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Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1

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Chinese Journal of Integrative Medicine 2024年第6期30卷 534-542页

作者： li jie CHEN Ya-feng GAO Lei li yi-jie FENG Dian-xu Department of General Surgery Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China

Objective To investigate the effect of honokiol(HON)and the role of high-mobility group protein B1(HMGB1)on the pathogenesis of severe acute pancreatitis(SAP).Methods Thirty mice were numbered according to weight,and randomly divided into 5 groups using a random number table,including control,SAP,SAP and normal saline(SAP+NS),SAP and ethyl pyruvate(SAP+EP),or SAP+HON groups,6 mice in each *** of pancreas,intestine,and blood were collected 12 h after SAP model induction for examination of pathologic changes,immune function alterations by enzyme linked immunosorbent assay(EliSA),and Western *** vitro experiments,macrophages were divided into 5 groups,the control,lipopolysaccharide(LPS),LPS+DMSO(DMSO),LPS+anti-HMGB1 monoclonal antibody(mAb),and LPS+HON *** tight connection level was determined by transmission electron microscopy and fluorescein *** location and acetylation of HMGB1 were measured by Western ***,pyridone 6 and silencing signal transducer and activator of the transcription 1(siSTAT1)combined with honokiol were added to determine whether the Janus kinase(JAK)/STAT1 participated in the regulation of honokiol on *** protein expression levels of HMGB1,JAK,and STAT1 were detected using Western *** Mice with SAP had inflammatory injury in the pancreas,bleeding of intestinal tissues,and cells with disrupted *** in the SAP+HON group had significantly fewer pathological *** with SAP also had significant increases in the serum levels of amylase,lipase,HMGB1,tumor necrosis factor-α,interleukin-6,diamine oxidase,endotoxin-1,and *** in the SAP+HON group did not show these abnormalities(Plity,decreased the levels of junctional adhesion molecule C,and elevated intercellular permeability(P<0.01).HON treatment blocked these *** of

关键词： severe acute pancreatitis intestinal barrier dysfunction honokiol high-mobility group protein B1 Januskinase signal transducerand activatorof transcription1

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英美土壤污染生态风险评估技术体系研究及启示

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生态与农村环境学报 2024年第1期40卷 1-10页

作者：李奕杰许秋云柯玲杰史雅娟邵秀清生态环境部对外合作与交流中心北京100035 中国科学院生态环境研究中心北京100089 中国科学院大学北京100049

随着经济的发展,人为活动产生的大量有害物质进入土壤,造成了严重的土壤污染问题。生态风险评估是预测风险源对生态系统产生风险的方法体系,其作为污染土壤生态风险管控及修复治理的重要依据,决定着是否需要采取风险管控和修复治理措施... 详细信息

随着经济的发展,人为活动产生的大量有害物质进入土壤,造成了严重的土壤污染问题。生态风险评估是预测风险源对生态系统产生风险的方法体系,其作为污染土壤生态风险管控及修复治理的重要依据,决定着是否需要采取风险管控和修复治理措施及目标。由于研究的侧重角度不同,出现了诸多生态风险评估技术体系。英美两国拥有多年的污染地块管理经验,生态风险评估相关技术导则完善、法规健全且配套技术成熟,借鉴其经验有助于管理者从生态系统角度更加科学地分析土壤污染对环境的影响。通过对我国土壤污染生态风险评估现状的分析,以及对美国超级基金生态风险评估技术体系和英国土壤污染生态风险评估技术体系的讨论,得出我国在构建本土化的土壤污染生态风险评估技术体系时需要注意的关键点:(1)构建层次化的生态风险评估技术体系;(2)开发从污染物暴露到产生生态效应整个过程的污染地块生态风险评估概念模型;(3)加强污染物与生态受体所受影响之间的因果关系分析;(4)提高生态风险评估过程的决策参与;(5)推动本土物种的毒理学研究。该文旨在推动我国土壤污染生态风险评估技术体系的构建,保障评估过程的顺利实施及后续污染土壤风险管控或修复治理工作的开展,促进土壤资源可持续安全利用。

关键词：土壤污染生态风险评估层次化技术体系因果关系决策概念模型

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HPV-16 E6E7抗原表位嵌合体DNA疫苗黏膜免疫抑制宫颈癌的效果研究

