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Genomes of Meniocus linifolius and Tetracme quadricornis reveal the ancestral karyotype and genomic features of core Brassicaceae

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Plant Communications 2024年第7期5卷 68-89页

作者： jie liu Shi-Zhao Zhou yun-Long liu Bin-Yan Zhao Dongmei Yu Mi-Cai Zhong Xiao-Dong Jiang Wei-Hua Cui Jiu-Xia Zhao Juan Qiu Liang-Min liu Zhen-Hua Guo Hong-Tao Li Dun-Yan Tan Jin-Yong Hu De-Zhu Li CAS Key Laboratory for Plant Diversity and Biogeography of East Asia&yunnan Key Laboratory of Crop Wild Relatives Omics Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Germplasm Bank of Wild Species&yunnan Key Laboratory for Crop Wild Relatives Omics Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China College of Life Sciences Xinjiang Agricultural UniversityÜrümqi 830052China University of Chinese Academy of Sciences Beijing 100049China These authors contributed equally to this article

Brassicaceae represents an important plant family from both a scientific and economic ***,genomic features related to the early diversification of this family have not been fully characterized,especially upon the uplift of the Tibetan Plateau,which was followed by increasing aridity in the Asian interior,intensifying monsoons in Eastern Asia,and significantly fluctuating daily ***,we reveal the genomic architecture that accompanied early Brassicaceae diversification by analyzing two high-quality chromosome-level genomes for Meniocus linifolius(Arabodae;clade D)and Tetracme quadricornis(Hesperodae;clade E),together with genomes representing all major Brassicaceae clades and the basal *** reconstructed an ancestral core Brassicaceae karyotype(CBK)containing 9 pseudochromosomes with 65 conserved syntenic genomic blocks and identified 9702 conserved genes in *** detected pervasive conflicting phylogenomic signals accompanied by widespread ancient hybridization events,which correlate well with the early divergence of core *** identified a successive Brassicaceae-specific expansion of the class I TREHALOSE-6-PHOSPHATE SYNTHASE 1(TPS1)gene family,which encodes enzymes with essential regulatory roles in flowering time and embryo *** TPS1s were mainly randomly amplified,followed by expression *** results provide fresh insights into historical genomic features coupled with Brassicaceae evolution and offer a potential model for broad-scale studies of adaptive radiation under an ever-changing environment.

关键词： Cruciferae genomic features ancient hybridization core Brassicaceae karyotype CBK TREHALOSE-6-PHOSPHATE SYNTHASE 1 genes TPS1s

Caveolin‑1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease

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Military Medical Research 2024年第2期11卷 206-227页

作者： Guang-Hui Deng Chao-Feng Wu yun-Jia Li Hao Shi Wei-Chao Zhong Mu-Keng Hong Jun-jie Li Jia-Min Zhao Chang liu Meng-Chen Qin Zhi-yun Zeng Wei-Min Zhang Ken Kin Lam yung Zhi-Ping Lv Lei Gao Department of Gastroenterology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Department of Hepatology Cancer CenterIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033GuangdongChina Department of Biology Hong Kong Baptist UniversityKowloon TongKowloonHong Kong SAR 999077China

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with disordered lipid and iron *** previous study has substantiated the pivotal role of Caveolin-1(Cav-1)in protecting hepatocytes and mediating iron metabolism in the *** study aimed to explore the specific mechanisms underlying the regulation of iron metabolism by Cav-1 in ***:Hepatocyte-specific Cav-1 overexpression mice and knockout mice were used in this ***-1-knockdown of RAW264.7 cells and mouse primary hepatocytes were performed to verify the changes in ***,a high-fat diet and palmitic acid plus oleic acid treatment were utilized to construct a NAFLD model in vivo and in vitro,respectively,while a high-iron diet was used to construct an in vivo iron overload ***,iron concentration,the expression of Cav-1 and iron metabolism-related proteins in liver tissue or serum were detected using iron assay kit,Prussian blue staining,Western blotting,immunofluorescence staining,immunohistochemical staining and *** related indicators of lipid metabolism and oxidative stress were evaluated by the corresponding reagent kit and ***:Significant disorder of lipid and iron metabolism occurred in *** expression of Cav-1 was decreased in NAFLD hepatocytes(P<0.05),accompanied by iron metabolism ***-1 enhanced the iron storage capacity of hepatocytes by activating the ferritin light chain/ferritin heavy chain pathway in NAFLD,subsequently alleviating the oxidative stress induced by excess ferrous ions in the ***,CD68^(+) CD163^(+) macrophages expressing Cav-1 were found to accelerate iron accumulation in the liver,which was contrary to the effect of Cav-1 in *** correlations were also observed between the serum Cav-1 concentration and the serum iron-related protein levels in NAFLD patients and healthy volunteers(P<0.05).Conclusions:These findings confirm that Cav-1 is an essential target protein that reg

