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Deciphering the mechanism of liu Wei di Huang Wan in treating premature ovarian failure:a comprehensive exploration through network pharmacology and molecular docking analysis

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Journal of Chinese Pharmaceutical Sciences 2024年第9期33卷 805-818页

作者： Ping Shang Lin liu Yi Fang Chongqing Health Center for Women and Children Women and Children's Hospital of Chongqing Medical UniversityChongqing 401147China

Premature ovarian failure(POF)is a prevalent gynecological disorder with significant implications for the physical and mental well-being of affected *** Wei di Huang Wan(LWDHW),a Chinese herbal compound,has demonstrated efficacy in alleviating the effects of ***,the underlying mechanism of action of LWDHW remains *** study aimed to elucidate the potential molecular mechanism of LWDHW in treating POF using network pharmacology and molecular docking *** active ingredients of LWDHW were initially screened through the TCMSP *** the same time,the relevant target genes associated with POF were identified using databases such as disgenet,TTD,Drugbank,Gene Cards,OMIM,and Pharm *** analysis was conducted using the R language,Cytoscape,and STRING to construct and analyze the traditional Chinese medicine(TCM)regulatory network and protein-protein interaction(PPI)network ***,GO and KEGG enrichment analyses were performed using the R ***,molecular docking was carried out between the protein receptors of the core genes and the corresponding small-molecule *** study revealed 49 components and 189 predicted targets(after de-duplication)of LWDHW,along with 4524 targets(after de-duplication)associated with *** comparative analysis,163 potential genes were identified as common targets of LWDHW and POF,participating in biological processes such as response to chemical substances,molecular function regulation,and signaling receptor *** biological pathways implicated included the MAPK signaling pathway,IL-17 signaling pathway,and HIF-1 signaling pathway,among *** docking results demonstrated a robust binding ability between the core genes of LWDHW and their corresponding *** conclusion,this comprehensive analysis provided insights into the potential molecular mechanisms of LWDHW in treating *** identified common targets and associated pathways contributed to

关键词： Network pharmacology liu Wei di Huang Wan Premature ovarian failure Molecular docking

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法压式冲泡对海南罗布斯塔咖啡感官品质的影响

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食品科学 2025年第1期46卷 108-120页

作者：刘迪劳菲董文江于鑫欣中国农业大学食品科学与营养工程学院国家果蔬加工工程技术研究中心农业农村部果蔬加工重点实验室北京市食品非热加工重点实验室北京100083 中国热带农业科学院香料饮料研究所海南万宁571533 海南省特色热带作物适宜性加工与品质控制重点实验室国家重要热带作物工程技术研究中心海南万宁571533

以中度烘焙海南罗布斯塔咖啡为研究对象,制备可溶性固形物质量分数为2%的法压式咖啡,采用喜好度评价对4种冲泡参数进行单因素和响应面试验优化,通过感官定量描述分析结合气相色谱-质谱联用法、超高效液相色谱法挖掘咖啡喜好度与其感官... 详细信息

以中度烘焙海南罗布斯塔咖啡为研究对象,制备可溶性固形物质量分数为2%的法压式咖啡,采用喜好度评价对4种冲泡参数进行单因素和响应面试验优化,通过感官定量描述分析结合气相色谱-质谱联用法、超高效液相色谱法挖掘咖啡喜好度与其感官特性及风味物质之间的相关性信息。结果表明,咖啡萃取质量浓度会随着咖啡粒径减小、粉水比增加、冲泡水温升高或冲泡时间延长而显著增大(P<0.05)。咖啡喜好度(0~6分,七点法)在粉水比1∶5(m/m)、研磨度8、冲泡水温92℃、冲泡6min时达到最高(3.3±1.6)。咖啡中共检测出78种挥发性成分,通过气味活性值分析得大马士酮、3-乙基-2,5-甲基吡嗪等关键香气化合物10种。Pearson相关性分析表明,喜好度与咖啡的圆润感、巧克力香属性呈正相关,与咖啡因、具有丁香味和酚味的4-乙基愈创木酚、4-乙烯基愈创木酚及具有粪臭味的3-甲基吲哚呈负相关。本研究能为挖掘海南罗布斯塔咖啡的风味喜好及其物质基础提供一定理论依据。

关键词：罗布斯塔咖啡冲泡参数感官定量描述分析气相色谱-质谱联用 Pearson相关性

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Atomic design of carbon-based dual-metal site catalysts for energy applications

