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Electrochemical chemoselective thiocarbamylation of late-stage Tyr-containing drugs and peptides

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Science China Chemistry 2024年第10期67卷 3382-3388页

作者： Wan-jie Wei Xin-Yu Wang Hai-Tao Tang Fei-Hu Cui yun-Qi Wu Ying-Ming Pan State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)Collaborative Innovation Center for Guangxi Ethnic MedicineSchool of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China

The synthesis and modification of peptides occupy a unique position in the field of drug development,and the functionalization of amino acids is a valuable strategy as an alternative to peptide ***,the development of tyrosine(Tyr)as a target amino acid is a major challenge in the field of ***,we report an electrochemical radical coupling reaction of labeling tyrosine-containing active drugs and peptides with thiocarbamate derivatives for the first *** tri-component,onepot reaction can be performed smoothly under simple,gentle,and clean electrochemical conditions and is suitable for the functionalization of various Tyr-containing drug molecular derivatives and peptides.

关键词： tyrosine electrochemical radical coupling chemical modification peptides

MPDZ variants associated with epilepsies and/or febrile seizures and the individualized genotype-phenotype correlation

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Genes & Diseases 2024年第4期11卷 124-127页

作者： Junxia Luo yun Li Yong Lv Xin Li Bing Qin Chuanfang Cheng Xiaorong liu Weiping Liao jie Wang Zaifen Gao Department of Epilepsy Center Children's Hospital Affiliated to Shandong UniversityJinanShandong 250022China Department of Epilepsy Center Jinan Children's HospitalJinanShandong 250022China Department of Brain Function and Neuroelectrophysiology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Pediatrics The First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)HefeiAnhui 230001China Department of Pediatrics The Second HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250033China Epilepsy Center and Department of Neurosurgery The First Affliated Hospital of Jinan UniversityGuangzhouGuangdong 510630China Department of Cardiology The Second Afiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510260China Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University GuangzhouGuangdong 510260China Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China GuangzhouGuangdong 510260China

The multiple PDZ domain crumbs cell polarity complex component gene(MPDZ;MIM:603785),is highly expressed in the brain across the whole *** encodes the multiple PDZ domain protein,which is a member of the NMDAR signaling complex that may play a role in the control of AMPAR potentiation and synaptic plasticity in excitatory synapses."Previously,MPDZ variants have been demonstrated to be associated with autosomal recessive congenital hydrocephalus-2(HYC2;MIM:615219)which is commonly complicated by brain abnormalities and developmental *** were reported in only one *** association between MPDz and epilepsy requires clarification.

关键词： epilepsy febrile congenital

A whole process damage constitutive model for layered sandstone under uniaxial compression based on Logistic function

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Journal of Central South University 2024年第7期31卷 2411-2430页

作者： liu Dong-qiao GUO yun-peng LING Kai LI jie-yu State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology-BeijingBeijing 100083China School of Mechanics and Civil Engineering China University of Mining and Technology-BeijingBeijing 100083China

Bedding structural planes significantly influence the mechanical properties and stability of engineering rock *** study conducts uniaxial compression tests on layered sandstone with various bedding angles(0°,15°,30°,45°,60°,75°and 90°)to explore the impact of bedding angle on the deformational mechanical response,failure mode,and damage evolution processes of *** develops a damage model based on the Logistic equation derived from the modulus’s degradation considering the combined effect of the sandstone bedding dip angle and *** model is employed to study the damage accumulation state and its evolution within the layered rock *** research also introduces a piecewise constitutive model that considers the initial compaction characteristics to simulate the whole deformation process of layered sandstone under uniaxial *** results revealed that as the bedding angle increases from 0°to 90°,the uniaxial compressive strength and elastic modulus of layered sandstone significantly decrease,slightly increase,and then decline *** corresponding failure modes transition from splitting tensile failure to slipping shear failure and back to splitting tensile *** indicated by the modulus’s degradation,the damage characteristics can be categorized into four stages:initial no damage,damage initiation,damage acceleration,and damage deceleration *** theoretical damage model based on the Logistic equation effectively simulates and predicts the entire damage evolution ***,the theoretical constitutive model curves closely align with the actual stress−strain curves of layered sandstone under uniaxial *** introduced constitutive model is concise,with fewer parameters,a straightforward parameter determination process,and a clear physical *** study offers valuable insights into the theory of layered rock mechanics and holds implications for ensuring the safety of rock engineering.