关键词： Caveolin-1 Nonalcoholic fatty liver disease Iron metabolism Ferritin Oxidative stress

MAPK9 as a therapeutic target:unveiling ferroptosis in localized prostate cancer progression

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BIOCELL 2024年第5期48卷 771-792页

作者： CHENG-GONG LUO JIAO ZHANG yun-ZHAO AN XUAN liu SHUAI-jie LI WEI ZHANG KAI LI XU ZHAO DONG-BO YUAN LING-YUE AN WEI CHEN YE TIAN BIN XU Department of Urology Guizhou Provincial People’s HospitalGuiyangChina Department of Urology First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

Background:Ferroptosis,a lipid peroxidation-mediated programmed cell death,is closely linked to tumor development,including prostate cancer(PCa).Despite established connections between ferroptosis and PCa,a comprehensive investigation is essential for understanding its impact on patient ***:A risk model incorporating four ferroptosis-related genes was developed and *** risk scores correlated with an increased likelihood of biochemical recurrence(BCR),diminished immune infiltration,and adverse clinicopathological *** corroborate these results,we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort(TCGA)and the Gene Expression Synthesis Cohort(GEO).Moreover,we conducted further investigations into the pivotal gene identified in our model to explore its impact on tumor characteristics through cell proliferation and invasion assays,as well as animal studies conducted in ***,we conducted further experiments involving ferroptosis-related analysis to validate its association with ***:The risk model demonstrated exceptional predictive capabilities for prognosis and therapeutic outcomes in PCa ***-activated protein kinase 9(MAPK9)emerged as a crucial gene within the *** vivo and in vitro experiments explored MAPK9’s role in ferroptosis and its influence on tumor migration and ***:The findings provide a novel perspective for advancing ferroptosis exploration in PCa,bridging basic research and clinical applications.

关键词： Ferroptosis Biochemical recurrence Prostate cancer TCGA GEO MAPK9

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中文自然语言驱动的自动几何建模方法

计算机集成制造系统 2014年第2期20卷 242-249页

作者：王振伟田野陈丰刘云杰电子科技大学航空航天学院四川成都611731 四川出入境检验检疫局四川成都610018

针对目前几何建模的人机交互能力不足、设计自动化水平不高等问题,提出中文自然语言驱动的自动几何建模方法。首先给出中文自然语言驱动的自动几何建模方法框架,对几何建模意图的自然语言描述与理解方法进行论述,建立了几何建模意图的... 详细信息

针对目前几何建模的人机交互能力不足、设计自动化水平不高等问题,提出中文自然语言驱动的自动几何建模方法。首先给出中文自然语言驱动的自动几何建模方法框架,对几何建模意图的自然语言描述与理解方法进行论述,建立了几何建模意图的自然语言描述规则和几何建模意图表达范式,提出了基于几何要素模式匹配的自然语言规范处理算法;然后阐述了几何要素的数据表达和映射方法,论述了几何要素表达范式的自动推理与建模数据模式识别,并对几何要素的STEP自动映射进行分析,给出几何要素冗余信息的处理过程,从而实现中文自然语言驱动的自动几何建模。通过开发相关的原型系统进行实验研究,验证了所提方法的合理性和可行性。

关键词：自动几何建模中文自然语言设计自动化产品数据表达与交换标准

CFD simulation of pumping ventilation in a three-story isolated building with internal partitioning:Effects of partition widths,heights and locations

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Building Simulation 2024年第2期17卷 267-284页

作者： Huai-Yu Zhong jie Sun Chao Lin Song-Heng Wu Jin Shang Hideki Kikumoto Fu-Ping Qian Carlos Jimenez-Bescos Fu-yun Zhao School of Energy and Environment Anhui University of TechnologyMa-An-ShanAnhui Province243002China State Key Laboratory of Green Building in Western China Xi’an University of Architecture&TechnologyXi’anShaanxi ProvinceChina School of Power and Mechanical Engineering Wuhan UniversityWuhanHubei Province430072China Institute of Industrial Science The University of Tokyo4-6-1 KomabaMeguro-kuTokyo153-8505Japan School of Built and Natural Environment University of DerbyDerbyUK