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Nano Research 2023年第5期16卷 6477-6506页

作者： Huishan Shang di liu School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Department of Chemistry Tsinghua UniversityBeijing 100084China

Carbon-based dual-metal sites catalysts(DMSCs)have emerged as a new frontier in the field of sustainable energy due to their unique coordination environments,electronic structure,the maximized atom *** reasonable utilization of carbonbased DMSCs provides new possibilities to achieve the outstanding catalytic performance,remarkable selectivity,recyclability in energy-related *** on this,this review intends to summarize the recent breakthroughs in carbonbased DMSCs for the energy ***,the definition and classifications of DMSCs are proposed,mainly dividing into three types(isolated dual-metal site pairs,binuclear homologous dual-metal sites pairs,binuclear heterologous dual-metal sites pairs).Subsequently,we discuss the potential of DMSCs targeting on energy conversion reactions,such as electrocatalytic hydrogen evolution reaction(HER),oxygen evolution reaction(OER),oxygen reduction reaction(ORR),CO_(2)reduction reaction(CO_(2)RR),N_(2) reduction reaction(NRR).Finally,we predict the remaining challenges and possible opportunities on the unique carbon-based DMSCs for energy applications in the future.

关键词： dual-metal site catalysts carbon atomic design energy applications

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Strong convergence rate of principle of averaging for jump-diffusion processes

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Frontiers of Mathematics in China 2012年第2期7卷 305-320页

作者： di liu Department of Mathematics Michigan State University East Lansing MI 48824 USA

We study jump-diffusion processes with two well-separated time scales. It is proved that the rate of strong convergence to the averaged effective dynamics is of order O（ε1/2）, where s 〈〈 1 is the parameter measuring the disparity of the time scales in the system. The convergence rate is shown to be optimal through examples. The result sheds light on the designing of efficient numerical methods for multiscale stochastic ,dynamics.

关键词： Stochastic differential equation time scale separation averaging ofperturbations

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A novel optimal data fusion algorithm and its application for the integrated navigation system of missile

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Chinese Journal of Aeronautics 2022年第5期35卷 53-68页

作者： di liu Xiyuan CHEN Xiao liu Key Laboratory of Micro-Inertial Instrument and Advanced Navigation Technology Ministry of Education School of Instrument Science and EngineeringSoutheast UniversityNanjing 210096China School of Electronic and Information Engineering(Department of Physics) Qilu University of TechnologyJinan 250353China

For Inertial Navigation System(INS)/Celestial Navigation System(CNS)/Global Navigation Satellite System(GNSS)integrated navigation system of the missile,the performance of data fusion algorithms based on the Cubature Kalman Filter(CKF)is seriously degraded when there are non-Gaussian noise and process-modeling errors in the system ***,a novel method is proposed,which is called Optimal Data Fusion algorithm based on the Adaptive Fading maximum Correntropy generalized high-degree CKF(AFCCKF-ODF).First,the Adaptive Fading maximum Correntropy generalized high-degree CKF(AFCCKF)is proposed and used as the local filter for the INS/GNSS and INS/CNS subsystems to improve the robustness of local state ***,the local state estimation is fused based on the minimum variance principle and highdegree cubature criterion to get the globally optimal ***,the experimental results verify that the proposed algorithm can significantly improve the robustness of the missile-borne INS/CNS/GNSS integrated navigation system to non-Gaussian noise and process modeling error and obtain the global optimal navigation information.

关键词： Data fusion High-degree cubature Kalman filter Integrated navigation Non-Gaussian noise Process-modeling error

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Hubbard model on an anisotropic checkerboard lattice at finite temperatures: Magnetic and metal–insulator transitions

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Chinese Physics B 2019年第10期28卷 498-503页

作者： Hai-di liu State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of Sciences

We study magnetic and Mott transitions of the Hubbard model on the geometrically frustrated anisotropic checkerboard lattice at half filling using cellular dynamical mean-field theory. Phase diagrams over a wide area of the parameter space are obtained by varying the interparticle interaction strength, geometric frustration strength, and temperature. Our results show that frustration and thermal fluctuations play a competing role against the interactions and in general favor a metallic phase without antiferromagnetic order. Due to their interplay, the system exhibits competition between antiferromagnetic insulator, antiferromagnetic metal, paramagnetic insulator, and paramagnetic metal phases in the intermediateinteraction regime. In the strong-interaction limit, which reduces to the Heisenberg model, our result is consistent with previous studies.