关键词： layered sandstone uniaxial compression damage evolution Logistic function constitutive model

考虑节点能量消耗的无线传感网络平衡路由算法设计

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科学技术与工程 2022年第1期22卷 277-282页

作者：刘运节包萍宁夏师范学院数学与计算机科学学院固原756000

传统方法设计无线传感网络路由中,往往忽略了节点的能量消耗以及不同节点能耗的差异性,导致出现节点分布不均匀、路由平衡度较差、整体开销成本较大、能耗高等问题。为此,提出了考虑节点能量消耗的无线传感网络平衡路由算法。构建节点... 详细信息

传统方法设计无线传感网络路由中,往往忽略了节点的能量消耗以及不同节点能耗的差异性,导致出现节点分布不均匀、路由平衡度较差、整体开销成本较大、能耗高等问题。为此,提出了考虑节点能量消耗的无线传感网络平衡路由算法。构建节点能耗模型,建立无线传感网络梯度和传感器节点之间的信息素,结合蚁群算法求解整体能耗模型,实现无线传感网络平衡路由的算法设计。实验结果表明,所提方法可提高无线传感网络中节点的均匀分布能力,降低整体能耗开销,减少能量消耗,有效实现无线传感网络平衡路由的算法设计。

关键词：节点能量消耗无线传感网络低能耗路由算法研究蚁群优化算法

Design and fabrication of lightweight AlCrFeNiTi_(x) compositionally complex alloys with exceptional specific strength

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Rare Metals 2024年第7期43卷 3314-3328页

作者： Jun-Zhi Li Wei-Zong Bao jie Chen Bo-Hua Yu Kun Zuo Tian Gao Ze-yun Cai Guo-Qiang Xie School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

This study focuses on compositionally complex alloys(CCAs),aiming to achieve a balance between high strength and low density for new energy and aerospace *** composition of AlCrFeNiTi_(x) CCAs is strategically guided by employing density functional theory and the theoretical design of thermodynamic *** CCAs,particularly AlCrFeNiTi_(0.25) alloy,demonstrate remarkable specific yield strength(1640.8 MPa) and 22.7% maximum *** incorporation of Ti facilitates the formation of lightweight and high-strength L2_(1)phase,contributing to the overall high specific *** effects of grain boundary strengthening,solid solution strengthening,Orowan strengthening and Peierls flow stress further enhance *** exploration of micros tructural changes during fracture reveals the role of ordered phases in suppressing crack propagation and absorbing energy within disordered phases,thereby improving the toughness and fracture resistance of *** methods and discoveries establish a robust foundation for advancing the development of novel lightweight CCAs.

关键词： Lightweight Compositionally complex alloys Specific yield strength

SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-jie Guan Yi-Lin Zhang Zhuo-Er Qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-yun Zhou jie Sheng Lei Zhao yun-Xin Zhu Jing Sun Jincun Zhao Wen-Liang Zhou Nan-Shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

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基于SDN拓扑集中更新的NDN路由策略

北京邮电大学学报 2018年第4期41卷 1-8页

作者：尹弼柏刘江张然黄韬刘韵洁北京邮电大学信息与通信工程学院

基于软件定义网络（SDN）拓扑集中更新的命名数据网络（NDN）路由策略,将路由的2个关键功能分离,拓扑更新功能集中置于SDN控制器中,而路由计算功能分布式地置于NDN内容节点中.同时,对网络拓扑进行负载加权预处理,在考虑网络状态的前提下... 详细信息

基于软件定义网络（SDN）拓扑集中更新的命名数据网络（NDN）路由策略,将路由的2个关键功能分离,拓扑更新功能集中置于SDN控制器中,而路由计算功能分布式地置于NDN内容节点中.同时,对网络拓扑进行负载加权预处理,在考虑网络状态的前提下,可优化路由计算.仿真结果表明,在基于SDN拓扑集中更新的NDN路由策略中,内容请求数据流的首包时延平均降低了90%,SDN控制器的负荷平均降低了10%~30%,全网实现了有效的负载均衡.

