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Expression of gastric cancer-associated MG7 antigen in gastric cancer,precancerous lesions and ***-associated gastric diseases

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World Journal of Gastroenterology 2002年第6期8卷 1009-1013页

作者： dong-li guo Ming dong Lan Wang li-Ping Sun Yuan Yuan,Cancer Institute,First Affiliated Hospital,China Medical University,Shenyang,110001,liaoning Province,China Cancer Institute First Affiliated Hospital China Medical University Shenyang 110001 Liaoning Province China.

AIM: To investigate the relationship between the antigen MG7 antigen expression and gastric cancer as well as precancerous condition; to study the relationship between the MG7 antigen expression and H. pyloriinfection in benign gastric lesions in order to find out the effect of H. pylori infection on the process of gastric cancer ***: The level of MG7 antigen expression was determined by immunohistochemical method in 383 gastric biopsied materials. The intestinal metaplasia was determined by histochemistry method. The H. pyloriinfection was determined by HE stain, PCR and EliSA in 291 specimens, among which only 34 cases of H. pylori-associated gastric lesions were followed ***: The positive rate of MG7 expression in normal gastric mucosa, intestinal metaplasia, dysplasia and gastric cancer increased gradually in ascending order (P＜0.01). The positive rate of MG7 antigen expression in type Ⅲ intestinal metaplasia of gastric mucosa was higher than that of type Ⅰand Ⅱ intestinal metaplasia, being highly significant (P＜0.05).The positive rate of MG7 antigen expression in superficial gastritis, atrophic gastritis and gastric cancer increased gradually (11.9 %, 64.8 %, 91.2 %, P＜0.01). There was no significant difference between ***-negative and H. pyloripositive intestinal metaplasia, atrophic gastritis and dysplasia of gastric epithelium in the positive rate of MG7 antigen expression. There was no expression of MG7 antigen in H. pylori-negative superficial gastritis. The positive rate of MG7 expression in H. pylori-positive superficial gastritis was 20.5 %, and the difference between them was significant (P＜0.05). During following up, one of the three H. pylori negative cases turned positive again, and its MG7 antigen expression turned to be stronger correspondingly. 3 of 31 H. pyloripositive cases were detected as early gastric cancer, among which one with '+++' MG7 antigen expression was diminished after H. pylori ***: M

关键词：胃癌 MG7抗原基因表达癌前病变幽门螺杆菌相关胃疾病

Preparation and Supercapacitive Properties of Fe_2O_3/Active Carbon Nanocomposites

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Chemical Research in Chinese Universities 2012年第5期28卷 780-783页

作者： LUO Pei-wen YU Jian-guo SHI Zhi-qiang HUANG Hua liU Lang ZHAO Yong-nan li guo-dong ZOU Yong-cun Institute of Nanostructured Materials&Tianjin Key Laboratory of Fiber Modification and Functional Fiber School of Materials Science and EngineeringTianjin Polytechnic UniversityTianjin 300160P R.China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012P.R.China

Fe2O3/active carbon（Fe2O3/AC） nanocomposites were readily fabricated by pyrolyzing Fe3＋ impregnated active carbon in a nitrogen atmosphere. The as-prepared composites were studied by X-ray powder diffraction（XRD）, X-ray photoelectron spectroscopy（XPS） and transmission electron microscopy（TEM）. The capacitive property of the composites was investigated by cyclic voltammetry（CV） and galvanostatic charge-discharge test. Physical characterizations show that the γ-Fe2O3 fine grains dispersed in the AC well, with a mean size of 21.24 nm. Electrochemical tests in 6 mol/L KOH solutions indicate that the as-prepared nanocomposites exhibited improved capacitive properties. The specific capacitance（SC） of Fe2O3/AC nanocomposites was up to 188.4 F/g that was derived from both electrochemical double-layer capacitance and pseudo-capacitance, which was 78% larger than that of pristine AC. A symmetric capacitor with Fe2O3/AC nanocomposites as electrode showed an excellent cycling stability. The SC was only reduced by a factor of 9.2% after 2000 cycles at a current density of 1 A/g.

关键词： Nanocomposite Fe2O3 Active carbon Supercapacitor

A secretory function of human insulin-producing cells in vivo

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Hepatobiliary & Pancreatic Diseases International 2009年第3期8卷 255-260页

作者： Hu, Yan-Hua Wu, De-Quan Gao, Feng li, guo-dong Yao, Lei Zhang, Xin-Chen Harbin Med Coll Dept Gen Surg Affiliated Hosp 2 Harbin 150086 Peoples R China

BACKGROUND: Mesenchymal stem cells derived from human umbilical cord blood (UCB-MSCs) have good research and application prospects in the treatment of diabetes. We once induced UCB-MSCs to differentiate into insulin-producing cells (IPCs) in vitro, but we did not know the functions of these cells in vivo. The aim of this study was to assess the functional effects of IPCs on insulin secretion and their role in the treatment of diabetes in vivo. METHODS: UCB-MSCs were induced to IPCs by an inducing protocol with extracellular matrix gel. BALB/C nude mice were made hyperglycemic by intraperitoneal injection of streptozotocin. The diabetic mice were transplanted with 1x10(7) IPCs under the renal capsule or with phosphate-buffered saline as a control. After transplantation, the grafts were analyzed by immunocytochemistry for the expression of human insulin; the serum human insulin levels were measured; and blood glucose and body weight status were monitored. RESULTS: Immunofluorescence showed that numerous IPCs under the kidney capsule were insulin-positive. On day 14 after transplantation, the serum human insulin level of the treatment group (n=9) averaged 0.44 +/- 0.12 mU/L, which was higher than that of the control group (n=9) that did not express insulin (t=10.842, Plin in diabetic mice, but more research is needed to make further use of them to regulate hyperglycemia and body weight in vivo. (Hepatobiliary Pancreat Dis Int 2009; 8: 255-260)

关键词： human umbilical cord blood mesenchymal stem cells insulin-producing cells diabetes cell transplantation

Mapping of QTL Associated with Drought Tolerance in a Semi-Automobile Rain Shelter in Maize (Zea mays L.)

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Agricultural Sciences in China 2011年第7期10卷 987-996页

作者： ZHU Jing-jing WANG Xiao-peng SUN Cui-xia ZHU Xiu-miao li Meng ZHANG guo-dong TIAN Yan-chen WANG Ze-li National Key Laboratory of Crop Biology Ministry of Science and Technology/College of Life Sciences Shandong Agricultural University Tai＇an 271018 P.R.China

Drought is a major constraint in maize production worldwide. We studied quantitative trait loci （QTL） underlying drought tolerance for maize plants grown in two different environments. Traits investigated included ASI, plant height, grain yield, ear height, and ear setting. A genetic linkage map was constructed with 120 simple sequence repeat （SSR） markers based on an F2 population derived from a cross between D5 （resistant parent） and 7924 （susceptible parent）. Correlation and heritability were calculated. QTLs of these traits were identified by composite interval mapping combined with a linkage map covering 1 790.3 cM. The markers were arranged in ten linkage groups. QTL mapping was made of the mean trait performance of the 180 F2：3 population. The results showed five, five, six, four, and five QTLs for ASI, plant height, grain yield, ear height, and ear setting under full irrigation condition, respectively, and four, seven, six, four, and four QTLs for ASI, plant height, grain yield, ear height, and ear setting under severe late stress conditions, respectively. Especially the four QTLs detected for five traits in 2008 and 2009. The universal QTLs information generated in this study will aid in undertaking an integrated breeding strategy for further genetic studies in drought tolerance improvement in maize.

关键词： maize drought tolerance simple sequence repeat quantitative trait loci

Determination of Effective Segregation Coefficient of Oxygen in Terbium During Floating Zone Refining

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Journal of Rare Earths 2001年第2期19卷 140-141页

作者：李国栋刘永林 Dept. of Phys. Inner Mongolia Univ. Hohhot 010021 China

The effective segregation coefficient K-e of oxygen in terbium metal was deduced from a comparison of the theoretical curves with the concentration distributions found experimentally after a floating zone refining treatment. Thp result shows that K-e is equal to 1.2 which is an important parameter for floating zone refining terbium.

关键词： rare earths terbium floating zone refining effective segregation coefficient of oxygen

Shexiang Tongxin Dropping Pill Promotes Angiogenesis through VEGF/eNOS Signaling Pathway on Diabetic Coronary Microcirculation Dysfunction

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Chinese Journal of Integrative Medicine 2024年第10期30卷 886-895页

作者： CUI Xin-yu liU Tian-hua BAI Ya-li ZHANG Meng-di li guo-dong ZHANG Yu-ting YUAN Yue-ying ZHANG Ya-wen YU li-shuang HAN li-na WU Yan School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029China Key Laboratory of Traditional Chinese Medicine Syndrome and Formula Ministry of Education Beijing University of Chinese MedicineBeijing100029China Beijing Research Institute of Chinese Medicine Beijing University of Chinese MedicineBeijing100029China

