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A state-of-the-art review of the development of self-healing concrete for resilient infrastructure

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 151-169页

作者： dong lu Xi JIANG Yao ZHANG Shaowei ZHANG Guoyang lu Zhen LENG Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China Laboratory of Fire Safety School of Safety Engineering and Emergency ManagementShijiazhuang Tiedao UniversityShijiazhuang 050043China Department of Architecture and Civil Engineering City University of Hong KongHong Kong 999077China

The brittleness of cement composites makes cracks almost inevitable,producing a serious limitation on the lifespan,resilience,and safety of concrete *** address this brittleness,self-healing concrete has been developed for regaining its mechanical and durability properties after becoming cracked,thereby promising sustainable development of concrete *** paper provides a comprehensive review of the latest developments in self-healing *** begins by summarizing the methods used to evaluate the self-healing efficiency of ***,it compares strategies for achieving healing *** then discusses the typical approaches for developing self-healing ***,critical insights are proposed to guide future studies on the development of novel self-healing *** review will be useful for researchers and practitioners interested in the field of self-healing concrete and its potential to improve the durability,resilience,and safety of concrete infrastructure.

关键词： resilient infrastructure sustainable concrete self-healing cracks

Discovering Latent Variables for the Tasks With Confounders in Multi-Agent Reinforcement Learning

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1591-1604页

作者： Kun Jiang Wenzhang Liu Yuanda Wang lu dong Changyin Sun the School of Automation Southeast UniversityNanjing 210096China the School of Artificial Intelligence Anhui UniversityHefei 230601China IEEE the School of Cyber Science and Engineering Southeast UniversityNanjing 211189China the Engineering Research Center of Autonomous Unmanned System Technology Ministry of EducationHefei 230601China

Efficient exploration in complex coordination tasks has been considered a challenging problem in multi-agent reinforcement learning(MARL). It is significantly more difficult for those tasks with latent variables that agents cannot directly observe. However, most of the existing latent variable discovery methods lack a clear representation of latent variables and an effective evaluation of the influence of latent variables on the agent. In this paper, we propose a new MARL algorithm based on the soft actor-critic method for complex continuous control tasks with confounders. It is called the multi-agent soft actor-critic with latent variable(MASAC-LV) algorithm, which uses variational inference theory to infer the compact latent variables representation space from a large amount of offline ***, we derive the counterfactual policy whose input has no latent variables and quantify the difference between the actual policy and the counterfactual policy via a distance function. This quantified difference is considered an intrinsic motivation that gives additional rewards based on how much the latent variable affects each agent. The proposed algorithm is evaluated on two collaboration tasks with confounders, and the experimental results demonstrate the effectiveness of MASAC-LV compared to other baseline algorithms.

关键词： Latent variable model maximum entropy multi-agent reinforcement learning(MARL) multi-agent system

Polysaccharides from Chinese herbal medicine:a review on the hepatoprotective and molecular mechanism

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Chinese Journal of Natural Medicines 2024年第1期22卷 4-14页

作者： LI Jifeng GUO Haolin dong Ying YUAN Shuo WEI Xiaotong ZHANG Yuxin dong lu WANG Fei BAI Ting YANG Yong Dalian Key Laboratory of Chronic Disease Research Center Dalian UniversityDalian 116622China Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of EducationCollege of PharmacyYanbian UniversityYanji 133002China

Polysaccharides,predominantly extracted from traditional Chinese medicinal herbs such as Lycium barbarum,Angelica sinensis,Astragalus membranaceus,Dendrobium officinale,Ganoderma lucidum,and Poria cocos,represent principal bioactive constituents extensively utilized in Chinese *** compounds have demonstrated significant anti-inflammatory capabilities,especially anti-liver injury activities,while exhibiting minimal adverse *** review summarized recent studies to elucidate the hepatoprotective efficacy and underlying molecular mechanisms of these herbal *** underscored the role of these polysaccharides in regulating hepatic function,enhancing immunological responses,and improving antioxidant capacities,thus contributing to the attenuation of hepatocyte apoptosis and liver *** of molecular pathways in these studies revealed the intricate and indispensable functions of traditional Chinese herbal polysaccharides in liver injury ***,this review provides a thorough examination of the hepatoprotective attributes and molecular mechanisms of these medicinal polysaccharides,thereby offering valuable insights for the advancement of polysaccharide-based therapeutic research and their potential clinical applications in liver disease treatment.