关键词： geometrical frustration checkerboard lattice Hubbard model

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Stochastic Simulation of the Cell Cycle Model for Budding Yeast

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Communications in Computational Physics 2011年第2期9卷 390-405页

作者： di liu Department of Mathematics Michigan State UniversityEast LansingMI 48824USA

We use the recently proposed Nested Stochastic Simulation Algorithm(Nested SSA)to simulate the cell cycle model for budding *** results show that Nested SSA is able to significantly reduce the computational cost while... 详细信息

关键词： Stochastic simulation algorithm stochastic process bio-chemical reacting network system biology

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Thermoelectric coolers:Infinite potentials for finite localized microchip cooling

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Journal of Materials Science & Technology 2022年第26期121卷 256-262页

作者： Zhi-Gang Chen Wei-di liu School of Chemistry and Physics Queensland University of TechnologyBrisbaneQLD 4001Australia Australian Institute of Biotechnology and Nanotechnology the University of QueenslandSt LuciaQLD 4072Australia

With the ever-growing semiconductor and microchip industries,increasing amount and categories of personal electronics have flooded into our daily *** is the key challenge limiting further performance enhancement of the high-speed microchips in *** cooling,a solid-state active cooling method,possesses great potential for localized cooling with the advantages of noise-free,vibration-free,maintenance-free,and liquid-media-free,and can solve the challenge in *** proper material engineering,such as carrier concentration,band engineering,hierarchical architecture engineering,high performance thermoelectric materials with high potential for thermoelectric cooling have been widely *** further proper device design based on state-of-art thermoelectric materials,such as vertical thin film thermoelectric device design,contact interface engineering and thermoelectric and microchip integration,thermoelectric coolers show infinite potentials for finite cooling requirement of microchips.

关键词： Microchip Cooling Thermoelectric Application

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Synthesis, characterization and hydrodesulfurization activity of silica-dispersed NiMoW trimetallic catalysts

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Journal of Natural Gas Chemistry 2010年第5期19卷 530-533页

作者： di liu Lihua liu Guangci Li Chenguang liu State Key Laboratory of Heavy Oil Processing Key Laboratory of Catalysis CNPC China University of Petroleum Qingdao 266555 Shandong China

Silica-dispersed NiMoW trimetallic hydrodesulfurization catalysts were prepared by deposition-precipitation method. For comparative pur- poses, bulk NiMoW trimetallic catalysts were obtained by co-precipitation. Silica was employed to disperse active metals for full utilization of active components and silica-dispersed NiMoW catalyst had high active metal content. BET analysis showed that silica-dispersed NiMoW trimetallic catalysts had a high surface area （165.1 m2/g） and pore volume （0.27 ml/g）. Transmission electron microscopy results proved that active components were well dispersed. Hydrodesulfurization activity of silica-dispersed NiMoW catalysts was much higher than that of comparative catalysts and up to twice greater than those of commercial NiMo alumina-supported systems per gram of catalyst.

关键词： hydrodesulfurization NiMoW SiO2 gel surface area

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Deep Hydrodesulfurization of diesel Fuel over diatomite-dispersed NiMoW Sulfide Catalyst

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China Petroleum Processing & Petrochemical Technology 2013年第4期15卷 38-43页

作者： liu di liu Chenguang College of Chemical and Environmental Engineering Shandong University of Science and Technology State Key Laboratory of Heavy Oil Processing Key Laboratory of Catalysis CNPC China University of Petroleum

diatomite-dispersed NiMoW catalyst was prepared and characterized,and the activity of catalyst samples was tested during the HDS reaction of FCC *** compounds in the feedstock and the hydrogenated products obtained over different catalysts were determined by *** test results showed that the diatomite-dispersed NiMoW catalyst had high hydrodesulfurization activity for FCC diesel,which could be contributed to the excellent hydrogenation performance of the said *** of catalyst by TEM and XRD indicated that the diatomite-dispersed NiMoW catalyst possessed higher layer stacking,larger curvature of MoS2or WS2,and segregated Ni3S2crystals relative to the supported *** kind of structure leads to high hydrogenation activity of the diatomite-dispersed NiMoW catalyst.

关键词： NiMoW catalyst diatomite hydrodesulfurization FCC diesel GC-PFPD

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