patients with insufficient future liver remnant （FLR）. ALPPS is still considered to be in an early developmental phase because surgical indications and techniques have not been standardized. This article aimed to review the current role and future developments of ALPPS. DATA SOURCES： Studies were identified by searching MED- LINE and PubMed for articles from January 2007 to October 2016 using the keywords ＂associating liver partition and portal vein ligation for staged hepatectomy＂ and ＂ALPPS＂ Addi- tional papers were identified by a manual search of references from key articles. RESULTS： ALPPS induces more hypertrophy of the FLR in less time than portal vein embolization or portal vein ligation. The benefits of ALPPS include rapid hypertrophy 47%-110% of the liver over a median of 6-16.4 days, and 95%-100% com- pletion rate of the second stage of ALPPS. The main criticisms of ALPPS are centered on its high morbidity and mortality rates. Morbidity rates after ALPPS have been reported to be 15.3%-100%, with ≥ the Clavien-Dindo grade III morbidity of 13.6%-44%. Mortality rates have been reported to be 0%-29%. The important questions to ask even if oncologic long-term results are acceptable are： whether the gain in quality and quantity of life can be off balance by the substantial risks of morbidity and mortality, and whether stimulation of rapid liver hypertrophy also accelerates rapid tumor progression and spread. Up till now, the documentations of the ALPPS procedure come mainly from case series, and most of these series include heterogeneous groups of malignancies. The numbers are also too small to separately evaluate survival for different tumor etiologies. CONCLUSIONS： Currently, knowledge on ALPPS is limited, and prospective randomized studies are lacking. From th

关键词： associating liver partition and portal vein ligation for staged hepatectomy portal vein embolization laparoscopy colorectal liver metastases hepatocellular carcinoma