检索结果-南通市图书馆

China Ocean Engineering 2024年第2期38卷 233-246页

作者： DING Xin-dong WANG Shu-qing liu wen-cheng YE Xiao-han College of Engineering Ocean University of ChinaQingdao 266100China Shandong Provincial Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao 266100China Department of Marine Technology Norwegian University of Science and Technology(NTNU)Trondheim NO-7491Norway

The collapse pressure is a key parameter when RTPs are applied in harsh deep-water *** investigate the collapse of RTPs,numerical simulations and hydrostatic pressure tests are *** the numerical simulations,the eigenvalue analysis and Riks analysis are combined,in which the Hashin failure criterion and fracture energy stiffness degradation model are used to simulate the progressive failure of composites,and the“infinite”boundary conditions are applied to eliminate the boundary *** for the hydrostatic pressure tests,RTP specimens were placed in a hydrostatic chamber after filled with *** has been observed that the cross-section of the middle part collapses when it reaches the maximum *** collapse pressure obtained from the numerical simulations agrees well with that in the ***,the applicability of NASA SP-8007 formula on the collapse pressure prediction was also *** has a relatively greater difference because of the ignorance of the progressive failure of *** the parametric study,it is found that RTPs have much higher first-ply-failure pressure when the winding angles are between 50°and 70°.Besides,the effect of debonding and initial ovality,and the contribution of the liner and coating are also discussed.

关键词： reinforced thermoplastic pipes post-buckling behavior progressive failure of composites debonding initial ovality

Reduction of Plasma MicroRNA-21 is Associated with Chemotherapeutic Response in Patients with Non-small Cell Lung Cancer

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2011年第2期23卷 123-128页

作者： Juan Wei Lian-ke liu wen Gao cheng-jun Zhu Yi-qian liu Ting cheng Yong-qian Shu Department of Oncology the First Affiliated Hospital Nanjing Medical University Nanjing 210029 China

Objective： To examine plasma microRNA-21 （miR-21） level in patients with non-small cell lung cancer （NSCLC） and its potential correlation with chemotherapeutic response. Methods： 77 NSCLC patients and 36 age and sex-matched healthy controls were included. Plasma miR-21 concentration was examined using a quantitative real-time reverse transcription polymerase chain reaction assay （qRT-PCR）. Potential correlation between plasma mir-21 concentrations with chemotherapeutic responses was analyzed in 35 patients with advanced NSCLC （stages IIIB and IV）. Results： Plasma miR-21 was significantly higher in NSCLC patients relative to the healthy controls （P0.0001）. As a biomarker, plasma mir-21 had a receiver operating characteristic （ROC） curve area of 0.729 with 61.04% sensitivity and 83.33% specificity. Chemotherapeutic response in the 35 patients with advanced NSCLC （stages IIIB and IV） included partial response （PR）（n=11）, stable disease and progression disease （SD＋PD）（n=24）. The overall response rate （CR＋PR） was 31.4%. Plasma miR-21 in patients who achieved PR was significantly lower than those who did not respond （SD＋PD）（P=0.0487）, and comparable to that of the healthy controls （P=0.2744）. Conclusion： Plasma miR-21 is a good biomarker for NSCLC, and could be used to predict responses to chemotherapy.

关键词： NSCLC miR-21 Biomarker Plasma Chemotherapeutic response

Expression of p53 and CD44 in Canine Breast Tumor

在线全文

学校读者我要写书评

暂无评论

Journal of Northeast Agricultural University(English Edition) 2008年第3期15卷 25-30页

作者： liu Yun CUI wen cheng Xi FENG Xinchang College of Veterinary Medicine Northeast Agricultural University Harbin 150030 China

The p53 and CD44 expression of 10 cases in canine breast tumor were examined utilizing immunohistochemical assay with rabbit anti-mouse polyclonal antibodies against p53 or CD44, respectively. The p53 expression was significantly higher in malignant than in benign breast tumor. The expression of CD44 was not significantly different in malignant breast cancer and benign breast tumor. This suggests that p53 can be used as an indicator for animal prognosis.

