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Combining lymph node ratio to develop prognostic models for postoperative gastric neuroendocrine neoplasm patients

World Journal of Gastrointestinal Oncology 2024年第8期16卷 3507-3520页

作者： wen liu Hong-Yu Wu Jia-Xi Lin Shu-Ting Qu Yi-Jie Gu Jin-Zhou Zhu Chun-Fang Xu Department of Gastroenterology Changzhou Hospital of Traditional Chinese MedicineChangzhou 213000Jiangsu ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Gastroenterology Suzhou Ninth Hospital Affiliated to Soochow UniversitySuzhou 215200Jiangsu ProvinceChina

BACKGROUND Lymph node ratio(LNR)was demonstrated to play a crucial role in the prognosis of many ***,research concerning the prognostic value of LNR in postoperative gastric neuroendocrine neoplasm(NEN)patients was *** To explore the prognostic value of LNR in postoperative gastric NEN patients and to combine LNR to develop prognostic *** A total of 286 patients from the Surveillance,Epidemiology,and End Results database were divided into the training set and validation set at a ratio of 8:2.92 patients from the First Affiliated Hospital of Soochow University in China were designated as a test *** regression analysis was used to explore the relationship between LNR and disease-specific survival(DSS)of gastric NEN *** survival forest(RSF)algorithm and Cox proportional hazards(CoxPH)analysis were applied to develop models to predict DSS respectively,and compared with the 8th edition American Joint Committee on Cancer(AJCC)tumornode-metastasis(TNM)*** Multivariate analyses indicated that LNR was an independent prognostic factor for postoperative gastric NEN patients and a higher LNR was accompanied by a higher risk of *** RSF model exhibited the best performance in predicting DSS,with the C-index in the test set being 0.769[95%confidence interval(CI):0.691-0.846]outperforming the CoxPH model(0.744,95%CI:0.665-0.822)and the 8th edition AJCC TNM staging(0.723,95%CI:0.613-0.833).The calibration curves and decision curve analysis(DCA)demonstrated the RSF model had good calibration and clinical ***,the RSF model could perform risk stratification and individual prognosis prediction *** A higher LNR indicated a lower DSS in postoperative gastric NEN *** RSF model outperformed the CoxPH model and the 8th edition AJCC TNM staging in the test set,showing potential in clinical practice.

关键词： Gastric neuroendocrine neoplasm Lymph node ratio Disease-specific survival Random survival forest Predictive model

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Pien Tze Huang Inhibits Migration and Invasion of Hepatocellular Carcinoma Cells by Repressing PDGFRB/YAP/CCN2 Axis Activity

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Chinese Journal of Integrative Medicine 2024年第2期30卷 115-124页

作者： LUO Zhi-yi TIAN Qi CHENG Niang-mei liu wen-han YANG Ye CHEN Wei ZHANG Xiang-zhi ZHENG Xiao-yuan CHEN Ming-sheng ZHUANG Qiu-yu ZHAO Bi-xing liu Cong-sheng liu Xiao-long LI Qin WANG Ying-chao The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development Zhangzhou Pien Tze Huang Pharmaceutical Co.Ltd.ZhangzhouFujian Province(363099)China College of Biological Science and Engineering and Mengchao Med-X Center Fuzhou UniversityFuzhou(350116)China Department of Internal Medicine Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China

Objective:To investigate the effects of Pien Tze Huang(PZH) on the migration and invasion of HCC cells and underlying molecular ***:Cell counting kit-8(CCK-8) was applied to evaluate the cell viabilities of SMMC-7721,SK-Hep-1,C3A and HL-7702(6 × 10^(3)cells/well) co-incubated with different concentrations of PZH(0,0.2,0.4,0.6,0.8 mg/mL) for 24 ***,wound healing assay,CCK-8and Annexin V-FITC/PI staining were conducted to investigate the effects of PZH on the migration,invasion,proliferation and apoptosis of SK-Hep-1 and SMMC-7721 cells(650 μg/mL for SK-Hep-1 cells and 330 μg/mL for SMMC-7721 cells),*** vivo,lung metastasis mouse model constructed by tail vein injection of HCC cells was used for evaluating the anti-metastasis function of ***-Hep-1 cells(10^(6)cells/200 μL per mice) were injected into B-NDG mice via tail *** 8 mice were randomly divided into PZH and control groups,4 mice in each *** 2-d inoculation,mice in the PZH group were administered with PZH(250 mg/kg,daily) and mice in the control group received only vehicle(PBS) from the 2nd day after xenograft to day *** analysis based on RNA-seq was subsequently used for deciphering anti-tumor mechanism of *** real-time polymerase chain reaction(qRT-PCR) and Western blot were applied to verify RNA-seq *** reporter assay was performed to examine the transcriptional activity of yes-associated protein(YAP).Results:PZH treatment significantly inhibited the migration,invasion,proliferation and promoted the apoptosis of HCC cells in vitro and in vivo(P<0.01).Transcriptome analysis indicated that Hippo signaling pathway was associated with anti-metastasis function of *** study showed PZH significantly inhibited the expressions of platelet derived growth factor receptor beta(PDGFRB),YAP,connective tissue growth factor(CCN2),N-cadherin,vimentin and matrix metallopeptidase 2(MMP2,P<0.01).Meanwhile,the phosphorylatio

关键词： PienTzeHuang hepatocellular carcinoma RNA-seq Hippo yes-associated protein

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我国木质家具制造行业VOCs排放特征及环境影响

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环境科学 2024年第8期45卷 4470-4483页

作者：刘文文邵霞滕巍北京市生态环境保护科学研究院国家城市环境污染控制工程技术研究中心城市大气挥发性有机物污染防治技术与应用北京市重点实验室北京100037 生态环境部环境工程评估中心北京100012

为研究木质家具制造行业挥发性有机化合物(VOCs)排放特征及其环境影响,选取9家典型的木质家具制造企业,对其涂装工序排气筒废气进行样品采集和VOCs检测,并通过最大增量反应活性法(MIR)和二次有机气溶胶(SOA)生成潜势法量化其对臭氧(O_(... 详细信息

为研究木质家具制造行业挥发性有机化合物(VOCs)排放特征及其环境影响,选取9家典型的木质家具制造企业,对其涂装工序排气筒废气进行样品采集和VOCs检测,并通过最大增量反应活性法(MIR)和二次有机气溶胶(SOA)生成潜势法量化其对臭氧(O_(3))和SOA的生成贡献.结果表明:①不同类型涂料排气筒VOCs排放浓度差异较大,溶剂型涂料排气筒VOCs排放浓度显著高于水性涂料和辐射固化(UV)涂料排气筒废气VOCs排放浓度,其ρ(VOCs)范围分别为2.82~155.37、1.13~104.45和0.57~1.15 mg·m^(-3);②溶剂型涂料排气筒废气中VOCs以酯类为主,质量分数高达45.88%,质量分数最高的VOCs物种为乙酸丁酯(31.07%);水性涂料和UV涂料排气筒废气中VOCs均以醇类为主,质量分数分别为47.04%和35.10%,且质量分数最高的VOCs物种均为乙醇,质量分数分别为46.63%和34.32%;③溶剂型涂料、水性涂料和UV涂料排气筒排放VOCs的OFP值分别为149.23、50.90和1.87 mg·m^(-3),不同类型涂料排气筒OFP的首要贡献组分分别为间/对-二甲苯(26.61%)、乙醇(36.35%)和乙醇(23.98%);④溶剂型涂料、水性涂料和UV涂料排气筒排放VOCs的SOA值分别为0.76、0.25和0.01 mg·m^(-3),对SOA生成贡献率最高的VOCs组分均为芳香烃(96.35%~98.96%),关键活性物种为甲苯、乙苯和二甲苯;(5)将溶剂型涂料、水性涂料和UV涂料排气筒废气对环境影响进行比较,发现溶剂型涂料排气筒排放的VOCs所产生的OFP与SOA远高于水性涂料和UV涂料,从源头上采用水性涂料和UV涂料替代溶剂型涂料可以大幅度降低VOCs排放浓度,并减少OFP和SOA的生成.

关键词：木质家具制造行业挥发性有机化合物(VOCs) 涂料类型排放特征环境影响

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Chinese Guidelines for the Diagnosis and Management of Atrial Fibrillation

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Journal of Geriatric Cardiology 2024年第3期21卷 251-314页

作者： Chang-Sheng MA Shu-Lin WU Shao-wen liu Ya-Ling HAN Chinese Society of Cardiology Chinese Medical Association Heart Rhythm Committee of Chinese Society of Biomedical Engineering Beijing Anzhen Hospital Capital Medical University Guandong Provincial People’s Hospital Shanghai First People’s Hospital General Hospital of Northern Theater Command 不详

Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,significantly impacting patients’quality of life and increasing the risk of death,stroke,heart failure,and *** the past two decades,there have been significant breakthroughs in AF risk prediction and screening,stroke prevention,rhythm control,catheter ablation,and integrated *** this period,the scale,quality,and experience of AF management in China have greatly improved,providing a solid foundation for the development of guidelines for the diagnosis and management of *** further promote standardized AF management,and apply new technologies and concepts to clinical practice in a timely and comprehensive manner,the Chinese Society of Cardiology of the Chinese Medical Association and the Heart Rhythm Committee of the Chinese Society of Biomedical Engineering have jointly developed the Chinese Guidelines for the Diagnosis and Management of Atrial *** guidelines have comprehensively elaborated on various aspects of AF management and proposed the CHA2DS2-VASc-60 stroke risk score based on the characteristics of AF in the Asian *** guidelines have also reevaluated the clinical application of AF screening,emphasized the significance of early rhythm control,and highlighted the central role of catheter ablation in rhythm control.

关键词： prevention sustained diagnosis

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Vascular Calcification:Where is the Cure?

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Chinese Medical Sciences Journal 2024年第3期39卷 203-216页

作者： wen-wen liu Mei-Lin liu Department of Geriatrics Peking University First HospitalBeijing 100034China

With the progress of aging,the incidence of vascular calcification(VC)gradually increases,which is correlated with cardiovascular events and all-cause death,aggravating global clinical *** the past several decades,accumulating approaches targeting the underlying pathogenesis of VC have provided some possibilities for the treatment of ***,none of the current interventions have achieved clinical effectiveness on reversing or curing *** purpose of this review is to make a summary of novel perspectives on the interventions of VC and provide reference for clinical decision-making.

关键词： vascular calcification clinical pathophysiology therapeutic strategies novel findings

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刘文娥治疗月经病常用药对经验

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吉林中医药 2024年第7期44卷 789-792页

作者：谭梦晨刘文娥湖南中医药大学长沙410208 湖南中医药大学第一附属医院长沙410007

月经病是女性的多发病,女性大部分疾病都会影响月经,包括经期、经量、经色、经质伴随症状等多个方面。刘文娥运用中药药对治疗多囊卵巢综合征、子宫内膜息肉、子宫肌瘤等疾病导致的月经异常时,随证加减,灵活调用,精当实效。总结刘文娥... 详细信息

月经病是女性的多发病,女性大部分疾病都会影响月经,包括经期、经量、经色、经质伴随症状等多个方面。刘文娥运用中药药对治疗多囊卵巢综合征、子宫内膜息肉、子宫肌瘤等疾病导致的月经异常时,随证加减,灵活调用,精当实效。总结刘文娥治疗月经病常用药对经验,以期为中医药治疗月经病提供新思路。

关键词：月经病药对经期延长痛经

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Investigating the impact of dynamic structural changes of Au/rutile catalysts on the catalytic activity of CO oxidation

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Carbon Energy 2024年第4期6卷 222-232页

作者： Xiaochun Hu Qianwenhao Fan Mingwu Tan Yuqing Luo Xianyue Wu Manoel Y.Manuputty Jie Ding Tej S.Choksi Markus Kraft Rong Xu Zhiqiang Sun wen liu School of Energy Science and Engineering Central South UniversityChangshaChina School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingaporeSingapore Cambridge Centre for Advanced Research and Education SingaporeSingapore Institute of Sustainability for Chemicals Energy and EnvironmentJurong IslandSingapore College of Chemistry and Chemical Engineering Central South UniversityChangshaChina Department of Chemical Engineering and Biotechnology University of CambridgeCambridgeUK

The surface properties of oxidic supports and their interaction with the supported metals play critical roles in governing the catalytic activities of oxide‐supported metal *** metals are supported on reducible oxides,dynamic surface reconstruction phenomena,including strong metal–support interaction(SMSI)and oxygen vacancy formation,complicate the determination of the structural–functional relationship at the active ***,we performed a systematic investigation of the dynamic behavior of Au nanocatalysts supported on flame‐synthesized TiO_(2),which takes predominantly a rutile phase,using CO oxidation above room temperature as a probe *** analysis conclusively elucidated a negative correlation between the catalytic activity of Au/TiO_(2) and the oxygen vacancy at the Au/TiO_(2) *** the reversible formation and retracting of SMSI overlayers have been ubiquitously observed on Au/TiO_(2) samples,the catalytic consequence of SMSI remains *** functional theory suggests that the electron transfer from TiO_(2) to Au is correlated to the presence of the interfacial oxygen vacancies,retarding the catalytic activation of CO oxidation.