Pumping ventilation(PV),a special single-sided ventilation(SSV),has been certified as an effective strategy to improve the air exchange rate of ***,most studies targeted on the single space,and few studies have been focused on the effect of internal partitioning on *** paper aims to evaluate the ventilation performance of PV influenced by different configurations of internal *** fluid dynamics(CFD)simulation was used to predict the flow fields and ventilation *** width(w/H),height(h/H)and location(d/H)are the three main internal partition parameters considered in this *** simulation results showed that the total,mean and fluctuating ventilation rates all decrease with wider internal *** normalized total ventilation rate decreases by 7.6%when w/H is increased from 50%to 75%.However,the reduction rate is only 0.23%between w/H=0 and 25%,and only 0.61%between w/H=25%and 50%.The ventilation rate is hardly reduced by increasing the partition width when w/H50%.Increasing the partition height will reduce the mean ventilation rate but promote the fluctuating and total ventilation rate in some *** increase of total ventilation rate by 1.4%is observed from h/H=50%to 75%.The ventilation rate is larger when the internal partition is attached to the leeward or windward *** total,mean and fluctuating ventilation rates for d/H=50%are relatively higher than d/H=0 by 1.5%,3.1%and 0.8%,*** the internal partition should be mounted attached to the windward wall so as to obtain the greatest pumping ventilation *** periodicity of pumping flow oscillation and pumping frequency are independent of the partition *** peak power of pumping flow is the lowest for the widest internal partition and is negatively affected by the partition height,but it generally has a positive correlation with the distance between the partition and leeward wa

关键词： pumping ventilation single-sided ventilation internal partitioning periodic oscillation ventilation rate

Machine-learning-aided Au-based single-atom alloy catalysts discovery for electrochemical NO reduction reaction to NH3

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Rare Metals 2024年第11期 5813-5822页

作者： Hui-Long Jin Qian-Nan Li yun-Yan Tian Shuo-Ao Wang Xing Chen jie-Yu liu Chang-Hong Wang Hebei Provincial Key Laboratory of Information Fusion and Intelligent Control College of EngineeringHebei Normal University Institute of Molecular Plus School of ScienceTianjin University

Direct electrochemical conversion of NO to NH3has attracted widespread interest as a green and sustainable strategy for both ammonia synthesis and nitric oxide ***,designing efficient catalysts remains challenging due to the complex reaction mechanism and competing side ***-atom alloy（SAA） catalysts,which increase the atomic efficiency and the chance to tailor the electronic properties of the active center,have become a frontier in this ***,we performed a systematic screening of transition metal-doped Au SAAs（denoted as TM/Au,TM=Sc,Ti,V,Cr,Mn,Fe,Co,Ni,Cu,Zn,Ru,Rh,Pd,Ag and Pt） to find potential catalysts for electrochemical NO reduction reaction（NORR） to *** employing a four-step screening strategy based on density functional theory（DFT） calculations,Zn/Au SAA has been identified as a promising NORR catalyst due to its superior structural stability,reaction activity and *** electron-involved steps on Zn/Au are thermodynamically spontaneous,which results in a positive limiting potential（UL） of 0.15 *** preferred NO affinity compared to H adatom demonstrates that Zn/Au can effectively suppress the hydrogen evolution ***-learning（ML）investigations were adopted to address the uncertainty between the physicochemical properties of SAAs and the NORR *** applied an extreme gradient boosting regression（XGBR） algorithm to predict the limiting potentials in terms of the intrinsic features of the reaction *** coefficient of determination（R2） is 0.97 for the training set and 0.96 for the test *** electronic structure an alysis combined with a compressed-sensing data-an alytics approach further quantitatively verifies the coeffect of d-band center,charge transfer and the radius of doped TM atoms,i.e.,features with the highest level of importance determined by the XGBR *** work provides a theoretical understanding of the complex NORR to NH3mechanisms and sheds light on the rational desi

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服务定制网络

通信学报 2014年第12期35卷 1-9页

作者：刘韵洁黄韬张娇刘江姚海鹏谢人超北京邮电大学网络与交换国家重点实验室北京100876

针对当前互联网中存在的2个亟待解决的问题:OTT(over the top)流量占用大量网络带宽以及信息高度冗余,提出了一种具有差异化服务能力的未来网络体系架构——服务定制网络(SCN,service customized networking)。SCN基于软件定义网络设计... 详细信息