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临床和实验医学杂志 2024年第7期23卷 673-678页

作者：李雨桐李新苹李轶杰新疆大学生命科学与技术学院新疆生物资源基因工程省部建重点实验室新疆乌鲁木齐830017

目的评价泛素及热休克蛋白70(HSP 70)C融合人乳头瘤病毒(HPV)16型E6E7表位嵌合体DNA疫苗鼻内黏膜免疫对宫颈癌移植瘤的预防和治疗效果。方法建立TC-1小鼠肿瘤模型,以壳聚糖为发送载体,通过滴鼻免疫给药免疫C57BL/6小鼠。MTT法和淋巴毒... 详细信息

目的评价泛素及热休克蛋白70(HSP 70)C融合人乳头瘤病毒(HPV)16型E6E7表位嵌合体DNA疫苗鼻内黏膜免疫对宫颈癌移植瘤的预防和治疗效果。方法建立TC-1小鼠肿瘤模型,以壳聚糖为发送载体,通过滴鼻免疫给药免疫C57BL/6小鼠。MTT法和淋巴毒性T细胞(CTL)反应检测小鼠脾脏T淋巴细胞增殖、流式细胞术检测细胞因子表达水平、肿瘤生长曲线和荷瘤小鼠存活时间评价壳聚糖包裹的HPV-16 E6E7嵌合体DNA疫苗鼻内黏膜免疫后对HPV-16型相关宫颈癌移植瘤的预防和治疗效果。结果与对照组pcD-UH相比,实验组pcD-UE和pcD-UEH均具有显著的CTL反应,延缓HPV-16型相关宫颈癌移植瘤生长,但对已生成肿瘤无影响。鼻内黏膜途径发送壳聚糖包裹HPV-16 E6E7抗原表位嵌合体DNA疫苗仅能产生较弱的细胞免疫应答。结论 HPV-16 E6E7抗原表位嵌合体DNA疫苗通过鼻腔免疫,具有一定的肿瘤治疗和显著的肿瘤预防效果,为新型HPV疫苗的研制奠定了基础。

关键词：人乳头瘤病毒16 DNA疫苗鼻黏膜抗原表位多肽表位

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定量分析抗VEGF药物联合激光光凝术治疗视网膜分支静脉阻塞前后视网膜血管的变化

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医学信息 2024年第15期37卷 95-98页

作者：李义杰段永刚殷俏江西医学高等专科学校第一附属医院眼科

目的分析抗VEGF药物联合激光光凝术治疗视网膜分支静脉阻塞前后视网膜血管的变化。方法选取2021年3月-2023年1月我院诊治的70例视网膜分支静脉阻塞患者作为观察组，另选取同期我院体检健康者70名作为对照组，观察组采用抗VEGF药物联... 详细信息

目的分析抗VEGF药物联合激光光凝术治疗视网膜分支静脉阻塞前后视网膜血管的变化。方法选取2021年3月-2023年1月我院诊治的70例视网膜分支静脉阻塞患者作为观察组，另选取同期我院体检健康者70名作为对照组，观察组采用抗VEGF药物联合激光治疗，比较两组视网膜动脉和静脉血管指标[血管壁厚度(WT)、血管壁截面面积(WCSA)、壁腔比(WLR)]；并分析观察组治疗前后视网膜静脉血管指标(WT、WCSA、WLR)、最佳矫正视力(BCVA)、中心视网膜厚度(CRT)及并发症发生率。结果观察组视网膜动脉WT、WCSA、WLR与对照组比较，差异无统计学意义(P>0.05)，而观察组视网膜静脉WT、WCSA、WLR均大于对照组(P<0.05)；观察组治疗3个月后WT、WCSA、WLR及CRT均小于治疗前，BCVA大于治疗前(P<0.05)；且观察组患者均无眼内炎、玻璃体积血、视网膜脱离等严重并发症，仅出现轻度结膜下出血，未进行干预后自行吸收；眼压升高患者给予针对性干预后均恢复正常。结论视网膜分支静脉阻塞患者视网膜血管管径狭窄，血管壁增厚，临床可将WT、WCSA、WLR指标作为预测视网膜分支静脉阻塞的重要参数指标，且抗VEGF药物联合激光光凝术治疗视网膜分支静脉阻塞的效果良好，可促进视网膜血管指标恢复。

