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Nanostructured hybrid materials for bone-tooth unit regeneration

Open Journal of Regenerative Medicine 2013年第3期2卷 47-52页

作者： Sabine Kuchler-Bopp Thibault Becavin Tunay Kokten Florence Fioretti Etienne Deveaux Nadia Benkirane-Jessel laetitia keller Institut National de la Santeet de la Recherche Medicale(INSERM) UMR 1109Osteoarticular and Dental RegenerativeNanomedicineFacultede MedecineStrasbourgFrance Universitede Strasbourg Facultede Chirurgie Dentaire1 Place de l’HopitalStrasbourgFrance 3.UniversitéLille Nord de FranceFacultede Chirurgie DentaireLilleFrance

As a part of regenerative medicine, biomaterials are largely used in this field of nanotechnology and tissue engineering research. We have recently developed a new scaffold using electrospun nanofibers of Poly (ε-caprolactone), PCL which is able to mimic the collagen extracellular matrix of cells. The aim of this study was to engineer a biological and implantable structure leading the regeneration of the tooth-bone unit. For this aim, we have cultured mouse osteoblasts embedded in a collagen gel on the nanofibrous membrane and coupled this structure with an embryonic dental germ before implantation. To follow bone and tooth regeneration, we have performed RT-PCR, histology and immunofluorescence analysis. We showed here that this leaving implantable structure represents an accurate strategy for bone-tooth unit regeneration. We report here the first demonstration of bone-tooth unit regeneration by using a strategy based on a synthetic nanostructured membrane. This electrospun membrane is manufactured by using an FDA approved polymer, PCL and functionalized with osteoblasts before incorporation of the tooth germs at ED14 (the first lower molars) to generate bone-tooth unit in vivo after implantation in mice. Our technology represents an excellent platform on which other sophisticated products could be based.

关键词： Bone Nanostructured Material Osteoblast Tissue Engineering Tooth

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Nanoscale Stiffness Distribution in Bone Metastasis

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World Journal of Nano Science and Engineering 2015年第4期5卷 219-228页

作者： Ludovic Richert laetitia keller Quentin Wagner Fabien Bornert Catherine Gros Sophie Bahi Francois Clauss William Bacon Philippe Clézardin Nadia Benkirane-Jessel Florence Fioretti Centre National de la Recherche Scientifique(CNRS) UMRFacultéde Pharmacie de l’Universitéde Strasbourg(UdS)IllkirchFrance Institut National de la Santéet de la Recherche Médicale(INSERM) Osteoarticular and Dental Regenerative NanomedicineUMRFacultéde Médecine de l’Universitéde Strasbourg and FMTSStrasbourgFrance Facultéde Chirurgie Dentaire de l’Universitéde Strasbourg(UdS) StrasbourgFrance Hopitaux Universitaires de Strasbourg StrasbourgFrance Institut National de la Santéet de la Recherche Médicale(INSERM) UMRFacultéde Médecine Laennec de l’UniversitéClaude Bernard Lyon 1LyonFrance

Nanomechanical heterogeneity is expected to have an effect on elasticity, injury and bone remodelling. In normal bone, we have two types of cells (osteoclasts and osteoblasts) working together to maintain existing bone. Bone cancers can produce factors that make the osteoclasts work harder. This means that more bone is destroyed than rebuilt, and leads to weakening of the affected bone. We report here the first demonstration of the nanoscale stiffness distribution in bone metastases before and after treatment of animals with the bisphosphonate Risedronate, a drug which is currently used for the treatment of bone metastases in patients with advanced cancers. The strategy used here is applicable to a wide class of biological tissues and may serve as a new reflection for biologically inspired scaffolds technologies.

关键词： Bone Metastasis Stiffness Risedronate

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