关键词： canine breast tumor p53 CD44

Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： Wei Xiong Xuan Ye Hongzhang cheng Xiaoming liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

城市轨道交通车辆基地工程接口管理探讨

铁道工程学报 2012年第2期29卷 78-85页

作者：刘成文中铁第四勘察设计院集团有限公司武汉430063

研究目的:轨道交通车辆段与综合基地是综合性极强,牵涉专业、部门、系统众多、接口关系纵横交错的市政工程之一,不同设计阶段,接口重点不同,如何把握关键接口、理顺接口关系,对整体工程质量、工程投资和建设工期有着重大影响。本文通过... 详细信息

研究目的:轨道交通车辆段与综合基地是综合性极强,牵涉专业、部门、系统众多、接口关系纵横交错的市政工程之一,不同设计阶段,接口重点不同,如何把握关键接口、理顺接口关系,对整体工程质量、工程投资和建设工期有着重大影响。本文通过分析车辆基地工程特点,工程建设参与方相互关系,结合各设计阶段研究目标,以设计阶段为轴线,分析梳理各设计阶段对工程有重大影响的主要接口内容、接口目的、接口执行方式,提出了车辆基地接口管理流程和主要技术接口风险及防范措施。研究结论:轨道交通车辆基地项目设计,应根据各设计阶段研究目的,车辆基地工程对应设计阶段应达到的目标,重视接口清理、理顺接口关系、明确接口标准、抓住接口重点,把握接口风险防范措施。

关键词：轨道交通车辆基地接口管理

Observation of topological charge transformations in acoustic vortex using passive periodic systems

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie liu Changqing Xu Da-Jian Wu Ying cheng Xiao-Jun liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong wen Minna liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

在线全文

学校读者我要写书评

暂无评论

一起机械故障导致的公交车火灾的调查

消防科学与技术 2021年第4期40卷 602-604页

作者：刘文成哈尔滨市消防救援支队火调技术处黑龙江哈尔滨150040

介绍了一起公交车火灾事故的调查,通过现场勘验、调查询问、综合分析等手段,认定起火原因为机械故障导致天然气泄漏,遇撞击或电线短路产生的火花引起火灾。从火灾调查入手,介绍了天然气公交车火灾的调查过程,总结办案经验与体会,对天然... 详细信息

介绍了一起公交车火灾事故的调查,通过现场勘验、调查询问、综合分析等手段,认定起火原因为机械故障导致天然气泄漏,遇撞击或电线短路产生的火花引起火灾。从火灾调查入手,介绍了天然气公交车火灾的调查过程,总结办案经验与体会,对天然气车辆火灾的办理起指导作用。

关键词：火灾调查天然气公交车机械故障

在线全文

学校读者我要写书评

暂无评论

一起重大火灾的调查和刑事案件办理

消防科学与技术 2018年第8期37卷 1155-1158页

作者：刘文成哈尔滨市消防支队黑龙江哈尔滨150040

介绍一起重大火灾的调查和刑事案件办理,通过现场勘验、调查询问、现场指认等手段,认定起火原因为私接电线,违章使用电暖器导致违章敷设的电气线路超负荷过热引燃周围可燃物引发火灾。从火灾调查入手,介绍消防责任事故案的办理过程,分... 详细信息

介绍一起重大火灾的调查和刑事案件办理,通过现场勘验、调查询问、现场指认等手段,认定起火原因为私接电线,违章使用电暖器导致违章敷设的电气线路超负荷过热引燃周围可燃物引发火灾。从火灾调查入手,介绍消防责任事故案的办理过程,分析办案经验与体会,对火灾刑事案件的办理起指导作用。

关键词：火灾调查消防责任事故消防刑事案件

Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou cheng Qing Zhao Mengjie Tao Jijun Du Xingxi Huang chengjun liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction