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Clinical characteristics and impactof comorbidities on the prognosis of senileepilepsy in Southwest China:a retrospectivecohort study

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Acta Epileptologica 2024年第2期7卷 100-109页

作者： Zhen Cao Yinping Li shengyi liu Zihua He Jinmei Li Department of Neurology West China HospitalSichuan UniversityChengdu 610041China Department of Geriatric The Second People’s Hospital of YibinYibin 644000China Department of Neurology Chengdu Shangjin Nanfu HospitalChengdu 610000China

Background Senile epilepsy and its comorbidities pose a tremendous burden on patients and the *** was aimed to investigate the clinical characteristics and comorbidities of senile epilepsy,as well as the impactof comorbidities on the prognosis of senile *** Information of patients with senile epilepsy was retrospectively collected from three tertiary hospitalsin Southwest China between December 2014 and December 2022.A total of 154 patients met the inclusion criteriaand were divided into two groups based on the presence or absence of *** prevalence,type,charac-teristics,and impacts of the comorbidities were *** characteristics of patients with and without comor-bidities were also *** Eighty-one percent of patients with senile epilepsy had at least one comorbidity,and 36%had three or *** different types of comorbidities were *** most common comorbidities were neu-rological(61%),followed by cardiovascular(45%)and psychiatric(26%)*** than one-third of patientshad bidirectional comorbidities,whereas more than half of the patients had additional causal *** types of comorbidities,neurological and psychiatric comorbidities were found to be associated with an increasedrisk of recurrent *** to patients without bidirectional comorbidities,those with at least one bidirec-tional comorbidity had a lower rate of achieving seizure *** higher the number of bidirectional comor-bidities,the lower the seizure-free *** analysis revealed that patients with neurological comorbidities hada higher risk of *** This study revealed a high comorbidity rate and a low seizure-freedom rate among patients with *** particular,neuropsychiatric comorbidities can increase the risk of seizures and affect the survival rateof patients with senile ***,preventing and managing these comorbidities may

关键词： Senile epilepsy Elderly Epilepsy Comorbidity Prognosis

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Chromosome-scale genome assembly-assisted identification of Brassica napus BnDCPA1 for improvement of plant architecture and yield heterosis

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Plant Communications 2024年第7期5卷 1-4页

作者： Chuanji Zhao Xiaobo Cui Meili Xie Yi Zhang Lingyi Zeng Yueying liu Junyan Huang Xiong Zhang Chaobo Tong Qiong Hu Lijiang liu shengyi liu Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences Key Laboratory of Biology and Genetic Improvement of Oil CropsMinistry of Agriculture and Rural AffairsWuhanChina These authors contributed equally to this article

Plant architecture can act as a pivotal determinant of crop yield by maximizing photosynthate accumulation in grains,but no *** rapeseed ideotype has yet been ***,semi-dwarf and compact(SDC)rapeseed plant types with the capacity to maximize silique number per hectare and seed weight per silique are expected to optimize plant architecture for groundbreaking seed yield,avoiding lodging and promoting mechanical harvest(liu et al.,2022).In this study,we report the mutant dc1,which exhibits DC plant architecture with significantly increased silique number in the main inflorescence compared with currently cultivated high and loose(HL)plant types like those of elite cultivars(Figure 1A and Supplemental Figure 1).

关键词： elite cultivar dwarf

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石菖蒲林下生态栽培技术

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安徽林业科技 2024年第4期50卷 49-51页

作者：何胜前刘盛益霍山县太平畈乡林业工作站安徽六安237200 霍山县林业局安徽六安237200

石菖蒲不仅具有较高的药用价值,还可制作室内盆景,与兰花、菊花、水仙并列为“花中四雅”,市场前景广阔。本文从林地选择、种苗繁育、苗株移栽、生长期管理、病虫害防治、采收加工及采收后管理等方面介绍了石菖蒲林下栽培技术要点,以期... 详细信息

石菖蒲不仅具有较高的药用价值,还可制作室内盆景,与兰花、菊花、水仙并列为“花中四雅”,市场前景广阔。本文从林地选择、种苗繁育、苗株移栽、生长期管理、病虫害防治、采收加工及采收后管理等方面介绍了石菖蒲林下栽培技术要点,以期为石菖蒲林下栽培提供参考。

关键词：石菖蒲种苗繁育林下栽培

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New multi-UAV formation keeping method based on improved artificial potential field

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Chinese Journal of Aeronautics 2023年第11期36卷 249-270页

作者： Hanlin SHENG Jie ZHANG Zongyuan YAN Bingxiong YIN shengyi liu Tingting Bai Daobo WANG College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Formation keeping is important for multiple Unmanned Aerial Vehicles(multi-UAV)to fully play their roles in cooperative combats and improve their mission success ***,in practical applications,it is difficult to achieve formation keeping precisely and obstacle avoidance autonomously at the same *** paper proposes a joint control method based on robust H∞ controller and improved Artificial Potential Field(APF)***,we build a formation flight model based on the “Leader-Follower”structure and design a robust H∞ controller with three channels X,Y and Z to eliminate dynamic uncertainties,so as to realize high-precision formation ***,to fulfill obstacle avoidance efficiently in complex situations where UAVs fly at high speed with high inertia,this paper comes up with the improved APF method with deformation factor *** judgment criterion is proposed and applied to ensure flight *** the end,the simulation results show that the designed controller is effective with the formation keeping a high accuracy and in the meantime,it enables UAVs to avoid obstacles autonomously and recover the formation rapidly when coming close to ***,the method proposed here boasts good engineering application prospect.

关键词： Formation flight Artificial potential field(APF) Multi-UAV Trajectory planning Flight control systems

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De novo design of future rapeseed crops:Challenges and opportunities

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The Crop Journal 2022年第3期10卷 587-596页

作者： shengyi liu Harsh Raman Yang Xiang Chuanji Zhao Junyan Huang Yuanyuan Zhang Key Laboratory of Biology and Genetic Improvement of Oil Crops the Ministry of Agriculture and Rural AffairsOil Crops Research InstituteChinese Academy of Agricultural SciencesWuhan 430062HubeiChina NSW Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNSW 2650Australia Guizhou Rapeseed Institute Guizhou Academy of Agricultural SciencesGuiyang 550008GuizhouChina

To address the global demand for rapeseed while considering farmers’profit,we face the challenges of making a quantum leap in seed yield and,at the same time,reducing yield loss due to biotic and abiotic *** also face the challenge of efficiently applying new transformative biotechnology tools such as gene editing and breeding by genome design to increase rapeseed productivity and *** this Perspective,we review advances in research on the physiological and genetic bases of both stress factorsaffected yield stability and seed yield potential,focusing on source–sink relationships and allocation of photosynthetic assimilates to vegetative growth and seed *** propose research directions and highlight the role of plant architecture in the relative contributions of the root system,leaves,and pods to seed *** call for de novo design of new rapeseed *** review trait variation in existing germplasm and biotechnologies available for crop ***,we discuss opportunities to apply fundamental knowledge and key germplasm to rapeseed production and propose an ideotype for de novo design of future rapeseed cultivars.

关键词： Oilseed rape Seed yield Stress tolerance Physiological basis Ideotype Gene editing Breeding by genome design

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Mapping loci controlling fatty acid profiles, oil and protein content by genome-wide association study in Brassica napus

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The Crop Journal 2019年第2期7卷 217-226页

作者： Minqiang Tang Yuanyuan Zhang Yueying liu Chaobo Tong Xiaohui Cheng Wei Zhu Zaiyun Li Junyan Huang shengyi liu The Key Laboratory of Biology and Genetic Improvement of Oil Crops The Ministry of Agriculture Oil Crops Research Institute of Chinese Academy of Agricultural Sciences National Key Laboratory of Crop Genetic Improvement National Center of Crop Molecular Breeding Technology National Center of Oil Crop Improvement (Wuhan) Huazhong Agricultural University Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources Faculty of Life Science Hubei University

Optimizing the profile and quantity of fatty acids in rapeseed(Brassica napus L.) is critical for maximizing the value of edible oil and biodiesel. However, selection of these complex seed quality traits is difficult before haplotypes controlling their contents are identified. To efficiently identify genetic loci influencing these traits and underlying candidate genes and networks, we performed a genome-wide association study(GWAS) of eight seed quality traits(oil and protein content, palmitic, stearic, oleic, linoleic, eicosenoic and erucic acids content). The GWAS population comprised 370 diverse accessions, which were phenotyped in five environments and genotyped using 60K SNP arrays. The results indicated that oil and protein contents generally showed negative correlations, while fatty acid contents showed positive or negative correlations,with palmitic and erucic acid contents directly affecting oil content. Seven SNPs on five chromosomes were associated with both seed oil and protein content, and five genes orthologous to genes in Arabidopsis thaliana were predicted as candidates. From resequencing data, besides known haplotypes in Bna ***1.a and Bna ***1.a, three accessions harboring a new haplotype conferring moderate erucic acid content were identified. Interestingly, in a haplotype block, one haplotype was associated with high palmitic acid content and low oil content, while the others showed the reverse effects. This finding was consistent with a negative correlation between palmitic acid and oil contents, suggesting historical selection for high oil content. The identification by this study of genetic variation and complex correlations of eight seed quality traits may be beneficial for crop selection strategies.

关键词： Brassica napus Oil content Fatty acid profiles Association study Haplotypes

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Pollen-mediated gene flow in Chinese commercial fields of glufosinate-resistant canola (Brassica napus)

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Chinese Science Bulletin 2008年第15期53卷 2333-2341页

作者： CAI Li ZHOU BiWen GUO XueLan DONG CaiHua HU XiaoJia HOU MingSheng liu shengyi Department of Plant Science and Technology Huazhong Agricultural University Wuhan 430070 China Key Lab of Genetic Improvement for Oil Crops of the Ministry of Agriculture Oil Crops Research Institute Chinese Academy ofAgricultural Sciences Wuhan 430062 China

One of the most pressing issues surrounding transgenic oilseed rape cultivation is the potential impact of GM genes entering neighboring non-GM oilseed rape plants, related weeds or closely related wild relatives. Following the principle of a case-by-case for transgenic crop safety assessment, we designed experiments to study pollen-mediated gene flow from herbicide-resistant transgenic oilseed rape to Chinese commercial varieties. The pollen dispersal was detected as the progeny of recipient plants that were identified as glufosinate resistant. The results indicated that pollen dispersal occurred up to 2000 m and its rate sharply decreased as the distance from the pollen source increased. However, the rate of long-distance pollen dispersal from 33 to 2000 m was less than 0.015% and did not present a gradual decrease, indicating the randomization of dispersal and pollination. Most pollen dispersed within a 4.5 m area around the transgenic pollen source plot, with a maximum of 1.19% at the sampling site of 1.4 m. Wind direction significantly affected the direction and the distance of pollen dispersal, resulting in the more and farther dispersal in southwest direction. However, the number of potentially pollinating bees was not correlated with direction and distance from the pollen source plot, suggesting that bee density and distribution would not contribute to the differences in pollen dispersal among different directions. This paper is the first report on research in a large-scale experiment of pollen-mediated gene flow un-der the China’s environmental conditions and provided scientific evidence for the effective commer-cialization of transgenic oilseed rape and its safe management. Our results also provided important data on pollen spatial distribution pattern.

关键词：芥花籽油除草剂抗体花粉扩散生物安全性

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Syntenic quantitative trait loci and genomic divergence for Sclerotinia resistance and ?owering time in Brassica napus

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Journal of Integrative Plant Biology 2019年第1期61卷 75-88页

作者： Fengqi Zhang Junyan Huang Minqiang Tang Xiaohui Cheng Yueying liu Chaobo Tong Jingyin Yu Tehrim Sadia Caihua Dong Lingyan liu Baojun Tang Jianguo Chen shengyi liu Key Laboratory of Biology and Genetic Improvement of Oil Crops the Ministry of AgricultureOil Crops Research Institute of CAAS Cereal Crops Research Institute Henan Academy of Agricultural Sciences Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources Faculty of Life ScienceHubei University

Oilseed rape(Brassica napus) is an allotetraploid with two subgenomes descended from a common ancestor. Accordingly, its genome contains syntenic regions with many duplicate genes, some of which may have retained their original functions, whereas others may have diverged. Here, we mapped quantitative trait loci(QTL) for stem rot resistance(SRR), a disease caused by the fungus Sclerotinia sclerotiorum, and flowering time(FT) in a recombinant inbred line population. The population was genotyped using *** 60 K single nucleotide polymorphism arrays and phenotyped in six(FT) and nine(SSR) experimental conditions or environments. In total, we detected 30 SRR QTL and 22 FT QTL and show that some of the major QTL associated with these two traits were co-localized,suggesting a genetic linkage between them. Two SRR QTL on chromosome A2 and two on chromosome C2 were shown to be syntenic, suggesting the functional conservation of these regions. We used the syntenic properties of the genomic regions to exclude genes for selection candidates responsible for QTL-associated traits. For example, 152 of the 185 genes could be excluded from a syntenic A2–C2 region. These findings will help to elucidate polyploid genomics in future studies, in addition to providing useful information for B. napus breeding programs.

关键词： napus Oilseed rape

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Mutation of the PHYTOENE DESATURASE 3 gene causes yellowish-white petals in Brassica napus

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The Crop Journal 2021年第5期9卷 1124-1134页

作者： Chuanji Zhao Luqman Bin Safdar Meili Xie Meijuan Shi Zhixue Dong Li Yang Xiaohui Cheng Yueying liu Zetao Bai Yang Xiang Chaobo Tong Junyan Huang Lijiang liu shengyi liu Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences/The Key Laboratory of Biology and Genetic Improvement of Oil Crops The Ministry of Agriculture and Rural AffairsWuhan 430062HubeiChina National Key Laboratory of Crop Genetic Improvement National Center of Rapeseed ImprovementHuazhong Agricultural UniversityWuhan 430070HubeiChina Biosystematics Group Experimental Plant SciencesWageningen University and ResearchWageningenNetherlands Guizhou Rapeseed Institute Guizhou Academy of Agricultural SciencesGuiyang 550008GuizhouChina

Oilseed rape (Brassica napus) with yellow flowers is an attractive ornamental landscape plant during the flowering period,and the development of different petal colors has become a breeding *** yellowish flower color is a common variant observed in field-grown oilseed rape,the genetics behind this variation remains *** obtained a yellowish-white flower (ywf) mutant from Zhongshuang 9 (ZS9) by ethyl methanesulfonate mutagenesis (EMS) *** with ZS9,ywf exhibited a lower carotenoid content with a reduced and defective chromoplast ultrastructure in the *** analysis revealed that the yellowish-white trait was controlled by a single recessive *** bulked-segregant analysis sequencing (BSA-seq) and kompetitive allele-specific PCR(KASP),we performed map-based cloning of the ywf locus on chromosome A08 and found that ywf harbored a C-to-T substitution in the coding region,resulting in a premature translation ***,encoding phytoene desaturase 3 (PDS3),was highly expressed in oilseed rape petals and involved in carotenoid *** enrichment analysis of the transcriptome profiles from ZS9 and ywf indicated the carotenoid biosynthesis pathway to be highly *** analyses of differentially expressed genes and carotenoid components revealed that the truncated Bna ***3 resulted in decreased carotenoid biosynthesis in the *** results contribute to an understanding of the carotenoid biosynthesis pathway and manipulation of flower-color variation in ***.

关键词： Yellowish-white flower BSA-seq RNA-seq BnaA08.PDS3 Carotenoid biosynthesis

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一种高精度低噪声低压差线性稳压器电路

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微处理机 2024年第4期45卷 21-24页

作者：张荠王莉刘盛意张锡来卢展鹏陈丽媛大连东软信息学院智能与电子工程学院辽宁大连116023

在现有产品基础上加以改进,设计一种高精度低噪声低压差线性稳压器电路。设计采用折叠式共源共栅结构放大器来降低噪声,提高增益;使用PMOS管代替过热保护电路中的电阻,降低功耗,同时采用栅极驱动结构以及电流控制方式实现开关管导通与... 详细信息

在现有产品基础上加以改进,设计一种高精度低噪声低压差线性稳压器电路。设计采用折叠式共源共栅结构放大器来降低噪声,提高增益;使用PMOS管代替过热保护电路中的电阻,降低功耗,同时采用栅极驱动结构以及电流控制方式实现开关管导通与关断。基于TSMC 0.35μm B iCMOS工艺结合Cadence软件进行设计、版图绘制和前、后仿真,在后仿真中得出相关参数值。对各参数做出详细分析,并对不同频率下的电源电压抑制比进行了对比。实验结果表明本设计达到了高精度低功耗的设计目标。

关键词：低压差线性稳压器放大器过热保护电源电压抑制比

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