针对当前互联网中存在的2个亟待解决的问题:OTT(over the top)流量占用大量网络带宽以及信息高度冗余,提出了一种具有差异化服务能力的未来网络体系架构——服务定制网络(SCN,service customized networking)。SCN基于软件定义网络设计,继承了其数据控制分离以及网络可编程的主要特点,并针对当前互联网中的问题,增加了网络虚拟化能力以及内容智能调度能力。通过构建具有不同等级服务能力的虚拟网络,SCN可以避免OTT业务大量占用带宽。同时,通过信息资源智能有序调度,SCN可以消减信息冗余。在小规模真实网络平台上进行的实验结果表明,SCN确实具备为不同用户提供差异化服务能力以及有效减少信息冗余的能力。

关键词：未来网络体系架构服务定制差异化信息冗余网络虚拟化

Spatial construction of ultrasmall Pt-decorated 3D spinel oxidemodified N-doped graphene nanoarchitectures as high-efficiency methanol oxidation electrocatalysts

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Rare Metals 2024年第1期43卷 186-197页

作者： Qi Zhang Min-Min Yan Wen-Fa Du Chen-Yu Yin Jian Zhang Lu Yang yun-Qing Kang Hai-Yan He Hua-jie Huang College of Mechanics and Materials Hohai UniversityNanjing 210098China New Energy Technology Engineering Lab of Jiangsu Province College of ScienceNanjing University of Posts&Telecommunications(NUPT)Nanjing 210023China International Center for Materials Nanoarchitectonics(WPIMANA) National Institute for Materials ScienceTsukuba 305-0044IbarakiJapan

Direct methanol fuel cell technology recently becomes the focus of both academic and engineering circles,which stimulates the exploitation and utilization of advanced electrode catalysts with high activity and long ***,we demonstrate a robust bottom-up approach to the spatial construction of three-dimensional(3D) spinel manganese-cobalt oxide-modified N-doped graphene nanoarchitectures decorated with ultrasmall Pt nanoparticles(Pt/MnCo_(2)O_(4)-NG) via a controllable selfassembly *** incorporation of MnCo_(2)O_(4)nanocrystals provides abundant hydroxyl sources to promote the oxidative removal of CO-like byproducts on Pt sites,while the existence of 3D porous N-doped graphene networks facilitates the transportation of both ions and electrons in the hybrid system,thus giving rise to remarkable synergetic coupling effects during the methanol oxidation ***,the optimized Pt/MnCo_(2)O_(4)-NG nano architecture expres ses exceptional electrocatalytic properties with a large electrochemically active surface area of 99.5 m^(2)·g^(-1),a high mass activity of1508.3 mA·mg^(-1),strong toxicity resistance and reliable long-term durability,which have obvious competitive advantages over those of conventional Pt/carbon black,Pt/carbon nano tube,Pt/graphene,and Pt/N-doped graphene catalysts with the same Pt usage.

关键词： Platinum MnCo_(2)O_(4) 3D graphene Electrocatalysts Methanol oxidation

一种基于逗留时间的新型内容中心网络缓存策略

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计算机学报 2015年第3期38卷 472-482页

作者：王国卿黄韬刘江陈建亚刘韵洁北京邮电大学网络与交换技术国家重点实验室北京100876 北京邮电大学北京市网络体系构建与融合重点实验室北京100876

内容中心网络(Content-Centric Networking,CCN)作为一种以内容为中心进行路由、缓存的新型未来网络体系架构受到了广泛的关注.在CCN中,关键技术问题之一是网络缓存问题,现有方案主要采用ALWAYSLRU缓存策略,然而该策略容易出现相邻节点... 详细信息

内容中心网络(Content-Centric Networking,CCN)作为一种以内容为中心进行路由、缓存的新型未来网络体系架构受到了广泛的关注.在CCN中,关键技术问题之一是网络缓存问题,现有方案主要采用ALWAYSLRU缓存策略,然而该策略容易出现相邻节点重复缓存的问题,使得网络整体缓存效率较低.针对这一问题,文中提出了一种基于逗留时间的新型缓存决定策略,设计了一种适用于CCN的合作缓存机制.在请求泊松到达的假设下,通过在单个缓存器对LRU(Least Recently Used)替换策略使用马尔可夫链建模,该文得到了内容在各缓存器平均逗留时间的近似计算公式.数值仿真结果显示,该方案相比传统缓存策略,有效地提升了网络缓存的效率和缓存内容的多样性,进而减少了用户请求服务的总跳数,增加了内容访问的命中率.

关键词：内容中心网络(CCN) 逗留时间 LRU 未命中率