关键词： CO oxidation electronic metal-support interactions flame‐synthesis metal-support interactions oxygen vacancy strong metal-support interaction

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岷江上游热务沟藏族多声部民歌的术语、分类与传承组织探析

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中国音乐 2024年第1期 81-90页

作者：刘雯四川音乐学院

岷江上游热务沟藏族多声部民歌分为“敬、唱、跳、念”四类,溯源性音乐术语凸显出热务沟藏人的有序传习与寻“根”意识,其唱法主要分为“策过鲁”与“涅些过鲁”两种。较为固定的歌师家族和“鲁达、鲁莎”的年龄组织是多声部民歌传承至... 详细信息

岷江上游热务沟藏族多声部民歌分为“敬、唱、跳、念”四类,溯源性音乐术语凸显出热务沟藏人的有序传习与寻“根”意识,其唱法主要分为“策过鲁”与“涅些过鲁”两种。较为固定的歌师家族和“鲁达、鲁莎”的年龄组织是多声部民歌传承至今的重要保障。岷江上游热务沟藏族多声部民歌具有驱邪祈福功能的歌声与唱词反映了藏人神圣的多声歌唱观念,歌师运用所学知识创造出文字谱,折射出热务沟藏族多声部民歌传承从口头传承转向口头与书写传承并驾的传承模式。

关键词：多声部民歌藏族传承

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沈约诗文创作与《维摩诘经》

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世界宗教文化 2024年第1期 173-180页

作者：刘雯四川大学中国俗文化研究所

本文通过对沈约与《维摩诘经》关系的考察,讨论了该经对沈约诗文创作的影响,认为:南齐时期,沈约在萧子良弘法的背景之下,得以接触《维摩诘经》,并在诗文中运用该经典故,有将法华一乘思想与维摩不二法门相结合的特征。梁武帝时期,沈约进... 详细信息

本文通过对沈约与《维摩诘经》关系的考察,讨论了该经对沈约诗文创作的影响,认为:南齐时期,沈约在萧子良弘法的背景之下,得以接触《维摩诘经》,并在诗文中运用该经典故,有将法华一乘思想与维摩不二法门相结合的特征。梁武帝时期,沈约进一步研习该经,《维摩诘经》所述是身无常、方便法门等义理成为这一时期沈约佛教诗文思想的重要来源之一,沈约于晚年所作《忏悔文》表现了该经示罪性空、直心忏悔的忏罪思想。

关键词：沈约《维摩诘经》《忏悔文》

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Label-Aware Chinese Event Detection with Heterogeneous Graph Attention Network

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Journal of Computer Science & Technology 2024年第1期39卷 227-242页

作者：崔诗尧郁博文从鑫柳厅文谭庆丰时金桥 Institute of Information Engineering Chinese Academy of SciencesBeijing 100190China School of Cyber Security University of Chinese Academy of SciencesBeijing 100049China Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhou 510006China School of Cyber Security Beijing University of Posts and TelecommunicationsBeijing 100088China

Event detection(ED)seeks to recognize event triggers and classify them into the predefined event *** ED is formulated as a character-level task owing to the uncertain word *** methods try to incorpo-rate word-level information into characters to enhance their ***,they experience two ***,they fail to incorporate word-level information into each character the word encompasses,causing the insufficient word-charac-ter interaction ***,they struggle to distinguish events of similar types with limited annotated instances,which is called the event confusing *** paper proposes a novel model named Label-Aware Heterogeneous Graph Attention Network(L-HGAT)to address these two ***,we first build a heterogeneous graph of two node types and three edge types to maximally preserve word-character interactions,and then deploy a heterogeneous graph attention network to enhance the semantic propagation between characters and ***,we design a pushing-away game to enlarge the predicting gap between the ground-truth event type and its confusing counterpart for each *** results show that our L-HGAT model consistently achieves superior performance over prior competitive methods.

关键词： Chinese event detection heterogeneous graph attention network(HGAT) label embedding

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