Objective:To study the effect of Shexiang Tongxin Dropping Pill(STDP)on angiogenesis in diabetic cardiomyopathy mice with coronary microcirculation dysfunction(CMD).Methods:According to a random number table,6 of 36 SPF male C57BL/6 mice were randomly selected as the control group,and the remaining 30 mice were injected with streptozotocin intraperitoneally to replicate the type 1 diabetes *** successfully copied the diabetes model were randomly divided into the model group,STDP low-dose group[15 mg/(kg·d)],medium-dose group[30 mg/(kg·d)],high-dose group[60 mg/(kg·d)],and nicorandil group[15 mg/(kg·d)],6 in each *** drug was given by continuous gavage for 12 *** cardiac function of mice in each group was detected at the end of the experiment,and coronary flow reserve(CFR)was detected by chest Doppler *** changes of myocardium were observed by hematoxylin-eosin staining,collagen fiber deposition was detected by masson staining,the number of myocardial capillaries was detected by platelet endothelial cell adhesion molecule-1 staining,and the degree of myocardial hypertrophy was detected by wheat germ agglutinin *** expression of the vascular endothlial growth factor(VEGF)/endothelial nitric oxide synthase(eNOS)signaling pathway-related proteins in myocardial tissue was detected by Western ***:Compared with the model group,medium-and high-dose STDP significantly increased the left ventricular ejection fraction and left ventricular fraction shortening(Plial growth factor receptor 2,phosphoinositide 3-kinase,protein kinase B,and eNOS(P<0.05 or P<0.01).Conclusion:STDP has a definite therapeuti

关键词： Shexiang Tongxin Dropping Pill type 1 diabetes diabetic cardiomyopathy coronary microcirculation dysfunction angiogenesis

Morphological Mechanism and Experimental Verification of Self-healing of Basalt-fiber Modified Water-soaked Asphalt

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 171-186页

作者： XIAO Minmin dong Jinyong li Chunyan guo Xu REN Jianguo School of Urban Construction and Safety Engineering Shanghai Institute of TechnologyShanghai 201418China

This study investigates the mechanism of action of representative molecules of basalt fibers on the healing of water-soaked *** parameters,morphological characteristics,interfacial healing energy,and interfacial healing strength were analyzed using molecular dynamics and macroscopic tests under different time,temperature,and water conditions to evaluate the specific states and critical conditions involved in *** results indicate that basalt-fiber molecules can induce rearrangement and a combination of water-soaked asphalt at the healing *** groups with different bonding states increase the interfacial adsorption capacity of water-soaked *** interaction between basalt fiber molecules and water molecules leads to a"hoop"phenomenon,while aromatics-2 molecules exhibit a"ring band aggregation"*** former reduces the miscibility of water and asphalt molecules,while the latter causes slow diffusion of the ***,a micro-macro dual-scale comparison of interfacial healing strength was conducted at temperatures of 297.15 and 312.15 K to identify the strength transition point and critical temperature of 299.4 K during the self-healing process of basalt-fiber modified water-soaked asphalt.

关键词： water-soaked asphalt basalt-fibers self-healing properties moisture status molecular characterization

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： Mei Zhang Wenhao li Yangfei Chen Yang Jiang Xiaofei guo Han dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

Treatment of type C3 distal radius fracture resulted from high-energy injuries by volar plate in combination with external fixator

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Chinese Medical Journal 2009年第13期122卷 1517-1520页

作者： ZHANG Qiu-lin ZHU Xiao-dong li guo-dong TANG Hao li Ming WU Da-jiang Department of Orthopedics Changhal Hospital Second Military Medical University Shanghai 200433 China

Background With a type C3 distal radius fracture it is extremely difficult to maintain the reduction and to restore congruity of the articular surface because the support for the volar and dorsal bone cortex has been lost. An external fixator crossing wrist in combination with Kirschner wire （K-wire） fixation was popularly used by most studies in recent years. But loss of reduction often occurred especially in the volar sides. Methods A total of 30 cases of type C3 distal radius fracture were treated by a volar buttress plate combined with a transarticular external fixator and other techniques such as K-wire fixation and bone grafting if necessary. The postoperative volar tilt angles, ulnar inclinations, radial heights, range of motion, grip strength and complications were recorded to assess the therapeutic effects. Results Of the 30 patients, 27 patients were followed up for 12-29 （mean 18） months and all fractures healed in 8-13 weeks after surgery （mean 10 weeks）. The wrist function was excellent in 8 cases, good in 16 cases and fair in 3 cases according to the Sarmiento scoring system （modified by Stewart）. Conclusions For type C3 comminuted fracture with severe volar and dorsal instability, fixation by volar buttress plate combined with transarticular external fixator should be adopted. Dorsal instability could be further stabilized by other techniques such as Kirschner wire fixation, and bone grafting.

关键词： distal radius fracture internal fixation external fixator