关键词： Polysaccharides Hepatoprotective Chinese herbal medicine Mechanism

New roles of research data infrastructure in research paradigm evolution

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Journal of Data and Information Science 2024年第2期9卷 104-119页

作者： Yizhan Li lu dong Xiaoxiao Fan Ren Wei Shijie Guo Wenzhen Ma Zexia Li National Library Science Chinese Academy of SciencesBeijing 100190China Department of Information Resources Management School of Economics and ManagementUniversity of Chinese Academy of SciencesBeijing100190China Bureau of Facility Support and Budget Chinese Academy of SciencesBeijing 100864China

Research data infrastructures form the cornerstone in both cyber and physical spaces,driving the progression of the data-intensive scientific research *** opinion paper presents an overview of global research data infrastructure,drawing insights from national roadmaps and strategic documents related to research data *** emphasizes the pivotal role of research data infrastructures by delineating four new missions aimed at positioning them at the core of the current scientific research and communication *** four new missions of research data infrastructures are:(1)as a pioneer,to transcend the disciplinary border and address complex,cutting-edge scientific and social challenges with problem-and data-oriented insights;(2)as an architect,to establish a digital,intelligent,flexible research and knowledge services environment;(3)as a platform,to foster the high-end academic communication;(4)as a coordinator,to balance scientific openness with ethics needs.

关键词： Research data infrastructure Landscape Data-centric Problem-oriented

An improved analysis method for assessing the nuclear-heating impact on the stability of toroidal field magnets in fusion reactors

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Nuclear Science and Techniques 2024年第6期35卷 163-176页

作者： Yu-dong lu Jin-Xing Zheng Xu-Feng Liu Huan Wu Jian Ge Kun Xu Ming Li Hai-Yang Liu Lei Zhu Fei Liu Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China

The superconducting magnet system of a fusion reactor plays a vital role in plasma confinement,a process that can be dis-rupted by various operational factors.A critical parameter for evaluating the temperature margin of superconducting magnets during normal operation is the nuclear heating caused by D-T *** study investigates the impact of nuclear heat-ing on a superconducting magnet system by employing an improved analysis method that combines neutronics and thermal *** the magnet system,toroidal field(TF)magnets are positioned closest to the plasma and bear the highest nuclear-heat load,making them prime candidates for evaluating the influence of nuclear heating on *** enhance the modeling accuracy and facilitate design modifications,a parametric TF model that incorporates heterogeneity is established to expedite the optimization design process and enhance the accuracy of the computations.A comparative analysis with a homogeneous TF model reveals that the heterogeneous model improves accuracy by over 12%.Considering factors such as heat load,magnetic-field strength,and cooling conditions,the cooling circuit facing the most severe conditions is selected to calculate the temperature of the *** selection streamlines the workload associated with thermal-hydraulic *** approach enables a more efficient and precise evaluation of the temperature margin of TF ***,it offers insights that can guide the optimization of both the structure and cooling strategy of superconducting magnet systems.

关键词： Superconducting magnet Nuclear heating Neutronics Thermal hydraulics

High dietary methionine induces secondary bile acids dysmetabolism and promotes the development of colorectal cancer in mice

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Food Science and Human Wellness 2024年

作者： Wanhua Li Aiying Shi Xiaoxia Liu Yunhui Zhang Yingshuang lu lu dong Jin Wang Yan Zhang Shuo Wang Tianjin Key Laboratory of Food Science and Health， School of Medicine， Nankai University

Methionine， an essential amino acid， is abundant in animal protein. High dietary methionine intake is associated with the promotion of colorectal cancer (CRC); however， the mechanisms remain unclear. This study aimed to investigate the underlying mechanisms of high dietary methionine promoting CRC and evaluate the effect of high dietary methionine on healthy intestine. Our results demonstrated that high dietary methionine intake exhibited a higher incidence and invasion of tumors in AOM/DSS-induced mice. Meanwhile， the gut microbiota were disturbed， consequently fostering the metabolism of secondary bile acids. The contents of lithocholic acid (LCA) and deoxycholic acid (DCA) significantly increased (P lusion， dysregulation of bile acid metabolism and activation of the corresponding receptor TGR5 were mechanisms promoting CRC associated with high dietary methionine intake.