关键词：抗VEGF药物激光光凝术视网膜分支静脉阻塞中心视网膜厚度

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Effect of the O2/Ar Pressure Ratio on the Microstructure and Surface Morphology of Epi-MgO/IBAD-MgO Templates for GdBa2Cu3O7？δ Coated Conductors

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Chinese Physics Letters 2014年第3期31卷 160-163页

作者： LUO Qiang liU lin-Fei XIAO Gui-Na li yi-jie Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai 200240

High-quality epi-MgO buffer layers under different O2/Ar pressure ratios are fabricated by rf magnetron sputtering on textured IBAD-MgO templates. Under the total deposition pressure remaining constant （14 Pa）, the effect of changing the ratio of O2/Ar pressure from 1：4 to 3：2 on the microstructure and surface morphology of epi-MgO films is studied. The microstructure and morphology of epi-MgO are fully characterized by x-ray diffraction, atom force microscope and scanning electron microscope. The best texture quality of epi-MgO with an out-plane Δω value of 1.8° and an in-plane Δ？ value of 5.22° are obtained under the ratio of O2/Ar pressure 3：2. Further, the surface morphology indicates that the surface of epi-MgO is smooth with rms surface roughness about 4.7 nm at O2/Ar pressure ratio 3：2. After that, GdBa2Cu3O7？δ （GBCO） layers are deposited on the CeO2 cap layer buffered epi-MgO/IBAD-MgO templates to assess the efficiency of such a buffer layer stack. The critical current density of GBCO films （thickness of 200 nm） is higher than 3 MA/cm2, indicating that epi-MgO/IBAD-MgO is promising for depositing superconducting layers with a higher critical current density.

关键词： MAGNETRON sputtering RESEARCH SURFACE morphology MICROSTRUCTURE THICK films PHYSICS research

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植保无人机在柑橘生产上的应用

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南方园艺 2024年第4期35卷 56-60页

作者：韩旸李怡杰雷翠云娄兵海广西桂北特色经济作物种质创新与利用重点实验室/广西柑橘育种与栽培技术创新中心/广西特色作物研究院广西桂林541010

植保无人机作为现代农业的重要技术装备在农业领域的应用越来越广泛,在柑橘产业中的应用也日趋成熟。本文综述了植保无人机的组成和优势以及其在柑橘产业上的应用,并阐述了现阶段存在的问题及发展趋势,以期为柑橘产业的可持续发展提供... 详细信息

植保无人机作为现代农业的重要技术装备在农业领域的应用越来越广泛,在柑橘产业中的应用也日趋成熟。本文综述了植保无人机的组成和优势以及其在柑橘产业上的应用,并阐述了现阶段存在的问题及发展趋势,以期为柑橘产业的可持续发展提供有益的参考。

关键词：植保无人机柑橘病虫害人工智能

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Reposition of coronary sinus lead dislocation only using pre-shaped stylet and guidewire： a case report

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Chinese Medical Journal 2011年第6期124卷 954-955页

作者： yi Fu SHEN Min WU Feng WANG Hai-chang GUO Wen-yi li Wei-jie liU Bing Department of Cardiovascular Medicine Xijing Hospital Fourth Military Medical University Xi'an Shaanxi 710032 China

Technologies associated with cardiac resynchronization therapy （CRT） devices and lead systems have ***, dislocation after coronary sinus （CS） lead placement continues to be a problem. We reported on the patient treated with CRT, in whom dislocation of CS lead occurred. In the case, we tried to reposition the CS lead without the left heart delivery system only using pre-shaped stylet and guidewire, and the dislocated CS lead could be successfully repositioned by the method. The method of only using a pre-shaped stylet and guidewire is easier than the conventional way, and it can shorten procedure duration and fluoroscopy time, as well as reduce the cost of treatment, but it is not always feasible.