关键词：软件定义网络命名数据网络拓扑更新路由计算

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基于内容轨迹的内容中心网络多径路由策略

北京邮电大学学报 2014年第3期37卷 98-103页

作者：张岩黄韬刘江陈建亚刘韵洁北京邮电大学网络与交换技术国家重点实验室北京100876 北京邮电大学网络体系构建与融合北京市重点实验室北京100876

内容中心网络路由的研究主要关注利用转发信息库端口来获取到达服务器的最优路径,路由路径外的节点缓存中内容无法得到充分利用.而利用多个转发信息库端口的多径路由虽可对缓存充分利用,但会带来冗余传输.针对这些问题,提出了一种基于... 详细信息

内容中心网络路由的研究主要关注利用转发信息库端口来获取到达服务器的最优路径,路由路径外的节点缓存中内容无法得到充分利用.而利用多个转发信息库端口的多径路由虽可对缓存充分利用,但会带来冗余传输.针对这些问题,提出了一种基于内容轨迹的多径路由策略,利用内容轨迹将兴趣报文引导至原有路由表路径外的缓存处,使兴趣报文在到达服务器前搜索更多缓存,增加网内缓存命中率,减小服务器负载和兴趣报文平均跳数,并将多径路由冗余控制在一定范围内.仿真结果表明,基于内容轨迹的多径路由策略相对现有策略服务器负载降低约10%,且在服务器较远的场景下可有效降低请求平均跳数.相对于单径路由,基于内容轨迹的多径路由策略将网内缓存命中率提升了约20%;相对于多径路由冗余降低10%以上,且具有相近的网内缓存命中率.

关键词：内容中心网络多路径路由内容轨迹多径搜索表

Analysis on health information extracted from an urban professional population in Beijing

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Chinese Medical Journal 2011年第2期000卷 189-193页

作者： ZHANG Tie-mei ZHU Ling LUO Sen-lin HAN Yi-wen ZHANG Yan YANG Shu-wen liu An-nan MA Lan-jun ZHAO Yan-yan liu Bin JIA Hong-bo liu yun-jie Beijing Hospital Beijing 100730 China Beijing Institute of Technology Beijing 100730 China Beijing Institute of Geriatrics Ministry of Health Beijing 100730 China

Background The assembled data from a population could provide information on health trends within the *** aim of this research was to extract and know basic health information from an urban professional population in *** Data analysis was carried out in a population who underwent a routine medical check-up and aged 〉20 years,including 30 058 *** information,data from physical examinations and blood samples were collected in the same *** health status was separated into three groups by the criteria generated in this study,i.e.,people with common chronic diseases,people in a sub-clinic situation,and healthy *** proportion of both common diseases suffered and health risk distribution of different age groups were also *** The proportion of people with common chronic diseases,in the sub-clinic group and in the healthy group was 28.6%,67.8% and 3.6% *** were significant differences in the health situation in different age *** was on the top of list of self-reported *** proportion of chronic diseases increased significantly in people after 35 years of ***,the proportion of sub-clinic conditions was decreasing at the same *** complex risk factors to health in this population were metabolic disturbances （61.3%）,risk for tumor （2.7%）,abnormal results of morphological examination （8.2%） and abnormal results of lab tests of serum （27.8%）.Conclusions Health information could be extracted from a complex data set from the heath check-ups of the general *** information should be applied to support prevention and control chronic diseases as well as for directing intervention for patients with risk factors for disease.

关键词： routine health check-up health assessment physical examination