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Polysaccharides from Chinese herbal medicine: a review on the hepatoprotective and molecular mechanism

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Chinese Journal of Natural Medicines 2024年第01期 4-14页

作者： LI Jifeng GUO Haolin dong Ying YUAN Shuo WEI Xiaotong ZHANG Yuxin dong lu WANG Fei BAI Ting YANG Yong Dalian Key Laboratory of Chronic Disease Research Center Dalian University Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of Education College of Pharmacy Yanbian University

Polysaccharides, predominantly extracted from traditional Chinese medicinal herbs such as Lycium barbarum, Angelica sinensis, Astragalus membranaceus, Dendrobium officinale, Ganoderma lucidum, and Poria cocos, represent principal bioactive constituents extensively utilized in Chinese medicine. These compounds have demonstrated significant anti-inflammatory capabilities,especially anti-liver injury activities, while exhibiting minimal adverse effects. This review summarized recent studies to elucidate the hepatoprotective efficacy and underlying molecular mechanisms of these herbal polysaccharides. It underscored the role of these polysaccharides in regulating hepatic function, enhancing immunological responses, and improving antioxidant capacities, thus contributing to the attenuation of hepatocyte apoptosis and liver protection. Analyses of molecular pathways in these studies revealed the intricate and indispensable functions of traditional Chinese herbal polysaccharides in liver injury management. Therefore, this review provides a thorough examination of the hepatoprotective attributes and molecular mechanisms of these medicinal polysaccharides,thereby offering valuable insights for the advancement of polysaccharide-based therapeutic research and their potential clinical applications in liver disease treatment.

关键词：

Prolonged Consumption of Dietary Advanced Lipoxidation End Products contributes to renal impairment in mice through Dysregulated Intestinal homeostasis

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Food Science and Human Wellness 2024年

作者： Yaya Wang lu dong Yaozhong Hu Tianchang Zhang Ruican Wang Linqing Nie Junping Wang Yan Zhang Shuo Wang Tianjin Key Laboratory of Food Science and Health， School of Medicine， Nankai University State Key Laboratory of Food Nutrition and Safety， Key Laboratory of Food Nutrition and Safety， College of Food Engineering and Biotechnology， Tianjin University of Science and Technology

Heat processing of food has been well validated as the trigger to generate heat-processing side product of advanced lipoxidation end products (ALEs)， which potentially engenders the threat on systemic health or progression of diseases， especially the accumulated effect after long-term intake. Thus， the study was proposed to evaluate the effect of dietary ALEs on health after long-term ingestion， specifically through simulating the intake of dietary ALE in mice within 9 months to investigate the intervention effect and underlying mechanism. The unexpected observation of renal insufficiency or impairment after long-term intake of dietary ALEs indicated the negative impact on renal health， which has been verified by the pathological analysis. Further studies revealed that a high-ALEs diet disrupted the intestinal barrier， with enhanced impact after disturbing the gut microbiota to potentially lower the abundance of beneficial microbiome through producing nephrotoxic metabolites. Correlation analysis showed that the proliferation of harmful bacteria and the reduction of beneficial bacteria were strongly correlated with intestinal barrier damage and the development of renal insufficiency. Furthermore， the underlying mechanism was unveiled as that ALEs could inhibit AMPK/SIRT1 signaling to fundamentally induce renal inflammation and oxidative stress. Thus， it was revealed that long-term intake of dietary ALE could result in renal impairment， and the results emphasized the control or intervention on dietary ALE to decrease to accumulated impairment on systemic health.

关键词：

债务型资本流入、国内信贷周期与汇率制度选择

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金融研究 2024年第5期 1-19页

作者：刘家琳芦东北京化工大学经济管理学院北京102202 中国人民大学财政金融学院北京100872

汇率是全球金融周期与各国国内金融周期联动的纽带。本文基于28个新兴市场经济体数据,研究跨境资本流动与各国国内信贷周期的关系发现:债务型资本(跨国银行资本和债券资本)流入,与国内信贷总体上呈顺周期关系;相比于固定汇率制国家,在... 详细信息

汇率是全球金融周期与各国国内金融周期联动的纽带。本文基于28个新兴市场经济体数据,研究跨境资本流动与各国国内信贷周期的关系发现:债务型资本(跨国银行资本和债券资本)流入,与国内信贷总体上呈顺周期关系;相比于固定汇率制国家,在浮动汇率制国家,跨国银行资本流入与国内信贷的顺周期关系减弱(浮动汇率起到稳定器作用),但债券资本流入与国内信贷的顺周期关系有所增强。进一步分析显示,浮动汇率制能稳定未触发银行危机的“好的”信贷繁荣,但不能抑制以银行危机结束的“坏的”信贷繁荣。浮动汇率制须与加强宏观审慎管理相配合,方可有效降低国内信贷繁荣之后银行危机发生概率。本文可为我国汇率制度选择和系统性金融风险防范提供理论基础和经验依据。

关键词：债务型资本流人国内信贷周期信贷繁荣汇率制度