关键词： cardiac resynchronization therapy coronary sinus lead dislocation reposition

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2D multifunctional devices:from material preparation to device fabrication and neuromorphic applications

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International Journal of Extreme Manufacturing 2024年第3期6卷 91-118页

作者： Zhuohui Huang Yanran li yi Zhang jiewei Chen Jun He jie Jiang Hunan Key Laboratory of Nanophotonics and Devices School of PhysicsCentral South UniversityChangshaHunanPeople’s Republic of China Department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong Special Administrative Region of ChinaPeople’s Republic of China

Neuromorphic computing systems,which mimic the operation of neurons and synapses in the human brain,are seen as an appealing next-generation computing method due to their strong and efficient computing ***-dimensional (2D) materials with dangling bond-free surfaces and atomic-level thicknesses have emerged as promising candidates for neuromorphic computing *** a result,2D neuromorphic devices may provide an ideal platform for developing multifunctional neuromorphic ***,we review the recent neuromorphic devices based on 2D material and their multifunctional *** synthesis and next micro–nano fabrication methods of 2D materials and their heterostructures are first *** recent advances of neuromorphic 2D devices are discussed in detail using different operating *** importantly,we present a review of emerging multifunctional neuromorphic applications,including neuromorphic visual,auditory,tactile,and nociceptive systems based on 2D *** the end,we discuss the problems and methods for 2D neuromorphic device developments in the *** paper will give insights into designing 2D neuromorphic devices and applying them to the future neuromorphic systems.

关键词： 2D material micro–nano fabrication multifunctional system neuromorphic electronics artificial intelligence

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Hybrid Analytical and Data-Driven Model Based Instance-Transfer Method for Power System Online Transient Stability Assessment

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1664-1675页

作者： Feng li Qi Wang yi Tang Yan Xu jie Dang School of Electrical Engineering Southeast UniversityNanjing 210000China Center for Power Engineering(CPE) School of Electrical and Electronic EngineeringNanyang Technological UniversitySingapore 639798Singapore Central China Branch of State Grid Corporation of China Wuhan 430077China

Data-driven methods are widely recognized and generate conducive results for online transient stability ***,the tedious and time-consuming process of sample collection is often *** functioning of power systems involves repetitive sample collection due to the constant variations occurring in the operation mode,thereby highlighting the importance of collection *** a means to achieve high sample collection efficiency following the operation mode change,we propose a novel instance-transfer method based on compression and matching strategy,which facilitates the direct acquisition of useful previous samples,used for creating the new sample ***,we present a hybrid model to ensure rationality in the process of sample similarity comparison and selection,where features of analytical modeling with special significance are introduced into data-driven *** the same time,a data-driven method can also be integrated in the hybrid model to achieve rapid error correction of analytical models,enabling fast and accurate post-disturbance transient stability *** a paradigm,we consider a scheme for online critical clearing time estimation,where integrated extended equal area criterion and extreme learning machine are employed as analytical model part and data-driven error correction model part,*** results validate the credible efficacy of the proposed method.

关键词： Critical clearing time extreme learning machine instance-transfer method transient stability assessment

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Atomistic study on the microscopic mechanism of grain boundary embrittlement induced by small dense helium bubbles in iron

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Nuclear Science and Techniques 2024年第3期35卷 84-95页

作者： Lei Peng Yong-jie Sun Jing-yi Shi yi-Fei liu Shang-Ming Chen liu-liu li State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610213China

The helium bubbles induced by 14 MeV neutron irradiation can cause intergranular fractures in reduced activation ferritic martensitic steel,which is a candidate structural material for fusion *** order to elucidate the susceptibility of different grain boundaries(GBs)to helium-induced embrittlement,the tensile fracture processes of 10 types of GBs with and without helium bubbles in body-centered cubic(bcc)iron at the relevant service temperature of 600 K were investigated via molecular dynamics *** results indicate that in the absence of helium bubbles,the GBs studied here can be classified into two distinct categories:brittle GBs and ductile *** atomic scale analysis shows that the plastic deformation of ductile GB at high temperatures originates from complex plastic deformation mechanisms,including the Bain/Burgers path phase transition and deformation twinning,in which the Bain path phase transition is the most dominant plastic deformation ***,the presence of helium bubbles severely inhibits the plastic deformation channels of the GBs,resulting in a significant decrease in elongation at *** bubble-decorated GBs,the ultimate tensile strength increases with the increase in the misorientation ***,the coherent twin boundary∑3{112}was found to maintain relatively high fracture strength and maximum failure strain under the influence of helium bubbles.

关键词： Helium bubble Grain boundary Embrittlement Reduced activation ferritic martensitic steel Molecular dynamics Bain path

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