检索结果-南通市图书馆

Novel pluripotent stem cell lines for enrich.d grafting in Parkinson’s disease

Neural Regeneration Research 2020年第2期15卷 255-256页

作者： Agustin Cota-Coronado lachlan h.thompson N.Emmanuel Diaz-Martinez Biotecnologia Medica y Farmaceutica Centro de Investigacion y Asistencia en Tecnologia y Diseno del Estado de JaliscoGuadalajaraMexico Th. Florey Institute of Neuroscience and Mental h.alth The University of MelbourneMelbourneAustralia

Parkinson's disease (PD) is th. second most common neurodegenerative disease, affecting 1% of th. population over 55 years of age and up to 4% of th. population over 80 years of age (Blesa et al., 2012). Th.s progressive and neurodegenerative condition results from an excessive loss of dopaminergic neurons (50-70%) of th. substantia nigra pars compacta, leading to a significant decrease in dopamine (DA) levels in th. striatum and consequently a functional deterioration of motor circuity (Blesa et al., 2012;Nielsen et al., 2016).

关键词： Parkinson's disease striatum neurodegenerative

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modulating Wnt signaling to improve cell replacement th.rapy for Parkinson＇s disease

引用

Journal of Molecular Cell Biology 2014年第1期8卷 54-63页

作者： Clare L. Parish.lachlan h. thompson Florey Institute of Neuroscience and Mental h.alth The University of Melbourne Parkville VIC 3010 Australia

Clinical trials h.ve demonstrated th. capacity for dopamine neurons, transplanted ectopicaUy into th. striatum, to structurally inte- grate, restore dopamine transmission, and induce long-term functional benefits for Parkinson＇s disease （PD） patients. Despite th.s proof of principle, a number of limitations h.ve h.ndered th. development of cell replacement th.rapy over th. past 20 years, particu- larly tissue availability, graft survival, and adequate reinnervation of th. h.st brain. With.a greater understanding of failure in prior clinical trials, increased knowledge of midbrain dopamine development （now including Wnts）, and th. development of pluripotent stem cell tech.ologies, we are better equipped th.n ever to re-address a number of th.se ch.llenges. Th.s review summarizes th. trials, tribulations, and progress in cell replacement th.rapy for PD. We discuss th. prospects of modulating canonical and non-canon- ical Wnt signalingto improve cell th.rapy based upon th.ir roles in dopamine neural development and th. adult brain. Th.s will include th. potential of Wnts to （i） expand fetaUy derived tissue in vitro and foUowing transplantation, （ii） promote th. differentiation of pluripotent stem cells, （iii） increase graft integration and restoration of neural circuitry, and finally （iv） enh.nce graft survival.

关键词： Wnt dopamine Parkinson's disease cell transplantation neurogenesis axon growth motor function

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combined immunoh.stoch.mical and retrograde tracing reveals little evidence of innervation of th. rat dentate gyrus by midbrain dopamine neurons

引用

Frontiers in Biology 2016年第3期11卷 246-255页

作者： Ch.rlotte M. Ermine Jordan L. Wrigh. Clare L. Parish.Davor Stanic lachlan h. thompson Th. Florey Institute for Neuroscience and Mental h.alth The University of Melbourne Parkville Victoria 3010 Australia Current address Wolfson Institute for Biomedical Research University College London Gower Street London WC1E 6BT UK

Alth.ugh.th. functional neuroanatomy of th. midbrain dopamine （mDA） system h.s been well ch.racterized, th. literature regarding its capacity to innervate th. h.ppocampal formation h.s been inconsistent. Th. lack of expression of definitive markers for dopaminergic fibers, such.as th. dopamine transporter, in th. h.ppocampus h.s complicated studies in th.s area. h.re we h.ve used immunoh.stoch.mical tech.iques to ch.racterize th. tyrosine h.droxylase expressing fiber network in th. rat h.ppocampus, combined with.retrograde tracing from th. dentate gyrus to assess th. capacity for afferent innervation by mDA neurons. Th. results indicate th.t virtually all tyrosine h.droxylase fibers th.ough.ut th. h.ppocampus are of a noradrenergic ph.notype, wh.le th. overlying cortex contains both.dopaminergic and noradrenergic fiber networks. Furth.rmore, retrograde tracing from th. dentate gyrus robustly labels tyrosine h.droxylase-immunoreactive noradrenergic neurons in th. locus coeruleus but not mDA neurons.

关键词： noradrenaline h.ppocampus connectivity DAT neurogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tiny insects against th. weath.r fligh. and foraging patterns of Frankliniella sch.ltzei (Th.ipidae) not altered by onset of rainfall

引用

Insect Science 2018年第6期25卷 1119-1127页

作者： lachlan C.Jones Brodie J.Foster Mich.lle A.Rafter Gimme h.Walter Sch.ol of Biological Sciences The University of QueenslandSt LuciaBrisbaneQueenslandAustrafia

To survive in nature,organisms may need to take direct action to mitigate specific dangers from th.ir environmental *** flying insects are th.ugh. to be at particular risk from rainfall th.t would be of negligible concern to larger *** study species Frankliniella sch.ltzei is a th.ips th.t inh.bits flowers and feeds mostly on petal tissue and *** found to respond in th. laboratory to decreases in atmosph.ric pressure associated with.cyclonic conditions (rath.r th.n merely h.avy rainfall),th.ir responses to conditions preceding rainfall h.ve not been tested in th. *** field sampling investigated th. relationsh.p between floral development and sites at wh.ch.male,female,and larval th.ips were generally present on sunny *** th.n designed a sampling strategy to test if th.se th.ips can anticipate imminent rainfall or storms and so seek sh.lter deep with.n flowers,by sampling h.st flowers (in sections)on multiple days with.different weath.r *** traps were used to intercept th.ips in fligh.,th.s providing a measure of fligh. beh.vior across different *** initial sampling found adult th.ips primarily at th. petal apex of anth.sis-stage flowers wh.re pollen is distributed. We subsequently found th.t rainfall,atmosph.ric pressure ch.nge,temperature,h.midity and wind h.d no effect on fligh. beh.vior of E sch.ltzei,or on th.ir positions with.n *** findings suggest rainfall is not a serious h.zard for *** th.ips can survive raindrop collisions during fligh.,as impacts with.water droplets are not expected to break th. surface tension.

关键词： barometric pressure Frankliniella sch.ltzei Malvaviscus arboreus rainfall sh.lter th.ips

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

澳大利亚寒武纪h.ath.ote绿岩带中变质拉斑玄武岩和层间沉积物:维多利亚州金矿化的来源?

引用

贵金属地质 1998年第4期7卷 304-307页

作者： F.P.Bierlein D.C.Arne W.R.h.Ramsay 王海俊沈阳地质矿产研究所

ＬａｋｅＣｏｏｐｅｒ露天矿区寒武系变质拉斑玄武岩和层间沉积物由９个块状－枕状熔岩和７层沉积物组成，位于澳大利亚维多利亚州中部Ｈｅａｔｈｃｏｔｅ绿岩带的北部，岩层厚度为２８１ｍ．矿区的变质玄武岩在岩性和地球化学上与正常... 详细信息

ＬａｋｅＣｏｏｐｅｒ露天矿区寒武系变质拉斑玄武岩和层间沉积物由９个块状－枕状熔岩和７层沉积物组成，位于澳大利亚维多利亚州中部Ｈｅａｔｈｃｏｔｅ绿岩带的北部，岩层厚度为２８１ｍ．矿区的变质玄武岩在岩性和地球化学上与正常的大洋中脊玄武岩及维多利亚州其他地区绿岩体中的变质玄武岩极为相似，并且未遭受热液蚀变作用．层间沉积物由细条带状硫化物、层状含硫化物的碳质泥岩、燧石和沉积碳酸盐岩组成．沉积物中异常矿物组合、微量元素、稀土元素等特征表明，沉积物为喷气火山成因．露天矿中的变质拉斑玄武岩含金低于５×１０－９，而层间沉积物金品位随Ａｓ、Ｃｕ、Ｚｎ含量变化而变化，金含量平均为６７×１０－９．根据沉积学特征和硫化物矿物推测，沉积物中成矿金属元素是在喷气沉积期间聚集的，即可能是从区内拉斑玄武岩之下的厚层玻古山岩中萃取和交换出来的．物质平衡计算表明，早—中古生代期间变质流体使金从层间沉积物中活化并在构造薄弱带、膨胀带再沉淀，故喷气成因的变沉积岩在金聚集和提供金源上起了重要作用，在维多利亚州Ｌａｃｈｌａｎ褶皱带中形成浊积围岩型岩金矿床．

关键词：寒武纪绿岩带拉斑玄武岩变质岩金矿床矿化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：